Sandra Galic

Blocking AMPK?1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis

Katyayanee Neopane, Natalie Kozlov, Florentina Negoita, Lisa Murray-Segal, Robert Brink, Ashfaqul Hoque, Ashley J Ovens, Gavin Tjin, Luke M McAloon, Dingyi Yu, Naomi XY Ling, Matthew J Sanders, Jonathan S Oakhill, John W Scott, Gregory R Steinberg, Kim Loh, Bruce E Kemp, Kei Sakamoto, Sandra Galic

Journal article  |  2022  |  CELL REPORTS

AMP-activated protein kinase (AMPK) is a master regulator of cellular energy homeostasis and a therapeutic target for metabolic di..

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance (vol 14, pg 684, 2011)

Kim Loh, Atsushi Fukushima, Xinmei Zhang, Sandra Galic, Dana Briggs, Pablo J Enriori, Stephanie Simonds, Florian Wiede, Alexander Reichenbach, Christine Hauser, Natalie A Sims, Kendra K Bence, Sheng Zhang, Zhong-Yin Zhang, Barbara B Kahn, Benjamin G Neel, Zane B Andrews, Michael A Cowley, Tony Tiganis

Journal article  |  2022  |  CELL METABOLISM

(Cell Metabolism 14, 684–699; November 2, 2011) We regret to inform that a mistake was made when preparing Figure 4A. In the figur..

Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator

Ashley J Ovens, Yi Sing Gee, Naomi XY Ling, Dingyi Yu, Justin P Hardee, Jin D Chung, Kevin RW Ngoei, Nicholas J Waters, Nolan J Hoffman, John W Scott, Kim Loh, Katrin Spengler, Regine Heller, Michael W Parker, Gordon S Lynch, Fei Huang, Sandra Galic, Bruce E Kemp, Jonathan B Baell, Jonathan S Oakhill, et al.

Journal article  |  2022  |  BIOCHEMICAL JOURNAL

The AMP-activated protein kinase (AMPK) αβγ heterotrimer is a primary cellular energy sensor and central regulator of energy homeo..

Defective AMPK regulation of cholesterol metabolism accelerates atherosclerosis by promoting HSPC mobilization and myelopoiesis

Man KS Lee, Olivia D Cooney, Xuzhu Lin, Shaktypreya Nadarajah, Dragana Dragoljevic, Kevin Huynh, Danise-Ann Onda, Sandra Galic, Peter J Meikle, Thomas Edlund, Morgan D Fullerton, Bruce E Kemp, Andrew J Murphy, Kim Loh

Journal article  |  2022  |  MOLECULAR METABOLISM

OBJECTIVES: Dysregulation of cholesterol metabolism in the liver and hematopoietic stem and progenitor cells (HSPCs) promotes athe..

An AMPKa2-specific phospho-switch controls lysosomal targeting for activation

Kaitlin R Morrison, William J Smiles, Naomi XY Ling, Ashfaqul Hoque, Gabrielle Shea, Kevin RW Ngoei, Dingyi Yu, Lisa Murray-Segal, John W Scott, Sandra Galic, Bruce E Kemp, Janni Petersen, Jonathan S Oakhill

Journal article  |  2022  |  CELL REPORTS

AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin complex 1 (mTORC1) are metabolic kinases that co-ordinate ..

Neuropeptide Y1 receptor antagonism protects beta-cells and improves glycemic control in type 2 diabetes

Chieh-Hsin Yang, Danise Ann-Onda, Xuzhu Lin, Stacey Fynch, Shaktypreya Nadarajah, Evan G Pappas, Xin Liu, John W Scott, Jonathan S Oakhill, Sandra Galic, Yanchuan Shi, Alba Moreno-Asso, Cassandra Smith, Thomas Loudovaris, Itamar Levinger, Decio L Eizirik, D Ross Laybutt, Herbert Herzog, Helen E Thomas, Kim Loh

Journal article  |  2021  |  MOLECULAR METABOLISM

OBJECTIVES: Loss of functional β-cell mass is a key factor contributing to poor glycemic control in advanced type 2 diabetes (T2D)..

Regulation of Pancreatic beta-Cell Function by the NPY System

Chieh-Hsin Yang, Danise-Ann Onda, Jonathan S Oakhill, John W Scott, Sandra Galic, Kim Loh

Journal article  |  2021  |  ENDOCRINOLOGY

The neuropeptide Y (NPY) system has been recognized as one of the most critical molecules in the regulation of energy homeostasis ..

Molecular Mechanisms Underlying the Beneficial Effects of Exercise on Brain Function and Neurological Disorders

Kevin Nay, William J Smiles, Jacqueline Kaiser, Luke M McAloon, Kim Loh, Sandra Galic, Jonathan S Oakhill, Andrew L Gundlach, John W Scott

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

As life expectancy has increased, particularly in developed countries, due to medical advances and increased prosperity, age-relat..

CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins

Christopher G Langendorf, Matthew T O'Brien, Kevin RW Ngoei, Luke M McAloon, Urmi Dhagat, Ashfaqul Hoque, Naomi XY Ling, Toby A Dite, Sandra Galic, Kim Loh, Michael W Parker, Jonathan S Oakhill, Bruce E Kemp, John W Scott

Journal article  |  2020  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The calcium-calmodulin-dependent protein kinase kinase-2 (CaMKK2) is a key regulator of cellular and whole-body energy metabolism...

Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism

Nolan J Hoffman, Jamie Whitfield, Natalie R Janzen, Mehdi R Belhaj, Sandra Galic, Lisa Murray-Segal, William J Smiles, Naomi XY Ling, Toby A Dite, John W Scott, Jonathan S Oakhill, Robert Brink, Bruce E Kemp, John A Hawley

Journal article  |  2020  |  MOLECULAR METABOLISM

OBJECTIVE: Glycogen is a major energy reserve in liver and skeletal muscle. The master metabolic regulator AMP-activated protein k..