Tony Velkov

Rescuing the Last-Line Polymyxins: Achievements and Challenges.

Sue C Nang, Mohammad AK Azad, Tony Velkov, Qi Tony Zhou, Jian Li

Journal article  |  2021  |  Pharmacological Reviews

Antibiotic resistance is a major global health challenge and, worryingly, several key Gram negative pathogens can become resistant..

Evaluation Strategies for Triple-Drug Combinations against Carbapenemase-Producing Klebsiella Pneumoniae in an In Vitro Hollow-Fiber Infection Model

Estefany Garcia, John K Diep, Rajnikant Sharma, Patrick O Hanafin, Cely S Abboud, Keith S Kaye, Jian Li, Tony Velkov, Gauri G Rao

Journal article  |  2021  |  Clinical Pharmacology & Therapeutics

Mounting antimicrobial resistance to carbapenemase-producing Klebsiella pneumoniae (CPKP) highlights the need to optimize currentl..

Synchrotron-based X-ray fluorescence microscopy reveals accumulation of polymyxins in single human alveolar epithelial cells.

Mohamad AK Azad, Shuo Zhang, Jiayao Li, Yeonuk Kim, Heidi H Yu, Alex J Fulcher, Daryl L Howard, Martin D de Jonge, Simon A James, Kade D Roberts, Tony Velkov, Jing Fu, Qi Tony Zhou, Jian Li

Journal article  |  2021  |  Antimicrobial Agents and Chemotherapy

Intravenous administration of the last-line polymyxins results in poor drug exposure in the lungs and potential nephrotoxicity; wh..

In vitro evaluation of drug delivery behavior for inhalable amorphous nanoparticle formulations in a human lung epithelial cell model

Jianting Chen, Maizbha U Ahmed, Chune Zhu, Shihui Yu, Weisan Pan, Tony Velkov, Jian Li, Qi Tony Zhou

Journal article  |  2021  |  International Journal of Pharmaceutics

Respiratory tract infections caused by multidrug-resistant (MDR) Gram-negative bacteria such as Pseudomonas aeruginosa are serious..

Comparative metabolomics reveals key pathways associated with the synergistic activity of polymyxin B and rifampicin combination against multidrug-resistant Acinetobacter baumannii

Jinxin Zhao, Mei-Ling Han, Yan Zhu, Yu-Wei Lin, Yi-Wen Wang, Jing Lu, Yang Hu, Qi Tony Zhou, Tony Velkov, Jian Li

Journal article  |  2021  |  Biochemical Pharmacology

Multidrug-resistant (MDR) Acinetobacter baumannii presents a critical challenge to human health worldwide and polymyxins are incre..

Molecular dynamics simulations informed by membrane lipidomics reveal the structure-interaction relationship of polymyxins with the lipid A-based outer membrane of Acinetobacter baumannii

Xukai Jiang, Kai Yang, Bing Yuan, Meiling Han, Yan Zhu, Kade D Roberts, Nitin A Patil, Jingliang Li, Bin Gong, Robert EW Hancock, Tony Velkov, Falk Schreiber, Lushan Wang, Jian Li

Journal article  |  2020  |  Journal of Antimicrobial Chemotherapy

BACKGROUND: MDR bacteria represent an urgent threat to human health globally. Polymyxins are a last-line therapy against life-thre..

Structure-Activity Relationships of Daptomycin Lipopeptides

John A Karas, Glen P Carter, Benjamin P Howden, Adrianna M Turner, Olivia KA Paulin, James D Swarbrick, Mark A Baker, Jian Li, Tony Velkov

Journal article  |  2020  |  Journal of Medicinal Chemistry

Daptomycin is a calcium-dependent cyclic lipodepsipeptide derived from the soil saprotroph Streptomyces roseosporus, and its antib..

Simulations of octapeptin-outer membrane interactions reveal conformational flexibility is linked to antimicrobial potency

Xukai Jiang, Kai Yang, Bing Yuan, Bin Gong, Lin Wan, Nitin A Patil, James D Swarbrick, Kade D Roberts, Falk Schreiber, Lushan Wang, Tony Velkov, Jian Li

Journal article  |  2020  |  Journal of Biological Chemistry

The octapeptins are lipopeptide antibiotics that are structurally similar to polymyxins yet retain activity against polymyxin-resi..

Genome-Scale Metabolic Modeling Reveals Metabolic Alterations of Multidrug-Resistant Acinetobacter baumannii in a Murine Bloodstream Infection Model

Jinxin Zhao, Yan Zhu, Jiru Han, Yu-Wei Lin, Michael Aichem, Jiping Wang, Ke Chen, Tony Velkov, Falk Schreiber, Jian Li

Journal article  |  2020  |  Microorganisms

Multidrug-resistant (MDR) Acinetobacter baumannii is a critical threat to human health globally. We constructed a genome-scale met..

Sialylation of Asparagine 612 Inhibits Aconitase Activity during Mouse Sperm Capacitation; a Possible Mechanism for the Switch from Oxidative Phosphorylation to Glycolysis

Ana Izabel Silva Balbin Villaverde, Rachel A Ogle, Peter Lewis, Vincenzo Carbone, Tony Velkov, Jacob K Netherton, Mark A Baker

Journal article  |  2020  |  Molecular & Cellular Proteomics

After ejaculation, mammalian spermatozoa must undergo a process known as capacitation in order to successfully fertilize the oocyt..