Tony Velkov

Structure-Interaction Relationship of Polymyxins with the Membrane of Human Kidney Proximal Tubular Cells.

Xukai Jiang, Shuo Zhang, Mohammad AK Azad, Kade D Roberts, Lin Wan, Bin Gong, Kai Yang, Bing Yuan, Hemayet Uddin, Jingliang Li, Philip E Thompson, Tony Velkov, Jing Fu, Lushan Wang, Jian Li

Journal article  |  2020  |  ACS Infectious Diseases

Multidrug-resistant Gram-negative bacteria are a serious global threat to human health. Polymyxins are increasingly used in patien..

The Antimicrobial Activity of Cannabinoids.

John A Karas, Labell JM Wong, Olivia KA Paulin, Amna C Mazeh, Maytham H Hussein, Jian Li, Tony Velkov

Journal article  |  2020  |  Antibiotics

A post-antibiotic world is fast becoming a reality, given the rapid emergence of pathogens that are resistant to current drugs. Th..

Transcriptomic responses of a New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae isolate to the combination of polymyxin B and chloramphenicol.

Nusaibah Abdul Rahim, Soon-Ee Cheah, Matthew D Johnson, Yan Zhu, Heidi H Yu, Hanna E Sidjabat, Mark S Butler, Matthew A Cooper, Jing Fu, David L Paterson, Roger L Nation, John D Boyce, Phillip J Bergen, Tony Velkov, Jian Li

Journal article  |  2020  |  International Journal of Antimicrobial Agents

The combination of polymyxins and chloramphenicol possesses synergistic killing activity against New Delhi metallo-β-lactamase (ND..

Nerve Growth Factor Confers Neuroprotection against Colistin-Induced Peripheral Neurotoxicity

Chongshan Dai, Jianli Xiong, Yang Wang, Jianzhong Shen, Tony Velkov, Xilong Xiao

Journal article  |  2020  |  ACS Infectious Diseases

Neurotoxicity is an unwanted side effect for patients when receiving parenteral colistin therapy. The development of effective neu..

Effective Strategy Targeting Polymyxin-Resistant Gram-Negative Pathogens: Polymyxin B in Combination with the Selective Serotonin Reuptake Inhibitor Sertraline

Maytham Hussein, Elena K Schneider-Futschik, Olivia KA Paulin, Rafah Allobawi, Simon Crawford, Qi Tony Zhou, Adil Hanif, Mark Baker, Yan Zhu, Jian Li, Tony Velkov

Journal article  |  2020  |  ACS Infectious Diseases

This study aimed to investigate synergistic antibacterial activity of polymyxin B in combination with the selective serotonin reup..

Polymyxins–Curcumin Combination Antimicrobial Therapy: Safety Implications and Efficacy for Infection Treatment

Tony Velkov

Journal article  |  2020  |  Antioxidants

The emergence of antimicrobial resistance in Gram‐negative bacteria poses a huge health challenge. The therapeutic use of polymyxi..

Polymyxins Bind to the Cell Surface of Unculturable Acinetobacter baumannii and Cause Unique Dependent Resistance

Yan Zhu, Jing Lu, Mei-Ling Han, Xukai Jiang, Mohammad AK Azad, Nitin A Patil, Yu-Wei Lin, Jinxin Zhao, Yang Hu, Heidi H Yu, Ke Chen, John D Boyce, Rhys A Dunstan, Trevor Lithgow, Christopher K Barlow, Weifeng Li, Elena K Schneider-Futschik, Jiping Wang, Bin Gong, Bjorn Sommer, et al.

Journal article  |  2020  |  Advanced Science

Curcumin Attenuates Colistin-Induced Peripheral Neurotoxicity in Mice

Chongshan Dai, Xilong Xiao, Yuan Zhang, Biao Xiang, Daniel Hoyer, Jianzhong Shen, Tony Velkov, Shusheng Tang

Journal article  |  2020  |  ACS Infectious Diseases

Peripheral neurotoxicity often occurs in patients receiving parenteral polymyxin therapy (i.e., colistin methanesulfonate or polym..

Regulating polymyxin resistance in Gram-negative bacteria: roles of two-component systems PhoPQ and PmrAB

Jiayuan Huang, Chen Li, Jiangning Song, Tony Velkov, Lushan Wang, Yan Zhu, Jian Li

Journal article  |  2020  |  Future Microbiology

Polymyxins (polymyxin B and colistin) are last-line antibiotics against multidrug-resistant Gram-negative pathogens. Polymyxin res..

Complete genome sequence and genome-scale metabolic modelling of Acinetobacter baumannii type strain ATCC 19606

Yan Zhu, Jing Lu, Jinxin Zhao, Xinru Zhang, Heidi H Yu, Tony Velkov, Jian Li

Journal article  |  2020  |  International Journal of Medical Microbiology

Multidrug-resistant (MDR) Acinetobacter baumannii is a critical threat to global health. The type strain ATCC 19606 has been widel..

Structure of micelle bound cationic peptides by NMR spectroscopy using a lanthanide shift reagent

James D Swarbrick, John A Karas, Jian Li, Tony Velkov

Journal article  |  2020  |  Chemical Communications

[Tm(DPA)3]3- was used to generate multiple, paramagnetic nuclear Overhauser effect NMR spectra of cationic peptides when weakly bo..

Inhalable liposomal powder formulations for co-delivery of synergistic ciprofloxacin and colistin against multi-drug resistant gram-negative lung infections

Shihui Yu, Shaoning Wang, Peizhi Zou, Guihong Chai, Yu-Wei Lin, Tony Velkov, Jian Li, Weisan Pan, Qi Tony Zhou

Journal article  |  2020  |  International Journal of Pharmaceutics

The aim of this study was to design and characterize dry powder inhaler formulations of ciprofloxacin and colistin co-loaded lipos..

Mass Spectrometry Reveals New Insights into the Production of Superoxide Anions and 4-Hydroxynonenal Adducted Proteins in Human Sperm.

Jacob Kendal Netherton, Louise Hetherington, Rachel Anne Ogle, Marum Mazloumi Gavgani, Tony Velkov, Ana Izabel Bilbin Villaverde, Nuch Tanphaichitr, Mark Andrew Baker

Journal article  |  2020  |  PROTEOMICS

Mass Spectrometry Reveals New Insights into the Production of Superoxide Anions and 4-Hydroxynonenal Adducted Proteins in Human Sperm

Jacob Kendal Netherton, Louise Hetherington, Rachel Anne Ogle, Marum Mazloumi Gavgani, Tony Velkov, Ana Izabel Bilbin Villaverde, Nuch Tanphaichitr, Mark Andrew Baker

Journal article  |  2020  |  PROTEOMICS

Polymyxin triple combinations against polymyxin-resistant, multidrug-resistant KPC-producing Klebsiella pneumoniae

Su Mon Aye, Irene Galani, Heidi Yu, Jiping Wang, Ke Chen, Hasini Wickremasinghe, Ilias Karaiskos, Phillip J Bergen, Jinxin Zhao, Tony Velkov, Helen Giamarellou, Yu-Wei Lin, Brian Tsuji, Jian Li

Journal article  |  2020  |  Antimicrobial Agents and Chemotherapy

Resistance to polymyxin antibiotics is increasing. Without new antibiotic classes, combination therapy is often required. We syste..

The Killing Mechanism of Teixobactin against Methicillin-Resistant Staphylococcus aureus: an Untargeted Metabolomics Study

Maytham Hussein, John A Karas, Elena K Schneider-Futschik, Fan Chen, James Swarbrick, Olivia KA Paulin, Daniel Hoyer, Mark Baker, Yan Zhu, Jian Li, Tony Velkov

Journal article  |  2020  |  mSystems

Antibiotics have served humankind through their use in modern medicine as effective treatments for otherwise fatal bacterial infec..

Pan-transcriptomic analysis identified common differentially expressed genes of Acinetobacter baumannii in response to polymyxin treatments

Mengyao Li, Su Mon Aye, Maizbha Uddin Ahmed, Mei-Ling Han, Chen Li, Jiangning Song, John Boyce, David Powell, Mohammad AK Azad, Tony Velkov, Yan Zhu, Jian Li

Journal article  |  2020  |  Molecular Omics

Multidrug-resistant Acinetobacter baumannii is a top-priority Gram-negative pathogen and polymyxins are a last-line therapeutic op..

Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa

Maytham Hussein, Mei-Ling Han, Yan Zhu, Qi Zhou, Yu-Wei Lin, Robert EW Hancock, Daniel Hoyer, Darren J Creek, Jian Li, Tony Velkov

Journal article  |  2020  |  Antimicrobial Agents and Chemotherapy

In the present study, we employed untargeted metabolomics to investigate the synergistic killing mechanism of polymyxin B in combi..

Synthesis and structure-activity relationships of teixobactin

John A Karas, Fan Chen, Elena K Schneider-Futschik, Zhisen Kang, Maytham Hussein, James Swarbrick, Daniel Hoyer, Andrew M Giltrap, Richard J Payne, Jian Li, Tony Velkov

Journal article  |  2019  |  Annals of the New York Academy of Sciences

An optimised Cu(0)-RDRP approach for the synthesis of lipidated oligomeric vinyl azlactone: toward a versatile antimicrobial materials screening platform

James L Grace, Maite Amado, Janet C Reid, Alysha G Elliott, Cornelia B Landersdorfer, Nghia P Truong, Kristian Kempe, Matthew A Cooper, Thomas P Davis, Veronique Montembault, Sagrario Pascual, Laurent Fontaine, Tony Velkov, John F Quinn, Michael R Whittaker

Journal article  |  2019  |  Journal of Materials Chemistry B

This report details the synthesis of lipidated 2-vinyl-4,4-dimethyl-5-oxazolone (VDM) oligomers via an optimised Cu(0)-mediated re..

T-2 toxin neurotoxicity: role of oxidative stress and mitochondrial dysfunction

Chongshan Dai, Xilong Xiao, Feifei Sun, Yuan Zhang, Daniel Hoyer, Jianzhong Shen, Shusheng Tang, Tony Velkov

Journal article  |  2019  |  Archives of Toxicology

Mycotoxins are highly diverse secondary metabolites produced in nature by a wide variety of fungi. Mycotoxins cause animal feed an..

Polymyxin resistance in Klebsiella pneumoniae: multifaceted mechanisms utilized in the presence and absence of the plasmid-encoded phosphoethanolamine transferase gene mcr-1

Sue C Nang, Mei-Ling Han, Heidi H Yu, Jiping Wang, Von Vergel L Torres, Chongshan Dai, Tony Velkov, Marina Harper, Jian Li

Journal article  |  2019  |  Journal of Antimicrobial Chemotherapy

OBJECTIVES: Until plasmid-mediated mcr-1 was discovered, it was believed that polymyxin resistance in Gram-negative bacteria was m..

DNA variants are an unlikely explanation for the changing quality of spermatozoa within the same individual

Jacob Netherton, Rachel Ogle, Louise Hetherington, Tony Velkov, Ryan Rose, Mark Baker

Journal article  |  2019  |  Human Fertility

Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-Resistant Pseudomonas aeruginosa

Yu-Wei Lin, Mei-Ling Han, Jinxin Zhao, Yan Zhu, Gauri Rao, Alan Forrest, Jiangning Song, Keith S Kaye, Paul Hertzog, Anthony Purcell, Darren Creek, Qi Tony Zhou, Tony Velkov, Jian Li

Journal article  |  2019  |  FRONTIERS IN PHARMACOLOGY

Multifaceted mechanisms of colistin resistance revealed by genomic analysis of multidrug-resistant Klebsiella pneumoniae isolates from individual patients before and after colistin treatment

Yan Zhua, Irene Galani, Ilias Karaiskos, Jing Lu, Su Mon Aye, Jiayuan Huang, Heidi H Yu, Tony Velkov, Helen Giamarellou, Jian Li

Journal article  |  2019  |  Journal of Infection

The impact of backbone N-methylation on the structure-activity relationship of Leu(10)-teixobactin

Tony Velkov, James D Swarbrick, Maytham H Hussein, Elena K Schneider-Futschik, Daniel Hoyer, Jian Li, John A Karas

Journal article  |  2019  |  Journal of Peptide Science

Comparative Metabolomics Reveals Key Pathways Associated With the Synergistic Killing of Colistin and Sulbactam Combination Against Multidrug-Resistant Acinetobacter baumannii

Mei-Ling Han, Xiaofen Liu, Tony Velkov, Yu-Wei Lin, Yan Zhu, Darren J Creek, Christopher K Barlow, Heidi H Yu, Zhihui Zhou, Jing Zhang, Jian Li

Journal article  |  2019  |  FRONTIERS IN PHARMACOLOGY

The rise and spread of mcr plasmid-mediated polymyxin resistance

Sue C Nang, Jian Li, Tony Velkov

Journal article  |  2019  |  Critical Reviews in Microbiology

Effects of the antibiotic component on in-vitro bacterial killing, physico-chemical properties, aerosolization and dissolution of a ternary-combinational inhalation powder formulation of antibiotics for pan-drug resistant Gram-negative lung infections

Sharad Mangal, Jiayang Huang, Nivedita Shetty, Heejun Park, Yu-Wei Lin, Heidi H Yu, Dmitry Zemlyanov, Tony Velkov, Jian Li, Qi Tony Zhou

Journal article  |  2019  |  International Journal of Pharmaceutics

Novel Polymyxin Combination with the Antiretroviral Zidovudine Exerts Synergistic Killing against NDM-Producing Multidrug-Resistant Klebsiella pneumoniae

Yu-Wei Lin, Nusaibah Abdul Rahim, Jinxin Zhao, Mei-Ling Han, Heidi H Yu, Hasini Wickremasinghe, Ke Chen, Jiping Wang, David L Paterson, Yan Zhu, Gauri G Rao, Qi Tony Zhou, Alan Forrest, Tony Velkov, Jian Li

Journal article  |  2019  |  Antimicrobial Agents and Chemotherapy

Discovery of Novel Polymyxin-Like Antibiotics

Tony Velkov, Kade D Roberts

Book Chapter  |  2019  |  Advances in Experimental Medicine and Biology

Global Metabolic Analyses of Acinetobacter baumannii.

Mohd Hafidz Mahamad Maifiah, Tony Velkov, Darren J Creek, Jian Li

Journal article  |  2019  |  Methods in molecular biology (Clifton, N.J.)

Acinetobacter baumannii is rapidly emerging as a multidrug-resistant pathogen responsible for nosocomial infections including pneu..

Metabolic Responses to Polymyxin Treatment in Acinetobacter baumannii ATCC 19606: Integrating Transcriptomics and Metabolomics with Genome-Scale Metabolic Modeling

Yan Zhu, Jinxin Zhao, Mohd Hafidz Mahamad Maifiah, Tony Velkov, Falk Schreiber, Jian Li

Journal article  |  2019  |  MSYSTEMS

Molecular Mechanisms of Neurotoxicity Induced by Polymyxins and Chemoprevention

Chongshan Dai, Xilong Xiao, Jichang Li, Giuseppe D Ciccotosto, Roberto Cappai, Shusheng Tang, Elena K Schneider-Futschik, Daniel Hoyer, Tony Velkov, Jianzhong Shen

Journal article  |  2019  |  ACS Chemical Neuroscience

Intracellular localization of polymyxins in human alveolar epithelial cells

Maizbha U Ahmed, Tony Velkov, Qi Tony Zhou, Alex J Fulcher, Judy Callaghan, Fanfan Zhou, Kim Chan, Mohammad AK Azad, Jian Li

Journal article  |  2019  |  Journal of Antimicrobial Chemotherapy

Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa

Mei-Ling Han, Yan Zhu, Darren J Creek, Yu-Wei Lin, Alina D Gutu, Paul Hertzog, Tony Purcell, Hsin-Hui Shen, Samuel M Moskowitz, Tony Velkov, Jian Li

Journal article  |  2019  |  MSYSTEMS

Polymyxins: Mode of Action

Zhifeng Li, Tony Velkov

Book Chapter  |  2019  |  Advances in Experimental Medicine and Biology

The dry antibiotic development pipeline coupled with the emergence of multi-drug resistant Gram-negative 'superbugs' has driven th..

