Jake Lacey

Epidemiological consequences of enduring strain-specific immunity requiring repeated episodes of infection

Rebecca H Chisholm, Nikki Sonenberg, Jake A Lacey, Malcolm I McDonald, Manisha Pandey, Mark R Davies, Steven YC Tong, Jodie McVernon, Nicholas Geard

Journal article  |  2020  |  PLOS COMPUTATIONAL BIOLOGY

Group A Streptococcus (GAS) skin infections are caused by a diverse array of strain types and are highly prevalent in disadvantage..

Longitudinal Analysis of Group A Streptococcus emm Types and emm Clusters in a High-Prevalence Setting: Relationship between Past and Future Infections.

Patricia Therese Campbell, Steven YC Tong, Nicholas Geard, Mark R Davies, Kate A Worthing, Jake A Lacey, Pierre R Smeesters, Michael R Batzloff, Joseph Kado, Adam WJ Jenney, Jodie Mcvernon, Andrew C Steer

Journal article  |  2020  |  The Journal of Infectious Diseases

Group A Streptococcus is a pathogen of global importance, but despite the ubiquity of group A Streptococcus infections, the relati..

Restricted Sequence Variation in Streptococcus pyogenes Penicillin Binding Proteins

Andrew Hayes, Jake A Lacey, Jacqueline M Morris, Mark R Davies, Steven YC Tong

Journal article  |  2020  |  mSphere

A recent clinical report has linked Streptococcus pyogenes β-lactam antibiotic resistance to mutation in the penicillin binding pr..

Global Trends in Proteome Remodeling of the Outer Membrane Modulate Antimicrobial Permeability in Klebsiella pneumoniae

Andrea Rocker, Jake A Lacey, Matthew J Belousoff, Jonathan J Wilkscha, Richard A Strugnell, Mark R Davies, Trevor Lithgow

Journal article  |  2020  |  mBio

In Gram-negative bacteria, the permeability of the outer membrane governs rates of antibiotic uptake and thus the efficacy of anti..

Focal duodenal necrosis in chickens: attempts to reproduce the disease experimentally and diagnostic considerations

Ana M Villegas, Lisa Stabler, Robert J Moore, Francisco A Uzal, Jake A Lacey, Charles Hofacre, Margie Lee, Naola Ferguson-Noel, Rosetta Barber, Claire-Sophie Rimet, Carmen Jerry, Woo Kyun Kim, Barquiesha Madison, Monique Franca

Journal article  |  2020  |  Journal of Veterinary Diagnostic Investigation

Focal duodenal necrosis (FDN) is an intestinal disease of egg-layer chickens characterized by multifocal necrosis of the duodenal ..

Whole Genome Sequence Analysis and Population Genomics of Group A Streptococci.

Jake A Lacey, Taylah B James, Steven YC Tong, Mark R Davies

Journal article  |  2020  |  Methods in molecular biology (Clifton, N.J.)

Whole-genome sequencing (WGS) is used to determine the genetic composition of an organism. This fast-moving field is continually e..

Scarlet fever changes its spots

Stephan Brouwer, Jake A Lacey, Yuanhai You, Mark R Davies, Mark J Walker

Journal article  |  2019  |  The Lancet Infectious Diseases

Epidemiological consequences of enduring strain-specific immunity requiring repeated episodes of infection

Rebecca Chisholm, Nikki Sonenberg, Jake Lacey, Malcolm McDonald, Manisha Pandey, Mark Davies, Steven Tong, Jodie McVernon, Nicholas Geard

Journal article  |  2019

Abstract Group A Streptococcus (GAS) skin infections are caused by a diverse array of strain types and are highly prevalent in Ind..

Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

Mark R Davies, Liam McIntyre, Ankur Mutreja, Jake A Lacey, John A Lees, Rebecca J Towers, Sebastian Duchene, Pierre R Smeesters, Hannah R Frost, David J Price, Matthew TG Holden, Sophia David, Philip M Giffard, Kate A Worthing, Anna C Seale, James A Berkley, Simon R Harris, Tania Rivera-Hernandez, Olga Berking, Amanda J Cork, et al.

Journal article  |  2019  |  Nature Genetics

Genomics of the Pathogenic Clostridia

Robert J Moore, Jake A Lacey

Journal article  |  2019  |  Microbiology Spectrum

Whole-genome sequences are now available for all the clinically important clostridia and many of the lesser or opportunistically p..