Rachel McQuade

Investigation of nerve pathways mediating colorectal dysfunction in Parkinson's disease model produced by lesion of nigrostriatal dopaminergic neurons

Xin-yi Chai, Shanti Diwakarla, Ruslan V Pustovit, Rachel M McQuade, Madeleine Di Natale, Charlotte M Ermine, Clare L Parish, David I Finkelstein, John B Furness

Journal article  |  2020  |  Neurogastroenterology & Motility

BACKGROUND: Gastrointestinal (GI) dysfunction, including constipation, is a common non-motor symptom of Parkinson's disease (PD). ..

Quantitation and chemical coding of enteroendocrine cell populations in the human jejunum

Therese E Fazio Coles, Linda J Fothergill, Billie Hunne, Mehrdad Nikfarjam, Adam Testro, Brid Callaghan, Rachel M McQuade, John B Furness

Journal article  |  2020  |  Cell and Tissue Research

Recent studies reveal substantial species and regional differences in enteroendocrine cell (EEC) populations, including difference..

Dietary Betaine Improves Intestinal Barrier Function and Ameliorates the Impact of Heat Stress in Multiple Vital Organs as Measured by Evans Blue Dye in Broiler Chickens

Majid Shakeri, Jeremy James Cottrell, Stuart Wilkinson, Weicheng Zhao, Hieu Huu Le, Rachel McQuade, John Barton Furness, Frank Rowland Dunshea

Journal article  |  2020  |  Animals

In a 2 × 2 factorial design, 60 male Ross-308 broilers were fed either a control or 1 g/kg betaine diet and housed under thermoneu..

Chronic isolation stress is associated with increased colonic and motor symptoms in the A53T mouse model of Parkinson's disease

Shanti Diwakarla, David I Finkelstein, Remy Constable, Olivia Artaiz, Madeleine Di Natale, Rachel M McQuade, Enie Lei, Xin-yi Chai, Mitchell T Ringuet, Linda J Fothergill, Victoria A Lawson, Laura J Ellett, Joel P Berger, John B Furness

Journal article  |  2019  |  Neurogastroenterology & Motility

BACKGROUND: Chronic stress exacerbates motor deficits and increases dopaminergic cell loss in several rodent models of Parkinson's..

Distributions and relationships of chemically defined enteroendocrine cells in the rat gastric mucosa

Billie Hunne, Martin J Stebbing, Rachel M McQuade, John B Furness

Journal article  |  2019  |  Cell and Tissue Research

This paper provides quantitative data on the distributions of enteroendocrine cells (EEC), defined by the hormones they contain, p..

Muscarinic receptor 1 allosteric modulators stimulate colorectal emptying in dog, mouse and rat and resolve constipation

Ruslan V Pustovit, Yasuo Itomi, Mitchell Ringuet, Shanti Diwakarla, Xin-yi Chai, Rachel M McQuade, Yasuhiro Tsukimi, John B Furness

Journal article  |  2019  |  Neurogastroenterology & Motility

Agonist-dependent development of delta opioid receptor tolerance in the colon

Jesse J DiCello, Ayame Saito, Pradeep Rajasekhar, Benjamin W Sebastian, Rachel M McQuade, Arisbel B Gondin, Nicholas A Veldhuis, Meritxell Canals, Simona E Carbone, Daniel P Poole

Journal article  |  2019  |  Cellular and Molecular Life Sciences

The use of opioid analgesics is severely limited due to the development of intractable constipation, mediated through activation o..

Co-treatment With BGP-15 Exacerbates 5-Fluorouracil-Induced Gastrointestinal Dysfunction

Rachel M McQuade, Maryam Al Thaalibi, Aaron C Petersen, Raquel Abalo, Joel C Bomstein, Emma Rybalka, Kulmira Nurgali

Journal article  |  2019  |  Frontiers in Neuroscience

Oxaliplatin Treatment Alters Systemic Immune Responses

Vanesa Stojanovska, Monica Prakash, Rachel McQuade, Sarah Fraser, Vasso Apostolopoulos, Samy Sakkal, Kulmira Nurgali

Journal article  |  2019  |  BioMed Research International

PARP inhibition in platinum-based chemotherapy: Chemopotentiation and neuroprotection

Rachel M McQuade, Vanesa Stojanovska, Joel C Bornstein, Kulmira Nurgali

Journal article  |  2018  |  Pharmacological Research