Dr. Chan obtained his PhD in Molecular and Cellular Pharmacology at the University of Wisconsin (USA) investigating the interplay between the intracellular calcium-dependent protease Calpain 2 and focal adhesion kinase (FAK) in cell migration and invasion. In 2010, he joined the Department of Cell Biology and Physiology at the University of North Carolina as a Postdoctoral Researcher where he examined how LKB1, the master regulator of AMP-dependent kinase (AMPK), suppresses melanoma metastasis.
Since 2014 he has been a Research Officer in the Cancer Signalling Laboratory at the Peter MacCallum Cancer Centre, redirecting his research interests toward understanding cancer development, with a particular focus on oncogene- and therapy-induced senescence as powerful tumour-suppressive mechanisms. He is currently exploring how therapy-induced senescence contributes to tumour dormancy in high-grade serous carcinoma (HGSC), the most common and deadliest subtype of ovarian cancer. He is also investigating ways to therapeutically target senescent HGSC cells, which have the potential to re-emerge and cause disease recurrence. Dr Chan employs high-throughput screening, RNA sequencing, cell and molecular biology as his primary research techniques.
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Keefe Chan's highlights
FEATURED Journal article
Inhibition of RNA polymerase I transcription activates targeted DNA damage response and enhances the efficacy of PARP inhibitors in high-grade serous ovarian cancer.
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Scholarly Works
Displaying the 29 most recent scholarly works by Keefe Chan.
Credentials
Positions
Honorary
The Sir Peter Maccallum Department Of Oncology
Education
Doctor of Philosophy, Molecular and Cellular Pharmacology
University of Wisconsin-Madison
Bachelor of Science, Bioengineering
Berkeley