Dr. Chan obtained his PhD in Molecular and Cellular Pharmacology at the University of Wisconsin (USA) investigating the interplay between the intracellular calcium-dependent protease Calpain 2 and focal adhesion kinase (FAK) in cell migration and invasion. In 2010, he joined the Department of Cell Biology and Physiology at the University of North Carolina as a Postdoctoral Researcher where he examined how LKB1, the master regulator of AMP-dependent kinase (AMPK), suppresses melanoma metastasis.
Since 2014 he has been a Research Officer in the Cancer Signalling Laboratory at the Peter MacCallum Cancer Centre, redirecting his research interests toward understanding cancer development, with a particular focus on oncogene- and therapy-induced senescence as powerful tumour-suppressive mechanisms. He is currently exploring how therapy-induced senescence contributes to tumour dormancy in high-grade serous carcinoma (HGSC), the most common and deadliest subtype of ovarian cancer. He is also investigating ways to therapeutically target senescent HGSC cells, which have the potential to re-emerge and cause disease recurrence. Dr Chan employs high-throughput screening, RNA sequencing, cell and molecular biology as his primary research techniques.
Find out more about Keefe Chan's experience
Keefe Chan's highlights
FEATURED Journal article
Inhibition of RNA polymerase I transcription activates targeted DNA damage response and enhances the efficacy of PARP inhibitors in high-grade serous ovarian cancer.Read more
Keefe Chan's selected work
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-gr..
Targeting RNA Polymerase I transcription synergises with TOP1 inhibition in potentiating t..
Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome bioge..
Displaying the 29 most recent scholarly works by Keefe Chan.
Inhibition of RNA polymerase I transcription activates targeted DNA damage response and enhances the efficacy of PARP inhibitors in high-grade serous ovarian cancer.
Elaine Sanij, Katherine Hannan, Jiachen Xuan, Shunfei Yan, Jessica A Ahern, Anna S Trigos, Natalie Brajanovski, Jinbae Son, Keefe T Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J Wakefield, Sarah Ellis, Carleen Cullinane, Gretchen Poortinga, Kum Kum Khanna, Linda Mileshkin, Grant A McArthur, John Soong, Els M Berns, et al.
Journal article | 2020 | CLINICAL CANCER RESEARCH
Abstract High-grade serous ovarian cancer (HGSOC) accounts for the majority of ovarian cancer and has a dismal prognosis. PARP inh..
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer
Elaine Sanij, Katherine M Hannan, Jiachen Xuan, Shunfei Yan, Jessica E Ahern, Anna S Trigos, Natalie Brajanovski, Jinbae Son, Keefe T Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J Wakefield, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Andrew J Deans, Kum Kum Khanna, et al.
Journal article | 2020 | NATURE COMMUNICATIONS
Acquired resistance to PARP inhibitors (PARPi) is a major challenge for the clinical management of high grade serous ovarian cance..
Oncogene-induced senescence: From biology to therapy
Haoran Zhu, Shaun Blake, Frances K Kusuma, Richard B Pearson, Jian Kang, Keefe T Chan
Journal article | 2020 | Mechanisms of Ageing and Development
Oncogene-induced senescence (OIS) is a powerful intrinsic tumor-suppressive mechanism, arresting cell cycle progression upon oncog..
A functional genetic screen defines the AKT-induced senescence signaling network
Keefe T Chan, Shaun Blake, Haoran Zhu, Jian Kang, Anna S Trigos, Piyush B Madhamshettiwar, Jeannine Diesch, Lassi Paavolainen, Peter Horvath, Ross D Hannan, Amee J George, Elaine Sanij, Katherine M Hannan, Kaylene J Simpson, Richard B Pearson
Journal article | 2020 | Cell Death and Differentiation
Exquisite regulation of PI3K/AKT/mTORC1 signaling is essential for homeostatic control of cell growth, proliferation, and survival..
Targeting RNA Polymerase I transcription synergises with TOP1 inhibition in potentiating the DNA damage response in high-grade serous ovarian cancer
Shunfei Yan, Piyush Madhamshettiwar, Kaylene Simpson, Sarah Ellis, Jian Kang, Carleen Cullinane, Karen Sheppard, Katherine Hannan, Ross Hannan, Elaine Sanij, Richard Pearson, Keefe Chan
Journal article | 2019
Abstract Limited effective therapeutic options are available for patients with recurrent high-grade serous carcinoma (HGSC), the m..
Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis
EP Kusnadi, AS Trigos, C Cullinane, DL Goode, O Larsson, JR Devlin, KT Chan, DP De Souza, MJ McConville, GA McArthur, G Thomas, E Sanij, G Poortinga, RD Hannan, KM Hannan, J Kang, RB Pearson
Journal article | 2019 | bioRxiv
Abstract Elevated ribosome biogenesis in oncogene-driven cancers is commonly targeted by DNA-damaging cytotoxic drugs. Our first-i..
Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma
Shatha AbuHammad, Carleen Cullinane, Claire Martin, Zoe Bacolas, Teresa Ward, Huiqin Chen, Alison Slater, Kerry Ardley, Laura Kirby, Keefe T Chan, Natalie Brajanovski, Lorey K Smith, Aparna D Rao, Emily J Lelliott, Margarete Kleinschmidt, Ismael A Vergara, Anthony T Papenfuss, Peter Lau, Prerana Ghosh, Sue Haupt, et al.
Journal article | 2019 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
A genome-wide RNAi screen identifies synthetic lethality of CX-5461 with homologous recombination repair deficiency in ovarian cancer
Shunfei Yan, Keefe T Chan, Kaylene J Simpson, Elaine Sanij, Karen E Sheppard, Katherine M Hannan, Ross D Hannan, Richard B Pearson
Conference Proceedings | 2017 | Synthetic Lethality and Viability
Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence
Keefe T Chan, Lassi Paavolainen, Katherine M Hannan, Amee J George, Ross D Hannan, Kaylene J Simpson, Peter Horvath, Richard B Pearson
Journal article | 2016 | ASSAY and Drug Development Technologies
Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling
Jaclyn Quin, Keefe T Chan, Jennifer R Devlin, Donald P Cameron, Jeannine Diesch, Carleen Cullinane, Jessica Ahern, Amit Khot, Nadine Hein, Amee J George, Katherine M Hannan, Gretchen Poortinga, Karen E Sheppard, Kum Kum Khanna, Ricky W Johnstone, Denis Drygin, Grant A McArthur, Richard B Pearson, Elaine Sanij, Ross D Hannan
Journal article | 2016 | ONCOTARGET
beta 2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion
Sarah J Creed, Caroline P Le, Mona Hassan, Cindy K Pon, Sabine Albold, Keefe T Chan, Matthew E Berginski, Zhendong Huang, James E Bear, J Robert Lane, Michelle L Halls, Davide Ferrari, Cameron J Nowell, Erica K Sloan
Journal article | 2015 | BREAST CANCER RESEARCH
IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma
Craig C Carson, Stergios J Moschos, Sharon N Edmiston, David B Darr, Nana Nikolaishvili-Feinberg, Pamela A Groben, Xin Zhou, Pei Fen Kuan, Shaily Pandey, Keefe T Chan, Jamie L Jordan, Honglin Hao, Jill S Frank, Dennis A Hopkinson, David C Gibbs, Virginia D Alldredge, Eloise Parrish, Sara C Hanna, Paula Berkowitz, David S Rubenstein, et al.
Journal article | 2015 | Clinical Cancer Research
LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues
Keefe T Chan, Sreeja B Asokan, Samantha J King, Tao Bo, Evan S Dubose, Wenjin Liu, Matthew E Berginski, Jeremy M Simon, Ian J Davis, Shawn M Gomez, Norman E Sharpless, James E Bear
Journal article | 2014 | JOURNAL OF CELL BIOLOGY
Intravital imaging of a spheroid-based orthotopic model of melanoma in the mouse ear skin
Keefe T Chan, Stephen W Jones, Hailey E Brighton, Tao Bo, Shelly D Cochran, Norman E Sharpless, James E Bear
Journal article | 2013 | IntraVital
Multiphoton microscopy is a powerful tool that enables the visualization of fluorescently tagged tumor cells and their stromal int..
LKB1/STK11 Inactivation Leads to Expansion of a Prometastatic Tumor Subpopulation in Melanoma
Wenjin Liu, Kimberly B Monahan, Adam D Pfefferle, Takeshi Shimamura, Jessica Sorrentino, Keefe T Chan, David W Roadcap, David W Ollila, Nancy E Thomas, Diego H Castrillon, C Ryan Miller, Charles M Perou, Kwok-Kin Wong, James E Bear, Norman E Sharpless
Journal article | 2012 | CANCER CELL
The Sir Peter Maccallum Department Of Oncology
Doctor of Philosophy, Molecular and Cellular Pharmacology
University of Wisconsin-Madison
Bachelor of Science, Bioengineering