Shashank Masaldan

Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy

Abdel Ali Belaidi, Shashank Masaldan, Adam Southon, Pawel Kalinowski, Karla Acevedo, Ambili T Appukuttan, Stuart Portbury, Peng Lei, Puja Agarwal, Sue E Leurgans, Julie Schneider, Marcus Conrad, Ashley Bush, Scott Ayton

Journal article  |  2022  |  MOLECULAR PSYCHIATRY

Allelic variation to the APOE gene confers the greatest genetic risk for sporadic Alzheimer's disease (AD). Independent of genotyp..

Therapeutic targeting of mitophagy in Parkinson's disease

Shashank Masaldan, Sylvie Callegari, Grant Dewson

Journal article  |  2022  |  BIOCHEMICAL SOCIETY TRANSACTIONS

Parkinson's disease is a neurodegenerative disorder characterised by cardinal motor symptoms and a diverse range of non-motor diso..

Look youse guys and gals, dat just ain't right

Daniel J Klionsky

Journal article  |  2021  |  AUTOPHAGY

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received inc..

Dynamic reconfiguration of pro-apoptotic BAK on membranes

Jarrod J Sandow, Iris Kl Tan, Alan S Huang, Shashank Masaldan, Jonathan P Bernardini, Ahmad Z Wardak, Richard W Birkinshaw, Robert L Ninnis, Ziyan Liu, Destiny Dalseno, Daisy Lio, Giuseppi Infusini, Peter E Czabotar, Andrew Webb, Grant Dewson

Journal article  |  2021  |  EMBO JOURNAL

BAK and BAX, the effectors of intrinsic apoptosis, each undergo major reconfiguration to an activated conformer that self-associat..

Characterization of Selenium Compounds for Anti-ferroptotic Activity in Neuronal Cells and After Cerebral Ischemia-Reperfusion Injury

Qing-Zhang Tuo, Shashank Masaldan, Adam Southon, Celeste Mawal, Scott Ayton, Ashley Bush, Peng Lei, Abdel Ali Belaidi

Journal article  |  2021  |  NEUROTHERAPEUTICS

The emergence of ferroptosis as a cell death pathway associated with brain disorders including stroke and neurodegenerative diseas..

Copper Ionophores as Novel Antiobesity Therapeutics

Peter M Meggyesy, Shashank Masaldan, Sharnel AS Clatworthy, Irene Volitakis, Daniel J Eyckens, Kathryn Aston-Mourney, Michael A Cater

Journal article  |  2020  |  MOLECULES

The therapeutic utility of the copper ionophore disulfiram was investigated in a diet-induced obesity mouse model (C57BL/6J backgr..

Redox active metals in neurodegenerative diseases

Karla Acevedo, Shashank Masaldan, Carlos M Opazo, Ashley I Bush

Journal article  |  2019  |  JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Copper (Cu) and iron (Fe) are redox active metals essential for the regulation of cellular pathways that are fundamental for brain..

Cellular Senescence and Iron Dyshomeostasis in Alzheimer's Disease

Shashank Masaldan, Abdel Ali Belaidi, Scott Ayton, Ashley Bush

Journal article  |  2019  |  PHARMACEUTICALS

Iron dyshomeostasis is a feature of Alzheimer's disease (AD). The impact of iron on AD is attributed to its interactions with the ..

Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration

Shashank Masaldan, Ashley I Bush, David Devos, Anne Sophie Rolland, Caroline Moreau

Journal article  |  2019  |  FREE RADICAL BIOLOGY AND MEDICINE

Perturbations in iron homeostasis and iron accumulation feature in several neurodegenerative disorders including Alzheimer's disea..

Copper accumulation in senescent cells: Interplay between copper transporters and impaired autophagy

Shashank Masaldan, Shamel AS Clatworthy, Cristina Gamell, Zoe M Smith, Paul S Francis, Delphine Denoyer, Peter M Meggyesy, Sharon La Fontaine, Michael A Cater

Journal article  |  2018  |  REDOX BIOLOGY

Cellular senescence is characterized by irreversible growth arrest incurred through either replicative exhaustion or by pro-oncoge..