Mechanisms of Polymyxin-Induced Nephrotoxicity

Mohammad AK Azad, Roger L Nation, Tony Velkov, Jian Li

Book Chapter  |  2019  |  Advances in Experimental Medicine and Biology

History, Chemistry and Antibacterial Spectrum

Tony Velkov, Philip E Thompson, Mohammad AK Azad, Kade D Roberts, Phillip J Bergen

Book Chapter  |  2019  |  Advances in Experimental Medicine and Biology

Contemporary Anti-Ebola Drug Discovery Approaches and Platforms

Elena K Schneider-Futschik, Daniel Hoyer, Alexander A Khromykh, Jonathan B Baell, Glenn A Marsh, Mark A Baker, Jian Li, Tony Velkov

Journal article  |  2019  |  ACS Infectious Diseases

Exploiting Macromolecular Design To Optimize the Antibacterial Activity of Alkylated Cationic Oligomers

James L Grace, Elena K Schneider-Futschik, Alysha G Elliott, Maite Amado, Nghia P Truong, Matthew A Cooper, Jian Li, Thomas P Davis, John F Quinn, Tony Velkov, Michael R Whittaker

Journal article  |  2018  |  Biomacromolecules

A Comparative Study of Outer Membrane Proteome between Paired Colistin-Susceptible and Extremely Colistin-Resistant Klebsiella pneumoniae Strains

Raad Jasim, Mark A Baker, Yan Zhu, Meiling Han, Elena K Schneider-Futschik, Maytham Hussein, Daniel Hoyer, Jian Li, Tony Velkov

Journal article  |  2018  |  ACS Infectious Diseases

Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis

Chongshan Dai, Xilong Xiao, Daowen Li, Sun Tun, Ying Wang, Tony Velkov, Shusheng Tang

Journal article  |  2018  |  CELL DEATH & DISEASE

Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant Acinetobacter baumannii

Mei-Ling Han, Xiaofen Liu, Tony Velkov, Yu-Wei Lin, Yan Zhu, Mengyao Li, Heidi H Yu, Zhihui Zhou, Darren J Creek, Jing Zhang, Jian Li

Journal article  |  2018  |  FRONTIERS IN MICROBIOLOGY

Composite particle formulations of colistin and meropenem with improved in-vitro bacterial killing and aerosolization for inhalation

Sharad Mangal, Heejun Park, Lingfei Zeng, Heidi H Yu, Yu-wei Lin, Tony Velkov, John A Denman, Dmitry Zemlyanov, Jian Li, Qi Tony Zhou

Journal article  |  2018  |  International Journal of Pharmaceutics

Graphene-Enhanced 3D Chemical Mapping of Biological Specimens at Near-Atomic Resolution

Vahid R Adineh, Changxi Zheng, Qianhui Zhang, Ross KW Marceau, Boyin Liu, Yu Chen, Kae J Si, Matthew Weyland, Tony Velkov, Wenlong Cheng, Jian Li, Jing Fu

Journal article  |  2018  |  Advanced Functional Materials

Lipidomic Analysis of the Outer Membrane Vesicles from Paired Polymyxin-Susceptible and -Resistant Klebsiella pneumoniae Clinical Isolates

Raad Jasim, Mei-Ling Han, Yan Zhu, Xiaohan Hu, Maytham H Hussein, Yu-Wei Lin, Qi Tony Zhou, Charlie Yao Da Dong, Jian Li, Tony Velkov

Journal article  |  2018  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Proteomic analysis of good- and poor-quality human sperm demonstrates that several proteins are routinely aberrantly regulated

Jacob K Netherton, Louise Hetherington, Rachel A Ogle, Tony Velkov, Mark A Baker

Journal article  |  2018  |  Biology of Reproduction

Polymyxin B causes DNA damage in HK-2 cells and mice (vol 92, pg 2259, 2018)

B Yun, T Zhang, MAK Azad, J Wang, CJ Nowell, P Kalitsis, T Velkov, DF Hudson, J Li

Journal article  |  2018  |  Archives of Toxicology

Polymyxin B causes DNA damage in HK-2 cells and mice

B Yun, T Zhang, MAK Azad, J Wang, CJ Nowell, P Kalitsis, T Velkov, DF Hudson, J Li

Journal article  |  2018  |  Archives of Toxicology

The potentially beneficial CNS-activity profile of ivacaftor

E Schneider, Carbone Vincenzo, Wilson John, Button Brenda, Daniel Hoyer, Li Jian, Tony Velkov

Conference Proceedings  |  2018

Polymyxin B in Combination with Enrofloxacin Exerts Synergistic Killing against Extensively Drug-Resistant Pseudomonas aeruginosa

Yu-Wei Lin, Heidi H Yu, Jinxin Zhao, Mei-Ling Han, Yan Zhu, Jesmin Akter, Hasini Wickremasinghe, Hasini Walpola, Veronika Wirth, Gauri G Rao, Alan Forrest, Tony Velkov, Jian Li

Journal article  |  2018  |  Antimicrobial Agents and Chemotherapy

Fitness cost of mcr-1-mediated polymyxin resistance in Klebsiella pneumoniae

Sue C Nang, Faye C Morris, Michael J McDonald, Mei-Ling Han, Jiping Wang, Richard A Strugnell, Tony Velkov, Jian Li

Journal article  |  2018  |  Journal of Antimicrobial Chemotherapy

Alterations of Metabolic and Lipid Profiles in Polymyxin-Resistant Pseudomonas aeruginosa

Mei-Ling Han, Yan Zhu, Darren J Creek, Yu-Wei Lin, Dovile Anderson, Hsin-Hui Shen, Brian Tsuji, Alina D Gutu, Samuel M Moskowitz, Tony Velkov, Jian Li

Journal article  |  2018  |  Antimicrobial Agents and Chemotherapy

Sputum Active Polymyxin Lipopeptides: Activity against Cystic Fibrosis Pseudomonas aeruginosa Isolates and Their Interactions with Sputum Biomolecules

Elena K Schneider-Futschik, Olivia KA Paulin, Daniel Hoyer, Kade D Roberts, James Ziogas, Mark A Baker, John Karas, Jian Li, Tony Velkov

Journal article  |  2018  |  ACS INFECTIOUS DISEASES

A Proof-of-Concept Study of the Efficacy of Systemically Administered Polymyxins in Mouse Burn Wound Infection Caused by Multidrug-Resistant Gram-Negative Pathogens

Yu-Wei Lin, Ke Chen, Jiping Wang, Tony Velkov, Qi Tony Zhou, Jian Li

Journal article  |  2018  |  Antimicrobial Agents and Chemotherapy

Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria

Tony Velkov, Alejandra Gallardo-Godoy, James D Swarbrick, Mark AT Blaskovich, Alysha G Elliott, Meiling Han, Philip E Thompson, Kade D Roberts, Johnny X Huang, Bernd Becker, Mark S Butler, Lawrence H Lash, Sonia Troeira Henriques, Roger L Nation, Sivashangarie Sivanesan, Marc-Antoine Sani, Frances Separovic, Haydyn Mertens, Dieter Bulach, Torsten Seemann, et al.

Journal article  |  2018  |  Cell Chemical Biology

Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant Acinetobacter baumannii: A Metabolomic Study

Thien B Tran, Phillip J Bergen, Darren J Creek, Tony Velkov, Jian Li

Journal article  |  2018  |  FRONTIERS IN PHARMACOLOGY

Novel Polymyxin Combination With Antineoplastic Mitotane Improved the Bacterial Killing Against Polymyxin-Resistant Multidrug-Resistant Gram-Negative Pathogens

Thien B Tran, Jiping Wang, Yohei Doi, Tony Velkov, Phillip J Bergen, Jian Li

Journal article  |  2018  |  FRONTIERS IN MICROBIOLOGY

T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway

Xiya Zhang, Ying Wang, Tony Velkov, Shusheng Tang, Chongshan Dai

Journal article  |  2018  |  Food and Chemical Toxicology

Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways

Chongshan Dai, Giuseppe D Ciccotosto, Roberto Cappai, Yang Wang, Shusheng Tang, Daniel Hoyer, Elena K Schneider, Tony Velkov, Xilong Xiao

Journal article  |  2018  |  ACS Chemical Neuroscience

Comparative analysis of phosphoethanolamine transferases involved in polymyxin resistance across 10 clinically relevant Gram-negative bacteria

Jiayuan Huang, Yan Zhu, Mei-Ling Han, Mengyao Li, Jiangning Song, Tony Velkov, Chen Li, Jian Li

