Gerald Murray

Doxycycline and Sitafloxacin Combination Therapy for Treating Highly Resistant Mycoplasma genitalium.

Duygu Durukan, Michelle Doyle, Gerald Murray, Kaveesha Bodiyabadu, Lenka Vodstrcil, Eric PF Chow, Jorgen S Jensen, Christopher K Fairley, Ivette Aguirre, Catriona S Bradshaw

Journal article  |  2020  |  Emerging Infectious Diseases

Antimicrobial-resistant Mycoplasma genitalium is becoming increasingly common and creating major treatment challenges. We present ..

Prevalence of mutations associated with resistance to macrolides and fluoroquinolones in Mycoplasma genitalium: a systematic review and meta-analysis.

Dorothy A Machalek, Yusha Tao, Hannah Shilling, Jørgen S Jensen, Magnus Unemo, Gerald Murray, Eric PF Chow, Nicola Low, Suzanne M Garland, Lenka A Vodstrcil, Christopher K Fairley, Jane S Hocking, Lei Zhang, Catriona S Bradshaw

Journal article  |  2020  |  The Lancet Infectious Diseases

BACKGROUND: Mycoplasma genitalium is now recognised as an important bacterial sexually transmitted infection. We summarised data f..

Moxifloxacin and Sitafloxacin Treatment Failure in Mycoplasma genitalium Infection: Association with parC Mutation G248T (S83I) and Concurrent gyrA Mutations

Gerald L Murray, Kaveesha Bodiyabadu, Jennifer Danielewski, Suzanne M Garland, Dorothy A Machalek, Christopher K Fairley, Jorgen S Jensen, Deborah A Williamson, Lit Y Tan, Elisa Mokany, Duygu Durukan, Catriona S Bradshaw

Journal article  |  2020  |  The Journal of Infectious Diseases

BACKGROUND: The basis of fluoroquinolone treatment failure for Mycoplasma genitalium is poorly understood. METHODS: To identify mu..

Gardnerella vaginalis Clade Distribution Is Associated With Behavioral Practices and Nugent Score in Women Who Have Sex With Women

Erica L Plummer, Lenka A Vodstrcil, Gerald L Murray, Christopher K Fairley, Jennifer A Danielewski, Suzanne M Garland, Eric PF Chow, Dieter M Bulach, Katherine A Fethers, Jane S Hocking, Catriona S Bradshaw

Journal article  |  2020  |  The Journal of Infectious Diseases

BACKGROUND: Gardnerella vaginalis is detected in women with and without bacterial vaginosis (BV). Identification of 4 G. vaginalis..

Monitoring human papillomavirus prevalence among young Australian women undergoing routine chlamydia screening

Hannah Shilling, Gerald Murray, Julia ML Brotherton, David Hawkes, Marion Saville, Terri Sivertsen, Ian Chambers, Jennifer Roberts, Annabelle Farnsworth, Suzanne M Garland, Jane S Hocking, John Kaldor, Rebecca Guy, Steph Atchison, Anna-Maria Costa, Monica Molano, Dorothy A Machalek

Journal article  |  2020  |  Vaccine

INTRODUCTION: Australia has recently implemented major changes in cervical cancer prevention policies including introduction of pr..

Bacterial Load of Chlamydia trachomatis in the Posterior Oropharynx, Tonsillar Fossae, and Saliva among Men Who Have Sex with Men with Untreated Oropharyngeal Chlamydia

Tiffany R Phillips, Christopher K Fairley, Kate Maddaford, Jennifer Danielewski, Jane S Hocking, David Lee, Deborah A Williamson, Gerald Murray, Fabian Kong, Vesna De Petra, Catriona S Bradshaw, Marcus Y Chen, Rebecca Wigan, Anthony Snow, Benjamin P Howden, Suzanne M Garland, Eric PF Chow

Journal article  |  2020  |  JOURNAL OF CLINICAL MICROBIOLOGY

The aim of this study was to determine whether Chlamydia trachomatis could be detected in saliva and if infection is specific to a..

Performance of the ResistancePlus MG diagnostic test for Mycoplasma genitalium using samples collected with Hologic Aptima Specimen Collection kits

Gerald L Murray, Jennifer Danielewski, Catriona S Bradshaw, Deborah A Williamson, Joshua Birnie, Jenny P Su, Vesna De Petra, Lit Y Tan, Rachel Wee, Dorothy A Machalek, Tim RH Read, Suzanne M Garland

Journal article  |  2020  |  Journal of Medical Microbiology

Introduction. Mycoplasma genitalium is a sexually transmitted organism with high levels of resistance to the recommended first..

