Justin Hardee

Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as anAMPK substrate regulating skeletal muscle function

Ronnie Blazev, Christian S Carl, Yaan-Kit Ng, Jeffrey Molendijk, Christian T Voldstedlund, Yuanyuan Zhao, Di Xiao, Andrew J Kueh, Paula M Miotto, Vanessa R Haynes, Justin P Hardee, Jin D Chung, James W McNamara, Hongwei Qian, Paul Gregorevic, Jonathan S Oakhill, Marco J Herold, Thomas E Jensen, Leszek Lisowski, Gordon S Lynch, et al.

Journal article  |  2022  |  CELL METABOLISM

Exercise induces signaling networks to improve muscle function and confer health benefits. To identify divergent and common signal..

Muscular contraction's therapeutic potential for cancer-induced wasting

Justin P Hardee, James A Carson

Journal article  |  2022  |  AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Skeletal muscle atrophy and dysfunction contribute to morbidity and mortality in patients with cancer. Cachexia pathophysiology is..

CORP: Gene delivery into murine skeletal muscle using in vivo electroporation

C David Hughes, P Justin Hardee, S David Waddell, A Craig Goodman

Journal article  |  2022  |  JOURNAL OF APPLIED PHYSIOLOGY

The strategy of gene delivery into skeletal muscles has provided exciting avenues in identifying new potential therapeutics toward..

Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator

Ashley J Ovens, Yi Sing Gee, Naomi XY Ling, Dingyi Yu, Justin P Hardee, Jin D Chung, Kevin RW Ngoei, Nicholas J Waters, Nolan J Hoffman, John W Scott, Kim Loh, Katrin Spengler, Regine Heller, Michael W Parker, Gordon S Lynch, Fei Huang, Sandra Galic, Bruce E Kemp, Jonathan B Baell, Jonathan S Oakhill, et al.

Journal article  |  2022  |  BIOCHEMICAL JOURNAL

The AMP-activated protein kinase (AMPK) αβγ heterotrimer is a primary cellular energy sensor and central regulator of energy homeo..

Iron overload and impaired iron handling contribute to the dystrophic pathology in models of Duchenne muscular dystrophy

Francesca M Alves, Kai Kysenius, Marissa K Caldow, Justin P Hardee, Jin D Chung, Jennifer Trieu, Dominic J Hare, Peter J Crouch, Scott Ayton, Ashley Bush, Gordon S Lynch, Rene Koopman

Journal article  |  2022  |  JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE

BACKGROUND: Oxidative stress is implicated in the pathophysiology of Duchenne muscular dystrophy (DMD, caused by mutations in the ..

Regenerative Rehabilitation

Book  |  2022

Regenerative Rehabilitation for Duchenne Muscular Dystrophy

Kristy Swiderski, Justin P Hardee, Gordon S Lynch

Book Chapter  |  2022

Dystrophin deficiency disrupts muscle clock expression and mitochondrial quality control in mdx mice

Justin P Hardee, Marissa K Caldow, Audrey SM Chan, Stuart K Plenderleith, Jennifer Trieu, Rene Koopman, Gordon S Lynch

Journal article  |  2021  |  AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Impaired oxidative capacity and mitochondrial function contribute to the dystrophic pathology in muscles of patients with Duchenne..

Bone Geometry Is Altered by Follistatin-Induced Muscle Growth in Young Adult Male Mice

Audrey SM Chan, Narelle E McGregor, Ingrid J Poulton, Justin P Hardee, Ellie H-J Cho, T John Martin, Paul Gregorevic, Natalie A Sims, Gordon S Lynch

Journal article  |  2021  |  JBMR PLUS

The development of the musculoskeletal system and its maintenance depends on the reciprocal relationship between muscle and bone. ..

Iron accumulation in skeletal muscles of old mice is associated with impaired regeneration after ischaemia-reperfusion damage

Francesca M Alves, Kai Kysenius, Marissa K Caldow, Justin P Hardee, Peter J Crouch, Scott Ayton, Ashley I Bush, Gordon S Lynch, Rene Koopman

Journal article  |  2021  |  JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE

BACKGROUND: Oxidative stress is implicated in the insidious loss of muscle mass and strength that occurs with age. However, few st..