Journal article  |  2018  |  International Journal of Antimicrobial Agents

The inhibitory effects of eighteen front-line antibiotics on the substrate uptake mediated by human Organic anion/cation transporters, Organic anion transporting polypeptides and Oligopeptide transporters in in vitro models

Xiaoxi Lu, Ting Chan, Ling Zhu, Xiaofeng Bao, Tony Velkov, Qi Tony Zhou, Jian Li, Hak-Kim Chan, Fanfan Zhou

Journal article  |  2018  |  European Journal of Pharmaceutical Sciences

Broad activity of diphenyleneiodonium analogues against Mycobacterium tuberculosis, malaria parasites and bacterial pathogens

Nguyen Nghi, Danny W Wilson, Gayathri Nagalingam, James A Triccas, Elena K Schneider, Jian Li, Tony Velkov, Jonathan Baell

Journal article  |  2018  |  European Journal of Medicinal Chemistry

Genome-scale metabolic modeling of responses to polymyxins in Pseudomonas aeruginosa

Yan Zhu, Tobias Czauderna, Jinxin Zhao, Matthias Klapperstueck, Mohd Hafidz Mahamad Maifiah, Mei-Ling Han, Jing Lu, Bjoern Sommer, Tony Velkov, Trevor Lithgow, Jiangning Song, Falk Schreiber, Jian Li

Journal article  |  2018  |  GIGASCIENCE

Polymyxins for CNS infections: Pharmacology and neurotoxicity

Tony Velkov, Chongshan Dai, Giuseppe D Ciccotosto, Roberto Cappai, Daniel Hoyer, Jian Li

Journal article  |  2018  |  Pharmacology & Therapeutics

The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites

Elena K Schneider, Rachel M McQuade, Vincenzo C Carbone, Felisa Reyes-Ortega, John W Wilson, Brenda Button, Ayame Saito, Daniel P Poole, Daniel Hoyer, Jian Li, Tony Velkov

Journal article  |  2018  |  ERJ OPEN RESEARCH

Ivacaftor-lumacaftor and ivacaftor are two new breakthrough cystic fibrosis transmembrane conductance modulators. The interactions..

Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR Pseudomonas aeruginosa

Maytham Hussein, Mei-Ling Han, Yan Zhu, Elena K Schneider-Futschik, Xiaohan Hu, Qi Tony Zhou, Yu-Wei Lin, Dovile Anderson, Darren J Creek, Daniel Hoyer, Jian Li, Tony Velkov

Journal article  |  2018  |  COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL

Methionine Ameliorates Polymyxin-Induced Nephrotoxicity by Attenuating Cellular Oxidative Stress

Mohammad AK Azad, Sivashangarie Sivanesan, Jiping Wang, Ke Chen, Roger L Nation, Philip E Thompson, Kade D Roberts, Tony Velkov, Jian Li

Journal article  |  2018  |  Antimicrobial Agents and Chemotherapy

Polymyxin-Induced Lipid A Deacylation in Pseudomonas aeruginosa Perturbs Polymyxin Penetration and Confers High-Level Resistance

Mei-Ling Han, Tony Velkov, Yan Zhu, Kade D Roberts, Anton P Le Brun, Seong Hoong Chow, Alina D Gutu, Samuel M Moskowitz, Hsin-Hui Shen, Jian Li

Journal article  |  2018  |  ACS Chemical Biology

Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis

Chongshan Dai, Giuseppe D Ciccotosto, Roberto Cappai, Shusheng Tang, Daowen Li, Sanlei Xie, Xilong Xiao, Tony Velkov

Journal article  |  2018  |  Molecular Neurobiology

A Portrait of the Sialyl Glycan Receptor Specificity of the H10 Influenza Virus Hemagglutinin-A Picture of an Avian Virus on the Verge of Becoming a Pandemic?

Elena K Schneider, Jian Li, Tony Velkov

Journal article  |  2017  |  VACCINES

Gelofusine Ameliorates Colistin-Induced Nephrotoxicity

Sivashangarie S Sivanesan, Mohammad AK Azad, Elena K Schneider, Maizbha U Ahmed, Jiayuan Huang, Jiping Wang, Jian Li, Roger L Nation, Tony Velkov

Journal article  |  2017  |  Antimicrobial Agents and Chemotherapy

Aminoglycoside Concentrations Required for Synergy with Carbapenems against Pseudomonas aeruginosa Determined via Mechanistic Studies and Modeling

Rajbharan Yadav, Jurgen B Bulitta, Elena K Schneider, Beom Soo Shin, Tony Velkov, Roger L Nation, Cornelia B Landersdorfer

Journal article  |  2017  |  Antimicrobial Agents and Chemotherapy

Design and Evaluation of Novel Polymyxin Fluorescent Probes

Bo Yun, Kade D Roberts, Philip E Thompson, Roger L Nation, Tony Velkov, Jian Li

Journal article  |  2017  |  SENSORS

Pulsed-voltage atom probe tomography of low conductivity and insulator materials by application of ultrathin metallic coating on nanoscale specimen geometry

Vahid R Adineh, Ross KW Marceau, Yu Chen, Kae J Si, Tony Velkov, Wenlong Cheng, Jian Li, Jing Fu

Journal article  |  2017  |  Ultramicroscopy

Optimized HPLC-MS Method for the High-Throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients

Elena K Schneider, Felisa Reyes-Ortega, Jian Li, Tony Velkov

Journal article  |  2017  |  Journal of Visualized Experiments

The first total synthesis and solution structure of a polypeptin, PE2, a cyclic lipopeptide with broad spectrum antibiotic activity

Simon J Mountford, Biswaranjan Mohanty, Kade D Roberts, Heidi H Yu, Martin J Scanlon, Roger L Nation, Tony Velkov, Jian Li, Philp E Thompson

Journal article  |  2017  |  Organic & Biomolecular Chemistry

Baicalein acts as a nephroprotectant that ameliorates colistin-induced nephrotoxicity by activating the antioxidant defence mechanism of the kidneys and down-regulating the inflammatory response

Chongshan Dai, Shusheng Tang, Yang Wang, Tony Velkov, Xilong Xiao

Journal article  |  2017  |  Journal of Antimicrobial Chemotherapy

A traceless reversible polymeric colistin prodrug to combat multidrug-resistant (MDR) gram-negative bacteria

Chongyu Zhu, Elena K Schneider, Jiping Wang, Kristian Kempe, Paul Wilson, Tony Velkov, Jian Li, Thomas P Davis, Michael R Whittaker, David M Haddleton

Journal article  |  2017  |  Journal of Controlled Release

Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes

Mei-Ling Han, Hsin-Hui Shen, Karl A Hansford, Elena K Schneider, Sivashangarie Sivanesan, Kade D Roberts, Philip E Thompson, Anton P Le Brun, Yan Zhu, Marc-Antoine Sani, Frances Separovic, Mark AT Blaskovich, Mark A Baker, Samuel M Moskowitz, Matthew A Cooper, Jian Li, Tony Velkov

Journal article  |  2017  |  ACS Infectious Diseases

From Breast Cancer to Antimicrobial: Combating Extremely Resistant Gram-Negative "Superbugs" Using Novel Combinations of Polymyxin B with Selective Estrogen Receptor Modulators

Maytham H Hussein, Elena K Schneider, Alysha G Elliott, Meiling Han, Felisa Reyes-Ortega, Faye Morris, Mark AT Blastovich, Raad Jasim, Bart Currie, Mark Mayo, Mark Baker, Matthew A Cooper, Jian Li, Tony Velkov

Journal article  |  2017  |  Microbial Drug Resistance

Hydrolyzable Poly[Poly(Ethylene Glycol) Methyl Ether Acrylate]-Colistin Prodrugs through Copper-Mediated Photoinduced Living Radical Polymerization

Chongyu Zhu, Elena K Schneider, Vasiliki Nikolaou, Tobias Klein, Jian Li, Thomas P Davis, Michael R Whittaker, Paul Wilson, Kristian Kempe, Tony Velkov, David M Haddleton

Journal article  |  2017  |  Bioconjugate Chemistry

Minocycline attenuates colistin-induced neurotoxicity via suppression of apoptosis, mitochondrial dysfunction and oxidative stress

