Renee Gloury

Antigen-driven EGR2 expression is required for exhausted CD8( ) T cell stability and maintenance

Mayura Wagle, Stephin J Vervoort, Madison J Kelly, Willem Van der Byl, Timothy J Peters, Ben P Martin, Luciano G Martelotto, Simone Nuessing, Kelly M Ramsbottom, James R Torpy, Deborah Knight, Sinead Reading, Kevin Thia, Lisa A Miosge, Debbie R Howard, Renee Gloury, Sarah S Gabriel, Daniel T Utzschneider, Jane Oliaro, Jonathan D Powell, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Chronic stimulation of CD8+ T cells triggers exhaustion, a distinct differentiation state with diminished effector function. Exhau..

Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment

Takumi Kobayashi, Pui Yeng Lam, Hui Jiang, Karolina Bednarska, Renee Elyse Gloury, Valentine Murigneux, Joshua Tay, Nicolas Jacquelot, Rui Li, Zewen Kelvin Tuong, Graham R Leggatt, Maher K Gandhi, Michelle M Hill, Gabrielle T Belz, Shyuan Ngo, Axel Kallies, Stephen R Mattarollo

Journal article  |  2020  |  BLOOD

Natural killer (NK) cells play critical roles in protection against hematological malignancies but can acquire a dysfunctional sta..

Early precursor T cells establish and propagate T cell exhaustion in chronic infection

Daniel T Utzschneider, Sarah S Gabriel, David Chisanga, Renee Gloury, Patrick M Gubser, Ajithkumar Vasanthakumar, Wei Shi, Axel Kallies

Journal article  |  2020  |  NATURE IMMUNOLOGY

CD8+ T cells responding to chronic infections or tumors acquire an 'exhausted' state associated with elevated expression of inhibi..

Sex-specific adipose tissue imprinting of regulatory T cells

Ajithkumar Vasanthakumar, David Chisanga, Jonas Blume, Renee Gloury, Kara Britt, Darren C Henstridge, Yifan Zhan, Santiago Valle Torres, Sebastian Liene, Nicholas Collins, Enyuan Cao, Tom Sidwell, Chaoran Li, Raul German Spallanzani, Yang Liao, Paul A Beavis, Thomas Gebhardt, Natalie Trevaskis, Stephen L Nutt, Jeffrey D Zajac, et al.

Journal article  |  2020  |  NATURE

Adipose tissue is an energy store and a dynamic endocrine organ1,2. In particular, visceral adipose tissue (VAT) is critical for t..

Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis

Tom Sidwell, Yang Liao, Alexandra L Garnham, Ajithkumar Vasanthakumar, Renee Gloury, Jonas Blume, Peggy P Teh, David Chisanga, Christoph Thelemann, Fabian de Labastida Rivera, Christian R Engwerda, Lynn Corcoran, Kohei Kometani, Tomohiro Kurosaki, Gordon K Smyth, Wei Shi, Axel Kallies

Journal article  |  2020  |  NATURE COMMUNICATIONS

Differentiation and homeostasis of Foxp3+ regulatory T (Treg) cells are strictly controlled by T-cell receptor (TCR) signals; howe..

IL-17( ) CD8( ) T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis

Christina Lueckel, Felix Picard, Hartmann Raifer, Lucia Campos Carrascosa, Anna Guralnik, Yajuan Zhang, Matthias Klein, Stefan Bittner, Falk Steffen, Sonja Moos, Federico Marini, Renee Gloury, Florian C Kurschus, Ying-Yin Chao, Wilhelm Bertrams, Veronika Sexl, Bernd Schmeck, Lynn Bonetti, Melanie Grusdat, Michael Lohoff, et al.

Journal article  |  2019  |  NATURE COMMUNICATIONS

IL-17-producing CD8+ (Tc17) cells are enriched in active lesions of patients with multiple sclerosis (MS), suggesting a role in th..

Transcription Factor T-bet in B Cells Modulates Germinal Center Polarization and Antibody Affinity Maturation in Response to Malaria

Ann Ly, Yang Liao, Halina Pietrzak, Lisa J Ioannidis, Tom Sidwell, Renee Gloury, Marcel Doerflinger, Tony Triglia, Raymond Z Qin, Joanna R Groom, Gabrielle T Belz, Kim L Good-Jacobson, Wei Shi, Axel Kallies, Diana S Hansen

Journal article  |  2019  |  CELL REPORTS

Despite the key role that antibodies play in protection, the cellular processes mediating the acquisition of humoral immunity agai..

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia

Helen M McRae, Alexandra L Garnham, Yifang Hu, Matthew T Witkowski, Mark A Corbett, Mathew P Dixon, Rose E May, Bilal N Sheikh, William Chiang, Andrew J Kueh, Tan A Nguyen, Kevin Man, Renee Gloury, Brandon J Aubrey, Antonia Policheni, Ladina Di Rago, Warren S Alexander, Daniel HD Gray, Andreas Strasser, Edwin D Hawkins, et al.

Journal article  |  2019  |  BLOOD

Somatically acquired mutations in PHF6 (plant homeodomain finger 6) frequently occur in hematopoietic malignancies and often coinc..

Transcription Factor IRF4 Promotes CD8( ) T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection

Kevin Man, Sarah S Gabriel, Yang Liao, Renee Gloury, Simon Preston, Darren C Henstridge, Marc Pellegrini, Dietmar Zehn, Friederike Berberich-Siebelt, Mark A Febbraio, Wei Shi, Axel Kallies

Journal article  |  2017  |  IMMUNITY

During chronic stimulation, CD8+ T cells acquire an exhausted phenotype characterized by expression of inhibitory receptors, down-..

The TNF Receptor Superfamily-NF-kappa B Axis Is Critical to Maintain Effector Regulatory T Cells in Lymphoid and Non-lymphoid Tissues

Ajithkumar Vasanthakumar, Yang Liao, Peggy Teh, Maria F Pascutti, Anna E Oja, Alexandra L Garnham, Renee Gloury, Jessica C Tempany, Tom Sidwell, Eloy Cuadrado, Paul Tuijnenburg, Taco W Kuijpers, Najoua Lalaoui, Lisa A Mielke, Vanessa L Bryant, Philip D Hodgkin, John Silke, Gordon K Smyth, Martijn A Nolte, Wei Shi, et al.

Journal article  |  2017  |  CELL REPORTS

After exiting the thymus, Foxp3+ regulatory T (Treg) cells undergo further differentiation in the periphery, resulting in the gene..