Simon Hogg

Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction

Kenji M Fujihara, Bonnie Z Zhang, Thomas D Jackson, Moses O Ogunkola, Brunda Nijagal, Julia Milne, David A Sallman, Ching-Seng Ang, Iva Nikolic, Conor J Kearney, Simon J Hogg, Carlos S Cabalag, Vivien R Sutton, Sally Watt, Asuka T Fujihara, Joseph A Trapani, Kaylene J Simpson, Diana Stojanovski, Silke Leimkuhler, Sue Haupt, et al.

Journal article  |  2022  |  SCIENCE ADVANCES

The mechanism of action of eprenetapopt (APR-246, PRIMA-1MET) as an anticancer agent remains unresolved, although the clinical dev..

Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML

Jessica M Salmon, Izabela Todorovski, Kym L Stanley, Claudia Bruedigam, Conor J Kearney, Luciano G Martelotto, Fernando Rossello, Timothy Semple, Gisela Mir Arnau, Magnus Zethoven, Michael Bots, Stefan Bjelosevic, Leonie A Cluse, Peter J Fraser, Veronique Litalien, Eva Vidacs, Kate McArthur, Antony Y Matthews, Elise Gressier, Nicole A de Weerd, et al.

Journal article  |  2022  |  CANCER DISCOVERY

UNLABELLED: Pharmacologic inhibition of epigenetic enzymes can have therapeutic benefit against hematologic malignancies. In addit..

Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia

Joan So, Alexander C Lewis, Lorey K Smith, Kym Stanley, Rheana Franich, David Yoannidis, Lizzy Pijpers, Pilar Dominguez, Simon J Hogg, Stephin J Vervoort, Fiona C Brown, Ricky W Johnstone, Gabrielle McDonald, Danielle B Ulanet, Josh Murtie, Emily Gruber, Lev M Kats

Journal article  |  2022  |  EMBO MOLECULAR MEDICINE

The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes one of the rate-limiting steps in de novo pyrimidine biosy..

Integrated clinical and genomic evaluation of guadecitabine (SGI-110) in peripheral T-cell lymphoma

Jonathan Wong, Emily Gruber, Belinda Maher, Mark Waltham, Zahra Sabouri-Thompson, Ian Jong, Quinton Luong, Sidney Levy, Beena Kumar, Daniella Brasacchio, Wendy Jia, Joan So, Hugh Skinner, Alexander Lewis, Simon J Hogg, Stephin Vervoort, Carmen DiCorleto, Micheleine Uhe, Jeanette Gamgee, Stephen Opat, et al.

Journal article  |  2022  |  LEUKEMIA

Peripheral T-cell lymphoma (PTCL) is a rare, heterogenous malignancy with dismal outcomes at relapse. Hypomethylating agents (HMA)..

BET Inhibition Enhances TNF-Mediated Antitumor Immunity

Lisa C Wellinger, Simon J Hogg, Dane M Newman, Thomas Friess, Daniela Geiss, Jessica Michie, Kelly M Ramsbottom, Marina Bacac, Tanja Fauti, Daniel Marbach, Laura Jarassier, Phillip Thienger, Axel Paehler, Leonie A Cluse, Conor J Kearney, Stephin J Vervoort, Joseph A Trapani, Jane Oliaro, Jake Shortt, Astrid Ruefli-Brasse, et al.

Journal article  |  2022  |  CANCER IMMUNOLOGY RESEARCH

Targeting chromatin binding proteins and modifying enzymes can concomitantly affect tumor cell proliferation and survival, as well..

Whole genome CRISPR screening identifies TOP2B as a potential target for IMiD sensitization in multiple myeloma

Matteo Costacurta, Stephin J Vervoort, Simon J Hogg, Benjamin P Martin, Ricky W Johnstone, Jake Shortt

Journal article  |  2021  |  HAEMATOLOGICA

Not available.

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

Stephin J Vervoort, Sarah A Welsh, Jennifer R Devlin, Elisa Barbieri, Deborah A Knight, Sarah Offley, Stefan Bjelosevic, Matteo Costacurta, Izabela Todorovski, Conor J Kearney, Jarrod J Sandow, Zheng Fan, Benjamin Blyth, Victoria McLeod, Joseph HA Vissers, Karolina Pavic, Ben P Martin, Gareth Gregory, Elena Demosthenous, Magnus Zethoven, et al.

Journal article  |  2021  |  CELL

Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent kinases (CDKs) at discrete checkpoints dur..

Serine Biosynthesis Is a Metabolic Vulnerability in FLT3-ITD-Driven Acute Myeloid Leukemia

Stefan Bjelosevic, Emily Gruber, Andrea Newbold, Carolyn Shembrey, Jennifer R Devlin, Simon J Hogg, Lev Kats, Izabela Todorovski, Zheng Fan, Thomas C Abrehart, Giovanna Pomilio, Andrew Wei, Gareth P Gregory, Stephin J Vervoort, Kristin K Brown, Ricky W Johnstone

Journal article  |  2021  |  CANCER DISCOVERY

Internal tandem duplication of the FMS-like tyrosine kinase 3 gene (FLT3-ITD) occurs in 30% of all acute myeloid leukemias (AML). ..

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

Simon J Hogg, Olga Motorna, Leonie A Cluse, Timothy M Johanson, Hannah D Coughlan, Ramya Raviram, Robert M Myers, Matteo Costacurta, Izabela Todorovski, Lizzy Pijpers, Stefan Bjelosevic, Tobias Williams, Shannon N Huskins, Conor J Kearney, Jennifer R Devlin, Zheng Fan, Jafar S Jabbari, Ben P Martin, Mohamed Fareh, Madison J Kelly, et al.

Journal article  |  2021  |  MOLECULAR CELL

To separate causal effects of histone acetylation on chromatin accessibility and transcriptional output, we used integrated epigen..

Targeting the epigenetic regulation of antitumour immunity

Simon J Hogg, Paul A Beavis, Mark A Dawson, Ricky W Johnstone

Journal article  |  2020  |  NATURE REVIEWS DRUG DISCOVERY

Dysregulation of the epigenome drives aberrant transcriptional programmes that promote cancer onset and progression. Although defe..