Rachel McQuade

ATH434 Reverses Colorectal Dysfunction in the A53T Mouse Model of Parkinson's Disease.

Shanti Diwakarla, Rachel M McQuade, Remy Constable, Olivia Artaiz, Enie Lei, Kevin J Barnham, Paul A Adlard, Robert A Cherny, Madeleine R Di Natale, Hongyi Wu, Xin-Yi Chai, Victoria A Lawson, David I Finkelstein, John B Furness

Journal article  |  2021  |  J Parkinsons Dis

BACKGROUND: Gastrointestinal (GI) complications, that severely impact patient quality of life, are a common occurrence in patients..

Anti-Inflammatory Influences of Cystic Fibrosis Transmembrane Conductance Regulator Drugs on Lung Inflammation in Cystic Fibrosis

Kiera H Harwood, Rachel M McQuade, Andrew Jarnicki, Elena K Schneider-Futschik

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cystic fibrosis (CF) is caused by a defect in the cystic fibrosis transmembrane conductance regulator protein (CFTR) which instiga..

The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson's disease

Rachel M McQuade, Lewis M Singleton, Hongyi Wu, Sophie Lee, Remy Constable, Madeleine Di Natale, Mitchell T Ringuet, Joel P Berger, Jessica Kauhausen, Clare L Parish, David Finkelstein, John B Furness, Shanti Diwakarla

Journal article  |  2021  |  SCIENTIFIC REPORTS

Parkinson's disease (PD) is associated with neuronal damage in the brain and gut. This work compares changes in the enteric nervou..

The effect of high-fat diet-induced metabolic disturbance on corneal neuroimmune features

Haihan Jiao, Alicia SL Lim, Therese E Fazio Coles, Rachel M McQuade, John B Furness, Holly R Chinnery

Journal article  |  2020  |  EXPERIMENTAL EYE RESEARCH

PURPOSE: The highly innervated cornea is susceptible to nerve loss secondary to systemic diseases such as diabetes and metabolic d..

Squalamine Restores the Function of the Enteric Nervous System in Mouse Models of Parkinson's Disease

Christine L West, Yu-Kang Mao, Thilini Delungahawatta, Jessica Y Amin, Sohana Farhin, Rachel M McQuade, Shanti Diwakarla, Ruslan Pustovit, Andrew M Stanisz, John Bienenstock, Denise Barbut, Michael Zasloff, John B Furness, Wolfgang A Kunze

Journal article  |  2020  |  JOURNAL OF PARKINSONS DISEASE

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder thought to be caused by accumulation of α-synucle..

Betaine and Isoquinoline Alkaloids Protect against Heat Stress and Colonic Permeability in Growing Pigs

Hieu Huu Le, Majid Shakeri, Hafiz Ansar Rasul Suleria, Weicheng Zhao, Rachel Mai McQuade, Deborah Jayne Phillips, Eva Vidacs, John Barton Furness, Frank Rowland Dunshea, Valeria Artuso-Ponte, Jeremy James Cottrell

Journal article  |  2020  |  ANTIOXIDANTS

Heat stress (HS) compromises productivity of pork production, in part as a result of increased oxidative stress and inflammatory r..

Impact of chemotherapy-induced enteric nervous system toxicity on gastrointestinal mucositis

Rachel M McQuade, Maryam Al Thaalibi, Kulmira Nurgali

Journal article  |  2020  |  CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE

PURPOSE OF REVIEW: Chemotherapy is a first-line treatment for many cancers; however, its use is hampered by a long list of side-ef..

Investigation of nerve pathways mediating colorectal dysfunction in Parkinson's disease model produced by lesion of nigrostriatal dopaminergic neurons

Xin-yi Chai, Shanti Diwakarla, Ruslan V Pustovit, Rachel M McQuade, Madeleine Di Natale, Charlotte M Ermine, Clare L Parish, David I Finkelstein, John B Furness

Journal article  |  2020  |  NEUROGASTROENTEROLOGY AND MOTILITY

BACKGROUND: Gastrointestinal (GI) dysfunction, including constipation, is a common non-motor symptom of Parkinson's disease (PD). ..

Dietary Betaine Improves Intestinal Barrier Function and Ameliorates the Impact of Heat Stress in Multiple Vital Organs as Measured by Evans Blue Dye in Broiler Chickens

Majid Shakeri, Jeremy James Cottrell, Stuart Wilkinson, Weicheng Zhao, Hieu Huu Le, Rachel McQuade, John Barton Furness, Frank Rowland Dunshea

Journal article  |  2020  |  ANIMALS

In a 2 × 2 factorial design, 60 male Ross-308 broilers were fed either a control or 1 g/kg betaine diet and housed under thermoneu..

Quantitation and chemical coding of enteroendocrine cell populations in the human jejunum

Therese E Fazio Coles, Linda J Fothergill, Billie Hunne, Mehrdad Nikfarjam, Adam Testro, Brid Callaghan, Rachel M McQuade, John B Furness

Journal article  |  2020  |  CELL AND TISSUE RESEARCH

Recent studies reveal substantial species and regional differences in enteroendocrine cell (EEC) populations, including difference..