Chongshan Dai, Giuseppe D Ciccotosto, Roberto Cappai, Yang Wang, Shusheng Tang, Xilong Xiao, Tony Velkov

Journal article  |  2017  |  Journal of Antimicrobial Chemotherapy

Potential Toxicity of Polymyxins in Human Lung Epithelial Cells

Maizbha U Ahmed, Tony Velkov, Yu-Wei Lin, Bo Yun, Cameron J Nowell, Fanfan Zhou, Qi Tony Zhou, Kim Chan, Mohammad AK Azad, Jian Li

Journal article  |  2017  |  Antimicrobial Agents and Chemotherapy

Deficiency in outer dense fiber 1 is a marker and potential driver of idiopathic male infertility (vol 15, pg 3685, 2016)

Louise Hetherington, Elena K Schneider, Caroline Scott, David DeKretser, Charles H Muller, Hubert Hondermarck, Tony Velkov, Mark A Baker

Journal article  |  2017  |  Molecular & Cellular Proteomics

Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401

Charles A Galea, Meiling Han, Yan Zhu, Kade Roberts, Jiping Wang, Philip E Thornpson, L Jian, Tony Velkov

Journal article  |  2017  |  Journal of Natural Products

Pharmacokinetics and relative bioavailability of an oral amoxicillin-apramycin combination in pigs

Chongshan Dai, Tingting Zhao, Xing Yang, Xilong Xiao, Tony Velkov, Shusheng Tang

Journal article  |  2017  |  PLOS ONE

A Fresh Shine on Cystic Fibrosis Inhalation Therapy: Antimicrobial Synergy of Polymyxin B in Combination with Silver Nanoparticles

Raad Jasim, Elena K Schneider, Meiling Han, Mohammad AK Azad, Maytham Hussein, Cameron Nowell, Mark A Baker, Jiping Wang, Jian Li, Tony Velkov

Journal article  |  2017  |  Journal of Biomedical Nanotechnology

Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii

Mohd Hafidz Mahamad Maifiah, Darren J Creek, Roger L Nation, Alan Forrest, Brian T Tsuji, Tony Velkov, Jian Li

Journal article  |  2017  |  SCIENTIFIC REPORTS

Rediscovering the octapeptins

Tony Velkov, Kade D Roberts, Jian Li

Journal article  |  2017  |  Natural Product Reports

Plasma Protein Binding Structure Activity Relationships Related to the N-Terminus of Daptomycin

Elena K Schneider, Johnny X Huang, Vincenzo Carbone, Meiling Han, Yan Zhu, Sue Nang, Keith K Khoo, Johnson Mak, Matthew A Cooper, Jian Li, Tony Velkov

Journal article  |  2017  |  ACS Infectious Diseases

The thermodynamics of Pr55(Gag)-RNA interaction regulate the assembly of HIV

Hanumant S Tanwar, Keith K Khoo, Megan Garvey, Lynne Waddington, Andrew Leis, Marcel Hijnen, Tony Velkov, Geoff J Dumsday, William J McKinstry, Johnson Mak

Journal article  |  2017  |  PLOS PATHOGENS

A Hydrogel-Based Localized Release of Colistin for Antimicrobial Treatment of Burn Wound Infection

Chongyu Zhu, Jinxin Zhao, Kristian Kempe, Paul Wilson, Jiping Wang, Tony Velkov, Jian Li, Thomas P Davis, Michael R Whittaker, David M Haddleton

Journal article  |  2017  |  Macromolecular Bioscience

Functional Characterization of the Unique Terminal Thioesterase Domain from Polymyxin Synthetase

Charles A Galea, Kade D Roberts, Yan Zhu, Philip E Thompson, Jian Li, Tony Velkov

Journal article  |  2017  |  Biochemistry

Cationic acrylate oligomers comprising amino acid mimic moieties demonstrate improved antibacterial killing efficiency

James L Grace, Alysha G Elliott, Johnny X Huang, Elena K Schneider, Nghia P Truong, Matthew A Cooper, Jian Li, Thomas P Davis, John F Quinn, Tony Velkov, Michael R Whittaker

Journal article  |  2017  |  Journal of Materials Chemistry B

Can Cystic Fibrosis Patients Finally Catch a Breath With Lumacaftor/Ivacaftor?

EK Schneider, F Reyes-Ortega, J Li, T Velkov

Journal article  |  2017  |  Clinical Pharmacology & Therapeutics

Antibiotic-non-antibiotic combinations for combating extremely drug-resistant Gram-negative 'superbugs'

Elena K Schneider, Felisa Reyes-Ortega, Tony Velkov, Jian Li

Journal article  |  2017  |  Essays in Biochemistry

Pharmacokinetics of the Individual Major Components of Polymyxin B and Colistin in Rats

Sivashangarie Sivanesan, Kade Roberts, Jiping Wang, Soon-Ee Chea, Philip E Thompson, Jian Li, Roger L Nation, Tony Velkov

Journal article  |  2017  |  Journal of Natural Products

Deficiency in Outer Dense Fiber 1 Is a Marker and Potential Driver of Idiopathic Male Infertility

Louise Hetherington, Elena K Schneider, David DeKretser, Charles H Muller, Hubert Hondermarck, Tony Velkov, Mark A Baker

Journal article  |  2016  |  Molecular & Cellular Proteomics

The Plasma Protein Binding Proteome of Ertapenem: A Novel Compound-Centric Proteomic Approach for Elucidating Drug-Plasma Protein Binding Interactions

Mark A Baker, Elena K Schneider, Johnny X Huang, Matthew A Cooper, Jian Li, Tony Velkov

Journal article  |  2016  |  ACS Chemical Biology

Pharmacokinetics/pharmacodynamics of colistin and polymyxin B: are we there yet?

Thien B Tran, Tony Velkov, Roger L Nation, Alan Forrest, Brian T Tsuji, Phillip J Bergen, Jian Li

Journal article  |  2016  |  International Journal of Antimicrobial Agents

Development of HPLC and LC-MS/MS methods for the analysis of ivacaftor, its major metabolites and lumacaftor in plasma and sputum of cystic fibrosis patients treated with ORKAMBI or KALYDECO

Elena K Schneider, Felisa Reyes-Ortega, John W Wilson, Tom Kotsimbos, Dominic Keating, Jian Li, Tony Velkov

Journal article  |  2016  |  Journal of Chromatography B

Near-Atomic Three-Dimensional Mapping for Site-Specific Chemistry of 'Superbugs'

Vahid R Adineh, Ross KW Marceau, Tony Velkov, Jian Li, Jing Fu

Journal article  |  2016  |  Nano Letters

Colistin-Induced Apoptosis of Neuroblastoma-2a Cells Involves the Generation of Reactive Oxygen Species, Mitochondrial Dysfunction, and Autophagy

Chongshan Dai, Shusheng Tang, Tony Velkov, Xilong Xiao

Journal article  |  2016  |  Molecular Neurobiology

Transcriptomic Analysis of the Activity of a Novel Polymyxin against Staphylococcus aureus

Jinxin Zhao, Soon-Ee Cheah, Kade D Roberts, Roger L Nation, Philip E Thompson, Tony Velkov, Zongjun Du, Matthew D Johnson, Jian Li

Journal article  |  2016  |  MSPHERE

An "Unlikely" Pair: The Antimicrobial Synergy of Polymyxin B in Combination with the Cystic Fibrosis Transmembrane Conductance Regulator Drugs KALYDECO and ORKAMBI

Elena K Schneider, Mohammad AK Azad, Mei-Ling Han, Qi Tony Zhou, Jiping Wang, Johnny X Huang, Matthew A Cooper, Yohei Doi, Mark A Baker, Phillip J Bergen, Mark T Muller, Jian Li, Tony Velkov

Journal article  |  2016  |  ACS Infectious Diseases

Pharmacokinetics of levobupivacaine following infant spinal anesthesia

Geoff Frawley, Ben Hallett, Tony Velkov, Andrew Bjorksten

Journal article  |  2016  |  Pediatric Anesthesia

Polymyxins: a new hope in combating Gram-negative superbugs?

