Vinzenz Hofferek

Multi-Omic Analysis to Characterize Metabolic Adaptation of the E. coli Lipidome in Response to Environmental Stress

Thomas Kralj, Madison Nuske, Vinzenz Hofferek, Marc-Antoine Sani, Tzong-Hsien Lee, Frances Separovic, Marie-Isabel Aguilar, Gavin E Reid

Journal article  |  2022  |  METABOLITES

As an adaptive survival response to exogenous stress, bacteria undergo dynamic remodelling of their lipid metabolism pathways to a..

In-cell DNP NMR reveals multiple targeting effect of antimicrobial peptide.

Frances Separovic, Vinzenz Hofferek, Anthony P Duff, Malcom J McConville, Marc-Antoine Sani

Journal article  |  2022  |  J Struct Biol X

Dynamic nuclear polarization NMR spectroscopy was used to investigate the effect of the antimicrobial peptide (AMP) maculatin 1.1 ..

The impact of antibacterial peptides on bacterial lipid membranes depends on stage of growth

Tzong-Hsien Lee, Vinzenz Hofferek, Marc-Antoine Sani, Frances Separovic, Gavin E Reid, Marie-Isabel Aguilar

Journal article  |  2021  |  FARADAY DISCUSSIONS

The impact of maculatin 1.1 (Mac1) on the mechanical properties of supported lipid membranes derived from exponential growth phase..

Chemical Derivatization-Aided High Resolution Mass Spectrometry for Shotgun Lipidome Analysis

Vinzenz Hofferek, Huaqi Su, Gavin E Reid

Journal article  |  2021  |  MASS SPECTROMETRY-BASED LIPIDOMICS

Chemical derivatization coupled with nano-electrospray ionization (nESI) and ultra-high resolution accurate mass spectrometry (UHR..

Cardiolipin is required for membrane docking of mitochondrial ribosomes and protein synthesis

Richard G Lee, Junjie Gao, Stefan J Siira, Anne-Marie Shearwood, Judith A Ermer, Vinzenz Hofferek, James C Mathews, Minghao Zheng, Gavin E Reid, Oliver Rackham, Aleksandra Filipovska

Journal article  |  2020  |  JOURNAL OF CELL SCIENCE

The mitochondrial inner membrane contains a unique phospholipid known as cardiolipin (CL), which stabilises the protein complexes ..

Solid-State NMR Study of Live Bacteria in the Presence of Antimicrobial Agents

Shiying Zhu, Sarah A Overall, Vinzenz Hofferek, Frances Separovic, Marc-Antoine Sani

Conference Proceedings  |  2020  |  BIOPHYSICAL JOURNAL

The role of bacterial lipid diversity and membrane properties in modulating antimicrobial peptide activity and drug resistance

Tzong-Hsien Lee, Vinzenz Hofferek, Frances Separovic, Gavin E Reid, Marie-Isabel Aguilar

Journal article  |  2019  |  CURRENT OPINION IN CHEMICAL BIOLOGY

This review provides an analysis of the role that membrane composition and structure plays in the resistance of microorganisms to ..

Nitroxide spin-labeled peptides for DNP-NMR in-cell studies

Marc-Antoine Sani, Shiying Zhu, Vinzenz Hofferek, Frances Separovic

Journal article  |  2019  |  FASEB JOURNAL

Antimicrobial peptides (AMPs) that target lipid membranes show promise as alternatives to conventional antibiotics. However, the m..

The alpha/beta-hydrolase domain-containing 4-and 5-related phospholipase Pummelig controls energy storage in Drosophila[S]

Philip Hehlert, Ymzenz Hofferek, Christoph Heier, Thomas O Eichmann, Dietmar Riedel, Jonathan Rosenberg, Anna Takacs, Harald M Nagy, Monika Oberer, Robert Zimmermann, Ronald P Kuehnlein

Journal article  |  2019  |  JOURNAL OF LIPID RESEARCH

Triglycerides (TGs) are the main energy storage form that accommodates changing organismal energy demands. In Drosophila melanogas..

A Non-canonical Pathway with Potential for Safer Modulation of Transforming Growth Factor-beta 1 in Steroid-Resistant Airway Diseases

Meina Li, Christine R Keenan, Guillermo Lopez-Campos, Jonathan E Mangum, Qianyu Chen, Danica Prodanovic, Yuxiu C Xia, Shenna Y Langenbach, Trudi Harris, Vinzenz Hofferek, Gavin E Reid, Alastair G Stewart

Journal article  |  2019  |  ISCIENCE

Impaired therapeutic responses to anti-inflammatory glucocorticoids (GC) in chronic respiratory diseases are partly attributable t..