Sandra Galic

Molecular Mechanisms Underlying the Beneficial Effects of Exercise on Brain Function and Neurological Disorders

Kevin Nay, William J Smiles, Jacqueline Kaiser, Luke M McAloon, Kim Loh, Sandra Galic, Jonathan S Oakhill, Andrew L Gundlach, John W Scott

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

As life expectancy has increased, particularly in developed countries, due to medical advances and increased prosperity, age-relat..

CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins

Christopher G Langendorf, Matthew T O'Brien, Kevin RW Ngoei, Luke M McAloon, Urmi Dhagat, Ashfaqul Hoque, Naomi XY Ling, Toby A Dite, Sandra Galic, Kim Loh, Michael W Parker, Jonathan S Oakhill, Bruce E Kemp, John W Scott

Journal article  |  2020  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The calcium-calmodulin-dependent protein kinase kinase-2 (CaMKK2) is a key regulator of cellular and whole-body energy metabolism...

Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism

Nolan J Hoffman, Jamie Whitfield, Natalie R Janzen, Mehdi R Belhaj, Sandra Galic, Lisa Murray-Segal, William J Smiles, Naomi XY Ling, Toby A Dite, John W Scott, Jonathan S Oakhill, Robert Brink, Bruce E Kemp, John A Hawley

Journal article  |  2020  |  MOLECULAR METABOLISM

OBJECTIVE: Glycogen is a major energy reserve in liver and skeletal muscle. The master metabolic regulator AMP-activated protein k..

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK beta 1 isoforms

Stephen L Pinkosky, John W Scott, Eric M Desjardins, Brennan K Smith, Emily A Day, Rebecca J Ford, Christopher G Langendorf, Naomi XY Ling, Tracy L Nero, Kim Loh, Sandra Galic, Ashfaqul Hoque, William J Smiles, Kevin RW Ngoei, Michael W Parker, Yan Yan, Karsten Melcher, Bruce E Kemp, Jonathan S Oakhill, Gregory R Steinberg

Journal article  |  2020  |  NATURE METABOLISM

Long-chain fatty acids (LCFAs) play important roles in cellular energy metabolism, acting as both an important energy source and s..

The myokine meteorin-like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPK alpha 2

Jung Ok Lee, Won Seok Byun, Min Ju Kang, Jeong Ah Han, Jiyoung Moon, Min-Jeong Shin, Ho Jun Lee, Ji Hyung Chung, Jin-Seok Lee, Chang-Gue Son, Kwon-Ho Song, Tae Woo Kim, Eun-Soo Lee, Hong Min Kim, Choon Hee Chung, Kevin RW Ngoei, Naomi XY Ling, Jonathan S Oakhill, Sandra Galic, Lisa Murray-Segal, et al.

Journal article  |  2020  |  FEBS JOURNAL

Meteorin-like (metrnl) is a recently identified adipomyokine that beneficially affects glucose metabolism; however, its underlying..

Functional analysis of an R311C variant of Ca2 -calmodulin-dependent protein kinase kinase-2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder

Naomi XY Ling, Christopher G Langendorf, Ashfaqul Hoque, Sandra Galic, Kim Loh, Bruce E Kemp, Andrew L Gundlach, Jonathan S Oakhill, John W Scott

Journal article  |  2020  |  BIPOLAR DISORDERS

OBJECTIVES: Loss-of-function mutations in the gene encoding the calcium-calmodulin (Ca2+ -CaM)-dependent protein kinase kinase-2 (..

ATP synthase inhibitory factor 1 (IF1), a novel myokine, regulates glucose metabolism by AMPK and Akt dual pathways

Hye Jeong Lee, Jiyoung Moon, InHyeok Chung, Ji Hyung Chung, Chan Park, Jung Ok Lee, Jeong Ah Han, Min Ju Kang, Eun Hye Yoo, So-Young Kwak, Garam Jo, Wonil Park, Jonghoon Park, Kyoung Min Kim, Soo Lim, Kevin RW Ngoei, Naomi XY Ling, Jonathan S Oakhill, Sandra Galic, Lisa Murray-Segal, et al.

Journal article  |  2019  |  The FASEB Journal

ATPase inhibitory factor 1 (IF1) is an ATP synthase‐interacting protein that suppresses the hydrolysis activity of ATP synthase. I..

Allosteric regulation of AMP-activated protein kinase by adenylate nucleotides and small-molecule drugs

Ana Laura de Souza Almeida Matos, Jonathan S Oakhill, Jose Moreira, Kim Loh, Sandra Galic, John W Scott

Journal article  |  2019  |  BIOCHEMICAL SOCIETY TRANSACTIONS

The AMP (adenosine 5'-monophosphate)-activated protein kinase (AMPK) is a key regulator of cellular and whole-body energy homeosta..

Absence of the beta 1 subunit of AMP-activated protein kinase reduces myofibroblast infiltration of the kidneys in early diabetes

Suet-Wan Choy, Scott A Fraser, Marina Katerelos, Sandra Galic, Bruce E Kemp, Peter F Mount, David A Power

Journal article  |  2019  |  INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Activation of the heterotrimeric energy-sensing kinase AMP-activated protein kinase (AMPK) has been reported to improve experiment..

Inhibition of Adenosine Monophosphate-Activated Protein Kinase-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance

Kim Loh, Shanna Tam, Lisa Murray-Segal, Kevin Huynh, Peter J Meikle, John W Scott, Bryce van Denderen, Zhiping Chen, Rohan Steel, Nicholas D LeBlond, Leah A Burkovsky, Conor O'Dwyer, Julia RC Nunes, Gregory R Steinberg, Morgan D Fullerton, Sandra Galic, Bruce E Kemp

Journal article  |  2019  |  HEPATOLOGY COMMUNICATIONS

Adenosine monophosphate-activated protein kinase (AMPK) regulates multiple signaling pathways involved in glucose and lipid metabo..