Tony Velkov, Kade D Roberts, Philip E Thompson, Jian Li

Journal article  |  2016  |  Future Medicinal Chemistry

Anthelmintic closantel enhances bacterial killing of polymyxin B against multidrug-resistant Acinetobacter baumannii

Thien B Tran, Soon-Ee Cheah, Heidi H Yu, Phillip J Bergen, Roger L Nation, Darren J Creek, Anthony Purcell, Alan Forrest, Yohei Doi, Jiangning Song, Tony Velkov, Jian Li

Journal article  |  2016  |  JOURNAL OF ANTIBIOTICS

A Novel Chemical Biology Approach for Mapping of Polymyxin Lipopeptide Antibody Binding Epitopes

Tony Velkov, Bo Yun, Elena K Schneider, Mohammad AK Azad, Olan Dolezal, Faye C Morris, Roger L Nation, Jiping Wang, Ke Chen, Heidi H Yu, Lv Wang, Philip E Thompson, Kade D Roberts, Jian Li

Journal article  |  2016  |  ACS Infectious Diseases

Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii

Mohd Hafidz Mahamad Maifiah, Soon-Ee Cheah, Matthew D Johnson, Mei-Ling Han, John D Boyce, Visanu Thamlikitkul, Alan Forrest, Keith S Kaye, Paul Hertzog, Anthony W Purcell, Jiangning Song, Tony Velkov, Darren J Creek, Jian Li

Journal article  |  2016  |  SCIENTIFIC REPORTS

Quantitation of Polymyxin-Lipopolysaccharide Interactions Using an Image-Based Fluorescent Probe

Mitchell P McInerney, Kade D Roberts, Philip E Thompson, Jian Li, Roger L Nation, Tony Velkov, Joseph A Nicolazzo

Journal article  |  2016  |  Journal of Pharmaceutical Sciences

Antibacterial low molecular weight cationic polymers: dissecting the contribution of hydrophobicity, chain length and charge to activity

James L Grace, Johnny X Huang, Soon-Ee Cheah, Nghia P Truong, Matthew A Cooper, Jian Li, Thomas P Davis, John F Quinn, Tony Velkov, Michael R Whittaker

Journal article  |  2016  |  RSC Advances

Cellular Uptake and Localization of Polymyxins in Renal Tubular Cells Using Rationally Designed Fluorescent Probes

Bo Yun, Mohammad AK Azad, Cameron J Nowell, Roger L Nation, Philip E Thompson, Kade D Roberts, Tony Velkov, Jian Li

Journal article  |  2015  |  Antimicrobial Agents and Chemotherapy

Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-Line Antibiotics against Multidrug-Resistant Gram-Negative Bacteria

Kade D Roberts, Mohammad AK Azad, Jiping Wang, Andrew S Horne, Philip E Thompson, Roger L Nation, Tony Velkov, Jian Li

Journal article  |  2015  |  ACS Infectious Diseases

Cold adaptation generates mutations associated with the growth of influenza B vaccine viruses

Hyunsuh Kim, Tony Velkov, Sarina Camuglia, Steven P Rockmand, Gregory A Tannock

Journal article  |  2015  |  Vaccine

Synergistic killing of NDM-producing MDR Klebsiella pneumoniae by two 'old' antibiotics-polymyxin B and chloramphenicol

Nusaibah Abdul Rahim, Soon-Ee Cheah, Matthew D Johnson, Heidi Yu, Hanna E Sidjabat, John Boyce, Mark S Butler, Matthew A Cooper, Jing Fu, David L Paterson, Roger L Nation, Phillip J Bergen, Tony Velkov, Jian Li

Journal article  |  2015  |  Journal of Antimicrobial Chemotherapy

Drug-drug plasma protein binding interactions of ivacaftor

Elena K Schneider, Johnny X Huang, Vincenzo Carbone, Mark Baker, Mohammad AK Azad, Matthew A Cooper, Jian Li, Tony Velkov

Journal article  |  2015  |  Journal of Molecular Recognition

Molecular Characterisation of the Haemagglutinin Glycan-Binding Specificity of Egg-Adapted Vaccine Strains of the Pandemic 2009 H1N1 Swine Influenza A Virus

Vincenzo Carbone, Elena K Schneider, Steve Rockman, Mark Baker, Johnny X Huang, Chi Ong, Matthew A Cooper, Elizabeth Yuriev, Jian Li, Tony Velkov

Journal article  |  2015  |  MOLECULES

Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor alpha in a Ligand-selective Manner

Maria LR Hughes, Bonan Liu, Michelle L Halls, Kylie M Wagstaff, Rahul Patil, Tony Velkov, David A Jans, Nigel W Bunnett, Martin J Scanlon, Christopher JH Porter

Journal article  |  2015  |  Journal of Biological Chemistry

Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead

Tony Velkov, Nusaibah Abdul Rahim, Qi Tony Zhou, Hak-Kim Chan, Jian Li

Journal article  |  2015  |  ADVANCED DRUG DELIVERY REVIEWS

Two Mechanisms of Killing of Pseudomonas aeruginosa by Tobramycin Assessed at Multiple Inocula via Mechanism-Based Modeling

Juergen B Bulitta, Neang S Ly, Cornelia B Landersdorfer, Nicholin A Wanigaratne, Tony Velkov, Rajbharan Yadav, Antonio Oliver, Lisandra Martin, Beom Soo Shin, Alan Forrest, Brian T Tsuji

Journal article  |  2015  |  Antimicrobial Agents and Chemotherapy

Major Pathways of Polymyxin-Induced Apoptosis in Rat Kidney Proximal Tubular Cells

Mohammad AK Azad, Jesmin Akter, Kelly L Rogers, Roger L Nation, Tony Velkov, Jian Li

Journal article  |  2015  |  Antimicrobial Agents and Chemotherapy

Defining the Mechanisms by Which the Reactive Oxygen Species By-Product, 4-Hydroxynonenal, Affects Human Sperm Cell Function

Mark A Baker, Anita Weinberg, Louise Hetherington, Ana-Izabel Villaverde, Tony Velkov, Jonathan Baell, Christopher P Gordon

Journal article  |  2015  |  Biology of Reproduction

Imaging the distribution of polymyxins in the kidney

Bo Yun, Mohammad AK Azad, Jiping Wang, Roger L Nation, Philip E Thompson, Kade D Roberts, Tony Velkov, Jian Li

Journal article  |  2015  |  Journal of Antimicrobial Chemotherapy

Significant Accumulation of Polymyxin in Single Renal Tubular Cells: A Medicinal Chemistry and Triple Correlative Microscopy Approach

Mohammad AK Azad, Kade D Roberts, Heidi H Yu, Boyin Liu, Alice V Schofield, Simon A James, Daryl L Howard, Roger L Nation, Kelly Rogers, Martin D de Jonge, Philip E Thompson, Jing Fu, Tony Velkov, Jian Li

Journal article  |  2015  |  ANALYTICAL CHEMISTRY

Methotrexate-Conjugated PEGylated Dendrimers Show Differential Patterns of Deposition and Activity in Tumor-Burdened Lymph Nodes after Intravenous and Subcutaneous Administration in Rats

Lisa M Kaminskas, Victoria M McLeod, David B Ascher, Gemma M Ryan, Seth Jones, John M Haynes, Natalie L Trevaskis, Linda J Chan, Erica K Sloan, Bentamin A Finnin, Mark Williamson, Tony Velkov, Elizabeth D Williams, Brian D Kelly, David J Owen, Christopher JH Porter

Journal article  |  2015  |  Molecular Pharmaceutics

The carbohydrate-binding promiscuity of Euonymus europaeus lectin is predicted to involve a single binding site

Mark Agostino, Tony Velkov, Tamir Dingjan, Spencer J Williams, Elizabeth Yuriev, Paul A Ramsland

Journal article  |  2015  |  Glycobiology

Lycopene Attenuates Colistin-Induced Nephrotoxicity in Mice via Activation of the Nrf2/HO-1 Pathway

Chongshan Dai, Shusheng Tang, Sijun Deng, Shen Zhang, Yan Zhou, Tony Velkov, Jian Li, Xilong Xiao

Journal article  |  2015  |  Antimicrobial Agents and Chemotherapy

Analysis of Protein Thiol Changes Occurring During Rat Sperm Epididymal Maturation

Mark A Baker, Anita Weinberg, Louise Hetherington, Ana Izabel SB Villaverde, Tony Velkov

Journal article  |  2015  |  Biology of Reproduction

Phosphopeptide Analysis of Rodent Epididymal Spermatozoa

Mark A Baker, Louise Hetherington, Anita Weinberg, Tony Velkov

Journal article  |  2014  |  JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

In situ probing the interior of single bacterial cells at nanometer scale

Boyin Liu, Md Hemayet Uddin, Tuck Wah Ng, David L Paterson, Tony Velkov, Jian Li, Jing Fu

Journal article  |  2014  |  Nanotechnology

Measuring polymyxin uptake by renal tubular cells: Is bodipy-polymyxin B an appropriate probe?