Sexual practices have a significant impact on the vaginal microbiota of women who have sex with women

Erica L Plummer, Lenka A Vodstrcil, Christopher K Fairley, Sepehr N Tabrizi, Suzanne M Garland, Matthew G Law, Jane S Hocking, Katherine A Fethers, Dieter M Bulach, Gerald L Murray, Catriona S Bradshaw

Journal article  |  2019  |  Scientific Reports

Women-who-have-sex-with-women (WSW) are at increased risk of bacterial vaginosis (BV). We investigated the impact of practices and..

Multicenter Clinical Evaluation of a Novel Multiplex Real-Time PCR (qPCR) Assay for Detection of Fluoroquinolone Resistance in Mycoplasma genitalium

Miguel Fernandez-Huerta, Kaveesha Bodiyabadu, Juliana Esperalba, Catriona S Bradshaw, Judit Serra-Pladevall, Suzanne M Garland, Candela Fernandez-Naval, Jorgen S Jensen, Tomas Pumarola, Samantha Ebeyan, Marie Lundgren, Lit Yeen Tan, Mateu Espasa, Gerald L Murray

Journal article  |  2019  |  Journal of Clinical Microbiology

Mycoplasma genitalium causes a common sexually transmitted infection with a marked propensity to develop antimicrobial resistance...

Anal human papillomavirus infections in young unvaccinated men who have sex with men attending a sexual health clinic for HPV vaccination in Melbourne, Australia

Eric PF Chow, Jennifer A Danielewski, Gerald L Murray, Glenda Fehler, Marcus Y Chen, Catriona S Bradshaw, Suzanne M Garland, Christopher K Fairley

Journal article  |  2019  |  Vaccine

The Victorian Government introduced a time-limited quadrivalent human papillomavirus (HPV) vaccination catch-up program targeting ..

Analysis of Infection Loads in Mycoplasma genitalium Clinical Specimens by Use of a Commercial Diagnostic Test

Gerald L Murray, Jennifer Danielewski, Kaveesha Bodiyabadu, Dorothy A Machalek, Catriona S Bradshaw, Anna-Maria Costa, Josh Birnie, Suzanne M Garland

Journal article  |  2019  |  Journal of Clinical Microbiology

Mycoplasma genitalium is a common sexually transmitted infection with a propensity to acquire resistance to commonly used antimicr..

The impact of sample storage on molecular-based detection of Mycoplasma genitalium

GL Murray, JP Su, J Birnie, J Danielewski, DA Machalek, CS Bradshaw, TRH Read, A-M Costa, SM Garland

Journal article  |  2019  |  Journal of Applied Microbiology

COMBINED ORAL AND TOPICAL ANTIBIOTIC THERAPY FOR MALE PARTNERS OF WOMEN WITH BACTERIAL VAGINOSIS: A PILOT STUDY

Erica Plummer, Lenka Vodstrcil, Christopher Fairley, Jennifer Danielewski, Gerald Murray, Michelle Doyle, Glenda Fehler, Marti Kaiser, Colette Mcguinness, Suzanne Garland, Dieter Bulach, Eric Chow, Jane Hocking, Catriona Bradshaw

Conference Proceedings  |  2019  |  Poster Presentations

MACROLIDE AND FLUOROQUINOLONE RESISTANCE-ASSOCIATED MUTATIONS IN MYCOPLASMA GENITALIUM: A SYSTEMATIC REVIEW AND META-ANALYSIS

Dorothy Machalek, Yusha Tao, Hannah Shilling, Jorgen Jensen, Magnus Unemo, Gerald Murray, Eric Chow, Nicola Low, Suzanne Garland, Christopher Fairley, Lenka Vodstrcil, Jane Hocking, Lei Zhang, Catriona Bradshaw

Conference Proceedings  |  2019  |  Poster Presentations

MYCOPLASMA GENITALIUM parC AND gyrA MUTATIONS ASSOCIATED WITH MOXIFLOXACIN AND SITAFLOXACIN TREATMENT FAILURE

Gerald Murray, Catriona Bradshaw, Kaveesha Bodiyabadu, Jennifer Danielewski, Josh Birnie, Litty Tan, Elisa Mokany, Tim Read, Dorothy Machalek, Christopher Fairley, Suzanne Garland

