Sarah Charnaud

Malaria in pregnancy (MiP) studies assessing the clinical performance of highly sensitive rapid diagnostic tests (HS-RDT) for Plasmodium falciparum detection.

Xavier C Ding, Sandra Incardona, Elisa Serra-Casas, Sarah C Charnaud, Hannah C Slater, Gonzalo J Domingo, Emily R Adams, Feiko O Ter Kuile, Aaron M Samuels, Simon Kariuki, Sabine Dittrich

Journal article  |  2023  |  Malar J

BACKGROUND: Rapid diagnostic tests (RDTs) are effective tools to diagnose and inform the treatment of malaria in adults and childr..

The Plasmodium falciparum parasitophorous vacuole protein P113 interacts with the parasite protein export machinery and maintains normal vacuole architecture

Hayley E Bullen, Paul R Sanders, Madeline G Dans, Thorey K Jonsdottir, David T Riglar, Oliver Looker, Catherine S Palmer, Betty Kouskousis, Sarah C Charnaud, Tony Triglia, Mikha Gabriela, Molly Parkyn Schneider, Jo-Anne Chan, Tania F de Koning-Ward, Jake Baum, James W Kazura, James G Beeson, Alan F Cowman, Paul R Gilson, Brendan S Crabb

Journal article  |  2022  |  MOLECULAR MICROBIOLOGY

Infection with Plasmodium falciparum parasites results in approximately 627,000 deaths from malaria annually. Key to the parasite'..

PacBio long-read amplicon sequencing enables scalable high-resolution population allele typing of the complex CYP2D6 locus.

Sarah Charnaud, Jacob E Munro, Lucie Semenec, Ramin Mazhari, Jessica Brewster, Caitlin Bourke, Shazia Ruybal-Pesántez, Robert James, Dulcie Lautu-Gumal, Harin Karunajeewa, Ivo Mueller, Melanie Bahlo

Journal article  |  2022  |  Commun Biol

The CYP2D6 enzyme is estimated to metabolize 25% of commonly used pharmaceuticals and is of intense pharmacogenetic interest due t..

Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation in relapsing malaria.

Aaron Jex, Ivo Mueller, Stefan Kappe, Sebastian Mikolajczak, Jetsumon Sattabongkot, Rapatbhorn Patrapuvich, Scott Lindner, Erika Flannery, Cristian Koepfli, Brendan Ansell, Anita Lerch, Samantha Emery, Sarah Charnaud, Jeffrey Smith, Nicholas Merrienne, Kristian Swearingen, Robert Moritz, Michaela Petter, M Duffy, Veruda Chuenchob

Journal article  |  2019  |  International Journal for Parasitology

Plasmodium vivax is the key obstacle to malaria elimination in Asia and Latin America, largely attributed to its ability to form r..

The N-terminus of EXP2 forms the membrane-associated pore of the protein exporting translocon PTEX in Plasmodium falciparum

Paul R Sanders, Benjamin K Dickerman, Sarah C Charnaud, Paul A Ramsland, Brendan S Crabb, Paul R Gilson

Journal article  |  2019  |  JOURNAL OF BIOCHEMISTRY

In order to facilitate a number of processes including nutrient acquisition and immune evasion, malaria parasites extensively remo..

Knockdown of the translocon protein EXP2 in Plasmodium falciparum reduces growth and protein export

Sarah C Charnaud, Rasika Kumarasingha, Hayley E Bullen, Brendan S Crabb, Paul R Gilson

Journal article  |  2018  |  PLOS ONE

Malaria parasites remodel their host erythrocytes to gain nutrients and avoid the immune system. Host erythrocytes are modified by..

Spatial organization of protein export in malaria parasite blood stages

Sarah C Charnaud, Thorey K Jonsdottir, Paul R Sanders, Hayley E Bullen, Benjamin K Dickerman, Betty Kouskousis, Catherine S Palmer, Halina M Pietrzak, Annamarie E Laumaea, Anna-Belen Erazo, Emma McHugh, Leann Tilley, Brendan S Crabb, Paul R Gilson

Journal article  |  2018  |  TRAFFIC

Plasmodium falciparum, which causes malaria, extensively remodels its human host cells, particularly erythrocytes. Remodelling is ..

The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites

Sarah C Charnaud, Matthew WA Dixon, Catherine Q Nie, Lia Chappell, Paul R Sanders, Thomas Nebl, Eric Hanssen, Matthew Berriman, Jo-Anne Chan, Adam J Blanch, James G Beeson, Julian C Rayner, Jude M Przyborski, Leann Tilley, Brendan S Crabb, Paul R Gilson

Journal article  |  2017  |  PLOS ONE

Malaria is caused by five different Plasmodium spp. in humans each of which modifies the host erythrocyte to survive and replicate..

An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes

Steven Batinovic, Emma McHugh, Scott A Chisholm, Kathryn Matthews, Boiyin Liu, Laure Dumont, Sarah C Charnaud, Molly Parkyn Schneider, Paul R Gilson, Tania F de Koning-Ward, MatthewW A Dixon, Leann Tilley

Journal article  |  2017  |  NATURE COMMUNICATIONS

The malaria parasite, Plasmodium falciparum, displays the P. falciparum erythrocyte membrane protein 1 (PfEMP1) on the surface of ..

Trafficking of the exported P. falciparum chaperone PfHsp70x

Manuel Rhiel, Verena Bittl, Anke Tribensky, Sarah C Charnaud, Maja Strecker, Sebastian Mueller, Michael Lanzer, Cecilia Sanchez, Christine Schaeffer-Reiss, Benoit Westermann, Brendan S Crabb, Paul R Gilson, Simone Kuelzer, Jude M Przyborski

Journal article  |  2016  |  SCIENTIFIC REPORTS

Plasmodium falciparum extensively modifies its chosen host cell, the mature human erythrocyte. This remodelling is carried out by ..