Ajith Vasanthakumar

Sex-specific adipose tissue imprinting of regulatory T cells (vol 579,pg 581, 2020)

Ajithkumar Vasanthakumar, David Chisanga, Jonas Blume, Renee Gloury, Kara Britt, Darren C Henstridge, Yifan Zhan, Santiago Valle Torres, Sebastian Liene, Nicholas Collins, Enyuan Cao, Tom Sidwell, Chaoran Li, Raul German Spallanzani, Yang Liao, Paul A Beavis, Thomas Gebhardt, Natalie Trevaskis, Stephen L Nutt, Jeffrey D Zajac, et al.

Journal article  |  2021  |  Nature

Early precursor T cells establish and propagate T cell exhaustion in chronic infection

Daniel T Utzschneider, Sarah S Gabriel, David Chisanga, Renee Gloury, Patrick M Gubser, Ajithkumar Vasanthakumar, Wei Shi, Axel Kallies

Journal article  |  2020  |  Nature Immunology

IRF4 instructs effector Treg differentiation and immune suppression in human cancer

Giorgia Alvisi, Jolanda Brummelman, Simone Puccio, Emilia MC Mazza, Elisa Paoluzzi Tomada, Agnese Losurdo, Veronica Zanon, Clelia Peano, Federico S Colombo, Alice Scarpa, Marco Alloisio, Ajithkumar Vasanthakumar, Rahul Roychoudhuri, Marinos Kallikourdis, Massimiliano Pagani, Egesta Lopci, Pierluigi Novellis, Jonas Blume, Axel Kallies, Giulia Veronesi, et al.

Journal article  |  2020  |  Journal of Clinical Investigation

The molecular mechanisms responsible for the high immunosuppressive capacity of CD4+ Tregs in tumors are not well known. High-dime..

Sex-specific adipose tissue imprinting of regulatory T cells

Ajithkumar Vasanthakumar, David Chisanga, Jonas Blume, Renee Gloury, Kara Britt, Darren C Henstridge, Yifan Zhan, Santiago Valle Torres, Sebastian Liene, Nicholas Collins, Enyuan Cao, Tom Sidwell, Chaoran Li, Raul German Spallanzani, Yang Liao, Paul A Beavis, Thomas Gebhardt, Natalie Trevaskis, Stephen L Nutt, Jeffrey D Zajac, et al.

Journal article  |  2020  |  Nature

Adipose tissue is an energy store and a dynamic endocrine organ1,2. In particular, visceral adipose tissue (VAT) is critical for t..

CCR2 enhances CD25 expression by FoxP3( ) regulatory T cells and regulates their abundance independently of chemotaxis and CCR2( ) myeloid cells

Yifan Zhan, Nancy Wang, Ajithkumar Vasanthakumar, Yuxia Zhang, Michael Chopin, Stephen L Nutt, Axel Kallies, Andrew M Lew

Journal article  |  2020  |  Cellular & Molecular Immunology

A wide array of chemokine receptors, including CCR2, are known to control Treg migration. Here, we report that CCR2 regulates Treg..

Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis

Tom Sidwell, Yang Liao, Alexandra L Garnham, Ajithkumar Vasanthakumar, Renee Gloury, Jonas Blume, Peggy P Teh, David Chisanga, Christoph Thelemann, Fabian de Labastida Rivera, Christian R Engwerda, Lynn Corcoran, Kohei Kometani, Tomohiro Kurosaki, Gordon K Smyth, Wei Shi, Axel Kallies

Journal article  |  2020  |  Nature Communications

Differentiation and homeostasis of Foxp3+ regulatory T (Treg) cells are strictly controlled by T-cell receptor (TCR) signals; howe..

c-Maf-dependent T-reg cell control of intestinal T(H)17 cells and IgA establishes host-microbiota homeostasis

Christian Neumann, Jonas Blume, Urmi Roy, Peggy P Teh, Ajithkumar Vasanthakumar, Alexander Beller, Yang Liao, Frederik Heinrich, Teresita L Arenzana, Jason A Hackney, Celine Eidenschenk, Eric JC Galvez, Christina Stehle, Gitta A Heinz, Patrick Maschmeyer, Tom Sidwell, Yifang Hu, Derk Amsen, Chiara Romagnani, Hyun-Dong Chang, et al.

Journal article  |  2019  |  Nature Immunology

Interleukin (IL)-33 and the IL-1 Family of Cytokines-Regulators of Inflammation and Tissue Homeostasis

Ajithkumar Vasanthakumar, Axel Kallies

Journal article  |  2019  |  Cold Spring Harbor Perspectives in Biology

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation

Garima Garg, Andreas Muschaweckh, Helena Moreno, Ajithkumar Vasanthakumar, Stefan Floess, Gildas Lepennetier, Rupert Oellinger, Yifan Zhan, Tommy Regen, Michael Hiltensperger, Christian Peter, Lilian Aly, Benjamin Knier, Lakshmi Reddy Palam, Reuben Kapur, Mark H Kaplan, Ari Waisman, Roland Rad, Gunnar Schotta, Jochen Huehn, et al.

Journal article  |  2019  |  Cell Reports

Regulatory T-cell heterogeneity

Kirsten A Ward-Hartstonge, Ajithkumar Vasanthakumar

Journal article  |  2018  |  Clinical and Translational Immunology