Conference Proceedings  |  2019  |  Oral Presentations

GARDNERELLA VAGINALIS CLADE DISTRIBUTION IS ASSOCIATED WITH BEHAVIOURS AND NUGENT SCORE IN WOMEN WHO HAVE SEX WITH WOMEN

Erica Plummer, Lenka Vodstrcil, Gerald Murray, Christopher Fairley, Jennifer Danielewski, Suzanne Garland, Eric Chow, Dieter Bulach, Katherine Fethers, Jane Hocking, Catriona Bradshaw

Conference Proceedings  |  2019  |  Poster Presentations

FACTORS ASSOCIATED WITH ONCOGENIC HUMAN PAPILLOMAVIRUS PREVALENCE AMONG AUSTRALIAN WOMEN FOLLOWING VACCINE INTRODUCTION

Dorothy Machalek, Hannah Shilling, Steph Atchison, Alyssa Cornall, Julia Brotherton, Deborah Bateson, Kathleen Mcnamee, Jane Hocking, John Kaldor, Marcus Chen, Christopher Fairley, Eric Chow, S Rachel Skinner, Gerald Murray, Monica Molano, Sepehr Tabrizi, Suzanne Garland

Conference Proceedings  |  2019  |  Poster Presentations

Symptoms, Sites, and Significance of Mycoplasma genitalium in Men Who Have Sex with Men

Tim RH Read, Gerald L Murray, Jennifer A Danielewski, Christopher K Fairley, Michelle Doyle, Karen Worthington, Jenny Su, Elisa Mokany, LT Tan, David Lee, Lenka A Vodstrcil, Eric PF Chow, Suzanne M Garland, Marcus Y Chen, Catriona S Bradshaw

Journal article  |  2019  |  Emerging Infectious Diseases

Outcomes of Resistance-guided Sequential Treatment of Mycoplasma genitalium Infections: A Prospective Evaluation

Tim RH Read, Christopher K Fairley, Gerald L Murray, Jorgen S Jensen, Jennifer Danielewski, Karen Worthington, Michelle Doyle, Elisa Mokany, Litty Tan, Eric PF Chow, Suzanne M Garland, Catriona S Bradshaw

Journal article  |  2019  |  Clinical Infectious Diseases

Gut microbiota of preterm infants supplemented with probiotics: sub-study of the ProPrems trial

Erica L Plummer, Dieter M Bulach, Gerald L Murray, Susan E Jacobs, Sepehr N Tabrizi, Suzanne M Garland

Journal article  |  2018  |  BMC Microbiology

Heterologous protection elicited by a live, attenuated, Leptospira vaccine

Gerald L Murray, Theeraya Simawaranon, Chamraj Kaewraemruaen, Ben Adler, Rasana W Sermswan

Journal article  |  2018  |  Veterinary Microbiology

A previously-described live, attenuated vaccine (M1352, serovar Manilae, serogroup Pyrogenes) was tested in the hamster model of i..

Clinical Characteristics of Anorectal Mycoplasma genitalium Infection and Microbial Cure in Men Who Have Sex With Men

Jason J Ong, Ei Aung, Tim RH Read, Christopher K Fairley, Suzanne M Garland, Gerald Murray, Marcus Y Chen, Eric PF Chow, Catriona S Bradshaw

Journal article  |  2018  |  Sexually Transmitted Diseases

Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic Leptospira

Haritha Adhikarla, Elsio A Wunder, Ariel E Mechaly, Sameet Mehta, Zheng Wang, Luciane Santos, Vimla Bisht, Peter Diggle, Gerald Murray, Ben Adler, Francesc Lopez, Jeffrey P Townsend, Eduardo Groisman, Mathieu Picardeau, Alejandro Buschiazzo, Albert I Ko

Journal article  |  2018  |  Frontiers in Cellular and Infection Microbiology

Leptospirosis is an emerging zoonotic disease with more than 1 million cases annually. Currently there is lack of evidence for sig..

