Daniel Utzschneider

Precursor exhausted T cells: key to successful immunotherapy?

Axel Kallies, Dietmar Zehn, Daniel T Utzschneider

Journal article  |  2020  |  Nature Reviews Immunology

Cytotoxic T cell immunity in response to chronic infections and tumours is maintained by a specialized population of CD8+ T cells ..

MiR-23 similar to 27 similar to 24-mediated control of humoral immunity reveals a TOX-driven regulatory circuit in follicular helper T cell differentiation

Cheng-Jang Wu, Sunglim Cho, Hsi-Yuan Huang, Chun-Hao Lu, Jasmin Russ, Leilani O Cruz, Flavia Franco da Cunha, Mei-Chi Chen, Ling-Li Lin, Lindsey M Warner, Hsin-Kai Liao, Daniel T Utzschneider, Sara Quon, Jacqueline Berner, Niels Olsen Saraiva Camara, Dietmar Zehn, Juan Carlos Izpisua Belmonte, Li-Chen Chen, Shiang-Fu Huang, Ming-Ling Kuo, et al.

Journal article  |  2019  |  Science Advances

Follicular helper T (TFH) cells are essential for generating protective humoral immunity. To date, microRNAs (miRNAs) have emerged..

Exhausted memory T cells maintain T cell responses in chronic infections and cancer

SS Gabriel, D Utzschneider, A Kallies

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

The role of CCR5 in the maintenance of intestinal immune homeostasis

X Huang, D Utzschneider, Y Fujita, H Wu, Q Lu, A Delpoux, S Hedrick

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

The transcription factor TOX controls differentiation and maintenance of CD8 T-cells in chronic infections.

F Alfei, K Kanev, M Wu, M Hofmann, HE Ghoneim, P Roelli, DT Utzschneider, K Steiger, B Youngblood, R Thimme, D Zehn

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

Francesca Alfei, Kristiyan Kanev, Maike Hofmann, Ming Wu, Hazem E Ghoneim, Patrick Roelli, Daniel T Utzschneider, Madlaina von Hoesslin, Jolie G Cullen, Yiping Fan, Vasyl Eisenberg, Dirk Wohlleber, Katja Steiger, Doron Merkler, Mauro Delorenzi, Percy A Knolle, Cyrille J Cohen, Robert Thimme, Benjamin Youngblood, Dietmar Zehn

Journal article  |  2019  |  Nature

Active Maintenance of T Cell Memory in Acute and Chronic Viral Infection Depends on Continuous Expression of FOXO1

Daniel T Utzschneider, Arnaud Delpoux, Dominik Wieland, Xin Huang, Chen-Yen Lai, Maike Hofmann, Robert Thimme, Stephen M Hedrick

Journal article  |  2018  |  Cell Reports

Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8( ) T cells

Arnaud Delpoux, Rodrigo Hess Michelini, Shilpi Verma, Chen-Yen Lai, Kyla D Omilusik, Daniel T Utzschneider, Alec J Redwood, Ananda W Goldrath, Chris A Benedict, Stephen M Hedrick

Journal article  |  2018  |  Journal of Experimental Medicine

Type I interferons induced by endogenous or exogenous viral infections promote metastasis and relapse of leishmaniasis

Matteo Rossi, Patrik Castiglioni, Mary-Anne Hartley, Remzi Onur Eren, Florence Prevel, Chantal Desponds, Daniel T Utzschneider, Dietmar Zehn, Maria G Cusi, Matthew Kuhlmann, Stephen M Beverley, Catherine Ronet, Nicolas Fasel

Journal article  |  2017  |  Proceedings of the National Academy of Sciences

Exacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid

Patrik Castiglioni, Mary-Anne Hartley, Matteo Rossi, Florence Prevel, Chantal Desponds, Daniel T Utzschneider, Remzi-Onur Eren, Haroun Zangger, Livia Brunner, Nicolas Collin, Dietmar Zehn, F Matthew Kuhlmann, Stephen M Beverley, Nicolas Fasel, Catherine Ronet

