Charles Pagel

The role of glycosylation in amyloid fibril formation of bovine κ-casein.

Barana Hewa Nadugala, Rick Hantink, Tom Nebl, Jacinta White, Charles N Pagel, CS Ranadheera, Amy Logan, Jared K Raynes

Journal article  |  2023  |  Curr Res Food Sci

In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (..

The effect of casein genetic variants, glycosylation and phosphorylation on bovine milk protein structure, technological properties, nutrition and product manufacture

B Hewa Nadugala, CN Pagel, JK Raynes, CS Ranadheera, A Logan

Journal article  |  2022  |  International Dairy Journal

Whilst there are only four genes that encode caseins found in bovine milk, there is a vast array of naturally occurring variants o..

Protease-activated receptor-2 dependent and independent responses of bone cells to prostate cancer cell secretory products

Charles N Pagel, Pamu K Kularathna, Reza Sanaei, Neil D Young, John D Hooper, Eleanor J Mackie

Journal article  |  2022  |  PROSTATE

BACKGROUND: Metastatic prostate cancer lesions in the skeleton are frequently characterized by excessive formation of bone. Prosta..

Tetrathiomolybdate Treatment Attenuates Bleomycin-Induced Angiogenesis and Lung Pathology in a Sheep Model of Pulmonary Fibrosis

Habtamu B Derseh, Kopiyawaththage UE Perera, Sasika N Vithana Dewage, Andrew Stent, Emmanuel Koumoundouros, Louise Organ, Charles N Pagel, Ken J Snibson

Journal article  |  2021  |  FRONTIERS IN PHARMACOLOGY

Idiopathic pulmonary fibrosis (IPF) is a progressive chronic lung disease characterized by excessive extracellular matrix (ECM) de..

Protease-activated receptor-2 promotes osteogenesis in skeletal mesenchymal stem cells at the expense of adipogenesis: Involvement of interleukin-6

R Sanaei, PK Kularathna, N Taghavi, JD Hooper, CN Pagel, EJ Mackie

Journal article  |  2021  |  BONE REPORTS

Bone marrow mesenchymal stem cells (MSCs) give rise to osteoblasts and adipocytes, with an inverse relationship between the two. T..

Small airway remodeling in a sheep model of bleomycin-induced pulmonary fibrosis

Habtamu B Derseh, Sasika N Vithana Dewage, Udari E Perera, Emmanuel Koumoundouros, Charles N Pagel, Louise Organ, Ken J Snibson

Journal article  |  2020  |  EXPERIMENTAL LUNG RESEARCH

BACKGROUND: Although IPF is described traditionally as a disease affecting lung parenchyma, there is renewed interest in the alter..

Tetrathiomolybdate Treatment Attenuates Microvascular Remodeling in a Large Animal Model of Bleomycin Induced Pulmonary Fibrosis

HB Derseh, KUE Perera, VDS Nimanthi, E Koumoundouros, CN Pagel, L Organ, K Snibson

Conference Proceedings  |  2020  |  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

K(Ca)3.1 channel blockade attenuates microvascular remodelling in a large animal model of bleomycin-induced pulmonary fibrosis

Habtamu B Derseh, Sasika N Vithana Dewage, Kopiyawaththage UE Perera, Charles N Pagel, Emmanuel Koumoundouros, Louise Organ, Ken J Snibson

Journal article  |  2019  |  SCIENTIFIC REPORTS

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with limited therapeutic options and poor prognosis. IPF..

Normal inflammation and regeneration of muscle following injury require osteopontin from both muscle and non-muscle cells

Dimuthu K Wasgewatte Wijesinghe, Eleanor J Mackie, Charles N Pagel

Journal article  |  2019  |  SKELETAL MUSCLE

BACKGROUND: Osteopontin is secreted by skeletal muscle myoblasts and macrophages, and its expression is upregulated in muscle foll..

Tetrathiomolybdate Treatment Attenuates Bleomycin-Induced Pulmonary Fibrosis in a Large Animal Model

HB Derseh, KUE Perera, VDS Nimanthi, E Koumoundouros, A Stent, CN Pagel, L Organ, K Snibson

Conference Proceedings  |  2019  |  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE