Shivakumar Keerthikumar

The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology

Gail P Risbridger, Ashlee K Clark, Laura H Porter, Roxanne Toivanen, Andrew Bakshi, Natalie L Lister, David Pook, Carmel J Pezaro, Shahneen Sandhu, Shivakumar Keerthikumar, Rosalia Quezada Urban, Melissa Papargiris, Jenna Kraska, Heather B Madsen, Hong Wang, Michelle G Richards, Birunthi Niranjan, Samantha O'Dea, Linda Teng, William Wheelahan, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Preclinical testing is a crucial step in evaluating cancer therapeutics. We aimed to establish a significant resource of patient-d..

Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis

Monisha Samuel, Pamali Fonseka, Rahul Sanwlani, Lahiru Gangoda, Sing Ho Chee, Shivakumar Keerthikumar, Alex Spurling, Sai V Chitti, Damien Zanker, Ching-Seng Ang, Ishara Atukorala, Taeyoung Kang, Sanjay Shahi, Akbar L Marzan, Christina Nedeva, Claire Vennin, Morghan C Lucas, Lesley Cheng, David Herrmann, Mohashin Pathan, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

The concept that extracellular vesicles (EVs) from the diet can be absorbed by the intestinal tract of the consuming organism, be ..

Mast Cell-Derived SAMD14 Is a Novel Regulator of the Human Prostate Tumor Microenvironment

Linda KH Teng, Brooke A Pereira, Shivakumar Keerthikumar, Cheng Huang, Birunthi Niranjan, Sophie N Lee, Michelle Richards, Ralf B Schittenhelm, Luc Furic, David L Goode, Mitchell G Lawrence, Renea A Taylor, Stuart J Ellem, Gail P Risbridger, Natalie L Lister

Journal article  |  2021  |  CANCERS

Mast cells (MCs) are important cellular components of the tumor microenvironment and are significantly associated with poor patien..

Analytical validation of an error-corrected ultra-sensitive ctDNA next-generation sequencing assay

Heidi Fettke, Jason A Steen, Edmond M Kwan, Patricia Bukczynska, Shivakumar Keerthikumar, David Goode, Maria Docanto, Nicole Ng, Luciano Martelotto, Christine Hauser, Melissa C Southey, Arun A Azad, Tu Nguyen-Dumont

Journal article  |  2020  |  BIOTECHNIQUES

Plasma circulating tumor DNA (ctDNA) analysis has emerged as a minimally invasive means to perform molecular tumor typing. Here we..

CRISP3 expression drives prostate cancer invasion and progression

Marianna Volpert, Luc Furic, Jinghua Hu, Anne E O'Connor, Richard J Rebello, Shivakumar Keerthikumar, Jemma Evans, D Jo Merriner, John Pedersen, Gail P Risbridger, Peter McIntyre, Moira K O'Bryan

Journal article  |  2020  |  ENDOCRINE-RELATED CANCER

Identifying the factors stimulating prostate cancer cells migration and invasion has the potential to bring new therapeutic target..

MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer

Arcadi Cipponi, David L Goode, Justin Bedo, Mark J McCabe, Marina Pajic, David R Croucher, Alvaro Gonzalez Rajal, Simon R Junankar, Darren N Saunders, Pavel Lobachevsky, Anthony T Papenfuss, Danielle Nessem, Max Nobis, Sean C Warren, Paul Timpson, Mark Cowley, Ana C Vargas, Min R Qiu, Daniele G Generali, Shivakumar Keerthikumar, et al.

Journal article  |  2020  |  Science

In microorganisms, evolutionarily conserved mechanisms facilitate adaptation to harsh conditions through stress-induced mutagenesi..

Extracellular vesicles containing oncogenic mutant beta-catenin activate Wnt signalling pathway in the recipient cells

Hina Kalra, Lahiru Gangoda, Pamali Fonseka, Sai Chitti, Michael Liem, Shivakumar Keerthikumar, Monisha Samuel, Stephanie Boukouris, Haidar Al Saffar, Christine Collins, Christopher G Adda, Ching-Seng Ang, Suresh Mathivanan

Journal article  |  2019  |  JOURNAL OF EXTRACELLULAR VESICLES

Mutations in β-catenin, especially at the residues critical for its degradation, render it constitutively active. Here, we show th..

Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity

Mercedes Davalos-Salas, Magdalene K Montgomery, Camilla M Reehorst, Rebecca Nightingale, Irvin Ng, Holly Anderton, Sheren Al-Obaidi, Analia Lesmana, Cameron M Scott, Paul Ioannidis, Hina Kalra, Shivakumar Keerthikumar, Lars Togel, Angela Rigopoulos, Sylvia J Gong, David S Williams, Prusoth Yoganantharaja, Kim Bell-Anderson, Suresh Mathivanan, Yann Gibert, et al.

Journal article  |  2019  |  NATURE COMMUNICATIONS

Histone deacetylase 3 (Hdac3) regulates the expression of lipid metabolism genes in multiple tissues, however its role in regulati..

Single cell transcriptome analysis reveals human prostate cancer cells upregulate retinoic acid signalling in response to androgen withdrawal

Ashlee K Clark, Hieu Nim, Natalie Lister, Mitchell G Lawrence, Shivakumar Keerthikumar, David L Goode, Hong Wang, Melissa Papargiris, Andrew Ryan, Arun Azad, Mark Frydenberg, Gail P Risbridger, Renea A Taylor

Conference Proceedings  |  2019  |  Oncology Abstracts

Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling

Kening Zhao, Mark Bleackley, David Chisanga, Lahiru Gangoda, Pamali Fonseka, Michael Liem, Hina Kalra, Haidar Al Saffar, Shivakumar Keerthikumar, Ching-Seng Ang, Christopher G Adda, Lanzhou Jiang, Kuok Yap, Ivan K Poon, Peter Lock, Vincent Bulone, Marilyn Anderson, Suresh Mathivanan

Journal article  |  2019  |  COMMUNICATIONS BIOLOGY

Extracellular vesicles (EVs) are membranous vesicles that are released by cells. In this study, the role of the Endosomal Sorting ..