Contaminated fingers: a potential cause of Chlamydia trachomatis-positive urine specimens

Philip M Giffard, Rachael A Lilliebridge, Judith Wilson, Gerald Murray, Samuel Phillips, Sepehr N Tabrizi, Suzanne M Garland, Louise Martin, Gurmeet Singh, Steven YC Tong, Deborah C Holt, Patiyan Andersson

Journal article  |  2018  |  Sexually Transmitted Infections

Use of Pristinamycin for Macrolide-Resistant Mycoplasma genitalium Infection

Tim RH Read, Jorgen S Jensen, Christopher K Fairley, Mieken Grant, Jennifer A Danielewski, Jenny Su, Gerald L Murray, Eric PF Chow, Karen Worthington, Suzanne M Garland, Sepehr N Tabrizi, Catriona S Bradshaw

Journal article  |  2018  |  Emerging Infectious Diseases

Combined oral and topical antimicrobial therapy for male partners of women with bacterial vaginosis: Acceptability, tolerability and impact on the genital microbiota of couples - A pilot study

Erica L Plummer, Lenka A Vodstrcil, Jennifer A Danielewski, Gerald L Murray, Christopher K Fairley, Suzanne M Garland, Jane S Hocking, Sepehr N Tabrizi, Catriona S Bradshaw

Journal article  |  2018  |  PLOS ONE

Evaluation of the SpeeDx ResistancePlus MG Diagnostic Test for Mycoplasma genitalium on the Applied Biosystems 7500 Fast Quantitative PCR Platform

Jenny P Su, Lit Y Tan, Suzanne M Garland, Sepehr N Tabrizi, Elisa Mokany, Samantha Walker, Catriona S Bradshaw, Tim Read, Gerald L Murray

Journal article  |  2018  |  Journal of Clinical Microbiology

Synthesis of novel 1,2,5-oxadiazoles and evaluation of action against Acinetobacter baumannii

Rebecca M Christoff, Gerald L Murray, Xenia P Kostoulias, Anton Y Peleg, Belinda M Abbott

Journal article  |  2017  |  Bioorganic & Medicinal Chemistry

MICROBIOLOGICAL FACTORS THAT CONTRIBUTE TO THE DEVELOPMENT OF BACTERIAL VAGINOSIS:A LONGITUDINAL STUDY

Catriona Bradshaw, Gerald Murray, Lenka Vodstrcil, Suzanne Garland, Erica Plummer, Agnes Tan, Jimmy Twin, Matthew Law, Jane Hocking, Dieter Bulach, Gayle Phillips, Christopher Fairley, Sepehr Tabrizi

Conference Proceedings  |  2017  |  Clinical Science

Increasing Macrolide and Fluoroquinolone Resistance in Mycoplasma genitalium

Gerald L Murray, Catriona S Bradshaw, Melanie Bissessor, Jennifer Danielewski, Suzanne M Garland, Jorgen S Jensen, Christopher K Fairley, Sepehr N Tabrizi

Journal article  |  2017  |  Emerging Infectious Diseases

Adipose tissue is the first colonization site of Leptospira interrogans in subcutaneously infected hamsters

Ryo Ozuru, Mitsumasa Saito, Takaaki Kanemaru, Satoshi Miyahara, Sharon YAM Villanueva, Gerald L Murray, Ben Adler, Jun Fujii, Shin-ichi Yoshida

Journal article  |  2017  |  PLOS ONE

Leptospirosis is one of the most widespread zoonoses in the world, and its most severe form in humans, "Weil's disease," may lead ..

Global Gene Expression Profile of Acinetobacter baumannii During Bacteremia

Gerald L Murray, Kirill Tsyganov, Xenia P Kostoulias, Dieter M Bulach, David Powell, Darren J Creek, John D Boyce, Ian T Paulsen, Anton Y Peleg

Journal article  |  2017  |  The Journal of Infectious Diseases

Acinetobacter baumannii phenylacetic acid metabolism influences infection outcome through a direct effect on neutrophil chemotaxis

Md Saruar Bhuiyan, Felix Ellett, Gerald L Murray, Xenia Kostoulias, Gustavo M Cerqueira, Keith E Schulze, Mohd Hafidz Mahamad Maifiah, Jian Li, Darren J Creek, Graham J Lieschke, Anton Y Peleg

Journal article  |  2016  |  Proceedings of the National Academy of Sciences

Innate cellular immune responses are a critical first-line defense against invading bacterial pathogens. Leukocyte migration from ..

