Jacqueline Schiesser

An INSULIN-GFP/GLUCAGON-mCherry reporter line for the study of human pancreatic endocrine cell development

Tanya Labonne, Andrew G Elefanty, Edouard G Stanley, Jacqueline Schiesser

Journal article  |  2021  |  STEM CELL RESEARCH

Insulin expressing beta cells and glucagon expressing alpha cells are the two most abundant endocrine cell types of the human panc..

Integrin alpha v beta 5 heterodimer is a specific marker of human pancreatic beta cells

Jacqueline Schiesser, Thomas Loudovaris, Helen E Thomas, Andrew G Elefanty, Edouard G Stanley

Journal article  |  2021  |  SCIENTIFIC REPORTS

The identification of cell surface markers specific to pancreatic beta cells is important for both the study of islet biology and ..

Multipotent RAG1 progenitors emerge directly from haemogenic endothelium in human pluripotent stem cell-derived haematopoietic organoids

Ali Motazedian, Freya F Bruveris, Santhosh V Kumar, Jacqueline V Schiesser, Tyrone Chen, Elizabeth S Ng, Ann P Chidgey, Christine A Wells, Andrew G Elefanty, Edouard G Stanley

Journal article  |  2020  |  NATURE CELL BIOLOGY

Defining the ontogeny of the human adaptive immune system during embryogenesis has implications for understanding childhood diseas..

Induced pluripotent stem cell macrophages present antigen to proinsulin-specific T cell receptors from donor-matched islet-infiltrating T cells in type 1 diabetes

Kriti Joshi, Colleen Elso, Ali Motazedian, Tanya Labonne, Jacqueline V Schiesser, Fergus Cameron, Stuart I Mannering, Andrew G Elefanty, Edouard G Stanley

Journal article  |  2019  |  DIABETOLOGIA

AIMS/HYPOTHESIS: Type 1 diabetes is an autoimmune disorder characterised by loss of insulin-producing beta cells of the pancreas. ..

MULTIPOTENT RAG1 PROGENITORS EMERGE DIRECTLY FROM HEMOGENIC ENDOTHELIUM IN HUMAN PSC DERIVED HEMOPOIETIC ORGANOIDS

Ali Motazedian, Freya Bruveris, Santhosh Kumar, Jacqueline Schiesser, Tyrone Chen, Elizabeth Ng, Ann Chidgey, Christine Wells, Andrew Elefanty, Edouard Stanley

Conference Proceedings  |  2019  |  EXPERIMENTAL HEMATOLOGY

3176 – MULTIPOTENT RAG1 PROGENITORS EMERGE DIRECTLY FROM HEMOGENIC ENDOTHELIUM IN HUMAN PSC DERIVED HEMOPOIETIC ORGANOIDS

Ali Motazedian, Freya Bruveris, Santhosh Kumar, Jacqueline Schiesser, Tyrone Chen, Elizabeth Ng, Ann Chidgey, Christine Wells, Andrew Elefanty, Edouard Stanley

Conference Proceedings  |  2019  |  Experimental Hematology

Generation of iPSC lines from peripheral blood mononuclear cells from 5 healthy adults

Katerina Vlahos, Koula Sourris, Robyn Mayberry, Penelope McDonald, Freya F Bruveris, Jacqueline V Schiesser, Kiymet Bozaoglu, Paul J Lockhart, Edouard G Stanley, Andrew G Elefanty

Journal article  |  2019  |  STEM CELL RESEARCH

We describe the generation and characterization of 5 human induced pluripotent stem cell (iPSC) lines derived from peripheral bloo..

Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets

Katie L Sinagoga, William J Stone, Jacqueline V Schiesser, Jamie I Schweitzer, Leesa Sampson, Yi Zheng, James M Wells

Journal article  |  2017  |  Journal of Cell Science

Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets

Katie L Sinagoga, William J Stone, Jacqueline V Schiesser, Jamie I Schweitzer, Leesa Sampson, Yi Zheng, James M Wells

Journal article  |  2017  |  DEVELOPMENT

While much is known about the molecular pathways that regulate embryonic development and adult homeostasis of the endocrine pancre..

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

Michael J Workman, Maxime M Mahe, Stephen Trisno, Holly M Poling, Carey L Watson, Nambirajan Sundaram, Ching-Fang Chang, Jacqueline Schiesser, Philippe Aubert, Edouard G Stanley, Andrew G Elefanty, Yuichiro Miyaoka, Mohammad A Mandegar, Bruce R Conklin, Michel Neunlist, Samantha A Brugmann, Michael A Helmrath, James M Wells

Journal article  |  2017  |  NATURE MEDICINE

The enteric nervous system (ENS) of the gastrointestinal tract controls many diverse functions, including motility and epithelial ..