Tony Velkov

Proof-of-concept for incorporating mechanistic insights from multi-omics analyses of polymyxin B in combination with chloramphenicol against Klebsiella pneumoniae.

Patrick O Hanafin, Nusaibah Abdul Rahim, Rajnikant Sharma, Colin G Cess, Stacey D Finley, Phillip J Bergen, Tony Velkov, Jian Li, Gauri G Rao

Journal article  |  2023  |  CPT Pharmacometrics Syst Pharmacol

Carbapenemase-resistant Klebsiella pneumoniae (KP) resistant to multiple antibiotic classes necessitates optimized combination the..

Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity

Nitin A Patil, Wendong Ma, Xukai Jiang, Xiaoji He, Heidi H Yu, Hasini Wickremasinghe, Jiping Wang, Philip E Thompson, Tony Velkov, Kade D Roberts, Jian Li

Journal article  |  2023  |  JOURNAL OF MEDICINAL CHEMISTRY

Polymyxins (polymyxin B and colistin) are lipopeptide antibiotics used as a last-line treatment for life-threatening multidrug-res..

Transcriptomic Responses to Polymyxin B and Analogues in Human Kidney Tubular Cells

Mengyao Li, Mohammad AK Azad, Philip E Thompson, Kade D Roberts, Tony Velkov, Yan Zhu, Jian Li

Journal article  |  2023  |  ANTIBIOTICS-BASEL

Polymyxins are last-line antibiotics for the treatment of Gram-negative 'superbugs'. However, nephrotoxicity can occur in up to 60..

Comparative Proteomics of Outer Membrane Vesicles from Polymyxin-Susceptible and Extremely Drug-Resistant Klebsiella pneumoniae

Maytham Hussein, Raad Jasim, Hakan Gocol, Mark Baker, Varsha JJ Thombare, James Ziogas, Aayush Purohit, Gauri GG Rao, Jian Li, Tony Velkov

Journal article  |  2023  |  MSPHERE

Outer membrane vesicles (OMVs) secreted by Gram-negative bacteria serve as transporters for the delivery of cargo such as virulenc..

Drug Repurposing Approaches towards Defeating Multidrug-Resistant Gram-Negative Pathogens: Novel Polymyxin/Non-Antibiotic Combinations

Augustine Koh Jing Jie, Maytham Hussein, Gauri GG Rao, Jian Li, Tony Velkov

Journal article  |  2022  |  PATHOGENS

Multidrug-resistant (MDR) Gram-negative pathogens remain an unmet public health threat. In recent times, increased rates of resist..

30: SPOT-MEDIATED UNIQUE METABOLIC REMODELLING POTENTIALLY UNDERLIES THE POLYMYXIN TOLERANCE IN ACINETOBACTER BAUMANNII

ZY Kho, J Zhao, M-L Han, MAK Azad, C Barlow, RB Schittenhelm, Y Zhu, T Velkov, J Li

Journal article  |  2022  |  Journal of Global Antimicrobial Resistance

SY4.1: COMBINATION OF BACTERIOPHAGE AND ANTIBIOTIC: IS IT AN ULTIMATE SOLUTION TO MULTIDRUG RESISTANCE?

SC Nang, J Lu, HH Yu, H Wickremasinghe, MAK Azad, ML Han, G Rao, PJ Bergen, T Velkov, N Sherry, S Aslam, RT Schooley, BP Howden, JJ Barr, Y Zhu, J Li

Journal article  |  2022  |  Journal of Global Antimicrobial Resistance

Transcriptomic Mapping of Neurotoxicity Pathways in the Rat Brain in Response to Intraventricular Polymyxin B

Jing Lu, Yan Zhu, Helena C Parkington, Maytham Hussein, Jinxin Zhao, Phillip Bergen, David Rudd, Mary A Deane, Sara Oberrauch, Linda Cornthwaite-Duncan, Rafah Allobawi, Rajnikant Sharma, Gauri Rao, Jian Li, Tony Velkov

Journal article  |  2022  |  MOLECULAR NEUROBIOLOGY

Intraventricular or intrathecal administration of polymyxins are increasingly used to treat multidrug-resistant (MDR) Gram-negativ..

Integrated metabolomic and transcriptomic analyses of the synergistic effect of polymyxin-rifampicin combination against Pseudomonas aeruginosa

Mohd Hafidz Mahamad Maifiah, Yan Zhu, Brian T Tsuji, Darren J Creek, Tony Velkov, Jian Li

Journal article  |  2022  |  JOURNAL OF BIOMEDICAL SCIENCE

BACKGROUND: Understanding the mechanism of antimicrobial action is critical for improving antibiotic therapy. For the first time, ..

Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection

Rajnikant Sharma, Shekhar Yeshwante, Quentin Valle, Maytham Hussein, Varsha Thombare, Sean Michael McCann, Robert Maile, Jian Li, Tony Velkov, Gauri Rao

Journal article  |  2022  |  JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Burn induction methodologies are inconsistently described in rat models. A uniform burn wound model, which represents the clinical..