Rachel McQuade

Gastrointestinal consequences of lipopolysaccharide-induced lung inflammation

Rachel M McQuade, Methma Bandara, Shanti Diwakarla, Lauren Sahakian, Myat Noe Han, Maryam Al Thaalibi, Madeleine R Di Natale, Marsha Tan, Kiera H Harwood, Elena K Schneider-Futschik, Andrew Jarnicki

Journal article  |  2022  |  INFLAMMATION RESEARCH

BACKGROUND: Respiratory inflammation is the body's response to lung infection, trauma or hypersensitivity and is often accompanied..

Gastrointestinal side effects of platinum-based and other chemotherapeutic drugs

P Semenye, R McQuade, R Abalo, K Nurgali

Book Chapter  |  2022

Ivacaftor Alters Macrophage and Lymphocyte Infiltration in the Lungs Following Lipopolysaccharide Exposure

Kiera H Harwood, Rachel M McQuade, Andrew Jarnicki, Elena K Schneider-Futschik

Journal article  |  2022  |  ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE

Background and purpose: Cystic fibrosis (CF) is associated with a myriad of respiratory complications including increased suscepti..

The innervation of the gastrointestinal tract

John B Furness, Ruslan V Pustovit, Linda J Fothergill, Rachel M McQuade, Martin J Stebbing

Book Chapter  |  2022

Gastrointestinal Dysfunction in Parkinson's Disease: Current and Potential Therapeutics

Myat Noe Han, David I Finkelstein, Rachel M McQuade, Shanti Diwakarla

Journal article  |  2022  |  JOURNAL OF PERSONALIZED MEDICINE

Abnormalities in the gastrointestinal (GI) tract of Parkinson's disease (PD) sufferers were first reported over 200 years ago; how..

A Critical Analysis of Intestinal Enteric Neuron Loss and Constipation in Parkinson's Disease.

Chelsea O'Day, David Isaac Finkelstein, Shanti Diwakarla, Rachel Mai McQuade

Journal article  |  2022  |  J Parkinsons Dis

Constipation afflicts many patients with Parkinson's disease (PD) and significantly impacts on patient quality of life. PD-related..

Molecular Targets to Alleviate Enteric Neuropathy and Gastrointestinal Dysfunction.

Lauren Sahakian, Rachel McQuade, Rhian Stavely, Ainsley Robinson, Rhiannon T Filippone, Majid Hassanzadeganroudsari, Raj Eri, Raquel Abalo, Joel C Bornstein, Mark R Kelley, Kulmira Nurgali

Book Chapter  |  2022  |  Advances in Experimental Medicine and Biology

Enteric neuropathy underlies long-term gastrointestinal (GI) dysfunction associated with several pathological conditions. Our prev..

Anti-Inflammatory Influences of Cystic Fibrosis Transmembrane Conductance Regulator Drugs on Lung Inflammation in Cystic Fibrosis

Kiera H Harwood, Rachel M McQuade, Andrew Jarnicki, Elena K Schneider-Futschik

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cystic fibrosis (CF) is caused by a defect in the cystic fibrosis transmembrane conductance regulator protein (CFTR) which instiga..

The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson's disease

Rachel M McQuade, Lewis M Singleton, Hongyi Wu, Sophie Lee, Remy Constable, Madeleine Di Natale, Mitchell T Ringuet, Joel P Berger, Jessica Kauhausen, Clare L Parish, David Finkelstein, John B Furness, Shanti Diwakarla

Journal article  |  2021  |  SCIENTIFIC REPORTS

Parkinson's disease (PD) is associated with neuronal damage in the brain and gut. This work compares changes in the enteric nervou..

ATH434 Reverses Colorectal Dysfunction in the A53T Mouse Model of Parkinson's Disease

Shanti Diwakarla, Rachel M McQuade, Remy Constable, Olivia Artaiz, Enie Lei, Kevin J Barnham, Paul A Adlard, Robert A Cherny, Madeleine R Di Natale, Hongyi Wu, Xin-Yi Chai, Victoria A Lawson, David Finkelstein, John B Furness

Journal article  |  2021  |  JOURNAL OF PARKINSONS DISEASE

BACKGROUND: Gastrointestinal (GI) complications, that severely impact patient quality of life, are a common occurrence in patients..