Claire Weekley

Potent Inhibition of Thioredoxin Reductase by the Rh Derivatives of Anticancer M(arene/Cp*)(NHC)Cl-2 Complexes

Dianna Truong, Matthew P Sullivan, Kelvin KH Tong, Tasha R Steel, Andre Prause, James H Lovett, Jake W Andersen, Stephen MF Jamieson, Hugh H Harris, Ingo Ott, Claire M Weekley, Katja Hummitzsch, Tilo Sohnel, Muhammad Hanif, Nils Metzler-Nolte, David C Goldstone, Christian G Hartinger

Journal article  |  2020  |  INORGANIC CHEMISTRY

Metal complexes provide a versatile platform to develop novel anticancer pharmacophores, and they form stable compounds with N-het..

Correction to: Selenite-mediated production of superoxide radical anions in A549 cancer cells is accompanied by a selective increase in SOD1 concentration, enhanced apoptosis and Se-Cu bonding.

Claire M Weekley, Gloria Jeong, Michael E Tierney, Farjaneh Hossain, Aung Min Maw, Anu Shanu, Hugh H Harris, Paul K Witting

Journal article  |  2019  |  J Biol Inorg Chem

In the original article there were errors in the methods section. Thus, within Table 1: (i) the primer sequence pair for SOD-2 was..

Inhibition of Copper Transport Induces Apoptosis in Triple-Negative Breast Cancer Cells and Suppresses Tumor Angiogenesis

Olga Karginova, Claire M Weekley, Akila Raoul, Alhareth Alsayed, Tong Wu, Steve Seung-Young Lee, Chuan He, Olufunmilayo Olopade

Journal article  |  2019  |  MOLECULAR CANCER THERAPEUTICS

Treatment of advanced breast cancer remains challenging. Copper and some of the copper-dependent proteins are emerging therapeutic..

Cellular Fates of Manganese(II) Pentaazamacrocyclic Superoxide Dismutase (SOD) Mimetics: Fluorescently Labeled MnSOD Mimetics, X-ray Absorption Spectroscopy, and X-ray Fluorescence Microscopy Studies

Claire M Weekley, Isabell Kenkel, Rainer Lippet, Shengwei We, Dominik Lieb, Tiffanny Cranwell, Jason L Wedding, Annika S Zillmann, Robin Rohr, Milos R Filipovic, Ivana Ivanovic-Burmazovic, Hugh H Harris

Journal article  |  2017  |  INORGANIC CHEMISTRY

Manganese(II) pentaazamacrocyclic complexes (MnPAMs) can act as small-molecule mimics of manganese superoxide dismutase (MnSOD) wi..

Developing drugs targeting transition metal homeostasis

Claire M Weekley, Chuan He

Journal article  |  2017  |  CURRENT OPINION IN CHEMICAL BIOLOGY

Metal dyshomeostasis is involved in the pathogenesis and progression of diseases including cancer and neurodegenerative diseases. ..

Selenite-mediated production of superoxide radical anions in A549 cancer cells is accompanied by a selective increase in SOD1 concentration, enhanced apoptosis and Se-Cu bonding

Claire M Weekley, Gloria Jeong, Michael E Tierney, Farjaneh Hossain, Aung Min Maw, Anu Shanu, Hugh H Harris, Paul K Witting

Journal article  |  2014  |  JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Selenite may exert its cytotoxic effects against cancer cells via the generation of reactive oxygen species (ROS). We investigated..

XAS and XFM studies of selenium and copper speciation and distribution in the kidneys of selenite-supplemented rats

Claire M Weekley, Anu Shanu, Jade B Aitken, Stefan Vogt, Paul K Witting, Hugh H Harris

Journal article  |  2014  |  METALLOMICS

Dietary selenium has been implicated in the prevention of cancer and other diseases, but its safety and efficacy is dependent on t..

XAS studies of Se speciation in selenite-fed rats

Claire M Weekley, Jade B Aitken, Paul K Witting, Hugh H Harris

Journal article  |  2014  |  METALLOMICS

The biological activity of selenium is dependent on its chemical form. Therefore, knowledge of Se chemistry in vivo is required fo..

Selenium Metabolism in Cancer Cells: The Combined Application of XAS and XFM Techniques to the Problem of Selenium Speciation in Biological Systems

Claire M Weekley, Jade B Aitken, Lydia Finney, Stefan Vogt, Paul K Witting, Hugh H Harris

Journal article  |  2013  |  NUTRIENTS

Determining the speciation of selenium in vivo is crucial to understanding the biological activity of this essential element, whic..

Selenium Inhibits Renal Oxidation and Inflammation But Not Acute Kidney Injury in an Animal Model of Rhabdomyolysis

Anu Shanu, Ludwig Groebler, Hyun Bo Kim, Sarah Wood, Claire M Weekley, Jade B Aitken, Hugh H Harris, Paul K Witting

Journal article  |  2013  |  ANTIOXIDANTS & REDOX SIGNALING

UNLABELLED: Acute kidney injury (AKI) is a manifestation of rhabdomyolysis (RM). Extracellular myoglobin accumulating in the kidne..