Daniel Utzschneider

Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection.

Sarah S Gabriel, Carlson Tsui, David Chisanga, Flora Weber, Manuela Llano-León, Patrick M Gubser, Laurent Bartholin, Fernando Souza-Fonseca-Guimaraes, Nicholas D Huntington, Wei Shi, Daniel T Utzschneider, Axel Kallies

Journal article  |  2021  |  Immunity

Antigen-specific CD8+ T cells in chronic viral infections and tumors functionally deteriorate, a process known as exhaustion. Exha..

Antigen-driven EGR2 expression is required for exhausted CD8( ) T cell stability and maintenance

Mayura Wagle, Stephin J Vervoort, Madison J Kelly, Willem Van der Byl, Timothy J Peters, Ben P Martin, Luciano G Martelotto, Simone Nuessing, Kelly M Ramsbottom, James R Torpy, Deborah Knight, Sinead Reading, Kevin Thia, Lisa A Miosge, Debbie R Howard, Renee Gloury, Sarah S Gabriel, Daniel T Utzschneider, Jane Oliaro, Jonathan D Powell, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Chronic stimulation of CD8+ T cells triggers exhaustion, a distinct differentiation state with diminished effector function. Exhau..

Editorial: Memory T Cells in Chronic Infections and Tumors

Maike Hofmann, Camilla Jandus, Lian Ni Lee, Daniel T Utzschneider

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

Early precursor T cells establish and propagate T cell exhaustion in chronic infection

Daniel T Utzschneider, Sarah S Gabriel, David Chisanga, Renee Gloury, Patrick M Gubser, Ajithkumar Vasanthakumar, Wei Shi, Axel Kallies

Journal article  |  2020  |  NATURE IMMUNOLOGY

CD8+ T cells responding to chronic infections or tumors acquire an 'exhausted' state associated with elevated expression of inhibi..

Human effector T cells express TOX-Not so "TOX"ic after all

Daniel T Utzschneider, Axel Kallies

Journal article  |  2020  |  SCIENCE IMMUNOLOGY

TOX expression is not restricted to exhausted T cells but a characteristic of all human effector CD8+ T cells.

Precursor exhausted T cells: key to successful immunotherapy?

Axel Kallies, Dietmar Zehn, Daniel T Utzschneider

Journal article  |  2020  |  NATURE REVIEWS IMMUNOLOGY

Cytotoxic T cell immunity in response to chronic infections and tumours is maintained by a specialized population of CD8+ T cells ..

MiR-23 similar to 27 similar to 24-mediated control of humoral immunity reveals a TOX-driven regulatory circuit in follicular helper T cell differentiation

Cheng-Jang Wu, Sunglim Cho, Hsi-Yuan Huang, Chun-Hao Lu, Jasmin Russ, Leilani O Cruz, Flavia Franco da Cunha, Mei-Chi Chen, Ling-Li Lin, Lindsey M Warner, Hsin-Kai Liao, Daniel T Utzschneider, Sara Quon, Jacqueline Berner, Niels Olsen Saraiva Camara, Dietmar Zehn, Juan Carlos Izpisua Belmonte, Li-Chen Chen, Shiang-Fu Huang, Ming-Ling Kuo, et al.

Journal article  |  2019  |  SCIENCE ADVANCES

Follicular helper T (TFH) cells are essential for generating protective humoral immunity. To date, microRNAs (miRNAs) have emerged..

Exhausted memory T cells maintain T cell responses in chronic infections and cancer

SS Gabriel, D Utzschneider, A Kallies

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

The role of CCR5 in the maintenance of intestinal immune homeostasis

X Huang, D Utzschneider, Y Fujita, H Wu, Q Lu, A Delpoux, S Hedrick

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

The transcription factor TOX controls differentiation and maintenance of CD8 T-cells in chronic infections.

F Alfei, K Kanev, M Wu, M Hofmann, HE Ghoneim, P Roelli, DT Utzschneider, K Steiger, B Youngblood, R Thimme, D Zehn

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY