Daniel Utzschneider

Early precursor T cells establish and propagate T cell exhaustion in chronic infection

Daniel T Utzschneider, Sarah S Gabriel, David Chisanga, Renee Gloury, Patrick M Gubser, Ajithkumar Vasanthakumar, Wei Shi, Axel Kallies

Journal article  |  2020  |  Nature Immunology

Human effector T cells express TOX-Not so "TOX"ic after all

Daniel T Utzschneider, Axel Kallies

Journal article  |  2020  |  Science Immunology

TOX expression is not restricted to exhausted T cells but a characteristic of all human effector CD8+ T cells.

Precursor exhausted T cells: key to successful immunotherapy?

Axel Kallies, Dietmar Zehn, Daniel T Utzschneider

Journal article  |  2020  |  Nature Reviews Immunology

Cytotoxic T cell immunity in response to chronic infections and tumours is maintained by a specialized population of CD8+ T cells ..

MiR-23 similar to 27 similar to 24-mediated control of humoral immunity reveals a TOX-driven regulatory circuit in follicular helper T cell differentiation

Cheng-Jang Wu, Sunglim Cho, Hsi-Yuan Huang, Chun-Hao Lu, Jasmin Russ, Leilani O Cruz, Flavia Franco da Cunha, Mei-Chi Chen, Ling-Li Lin, Lindsey M Warner, Hsin-Kai Liao, Daniel T Utzschneider, Sara Quon, Jacqueline Berner, Niels Olsen Saraiva Camara, Dietmar Zehn, Juan Carlos Izpisua Belmonte, Li-Chen Chen, Shiang-Fu Huang, Ming-Ling Kuo, et al.

Journal article  |  2019  |  Science Advances

Follicular helper T (TFH) cells are essential for generating protective humoral immunity. To date, microRNAs (miRNAs) have emerged..

Exhausted memory T cells maintain T cell responses in chronic infections and cancer

SS Gabriel, D Utzschneider, A Kallies

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

The role of CCR5 in the maintenance of intestinal immune homeostasis

X Huang, D Utzschneider, Y Fujita, H Wu, Q Lu, A Delpoux, S Hedrick

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

The transcription factor TOX controls differentiation and maintenance of CD8 T-cells in chronic infections.

F Alfei, K Kanev, M Wu, M Hofmann, HE Ghoneim, P Roelli, DT Utzschneider, K Steiger, B Youngblood, R Thimme, D Zehn

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

Francesca Alfei, Kristiyan Kanev, Maike Hofmann, Ming Wu, Hazem E Ghoneim, Patrick Roelli, Daniel T Utzschneider, Madlaina von Hoesslin, Jolie G Cullen, Yiping Fan, Vasyl Eisenberg, Dirk Wohlleber, Katja Steiger, Doron Merkler, Mauro Delorenzi, Percy A Knolle, Cyrille J Cohen, Robert Thimme, Benjamin Youngblood, Dietmar Zehn

Journal article  |  2019  |  Nature

Active Maintenance of T Cell Memory in Acute and Chronic Viral Infection Depends on Continuous Expression of FOXO1

Daniel T Utzschneider, Arnaud Delpoux, Dominik Wieland, Xin Huang, Chen-Yen Lai, Maike Hofmann, Robert Thimme, Stephen M Hedrick

Journal article  |  2018  |  Cell Reports

Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8( ) T cells

Arnaud Delpoux, Rodrigo Hess Michelini, Shilpi Verma, Chen-Yen Lai, Kyla D Omilusik, Daniel T Utzschneider, Alec J Redwood, Ananda W Goldrath, Chris A Benedict, Stephen M Hedrick

Journal article  |  2018  |  Journal of Experimental Medicine