Raj Rudraraju

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance

Mohamed Fareh, Wei Zhao, Wenxin Hu, Joshua ML Casan, Amit Kumar, Jori Symons, Jennifer M Zerbato, Danielle Fong, Ilia Voskoboinik, Paul G Ekert, Rajeev Rudraraju, Damian FJ Purcell, Sharon R Lewin, Joseph A Trapani

Journal article  |  2021  |  NATURE COMMUNICATIONS

The recent dramatic appearance of variants of concern of SARS-coronavirus-2 (SARS-CoV-2) highlights the need for innovative approa..

BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection

Richard J Mills, Sean J Humphrey, Patrick RJ Fortuna, Mary Lor, Simon R Foster, Gregory A Quaife-Ryan, Rebecca L Johnston, Troy Dumenil, Cameron Bishop, Rajeev Rudraraju, Daniel J Rawle, Thuy Le, Wei Zhao, Leo Lee, Charley Mackenzie-Kludas, Neda R Mehdiabadi, Christopher Halliday, Dean Gilham, Li Fu, Stephen J Nicholls, et al.

Journal article  |  2021  |  CELL

Cardiac injury and dysfunction occur in COVID-19 patients and increase the risk of mortality. Causes are ill defined but could be ..

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance

Mohamed Fareh, Wei Zhao, Wenxin Hu, Joshua ML Casan, Amit Kumar, Jori Symons, Ilia Voskoboinik, Paul Ekert, Rajeev Rudraraju, Sharon Lewin, Joseph Trapani

Journal article  |  2020

ABSTRACT Mutation-driven evolution of SARS coronavirus-2 (SARS-CoV-2) highlights the need for innovative approaches that simultane..

Convalescent plasma treatment for COVID-19: Tempering expectations with the influenza experience

Kanta Subbarao, Francesca Mordant, Rajeev Rudraraju

Journal article  |  2020  |  EUROPEAN JOURNAL OF IMMUNOLOGY

The COVID-19 pandemic caused by the zoonotic coronavirus, SARS-CoV-2 has swept the world in 5 months. A proportion of cases develo..

How Live Attenuated Vaccines Can Inform the Development of Broadly Cross-Protective Influenza Vaccines

Rajeev Rudraraju, Francesca Mordant, Kanta Subbarao

Journal article  |  2019  |  JOURNAL OF INFECTIOUS DISEASES

Passive immunization with influenza haemagglutinin specific monoclonal antibodies.

Rajeev Rudraraju, Kanta Subbarao

Journal article  |  2018  |  Hum Vaccin Immunother

The isolation of broadly neutralising antibodies against the influenza haemagglutinin has spurred investigation into their clinica..

APC-targeted proinsulin expression inactivates insulin-specific memory CD8( ) T cells in NOD mice

Peta LS Reeves, Rajeev Rudraraju, Xiao Liu, F Susan Wong, Emma E Hamilton-Williams, Raymond J Steptoe

Journal article  |  2017  |  IMMUNOLOGY AND CELL BIOLOGY

Type 1 diabetes (T1D) results from T-cell-mediated autoimmune destruction of pancreatic β cells. Effector T-cell responses emerge ..

Antigen presenting cell-targeted proinsulin expression converts insulin-specific CD8( ) T-cell priming to tolerance in autoimmune-prone NOD mice

Peta LS Reeves, Rajeev Rudraraju, F Susan Wong, Emma E Hamilton-Williams, Raymond J Steptoe

Journal article  |  2017  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Type 1 diabetes (T1D) results from autoimmune destruction of insulin-producing pancreatic β cells. Therapies need to incorporate s..

Allergen-encoding bone marrow transfer inactivates allergic T cell responses, alleviating airway inflammation

Jane Al-Kouba, Andrew N Wilkinson, Malcolm R Starkey, Rajeev Rudraraju, Rhiannon B Werder, Xiao Liu, Soi-Cheng Law, Jay C Horvat, Jeremy F Brooks, Geoffrey R Hill, Janet M Davies, Simon Phipps, Philip M Hansbro, Raymond J Steptoe

Journal article  |  2017  |  JCI INSIGHT

Memory Th2 cell responses underlie the development and perpetuation of allergic diseases. Because these states result from immune ..

Short-course rapamycin treatment enables engraftment of immunogenic gene-engineered bone marrow under low-dose irradiation to permit long-term immunological tolerance

Kunal H Bhatt, Rajeev Rudraraju, Jeremy F Brooks, Ji-Won Jung, Ryan Galea, James W Wells, Raymond J Steptoe

Journal article  |  2017  |  STEM CELL RESEARCH & THERAPY

BACKGROUND: Application of genetically modified hematopoietic stem cells is increasingly mooted as a clinically relevant approach ..