Vivien Sutton

Beyond target cell death - Granzyme serine proteases in health and disease.

Simone Nüssing, Vivien R Sutton, Joseph A Trapani, Ian A Parish

Journal article  |  2022  |  Mol Aspects Med

Granzymes are a family of small (∼32 kDa) serine proteases with a range of substrate specificities that are stored in, and release..

Small Molecule Inhibitors of Lymphocyte Perforin as Focused Immunosuppressants for Infection and Autoimmunity.

Julie A Spicer, Kristiina M Huttunen, Jiney Jose, Ivo Dimitrov, Hedieh Akhlaghi, Vivien R Sutton, Ilia Voskoboinik, Joseph Trapani

Journal article  |  2022  |  J Med Chem

New drugs that precisely target the immune mechanisms critical for cytotoxic T lymphocyte (CTL) and natural killer (NK) cell drive..

The effects of B-cell-activating factor on the population size, maturation and function of murine natural killer cells

Pin Shie Quah, Vivien Sutton, Eden Whitlock, William A Figgett, Daniel M Andrews, Kirsten A Fairfax, Fabienne Mackay

Journal article  |  2022  |  IMMUNOLOGY AND CELL BIOLOGY

The role of B-cell-activating factor (BAFF) in B-lymphocyte biology has been comprehensively studied, but its contributions to inn..

Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction

Kenji M Fujihara, Bonnie Z Zhang, Thomas D Jackson, Moses O Ogunkola, Brunda Nijagal, Julia Milne, David A Sallman, Ching-Seng Ang, Iva Nikolic, Conor J Kearney, Simon J Hogg, Carlos S Cabalag, Vivien R Sutton, Sally Watt, Asuka T Fujihara, Joseph A Trapani, Kaylene J Simpson, Diana Stojanovski, Silke Leimkuhler, Sue Haupt, et al.

Journal article  |  2022  |  SCIENCE ADVANCES

The mechanism of action of eprenetapopt (APR-246, PRIMA-1MET) as an anticancer agent remains unresolved, although the clinical dev..

Preclinical Activity and Pharmacokinetic/Pharmacodynamic Relationship for a Series of Novel Benzenesulfonamide Perforin Inhibitors

Kate H Gartlan, Jagdish K Jaiswal, Matthew R Bull, Hedieh Akhlaghi, Vivien R Sutton, Kylie A Alexander, Karshing Chang, Geoffrey R Hill, Christian K Miller, Patrick D O'Connor, Jiney Jose, Joseph A Trapani, Susan A Charman, Julie A Spicer, Stephen MF Jamieson

Journal article  |  2022  |  ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE

Perforin is a key effector of lymphocyte-mediated cell death pathways and contributes to transplant rejection of immunologically m..

Severely impaired CTL killing is a feature of the neurological disorder Niemann-Pick disease type C1

Daniela Castiblanco, Jesse A Rudd-Schmidt, Tahereh Noori, Vivien R Sutton, Ya Hui Hung, Thijs WH Flinsenberg, Adrian W Hodel, Neil D Young, Nicholas Smith, Drago Bratkovic, Heidi Peters, Mark Walterfang, Joseph A Trapani, Amelia J Brennan, Ilia Voskoboinik

Journal article  |  2022  |  BLOOD

Niemann-Pick disease type C1 (NP-C1) is a rare lysosomal storage disorder resulting from mutations in an endolysosomal cholesterol..

Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus

Vivien R Sutton, Christopher Andoniou, Michael G Leeming, Colin M House, Sally Watt, Sandra Verschoor, Annette Ciccone, Ilia Voskoboinik, Mariapia Degli-Esposti, Joseph A Trapani

Journal article  |  2020  |  BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

We investigated the molecular basis for the remarkably different survival outcomes of mice expressing different alloforms of the p..

ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome

Melody Cheong, Kate H Gartlan, Jason S Lee, Siok-Keen Tey, Ping Zhang, Rachel D Kuns, Christopher E Andoniou, Jose Paulo Martins, Karshing Chang, Vivien R Sutton, Greg Kelly, Antiopi Varelias, Slavica Vuckovic, Kate A Markey, Glen M Boyle, Mark J Smyth, Christian R Engwerda, Kelli PA MacDonald, Joseph A Trapani, Mariapia A Degli-Esposti, et al.

Journal article  |  2020  |  CANCER IMMUNOLOGY RESEARCH

The adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD) is known to facilitate caspase-1 activation, w..

Antigen-specific CD4( )CD25( ) T cells induced by locally expressed ICOS-Ig: the role of Foxp3, Perforin, Granzyme B and IL-10-an experimental study

Dale Christiansen, Effie Mouhtouris, Russell Hodgson, Vivien R Sutto, Joseph A Trapani, Francesco L Ierino, Mauro S Sandrin

Journal article  |  2019  |  TRANSPLANT INTERNATIONAL

We have previously reported that ICOS-Ig expressed locally by a PIEC xenograft induces a perigraft cellular accumulation of CD4+ C..

Tumor immune evasion arises through loss of TNF sensitivity

Conor J Kearney, Stephin J Vervoort, Simon J Hogg, Kelly M Ramsbottom, Andrew J Freeman, Najoua Lalaoui, Lizzy Pijpers, Jessica Michie, Kristin K Brown, Deborah A Knight, Vivien Sutton, Paul A Beavis, Ilia Voskoboinik, Phil K Darcy, John Silke, Joseph A Trapani, Ricky W Johnstone, Jane Oliaro

Journal article  |  2018  |  SCIENCE IMMUNOLOGY

Immunotherapy has revolutionized outcomes for cancer patients, but the mechanisms of resistance remain poorly defined. We used a s..