Ajith Vasanthakumar

Resident and migratory adipose immune cells control systemic metabolism and thermogenesis

Kevin Man, Axel Kallies, Ajithkumar Vasanthakumar

Journal article  |  2021  |  CELLULAR & MOLECULAR IMMUNOLOGY

Glucose is a vital source of energy for all mammals. The balance between glucose uptake, metabolism and storage determines the ene..

Going sugar free: Treg cells avoid glucose to maintain functional fitness.

Patrick M Gubser, Ajithkumar Vasanthakumar

Journal article  |  2021  |  Immunol Cell Biol

Editorial: Regulatory T Cell Heterogeneity: Canonical and Non-Canonical Functions.

Esen Sefik, Shohei Hori, Ajithkumar Vasanthakumar

Journal article  |  2021  |  Front Immunol

Early precursor T cells establish and propagate T cell exhaustion in chronic infection

Daniel T Utzschneider, Sarah S Gabriel, David Chisanga, Renee Gloury, Patrick M Gubser, Ajithkumar Vasanthakumar, Wei Shi, Axel Kallies

Journal article  |  2020  |  NATURE IMMUNOLOGY

CD8+ T cells responding to chronic infections or tumors acquire an 'exhausted' state associated with elevated expression of inhibi..

IRF4 instructs effector Treg differentiation and immune suppression in human cancer

Giorgia Alvisi, Jolanda Brummelman, Simone Puccio, Emilia MC Mazza, Elisa Paoluzzi Tomada, Agnese Losurdo, Veronica Zanon, Clelia Peano, Federico S Colombo, Alice Scarpa, Marco Alloisio, Ajithkumar Vasanthakumar, Rahul Roychoudhuri, Marinos Kallikourdis, Massimiliano Pagani, Egesta Lopci, Pierluigi Novellis, Jonas Blume, Axel Kallies, Giulia Veronesi, et al.

Journal article  |  2020  |  JOURNAL OF CLINICAL INVESTIGATION

The molecular mechanisms responsible for the high immunosuppressive capacity of CD4+ Tregs in tumors are not well known. High-dime..

Sex-specific adipose tissue imprinting of regulatory T cells

Ajithkumar Vasanthakumar, David Chisanga, Jonas Blume, Renee Gloury, Kara Britt, Darren C Henstridge, Yifan Zhan, Santiago Valle Torres, Sebastian Liene, Nicholas Collins, Enyuan Cao, Tom Sidwell, Chaoran Li, Raul German Spallanzani, Yang Liao, Paul A Beavis, Thomas Gebhardt, Natalie Trevaskis, Stephen L Nutt, Jeffrey D Zajac, et al.

Journal article  |  2020  |  NATURE

Adipose tissue is an energy store and a dynamic endocrine organ1,2. In particular, visceral adipose tissue (VAT) is critical for t..

CCR2 enhances CD25 expression by FoxP3( ) regulatory T cells and regulates their abundance independently of chemotaxis and CCR2( ) myeloid cells

Yifan Zhan, Nancy Wang, Ajithkumar Vasanthakumar, Yuxia Zhang, Michael Chopin, Stephen L Nutt, Axel Kallies, Andrew M Lew

Journal article  |  2020  |  CELLULAR & MOLECULAR IMMUNOLOGY

A wide array of chemokine receptors, including CCR2, are known to control Treg migration. Here, we report that CCR2 regulates Treg..

Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis

Tom Sidwell, Yang Liao, Alexandra L Garnham, Ajithkumar Vasanthakumar, Renee Gloury, Jonas Blume, Peggy P Teh, David Chisanga, Christoph Thelemann, Fabian de Labastida Rivera, Christian R Engwerda, Lynn Corcoran, Kohei Kometani, Tomohiro Kurosaki, Gordon K Smyth, Wei Shi, Axel Kallies

Journal article  |  2020  |  NATURE COMMUNICATIONS

Differentiation and homeostasis of Foxp3+ regulatory T (Treg) cells are strictly controlled by T-cell receptor (TCR) signals; howe..

c-Maf-dependent T-reg cell control of intestinal T(H)17 cells and IgA establishes host-microbiota homeostasis

Christian Neumann, Jonas Blume, Urmi Roy, Peggy P Teh, Ajithkumar Vasanthakumar, Alexander Beller, Yang Liao, Frederik Heinrich, Teresita L Arenzana, Jason A Hackney, Celine Eidenschenk, Eric JC Galvez, Christina Stehle, Gitta A Heinz, Patrick Maschmeyer, Tom Sidwell, Yifang Hu, Derk Amsen, Chiara Romagnani, Hyun-Dong Chang, et al.

Journal article  |  2019  |  NATURE IMMUNOLOGY

Foxp3+ regulatory T cells (Treg cells) are crucial for the maintenance of immune homeostasis both in lymphoid tissues and in non-l..

Interleukin (IL)-33 and the IL-1 Family of Cytokines-Regulators of Inflammation and Tissue Homeostasis

Ajithkumar Vasanthakumar, Axel Kallies

Journal article  |  2019  |  COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY

Cytokines play an integral role in shaping innate and adaptive immune responses. Members of the interleukin (IL)-1 family regulate..