Conserved transmembrane glycine residues in the Shigella flexneri polysaccharide co-polymerase protein WzzB influence protein-protein interactions

Magdalene Papadopoulos, Ngoc Hoa Tran Elizabeth, Gerald Laurence Murray, Renato Morona

Journal article  |  2016  |  Microbiology

The O antigen (Oag) component of lipopolysaccharides (LPS) is crucial for virulence and Oag chain-length regulation is controlled ..

Impact of a Cross-Kingdom Signaling Molecule of Candida albicans on Acinetobacter baumannii Physiology

Xenia Kostoulias, Gerald L Murray, Gustavo M Cerqueira, Jason B Kong, Farkad Bantun, Eleftherios Mylonakis, Chen Ai Khoo, Anton Y Peleg

Journal article  |  2016  |  Antimicrobial Agents and Chemotherapy

The influence of bacterial interaction on the virulence of Cryptococcus neoformans

Sanjiveeni Dhamgaye, Gerald L Murray, Anton Y Peleg

Journal article  |  2015  |  Virulence

Community-acquired Acinetobacter baumannii: clinical characteristics, epidemiology and pathogenesis

Carina Dexter, Gerald L Murray, Ian T Paulsen, Anton Y Peleg

Journal article  |  2015  |  Expert Review of Anti-infective Therapy

Community-acquired Acinetobacter baumannii (CA-Ab) is a rare but serious cause of community-acquired pneumonia in tropical regions..

Acinetobacter baumannii: Evolution of Antimicrobial Resistance-Treatment Options

Yohei Doi, Gerald L Murray, Anton Y Peleg

Journal article  |  2015  |  Seminars in Respiratory and Critical Care Medicine

The first decade of the 20th century witnessed a surge in the incidence of infections due to several highly antimicrobial-resistan..

The Molecular Basis of Leptospiral Pathogenesis

Gerald L Murray

Journal article  |  2015  |  Current Topics in Microbiology and Immunology

The mechanisms of disease pathogenesis in leptospirosis are poorly defined. Recent developments in the application of genetic tool..

Identification of genes essential for leptospirosis.

Thanatchaporn Bartpho, Gerald L Murray

Journal article  |  2015  |  Methods in Molecular Biology

The development of methods for the construction of defined mutants of pathogenic Leptospira has been a breakthrough in the study o..

Leptospiral outer membrane protein LMB216 is involved in enhancement of phagocytic uptake by macrophages

Claudia Toma, Gerald L Murray, Toshitsugu Nohara, Masaru Mizuyama, Nobuo Koizumi, Ben Adler, Toshihiko Suzuki

Journal article  |  2014  |  Cellular Microbiology

Leptospira interrogans is responsible for the zoonotic disease leptospirosis. The pathogenic mechanisms of this spirochaete remain..

Recombinant LipL32 stimulates interferon-gamma production in cattle vaccinated with a monovalent Leptospira borgpetersenii serovar Hardjo subtype Hardjobovis vaccine

Deanna S Deveson Lucas, Miranda Lo, Dieter M Bulach, Noelene S Quinsey, Gerald L Murray, Andy Allen, Ben Adler

Journal article  |  2014  |  Veterinary Microbiology

High-Temperature Protein G Is an Essential Virulence Factor of Leptospira interrogans

Amy M King, Gabriela Pretre, Thanatchaporn Bartpho, Rasana W Sermswan, Claudia Toma, Toshihiko Suzuki, Azad Eshghi, Mathieu Picardeau, Ben Adler, Gerald L Murray

Journal article  |  2014  |  Infection and Immunity

Leptospira interrogans is a global zoonotic pathogen and is the causative agent of leptospirosis, an endemic disease of humans and..

Structural and Functional Characterization of an Orphan ATP-Binding Cassette ATPase Involved in Manganese Utilization and Tolerance in Leptospira spp.

Nadia Benaroudj, Frederick Saul, Jacques Bellalou, Isabelle Miras, Patrick Weber, Vincent Bondet, Gerald L Murray, Ben Adler, Paula Ristow, Helene Louvel, Ahmed Haouz, Mathieu Picardeau

Journal article  |  2013  |  Journal of Bacteriology

Pathogenic Leptospira species are the etiological agents of the widespread zoonotic disease leptospirosis. Most organisms, includi..

