Vivien Sutton

Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus

Vivien R Sutton, Christopher Andoniou, Michael G Leeming, Colin M House, Sally Watt, Sandra Verschoor, Annette Ciccone, Ilia Voskoboinik, Mariapia Degli-Esposti, Joseph A Trapani

Journal article  |  2020  |  Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

We investigated the molecular basis for the remarkably different survival outcomes of mice expressing different alloforms of the p..

ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome

Melody Cheong, Kate H Gartlan, Jason S Lee, Siok-Keen Tey, Ping Zhang, Rachel D Kuns, Christopher E Andoniou, Jose Paulo Martins, Karshing Chang, Vivien R Sutton, Greg Kelly, Antiopi Varelias, Slavica Vuckovic, Kate A Markey, Glen M Boyle, Mark J Smyth, Christian R Engwerda, Kelli PA MacDonald, Joseph A Trapani, Mariapia A Degli-Esposti, et al.

Journal article  |  2020  |  Cancer Immunology Research

The adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD) is known to facilitate caspase-1 activation, w..

Antigen-specific CD4( )CD25( ) T cells induced by locally expressed ICOS-Ig: the role of Foxp3, Perforin, Granzyme B and IL-10-an experimental study

Dale Christiansen, Effie Mouhtouris, Russell Hodgson, Vivien R Sutto, Joseph A Trapani, Francesco L Ierino, Mauro S Sandrin

Journal article  |  2019  |  Transplant International

We have previously reported that ICOS-Ig expressed locally by a PIEC xenograft induces a perigraft cellular accumulation of CD4+ C..

A Colorimetric Assay that Specifically Measures Granzyme B Proteolytic Activity: Hydrolysis of Boc-Ala-Ala-Asp-S-Bzl

Magdalena Hagn, Vivien R Sutton, Joseph A Trapani

Journal article  |  2014  |  Journal of Visualized Experiments

Cathepsin C limits acute viral infection independently of NK cell and CD8( ) T-cell cytolytic function

Christopher E Andoniou, Peter Fleming, Vivien R Sutton, Joseph A Trapani, Mariapia A Degli-Esposti

Journal article  |  2011  |  Immunology and Cell Biology

Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity

KA Sedelies, A Ciccone, CJP Clarke, J Oliaro, VR Sutton, FL Scott, J Silke, O Susanto, DR Green, RW Johnstone, PI Bird, JA Trapani, NJ Waterhouse

Journal article  |  2008  |  Cell Death & Differentiation