Aung Aung Kywe Moe

Jugular vagal ganglia neurons and airway nociception: A target for treating chronic cough

Aung Aung Kywe Moe, Alice E McGovern, Stuart B Mazzone

Journal article  |  2021  |  The International Journal of Biochemistry & Cell Biology

The airways receive a dense supply of sensory nerve fibers that are responsive to damaging or potentially injurious stimuli. These..

The impact of influenza pulmonary infection and inflammation on vagal bronchopulmonary sensory neurons

Nathalie AJ Verzele, Brendon Y Chua, Charity W Law, Albert Zhang, Matthew E Ritchie, Oliver Wightman, Isaac N Edwards, Katina D Hulme, Conor J Bloxham, Helle Bielefeldt-Ohmann, Matthew W Trewella, Aung Aung Kywe Moe, Keng Yih Chew, Stuart B Mazzone, Kirsty R Short, Alice E McGovern

Journal article  |  2021  |  The FASEB Journal

Influenza A virus (IAV) is rapidly detected in the airways by the immune system, with resident parenchymal cells and leukocytes or..

Mini Review: Central Organization of Airway Afferent Nerve Circuits

Robert Behrens, Alice E McGovern, Michael J Farrell, Aung Aung Kywe Moe, Stuart B Mazzone

Journal article  |  2021  |  Neuroscience Letters

Airway afferents monitor the local chemical and physical micro-environments in the airway wall and lungs and send this information..

Dysfunction in nonsense-mediated decay, protein homeostasis, mitochondrial function, and brain connectivity in ALS-FUS mice with cognitive deficits

Wan Yun Ho, Ira Agrawal, Sheue-Houy Tyan, Emma Sanford, Wei-Tang Chang, Kenneth Lim, Jolynn Ong, Bernice Siu Yan Tan, Aung Aung Kywe Moe, Regina Yu, Peiyan Wong, Greg Tucker-Kellogg, Edward Koo, Kai-Hsiang Chuang, Shuo-Chien Ling

Journal article  |  2021  |  Acta Neuropathologica Communications

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) represent two ends of the same disease spectrum of adult-ons..

Peripheral and central mechanisms of cough hypersensitivity

Nabita Singh, Alexandria K Driessen, Alice E McGovern, Aung Aung Kywe Moe, Michael J Farrell, Stuart B Mazzone

Journal article  |  2020  |  Journal of Thoracic Disease

Chronic cough is a difficult to treat symptom of many respiratory and some non-respiratory diseases, indicating that varied pathol..

A role for neurokinin 1 receptor expressing neurons in the paratrigeminal nucleus in bradykinin-evoked cough in guinea-pigs

Alexandria K Driessen, Alice E McGovern, Robert Behrens, Aung Aung Kywe Moe, Michael J Farrell, Stuart B Mazzone

Journal article  |  2020  |  The Journal of Physiology

KEY POINTS: Airway projecting sensory neurons arising from the jugular vagal ganglia terminate centrally in the brainstem paratrig..

Transcriptional Profiling of Individual Airway Projecting Vagal Sensory Neurons

Stuart B Mazzone, Luyi Tian, Aung Aung Kywe Moe, Matthew W Trewella, Matthew E Ritchie, Alice E McGovern

Journal article  |  2019  |  Molecular Neurobiology

Bronchopulmonary sensory neurons are derived from the vagal sensory ganglia and are essential for monitoring the physical and chem..

Translational review: Neuroimmune mechanisms in cough and emerging therapeutic targets

Alice E McGovern, Kirsty R Short, Aung Aung Kywe Moe, Stuart B Mazzone

Journal article  |  2018  |  Journal of Allergy and Clinical Immunology

Cough is an essential defensive behavior for maintaining airway patency and to protect the lungs from potentially harmful agents. ..

Short- and long-term effects of risperidone on catalepsy sensitisation and acquisition of conditioned avoidance response: Adolescent vs adult rats

Aung Aung Kywe Moe, Gregory A Medely, Timothy Reeks, Thomas HJ Burne, Darryl W Eyles

Journal article  |  2017  |  Pharmacological Research

The effects of antipsychotic drugs (APDs) on the adolescent brain are poorly understood despite a dramatic increase in prescriptio..

Risperidone induces long-lasting changes in the conditioned avoidance response and accumbal gene expression selectively in animals treated as adolescents

Aung Aung Kywe Moe, Nyoman D Kurniawan, Suzanne Alexander, Xiaoying Cui, Thomas HJ Burne, Darryl W Eyles

Journal article  |  2016  |  Neuropharmacology

Adolescence is a period of dynamic remodeling and maturation in the brain. Exposure to psychotropic drugs during adolescence can p..