Rosemary Keogh

Valproic acid stimulates in vitro migration of the placenta-derived mesenchymal stem/stromal cell line CMSC29.

Balta Al-Sowayan, Rosemary J Keogh, Mohammed Abumaree, Harry M Georgiou, Bill Kalionis

Journal article  |  2019  |  Stem Cell Investig

BACKGROUND: The placenta is an abundant source of mesenchymal stem/stromal cells (MSC), but our understanding of their functional ..

An ex vivo human placental vessel perfusion method to study mesenchymal stem/stromal cell migration.

Balta Al-Sowayan, Rosemary J Keogh, Mohammed Abumaree, Harry M Georgiou, Bill Kalionis

Journal article  |  2019  |  Stem Cell Investig

BACKGROUND: To initiate tissue repair, mesenchymal stem/stromal cells (MSCs) must enter the blood stream, migrate to the targeted ..

Decidual ACVR2A regulates extravillous trophoblast functions of adhesion, proliferation, migration and invasion in vitro

Hannah EJ Yong, Padma Murthi, Bill Kalionis, Rosemary J Keogh, Shaun P Brennecke

Journal article  |  2018  |  PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH

Decidual stromal cells form the largest proportion of maternal cells at the maternal-fetal interface. Our aim was to investigate t..

The effect of endothelial cell activation and hypoxia on placental chorionic mesenchymal stem/stromal cell migration

Balta Al-Sowayan, Rosemary J Keogh, Mohammed Abumaree, Harry M Georgiou, Bill Kalionis

Journal article  |  2017  |  PLACENTA

INTRODUCTION: Chorionic mesenchymal stem/stromal cells (CMSC) can be isolated from the placenta in large numbers. Although their f..

Homeobox gene TGIF-1 is increased in placental endothelial cells of human fetal growth restriction

Tilini Gunatillake, Hannah EJ Yong, Caroline E Dunk, Rosemary J Keogh, Anthony J Borg, Judith E Cartwright, Guy S Whitley, Padma Murthi

Journal article  |  2016  |  REPRODUCTION

Aberrant placental angiogenesis is associated with fetal growth restriction (FGR). In mice, targeted disruption of the homeobox ge..

Anti-angiogenic collagen fragment arresten is increased from 16 weeks' gestation in pre-eclamptic plasma

Hannah EJ Yong, Padma Murthi, May H Wong, Bill Kalionis, Shaun P Brennecke, Rosemary J Keogh

Journal article  |  2015  |  PLACENTA

INTRODUCTION: Arresten and canstatin are endogenous anti-angiogenic factors derived from type IV collagen α-chains COL4A1 and COL4..

Effects of normal and high circulating concentrations of activin A on vascular endothelial cell functions and vasoactive factor production

Hannah EJ Yong, Padma Murthi, May H Wong, Bill Kalionis, Judith E Cartwright, Shaun P Brennecke, Rosemary J Keogh

Journal article  |  2015  |  PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH

OBJECTIVES: Activin A, a TGFβ family member, circulates in the maternal blood at increasing concentrations throughout gestation du..

Genome-Wide Transcriptome Directed Pathway Analysis of Maternal Pre-Eclampsia Susceptibility Genes

Hannah EJ Yong, Phillip E Melton, Matthew P Johnson, Katy A Freed, Bill Kalionis, Padma Murthi, Shaun P Brennecke, Rosemary J Keogh, Eric K Moses

Journal article  |  2015  |  PLOS ONE

BACKGROUND: Preeclampsia (PE) is a serious hypertensive pregnancy disorder with a significant genetic component. Numerous genetic ..

Decreased STAT3 in human idiopathic fetal growth restriction contributes to trophoblast dysfunction

AJ Borg, HEJ Yong, M Lappas, SA Degrelle, RJ Keogh, F Da Silva-Costa, T Fournier, M Abumaree, JA Keelan, B Kalionis, P Murthi

Journal article  |  2015  |  REPRODUCTION

Abnormal trophoblast function is associated with fetal growth restriction (FGR). The JAK-STAT pathway is one of the principal sign..

Placenta-derived angiogenic proteins and their contribution to the pathogenesis of preeclampsia

Anita Pratt, Fabricio Da Silva Costa, Anthony J Borg, Bill Kalionis, Rosemary Keogh, Padma Murthi

Journal article  |  2015  |  ANGIOGENESIS

Placental angiogenesis is critical to the success of human pregnancy. Angiogenesis is defined as the formation of new blood vessel..