MAK Azad, B Yun, KD Roberts, RL Nation, PE Thompson, T Velkov, J Li

Journal article  |  2014  |  Antimicrobial Agents and Chemotherapy

Measuring Polymyxin Uptake by Renal Tubular Cells: Is BODIPY-Polymyxin B an Appropriate Probe?

Mohammad AK Azad, Bo Yun, Kade D Roberts, Roger L Nation, Philip E Thompson, Tony Velkov, Jian Li

Journal article  |  2014  |  Antimicrobial Agents and Chemotherapy

Colistin and Polymyxin B: Peas in a Pod, or Chalk and Cheese?

Roger L Nation, Tony Velkov, Jian Li

Journal article  |  2014  |  Clinical Infectious Diseases

Teaching 'Old' Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative 'Superbugs'

Tony Velkov, Kade D Roberts, Roger L Nation, Jiping Wang, Philip E Thompson, Jian Li

Journal article  |  2014  |  ACS CHEMICAL BIOLOGY

Surface changes and polymyxin interactions with a resistant strain of Klebsiella pneumoniae

Tony Velkov, Zakuan Z Deris, Johnny X Huang, Mohammad AK Azad, Mark Butler, Sivashangarie Sivanesan, Lisa M Kaminskas, Yao-Da Dong, Ben Boyd, Mark A Baker, Matthew A Cooper, Roger L Nation, Jian Li

Journal article  |  2014  |  Innate Immunity

Nanoscale Focused Ion Beam Tomography of Single Bacterial Cells for Assessment of Antibiotic Effects

Boyin Liu, Heidi H Yu, Tuck Wah Ng, David L Paterson, Tony Velkov, Jian Li, Jing Fu

Journal article  |  2014  |  Microscopy and Microanalysis

Probing the Penetration of Antimicrobial Polymyxin Lipopeptides into Gram-Negative Bacteria

Zakuan Z Deris, James D Swarbrick, Kade D Roberts, Mohammad AK Azad, Jesmin Akter, Andrew S Horne, Roger L Nation, Kelly L Rogers, Phillip E Thompson, Tony Velkov, Jian Li

Journal article  |  2014  |  BIOCONJUGATE CHEMISTRY

A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

Zakuan Z Deris, Jesmin Akter, Sivashangarie Sivanesan, Kade D Roberts, Philip E Thompson, Roger L Nation, Jian Li, Tony Velkov

Journal article  |  2014  |  JOURNAL OF ANTIBIOTICS

The RNA-Dependent-RNA Polymerase, an Emerging Antiviral Drug Target for the Hendra Virus

Tony Velkov, Vincenzo Carbone, Jesmin Akter, Sivashangarie Sivanesan, Jian Li, Travis Beddoe, Glenn A Marsh

Journal article  |  2014  |  Current Drug Targets

Cyclosporines: Biosynthesis and Beyond

Tony Velkov, Alfons Lawen

Book Chapter  |  2014

The antigenic architecture of the hemagglutinin of influenza H5N1 viruses

Tony Velkov, Chi Ong, Mark A Baker, Hyunsuh Kim, Jian Li, Roger L Nation, Johnny X Huang, Matthew A Cooper, Steve Rockman

Journal article  |  2013  |  Molecular Immunology

Polymyxins and Analogues Bind to Ribosomal RNA and Interfere with Eukaryotic Translation in Vitro

Lisa S McCoy, Kade D Roberts, Roger L Nation, Philip E Thompson, Tony Velkov, Jian Li, Yitzhak Tor

Journal article  |  2013  |  ChemBioChem

The specificity of the influenza B virus hemagglutinin receptor binding pocket: what does it bind to?

Tony Velkov

Journal article  |  2013  |  Journal of Molecular Recognition

PK/PD models in antibacterial development

Tony Velkov, Phillip J Bergen, Jaime Lora-Tamayo, Cornelia B Landersdorfer, Jian Li

Journal article  |  2013  |  Current Opinion in Microbiology

Pharmacokinetics of four different brands of colistimethate and formed colistin in rats

Hui He, Ji-Chang Li, Roger L Nation, Jovan Jacob, Gong Chen, Hee Ji Lee, Brian T Tsuji, Philip E Thompson, Kade Roberts, Tony Velkov, Jian Li

Journal article  |  2013  |  Journal of Antimicrobial Chemotherapy

Polymyxin B Induces Apoptosis in Kidney Proximal Tubular Cells

Mohammad AK Azad, Ben A Finnin, Anima Poudyal, Kathryn Davis, Jinhua Li, Prue A Hill, Roger L Nation, Tony Velkov, Jian Li

Journal article  |  2013  |  Antimicrobial Agents and Chemotherapy

Interaction of Phthalates and Phenoxy Acid Herbicide Environmental Pollutants with Intestinal Intracellular Lipid Binding Proteins

Vincenzo Carbone, Tony Velkov

Journal article  |  2013  |  Chemical Research in Toxicology

Molecular basis for the increased polymyxin susceptibility of Klebsiella pneumoniae strains with under-acylated lipid A

Tony Velkov, Rachel L Soon, Pei L Chong, Johnny X Huang, Matthew A Cooper, Mohammad AK Azad, Mark A Baker, Philip E Thompson, Kade Roberts, Roger L Nation, Abigail Clements, Richard A Strugnell, Jian Li

Journal article  |  2013  |  Innate Immunity

Post-ejaculatory changes in the metabolic status of rat spermatozoa as measured by GC-MS

Mark A Baker, Anita S Weinberg, Louise Hetherington, Tony Velkov, R John Aitken

Journal article  |  2013  |  Metabolomics

Molecular basis for the increased polymyxin susceptibility ofKlebsiella pneumoniaestrains with under-acylated lipid A

Tony Velkov, Rachel L Soon, Pei L Chong, Johnny X Huang, Matthew A Cooper, Mohammad AK Azad, Mark A Baker, Philip E Thompson, Kade Roberts, Roger L Nation, Abigail Clements, Richard A Strugnell, Jian Li

Journal article  |  2013  |  Innate Immunity

Pharmacology of polymyxins: new insights into an 'old' class of antibiotics

Tony Velkov, Kade D Roberts, Roger L Nation, Philip E Thompson, Jian Li

Journal article  |  2013  |  Future Microbiology

Novel Analogues of the Antimicrobial Peptide Polymyxin B Targeting Polymyxin-resistant Gram-negative Bacteria

Kade D Roberts, Philip E Thompson, Tony Velkov, Roger L Nation, Jian Li

Conference Proceedings  |  2013  |  BIOPOLYMERS

Reverse engineering the antigenic architecture of the haemagglutinin from influenza H5N1 clade 1 and 2.2 viruses with fine epitope mapping using monoclonal antibodies

Steve Rockman, Sarina Camuglia, Kirsten Vandenberg, Chi Ong, Mark A Baker, Roger L Nation, Jian Li, Tony Velkov

Journal article  |  2013  |  Molecular Immunology

Head and flagella subcompartmental proteomic analysis of human spermatozoa

Mark A Baker, Nenad Naumovski, Louise Hetherington, Anita Weinberg, Tony Velkov, R John Aitken

Journal article  |  2013  |  PROTEOMICS

Interactions between Human Liver Fatty Acid Binding Protein and Peroxisome Proliferator Activated Receptor Selective Drugs

Tony Velkov

Journal article  |  2013  |  PPAR RESEARCH

Molecular characterization of the receptor binding structure-activity relationships of influenza B virus hemagglutinin

V Carbone, H Kim, JX Huang, MA Baker, C Ong, MA Cooper, J Li, S Rockman, T Velkov

Journal article  |  2013  |  Acta Virologica

Drug-binding energetics of human alpha-1-acid glycoprotein assessed by isothermal titration calorimetry and molecular docking simulations

Johnny X Huang, Matthew A Cooper, Mark A Baker, Mohammad AK Azad, Roger L Nation, Jian Li, Tony Velkov

