Elena Schneider-Futschik

Nuclear heterogeneity is prevalent in high-quality fractionated human sperm cells typically used for assisted conception.

RA Ogle, J Netherton, E Schneider, T Velkov, H Zhang, N Cole, L Hetherington, AISB Villaverde, MA Baker

Journal article  |  2021  |  Hum Reprod

STUDY QUESTION: What is the nuclear heterogeneity of high-density purified human spermatozoa typically used for IVF purposes. SUMM..

Entry of cystic fibrosis transmembrane conductance potentiator ivacaftor into the developing brain and lung.

Fiona Qiu, Mark D Habgood, Yifan Huang, Katarzyna M Dziegielewska, Sam Toll, Elena K Schneider-Futschik

Journal article  |  2021  |  J Cyst Fibros

BACKGROUND: The potential effects of ivacaftor during pregnancy and breastfeeding on the offspring are still unknown. This study a..

WS09.5 Clinical applications of using drug monitoring for standard caftor regimens

F Qiu, F Reyes-Ortega, E Schneider-Futschik

Journal article  |  2021  |  Journal of Cystic Fibrosis

Magnetic Nanoparticle-Based Drug Delivery Approaches for Preventing and Treating Biofilms in Cystic Fibrosis

Marsha Tan, Felisa Reyes-Ortega, Elena K Schneider-Futschik

Journal article  |  2020  |  MAGNETOCHEMISTRY

Biofilm-associated infections pose a huge burden on healthcare systems worldwide, with recurrent lung infections occurring due to ..

Multiple Reaction Monitoring Mass Spectrometry for the Drug Monitoring of Ivacaftor, Tezacaftor, and Elexacaftor Treatment Response in Cystic Fibrosis: A High-Throughput Method

Felisa Reyes-Ortega, Fiona Qiu, Elena K Schneider-Futschik

Journal article  |  2020  |  ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE

Ivacaftor-tezacaftor and ivacaftor-tezacaftor-elexacaftor are new breakthrough cystic fibrosis (CF) drug combinations that directl..

The Balance between the Safety of Mother, Fetus, and Newborn Undergoing Cystic Fibrosis Transmembrane Conductance Regulator Treatments during Pregnancy

Fiona Qiu, Mark Habgood, Elena K Schneider-Futschik

Journal article  |  2020  |  ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE

The recent development of modulators of cystic fibrosis transmembrane conductance regulator (CFTR) has allowed the life expectancy..

Metabolomic Description of Ivacaftor Elevating Polymyxin B Mediated Antibacterial Activity in Cystic Fibrosis Pseudomonas aeruginosa

Rafah Allobawi, Drishti P Ghelani, Elena K Schneider-Futschik

Journal article  |  2020  |  ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE

We have demonstrated that ivacaftor displays synergistic antibacterial activity in combination with polymyxin B against polymyxin-..

Effective Strategy Targeting Polymyxin-Resistant Gram-Negative Pathogens: Polymyxin B in Combination with the Selective Serotonin Reuptake Inhibitor Sertraline

Maytham Hussein, Elena K Schneider-Futschik, Olivia KA Paulin, Rafah Allobawi, Simon Crawford, Qi Tony Zhou, Adil Hanif, Mark Baker, Yan Zhu, Jian Li, Tony Velkov

Journal article  |  2020  |  ACS INFECTIOUS DISEASES

This study aimed to investigate synergistic antibacterial activity of polymyxin B in combination with the selective serotonin reup..

Polymyxins Bind to the Cell Surface of Unculturable Acinetobacter baumannii and Cause Unique Dependent Resistance

Yan Zhu, Jing Lu, Mei-Ling Han, Xukai Jiang, Mohammad AK Azad, Nitin A Patil, Yu-Wei Lin, Jinxin Zhao, Yang Hu, Heidi H Yu, Ke Chen, John D Boyce, Rhys A Dunstan, Trevor Lithgow, Christopher K Barlow, Weifeng Li, Elena K Schneider-Futschik, Jiping Wang, Bin Gong, Bjorn Sommer, et al.

Journal article  |  2020  |  ADVANCED SCIENCE

Multidrug-resistant Acinetobacter baumannii is a top-priority pathogen globally and polymyxins are a last-line therapy. Polymyxin ..

Successes and Challenges: Inhaled Treatment Approaches Using Magnetic Nanoparticles in Cystic Fibrosis

Marsha Tan, Felisa Reyes-Ortega, Elena K Schneider-Futschik

Journal article  |  2020  |  MAGNETOCHEMISTRY

Magnetic nanoparticles have been largely applied to increase the efficacy of antibiotics due to passive accumulation provided by e..