Freya Bruveris

Mimicry of embryonic circulation enhances the hoxa hemogenic niche and human blood development.

Jingjing Li, Osmond Lao, Freya F Bruveris, Liyuan Wang, Kajal Chaudry, Ziqi Yang, Nona Farbehi, Elizabeth S Ng, Edouard G Stanley, Richard P Harvey, Andrew G Elefanty, Robert E Nordon

Journal article  |  2022  |  Cell Rep

Precursors of the adult hematopoietic system arise from the aorta-gonad-mesonephros (AGM) region shortly after the embryonic circu..

2014 – MULTI-LINEAGE ENGRAFTMENT OF INDUCED HEMATOPOIETIC STEM CELLS (IHSCS) DIFFERENTIATED FROM HUMAN PLURIPOTENT STEM CELLS

Elizabeth Ng, Jacky Li, Ritika Saxena, Hasindu Edirisinghe, Gulcan Sarila, Freya Bruveris, Shicheng Sun, Tanya Labonne, Vincenzo Calvanese, Sandra Capellera-Garcia, Feiyang Ma, Hanna Mikkola, Edouard Stanley, Andrew Elefanty

Journal article  |  2022  |  Experimental Hematology

3042 – GROUP F SOX GENES DIRECT HUMAN EMBRYONIC VASCULAR AND HAEMATOPOIETIC DEVELOPMENT

Freya Bruveris, Andrew Elefanty, Ana Rita Leitoguinho, Ali Motazedian, Elizabeth Ng, Koula Sourris, Edouard Stanley, Katerina Vlahos

Journal article  |  2022  |  Experimental Hematology

VEGF, FGF2, and BMP4 regulate transitions of mesoderm to endothelium and blood cells in a human model of yolk sac hematopoiesis

Freya F Bruveris, Elizabeth S Ng, Edouard G Stanley, Andrew G Elefanty

Journal article  |  2021  |  EXPERIMENTAL HEMATOLOGY

Exogenous growth factors play an important role in mediating hematopoietic differentiation of human pluripotent stem cells. We exp..

3005 – GROUP F SOX GENES CONTROL HUMAN EMBRYONIC VASCULAR PATTERNING VIA NOTCH SIGNALING

Freya Bruveris, Andrew Elefanty, Ana Rita Leitoguinho, Ali Motazedian, Elizabeth Ng, Koula Sourris, Ed Stanley, Katerina Vlahos

Conference Proceedings  |  2021  |  Experimental Hematology

Human yolk sac-like haematopoiesis generates RUNX1-, GFI1- and/or GFI1B-dependent blood and SOX17-positive endothelium

Freya F Bruveris, Elizabeth S Ng, Ana Rita Leitoguinho, Ali Motazedian, Katerina Vlahos, Koula Sourris, Robyn Mayberry, Penelope McDonald, Lisa Azzola, Nadia M Davidson, Alicia Oshlack, Edouard G Stanley, Andrew G Elefanty

Journal article  |  2020  |  Development

The genetic regulatory network controlling early fate choices during human blood cell development are not well understood. We used..

Multipotent RAG1 progenitors emerge directly from haemogenic endothelium in human pluripotent stem cell-derived haematopoietic organoids

Ali Motazedian, Freya F Bruveris, Santhosh V Kumar, Jacqueline V Schiesser, Tyrone Chen, Elizabeth S Ng, Ann P Chidgey, Christine A Wells, Andrew G Elefanty, Edouard G Stanley

Journal article  |  2020  |  NATURE CELL BIOLOGY

Defining the ontogeny of the human adaptive immune system during embryogenesis has implications for understanding childhood diseas..

THE ROLE OF SHEAR STRESS IN THE GENERATION OF DEFINITIVE HAEMATOPOIETIC LINEAGES AND ARTERIAL VASCULATURE FROM HUMAN PLURIPOTENT STEM CELLS AT THE SINGLE-CELL LEVEL

Jingjing Li, Freya Bruveris, Stanley Ed, Andrew Elefanty, Osmond Lao, Elizabeth Ng, Robert Nordon, Patrick Ralph

Journal article  |  2019  |  Experimental Hematology

3176 – MULTIPOTENT RAG1 PROGENITORS EMERGE DIRECTLY FROM HEMOGENIC ENDOTHELIUM IN HUMAN PSC DERIVED HEMOPOIETIC ORGANOIDS

Ali Motazedian, Freya Bruveris, Santhosh Kumar, Jacqueline Schiesser, Tyrone Chen, Elizabeth Ng, Ann Chidgey, Christine Wells, Andrew Elefanty, Edouard Stanley

Conference Proceedings  |  2019  |  Experimental Hematology

RUNX1 AND GROUP F SOX GENES ARE REQUIRED AT DISTINCT STAGES FOR HUMAN HAEMATOPOIETIC DEVELOPMENT

Freya Bruveris, Elizabeth Ng, Ana Rita Leitoguinho, Ali Motazedian, Katerina Vlahos, Koula Sourris, Penelope McDonald, Nadia Davidson, Alicia Oshlack, Edouard Stanley, Andrew Elefanty

Conference Proceedings  |  2019  |  Experimental Hematology