Journal article  |  2012  |  Journal of Molecular Recognition

Analysis of Phosphopeptide Changes as Spermatozoa Acquire Functional Competence in the Epididymis Demonstrates Changes in the Post-translational Modification of Izumo1

Mark A Baker, Louise Hetherington, Anita Weinberg, Nenad Naumovski, Tony Velkov, Matthias Pelzing, Sebastiaan Dolman, Mark R Condina, R John Aitken

Journal article  |  2012  |  Journal of Proteome Research

The Combination of Colistin and Doripenem Is Synergistic against Klebsiella pneumoniae at Multiple Inocula and Suppresses Colistin Resistance in an In Vitro Pharmacokinetic/Pharmacodynamic Model

Zakuan Z Deris, Heidi H Yu, Kathryn Davis, Rachel L Soon, Jovan Jacob, Caron K Ku, Anima Poudyal, Phillip J Bergen, Brian T Tsuji, Jurgen B Bulitta, Alan Forrest, David L Paterson, Tony Velkov, Jian Li, Roger L Nation

Journal article  |  2012  |  Antimicrobial Agents and Chemotherapy

Structure-activity relationships for the binding of polymyxins with human alpha-1-acid glycoprotein

Mohammad AK Azad, Johnny X Huang, Matthew A Cooper, Kade D Roberts, Philip E Thompson, Roger L Nation, Jian Li, Tony Velkov

Journal article  |  2012  |  Biochemical Pharmacology

Characterization of the N-Methyltransferase Activities of the Multifunctional Polypeptide Cyclosporin Synthetase

Tony Velkov, James Horne, Martin J Scanlon, Ben Capuano, Elizabeth Yuriev, Alfons Lawen

Journal article  |  2011  |  Chemistry & Biology

Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactions

Rachel L Soon, Tony Velkov, Francis Chiu, Philip E Thompson, Rashmi Kancharla, Kade Roberts, Ian Larson, Roger L Nation, Jian Li

Journal article  |  2011  |  Analytical Biochemistry

A gel-capture assay for characterizing the sialyl-glycan selectivity of influenza viruses

T Velkov, PE Thompson, O El-Kabbani, F Lindh, J Stambas, S Rockman

Journal article  |  2011  |  Acta Virologica

Design, Synthesis and Evaluation of Novel Analogues of the Antimicrobial Peptide Polymyxin B

Kade D Roberts, Philip E Thompson, Tony Velkov, Roger L Nation, Jian Li

Conference Proceedings  |  2011  |  BIOPOLYMERS

Self-Assembly Behavior of Colistin and Its Prodrug Colistin Methanesulfonate: Implications for Solution Stability and Solubilization

Stephanie J Wallace, Jian Li, Roger L Nation, Richard J Prankerd, Tony Velkov, Ben J Boyd

Journal article  |  2010  |  The Journal of Physical Chemistry B

Ligand-enhanced expression and in-cell assay of human peroxisome proliferator-activated receptor alpha ligand binding domain

Tony Velkov, Kieran A Rimmer, Stephen J Headey

Journal article  |  2010  |  Protein Expression and Purification

Structure-Activity Relationships of Polymyxin Antibiotics

Tony Velkov, Philip E Thompson, Roger L Nation, Jian Li

Journal article  |  2010  |  Journal of Medicinal Chemistry

Developing an anion host for lipid A binding and antibacterial activity

Luke C Henderson, Jian Li, Roger L Nation, Tony Velkov, Frederick M Pfeffer

Journal article  |  2010  |  Chemical Communications

Probing the Fibrate Binding Specificity of Rat Liver Fatty Acid Binding Protein

Sara Chuang, Tony Velkov, James Horne, Jerome Wielens, David K Chalmers, Christopher JH Porter, Martin J Scanlon

Journal article  |  2009  |  Journal of Medicinal Chemistry

Characterization of lipophilic drug binding to rat intestinal fatty acid binding protein

Tony Velkov, Maria LR Lim, James Horne, Jamie S Simpson, Christopher JH Porter, Martin J Scanlon

Conference Proceedings  |  2009  |  Molecular and Cellular Biochemistry

Thermodynamics of Lipophilic Drug Binding to Intestinal Fatty Acid Binding Protein and Permeation across Membranes

Tony Velkov

Journal article  |  2009  |  Molecular Pharmaceutics

Structural and Biochemical Characterization of the Oxidoreductase NmDsbA3 from Neisseria meningitidis

Julian P Vivian, Jessica Scoullar, Amy L Robertson, Stephen P Bottomley, James Horne, Yanni Chin, Jerome Wielens, Philip E Thompson, Tony Velkov, Susannah Piek, Emma Byres, Travis Beddoe, Matthew CJ Wilce, Charlene M Kahler, Jamie Rossjohn, Martin J Scanlon

Journal article  |  2008  |  Journal of Biological Chemistry

Characterization of the drug binding specificity of rat liver fatty acid binding protein

Sara Chuang, Tony Velkov, James Horne, Christopher JH Porter, Martin J Scanlon

Journal article  |  2008  |  Journal of Medicinal Chemistry

A protocol for the combined sub-fractionation and delipidation of lipid binding proteins using hydrophobic interaction chromatography

Tony Velkov, Maria LR Lim, Benjamin Capuano, Richard Prankerd

Journal article  |  2008  |  Journal of Chromatography B

Ni2 -based immobilized metal ion affinity chromatography of lactose operon repressor protein from Escherichia Coli

Tony Velkov, Alun Jones, Maria LR Lim

Journal article  |  2008  |  Preparative Biochemistry and Biotechnology

Probing the flexibility of the DsbA oxidoreductase from Vibrio cholerae - a N-15-H-1 heteronuclear NMR relaxation analysis of oxidized and reduced forms of DsbA

James Horne, Edward J d'Auvergne, Murray Coles, Tony Velkov, Yanni Chin, William N Charman, Richard Prankerd, Paul R Gooley, Martin J Scanlon

Journal article  |  2007  |  Journal of Molecular Biology

Generation of mutant leukaemia inhibitory factor (LIF)-IgG heavy chain fusion proteins as bivalent antagonists of LIF

Jalal A Jazayeri, Nicole De Weerd, Warren Raye, Tony Velkov, Lanie Santos, David Taylor, Graerne J Carroll

Journal article  |  2007  |  Journal of Immunological Methods

Examination of the role of intestinal fatty acid-binding protein in drug absorption using a parallel artificial membrane permeability assay

Tony Velkov, James Horne, Aisha Laguerre, Eric Jones, Martin J Scanlon, Christopher JH Porter

Journal article  |  2007  |  Chemistry & Biology

An improved purification procedure for cyclosporin synthetase

T Velkov, LG Singaretnam, A Lawen

Journal article  |  2006  |  Protein Expression and Purification

An improved method for the purification of rat liver-type fatty acid binding protein from Escherichia coli

T Velkov, S Chuang, R Prankerd, H Sakellaris, CJH Porter, MJ Scanlon

Journal article  |  2005  |  Protein Expression and Purification

The interaction of lipophilic drugs with intestinal fatty acid-binding protein

T Velkov, S Chuang, J Wielens, H Sakellaris, WN Charman, CJH Porter, MJ Scanlon

Journal article  |  2005  |  Journal of Biological Chemistry

Photoaffinity labeling of the N-methyltransferase domains of cyclosporin synthetase

T Velkov, A Lawen

Journal article  |  2003  |  Photochemistry and Photobiology

Mapping and molecular modeling of S-adenosyl-L-methionine binding sites in N-methyltransferase domains of the multifunctional polypeptide cyclosporin synthetase

T Velkov, A Lawen

Journal article  |  2003  |  Journal of Biological Chemistry

Non-ribosomal peptide synthetases as technological platforms for the synthesis of highly modified peptide bioeffectors--Cyclosporin synthetase as a complex example.

Tony Velkov, Alfons Lawen

Book  |  2003  |  Biotechnology Annual Review

Many microbial peptide secondary metabolites possess important medicinal properties, of which the immunosuppressant cyclosporin A ..

Photoaffinity Labeling of the N-methyltransferase Domains of Cyclosporin Synthetase¶

Tony Velkov, Alfons Lawen

Journal article  |  2003  |  Photochemistry and Photobiology