Jake Lacey

Genomic sequencing of hypervirulent Klebsiella pneumoniae with novel patterns of virulence and global epidemiological linkage.

Sadid F Khan, Jake A Lacey, Claire Gorrie, Steven YC Tong

Journal article  |  2021  |  Pathology

Global genomic epidemiology of Streptococcus pyogenes

Magnus G Jespersen, Jake A Lacey, Steven YC Tong, Mark R Davies

Journal article  |  2020  |  Infection Genetics and Evolution

Streptococcus pyogenes is one of the Top 10 human infectious disease killers worldwide causing a range of clinical manifestations ..

Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis

David MP De Oliveira, Lisa Bohlmann, Trent Conroy, Freda E-C Jen, Arun Everest-Dass, Karl A Hansford, Raghu Bolisetti, Ibrahim M El-Deeb, Brian M Forde, Phan Minh-Duy, Jake A Lacey, Aimee Tan, Tania Rivera-Hernandez, Stephan Brouwer, Nadia Keller, Timothy J Kidd, Amanda J Cork, Michelle J Bauer, Gregory M Cook, Mark R Davies, et al.

Journal article  |  2020  |  Science Translational Medicine

The emergence of polymyxin resistance in carbapenem-resistant and extended-spectrum β-lactamase (ESBL)-producing bacteria is a cri..

Epidemiological consequences of enduring strain-specific immunity requiring repeated episodes of infection

Rebecca H Chisholm, Nikki Sonenberg, Jake A Lacey, Malcolm I McDonald, Manisha Pandey, Mark R Davies, Steven YC Tong, Jodie McVernon, Nicholas Geard

Journal article  |  2020  |  PLOS COMPUTATIONAL BIOLOGY

Group A Streptococcus (GAS) skin infections are caused by a diverse array of strain types and are highly prevalent in disadvantage..

Longitudinal Analysis of Group A Streptococcus emm Types and emm Clusters in a High-Prevalence Setting: Relationship between Past and Future Infections.

Patricia Therese Campbell, Steven YC Tong, Nicholas Geard, Mark R Davies, Kate A Worthing, Jake A Lacey, Pierre R Smeesters, Michael R Batzloff, Joseph Kado, Adam WJ Jenney, Jodie Mcvernon, Andrew C Steer

Journal article  |  2020  |  Journal of Infectious Diseases

Group A Streptococcus is a pathogen of global importance, but despite the ubiquity of group A Streptococcus infections, the relati..

Global Trends in Proteome Remodeling of the Outer Membrane Modulate Antimicrobial Permeability in Klebsiella pneumoniae

Andrea Rocker, Jake A Lacey, Matthew J Belousoff, Jonathan J Wilkscha, Richard A Strugnell, Mark R Davies, Trevor Lithgow

Journal article  |  2020  |  mBio

In Gram-negative bacteria, the permeability of the outer membrane governs rates of antibiotic uptake and thus the efficacy of anti..

Restricted Sequence Variation in Streptococcus pyogenes Penicillin Binding Proteins

Andrew Hayes, Jake A Lacey, Jacqueline M Morris, Mark R Davies, Steven YC Tong

Journal article  |  2020  |  mSphere

A recent clinical report has linked Streptococcus pyogenes β-lactam antibiotic resistance to mutation in the penicillin binding pr..

Focal duodenal necrosis in chickens: attempts to reproduce the disease experimentally and diagnostic considerations

Ana M Villegas, Lisa Stabler, Robert J Moore, Francisco A Uzal, Jake A Lacey, Charles Hofacre, Margie Lee, Naola Ferguson-Noel, Rosetta Barber, Claire-Sophie Rimet, Carmen Jerry, Woo Kyun Kim, Barquiesha Madison, Monique Franca

Journal article  |  2020  |  Journal of Veterinary Diagnostic Investigation

Focal duodenal necrosis (FDN) is an intestinal disease of egg-layer chickens characterized by multifocal necrosis of the duodenal ..

Whole Genome Sequence Analysis and Population Genomics of Group A Streptococci.

Jake A Lacey, Taylah B James, Steven YC Tong, Mark R Davies

Journal article  |  2020  |  Methods in molecular biology (Clifton, N.J.)

Whole-genome sequencing (WGS) is used to determine the genetic composition of an organism. This fast-moving field is continually e..

Scarlet fever changes its spots

Stephan Brouwer, Jake A Lacey, Yuanhai You, Mark R Davies, Mark J Walker

Journal article  |  2019  |  The Lancet Infectious Diseases