Journal article  |  2017  |  PLOS Neglected Tropical Diseases

High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival

Daniel T Utzschneider, Francesca Alfei, Patrick Roelli, David Barras, Vijaykumar Chennupati, Stephanie Darbre, Mauro Delorenzi, Daniel D Pinschewer, Dietmar Zehn

Journal article  |  2016  |  The Journal of Experimental Medicine

T Cell Factor 1-Expressing Memory-like CD8( ) T Cells Sustain the Immune Response to Chronic Viral Infections

Daniel T Utzschneider, Melanie Charmoy, Vijaykumar Chennupati, Laurene Pousse, Daniela Pais Ferreira, Sandra Calderon-Copete, Maxime Danilo, Francesca Alfei, Maike Hofmann, Dominik Wieland, Sylvain Pradervand, Robert Thimme, Dietmar Zehn, Werner Held

Journal article  |  2016  |  Immunity

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

Jie Jiang, Qiang Zhu, Tania F Gendron, Shahram Saberi, Melissa McAlonis-Downes, Amanda Seelman, Jennifer E Stauffer, Paymaan Jafar-nejad, Kevin Drenner, Derek Schulte, Seung Chun, Shuying Sun, Shuo-Chien Ling, Brian Myers, Jeffery Engelhardt, Melanie Katz, Michael Baughn, Oleksandr Platoshyn, Martin Marsala, Andy Watt, et al.

Journal article  |  2016  |  Neuron

Immune-sunreillance through exhausted effector T-cells

Dietmar Zehn, Daniel T Utzschneider, Robert Thimme

Journal article  |  2016  |  Current Opinion in Virology

NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions

Kristina Ludigs, Camilla Jandus, Daniel T Utzschneider, Francesco Staehli, Stephanie Bessoles, Anh Thu Dang, Giorgia Rota, Wilson Castro, Dietmar Zehn, Eric Vivier, Werner Held, Pedro Romero, Greta Guarda

Journal article  |  2016  |  Nature Communications

Structure-Function Analyses of Human Kallikrein-related Peptidase 2 Establish the 99-Loop as Master Regulator of Activity

Wolfgang Skala, Daniel T Utzschneider, Viktor Magdolen, Mekdes Debela, Shihui Guo, Charles S Craik, Hans Brandstetter, Peter Goettig

Journal article  |  2014  |  Journal of Biological Chemistry

T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion?

Daniel E Speiser, Daniel T Utzschneider, Susanne G Oberle, Christian Muenz, Pedro Romero, Dietmar Zehn

Journal article  |  2014  |  Nature Reviews Immunology

T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion

Daniel T Utzschneider, Amandine Legat, Silvia A Fuertes Marraco, Lucie Carrie, Immanuel Luescher, Daniel E Speiser, Dietmar Zehn

Journal article  |  2013  |  Nature Immunology

MicroRNA-155 Is Required for Effector CD8( ) T Cell Responses to Virus Infection and Cancer

Jan C Dudda, Bruno Salaun, Yun Ji, Douglas C Palmer, Gwennaelle C Monnot, Estelle Merck, Caroline Boudousquie, Daniel T Utzschneider, Thelma M Escobar, Rachel Perret, Stefan A Muljo, Michael Hebeisen, Nathalie Rufer, Dietmar Zehn, Alena Donda, Nicholas P Restifo, Werner Held, Luca Gattinoni, Pedro Romero

Journal article  |  2013  |  Immunity

Functional Avidity: A Measure to Predict the Efficacy of Effector T Cells?

Selena Vigano, Daniel T Utzschneider, Matthieu Perreau, Giuseppe Pantaleo, Dietmar Zehn, Alexandre Harari

Journal article  |  2012  |  Clinical and Developmental Immunology

Interdependence of kallikrein-related peptidases in proteolytic networks

Nathalie Beaufort, Karolina Plaza, Daniel Utzschneider, Amelie Schwarz, Julia M Burkhart, Sabine Creutzburg, Mekdes Debela, Manfred Schmitt, Christian Ries, Viktor Magdolen

Journal article  |  2010  |  Biological Chemistry