Leptospiral LruA Is Required for Virulence and Modulates an Interaction with Mammalian Apolipoprotein AI

Kunkun Zhang, Gerald L Murray, Torsten Seemann, Amporn Srikram, Thanatchaporn Bartpho, Rasana W Sermswan, Ben Adler, David E Hoke

Journal article  |  2013  |  Infection and immunity

Use of a high-throughput screen to identify Leptospira mutants unable to colonize the carrier host or cause disease in the acute model of infection

Renee A Marcsisin, Thanatchaporn Bartpho, Dieter M Bulach, Amporn Srikram, Rasana W Sermswan, Ben Adler, Gerald L Murray

Journal article  |  2013  |  Journal of Medical Microbiology

Leptospiral Outer Membrane Protein LipL41 Is Not Essential for Acute Leptospirosis but Requires a Small Chaperone Protein, Lep, for Stable Expression

Amy M King, Thanatchaporn Bartpho, Rasana W Sermswan, Dieter M Bulach, Azad Eshghi, Mathieu Picardeau, Ben Adler, Gerald L Murray

Journal article  |  2013  |  Infection and Immunity

Precipitation of Iron on the Surface of Leptospira interrogans Is Associated with Mutation of the Stress Response Metalloprotease HtpX

Rebekah Henry, Miranda Lo, Chenai Khoo, Hailong Zhang, Reinhard I Boysen, Mathieu Picardeau, Gerald L Murray, Dieter M Bulach, Ben Adler

Journal article  |  2013  |  Applied and Environmental Microbiology

The lipoprotein LipL32, an enigma of leptospiral biology

Gerald L Murray

Journal article  |  2013  |  Veterinary Microbiology

Spirochetes of the genus Leptospira are responsible for the widespread, but neglected, zoonotic disease leptospirosis. In recent y..

Evaluation of 238 antigens of Leptospira borgpetersenii serovar Hardjo for protection against kidney colonisation

Gerald L Murray, Miranda Lo, Dieter M Bulach, Amporn Srikram, Torsten Seemann, Noelene S Quinsey, Rasana W Sermswan, Andy Allen, Ben Adler

Journal article  |  2013  |  Vaccine

Leptospira interrogans Catalase Is Required for Resistance to H2O2 and for Virulence

Azad Eshghi, Kristel Lourdault, Gerald L Murray, Thanatchaporn Bartpho, Rasana W Sermswan, Mathieu Picardeau, Ben Adler, Brendan Snarr, Richard L Zuerner, Caroline E Cameron

Journal article  |  2012  |  Infection and Immunity

Pathogenic Leptospira spp. are likely to encounter higher concentrations of reactive oxygen species induced by the host innate imm..

FlaA Proteins in Leptospira interrogans Are Essential for Motility and Virulence but Are Not Required for Formation of the Flagellum Sheath

Ambroise Lambert, Mathieu Picardeau, David A Haake, Rasana W Sermswan, Amporn Srikram, Ben Adler, Gerald A Murray

Journal article  |  2012  |  Infection and Immunity

Spirochetes have periplasmic flagella composed of a core surrounded by a sheath. The pathogen Leptospira interrogans has four flaB..

Pathogenesis of leptospirosis: The influence of genomics

Ben Adler, Miranda Lo, Torsten Seemann, Gerald L Murray

Journal article  |  2011  |  Veterinary microbiology

Cross-protective Immunity Against Leptospirosis Elicited by a Live, Attenuated Lipopolysaccharide Mutant

Amporn Srikram, Kunkun Zhang, Thanatchaporn Bartpho, Miranda Lo, David E Hoke, Rasana W Sermswan, Ben Adler, Gerald L Murray

Journal article  |  2011  |  The Journal of Infectious Diseases

BACKGROUND: Leptospira species cause leptospirosis, a zoonotic disease found worldwide. Current vaccines against leptospirosis pro..

Transcriptional Response of Leptospira interrogans to Iron Limitation and Characterization of a PerR Homolog

Miranda Lo, Gerald L Murray, Chen Ai Khoo, David A Haake, Richard L Zuerner, Ben Adler

Journal article  |  2010  |  Infection and Immunity

Leptospirosis is a globally significant zoonosis caused by Leptospira spp. Iron is essential for growth of most bacterial species...

Mutations affecting Leptospira interrogans lipopolysaccharide attenuate virulence

Gerald L Murray, Amporn Srikram, Rebekah Henry, Rudy A Hartskeerl, Rasana W Sermswan, Ben Adler

Journal article  |  2010  |  Molecular Microbiology

Leptospira interrogans is the causative agent of leptospirosis. Lipopolysaccharide (LPS) is the major outer membrane component of ..

Use of Luminescent Leptospira interrogans for Enumeration in Biological Assays

Gerald L Murray, Amy M King, Amporn Srikram, Rasana W Sermswan, Ben Adler

Journal article  |  2010  |  Journal of Clinical Microbiology

Rapid and reliable in vitro methods for the detection of pathogenic leptospires, such as Leptospira interrogans, are lacking. The ..

Crystal Structure of LipL32, the Most Abundant Surface Protein of Pathogenic Leptospira spp.

Julian P Vivian, Travis Beddoe, Adrian D McAlister, Matthew CJ Wilce, Leyla Zaker-Tabrizi, Sally Troy, Emma Byres, David E Hoke, Paul A Cullen, Miranda Lo, Gerald L Murray, Ben Adler, Jamie Rossjohn

Journal article  |  2009  |  Journal of Molecular Biology

Spirochetes of the genus Leptospira cause leptospirosis in humans and animals worldwide. Proteins exposed on the bacterial cell su..

Major Surface Protein LipL32 Is Not Required for Either Acute or Chronic Infection with Leptospira interrogans

Gerald L Murray, Amporn Srikram, David E Hoke, Elsio A Wunder, Rebekah Henry, Miranda Lo, Kunkun Zhang, Rasana W Sermswan, Albert I Ko, Ben Adler

Journal article  |  2009  |  Infection and Immunity

Leptospira interrogans is responsible for leptospirosis, a zoonosis of worldwide distribution. LipL32 is the major outer membrane ..

Genome-Wide Transposon Mutagenesis in Pathogenic Leptospira Species

Gerald L Murray, Viviane Morel, Gustavo M Cerqueira, Julio Croda, Amporn Srikram, Rebekah Henry, Albert I Ko, Odir A Dellagostin, Dieter M Bulach, Rasana W Sermswan, Ben Adler, Mathieu Picardeau

Journal article  |  2009  |  Infection and Immunity

Leptospira interrogans requires heme oxygenase for disease pathogenesis

Gerald L Murray, Arnporn Srikram, Rebekah Henry, Anucha Puapairoj, Rasana W Sermswan, Ben Adler

Journal article  |  2009  |  Microbes and Infection

We recently characterised the Leptospira interrogans heme oxygenase (hemO) gene and showed that HemO was required for growth with ..

Leptospira interrogans requires a functional heme oxygenase to scavenge iron from hemoglobin

Gerald L Murray, Katherine M Ellis, Miranda Lo, Ben Adler

Journal article  |  2008  |  Microbes and Infection

The transposon TnSC189 was used to construct a mutant in the putative heme oxygenase gene hemO (LB186) of Leptospira interrogans. ..

Altering the length of the lipopolysaccharide O antigen has an impact on the interaction of Salmonella enterica serovar typhimurium with macrophages and complement

GL Murray, SR Attridge, R Morona

Journal article  |  2006  |  Journal of Bacteriology

A panel of isogenic Salmonella enterica serovar Typhimurium strains that vary only in the length of the O antigen was constructed ..

Inducible serum resistance in Salmonella typhimurium is dependent on wzz(fepE)-regulated very long O antigen chains

GL Murray, SR Attridge, R Morona

Journal article  |  2005  |  Microbes and Infection

Salmonella typhimurium possesses two wzz genes conferring long (wzz(ST)) and very long (wzz(fepE)) lipopolysaccharide O antigen mo..

Regulation of Salmonella typhimurium lipopolysaccharide O antigen chain length is required for virulence; identification of FepE as a second Wzz

GL Murray, SR Attridge, R Morona

Journal article  |  2003  |  Molecular Microbiology

Wzz proteins regulate the degree of polymerization of the O antigen (Oag) subunits in lipopolysaccharide (LPS) biosynthesis. Altho..

Disruption of the MRP-L23 gene encoding the mitochondrial ribosomal protein L23 is lethal for Kluyveromyces lactis but not for Saccharomyces cerevisiae

GL Murray, WG Bao, H Fukuhara, XM Zuo, GD Clark-Walker, XJ Chen

Journal article  |  2000  |  Current Genetics

The Kluyveromyces lactis nuclear gene, MRP-L23, encodes a polypeptide of 155 amino acids that shares 70% and 43% identity to the r..