Magda Montgomery

Investigating dual inhibition of ACC and CD36 for the treatment of nonalcoholic fatty liver disease in mice.

Camille J Devereux, Jacqueline Bayliss, Stacey N Keenan, Magdalene K Montgomery, Matthew J Watt

Journal article  |  2023  |  Am J Physiol Endocrinol Metab

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Dysregulation in hepatic lipid metabo..

Proteomic analysis reveals exercise training induced remodelling of hepatokine secretion and uncovers syndecan-4 as a regulator of hepatic lipid metabolism

William De Nardo, Paula M Miotto, Jacqueline Bayliss, Shuai Nie, Stacey N Keenan, Magdalene K Montgomery, Matthew J Watt

Journal article  |  2022  |  MOLECULAR METABOLISM

OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is linked to impaired lipid metabolism and systemic insulin resistance, which..

Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control

Magdalene K Montgomery, Jacqueline Bayliss, Shuai Nie, William De Nardo, Stacey N Keenan, Paula M Miotto, Hamzeh Karimkhanloo, Cheng Huang, Ralf B Schittenhelm, Anthony S Don, Andrew Ryan, Nicholas A Williamson, Geraldine J Ooi, Wendy A Brown, Paul R Burton, Benjamin L Parker, Matthew J Watt

Journal article  |  2022  |  NATURE COMMUNICATIONS

Non-alcoholic steatohepatitis (NASH) and type 2 diabetes are closely linked, yet the pathophysiological mechanisms underpinning th..

Hexosaminidase A (HEXA) regulates hepatic sphingolipid and lipoprotein metabolism in mice

Magdalene K Montgomery, Amanuiel Z Taddese, Jacqueline Bayliss, Shuai Nie, Nicholas A Williamson, Matthew J Watt

Journal article  |  2021  |  FASEB JOURNAL

Hexosaminidase A (HexA), a heterodimer consisting of HEXA and HEXB, converts the ganglioside sphingolipid GM2 to GM3 by removing a..

Western Diet Induced Remodelling of the Tongue Proteome

Mriga Dutt, Yaan-Kit Ng, Jeffrey Molendijk, Hamzeh Karimkhanloo, Luoping Liao, Ronnie Blazev, Magdalene K Montgomery, Matthew J Watt, Benjamin L Parker

Journal article  |  2021  |  PROTEOMES

The tongue is a heavily innervated and vascularized striated muscle that plays an important role in vocalization, swallowing and d..

Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease

K Watt, DC Henstridge, M Ziemann, CB Sim, MK Montgomery, D Samocha-Bonet, BL Parker, GT Dodd, ST Bond, TM Salmi, RS Lee, RE Thomson, A Hagg, JR Davey, H Qian, R Koopman, A El-Osta, JR Greenfield, MJ Watt, MA Febbraio, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Obesity is a major risk factor underlying the development of metabolic disease and a growing public health concern globally. Strat..

Ectodysplasin A Is Increased in Non-Alcoholic Fatty Liver Disease, But Is Not Associated With Type 2 Diabetes

Jacqueline Bayliss, Geraldine J Ooi, William De Nardo, Yazmin Johari Halim Shah, Magdalene K Montgomery, Catriona McLean, William Kemp, Stuart K Roberts, Wendy A Brown, Paul R Burton, Matthew J Watt

Journal article  |  2021  |  FRONTIERS IN ENDOCRINOLOGY

UNLABELLED: Ectodysplasin A (EDA) was recently identified as a liver-secreted protein that is increased in the liver and plasma of..

EGFRvIII Promotes Cell Survival during Endoplasmic Reticulum Stress through a Reticulocalbin 1-Dependent Mechanism

Juliana Gomez, Zammam Areeb, Sarah F Stuart, Hong PT Nguyen, Lucia Paradiso, Ahmad Zulkifli, Sonakshi Madan, Vijay Rajagopal, Magdalene K Montgomery, Hui K Gan, Andrew M Scott, Jordan Jones, Andrew H Kaye, Andrew P Morokoff, Rodney B Luwor

Journal article  |  2021  |  CANCERS

Reticulocalbin 1 (RCN1) is an endoplasmic reticulum (ER)-residing protein, involved in promoting cell survival during pathophysiol..

Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control

Stacey N Keenan, William De Nardo, Jieqiong Lou, Ralf B Schittenhelm, Magdalene K Montgomery, James G Granneman, Elizabeth Hinde, Matthew J Watt

Journal article  |  2021  |  JOURNAL OF LIPID RESEARCH

Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and..

Circulating cathepsin S improves glycaemic control in mice

Hamzeh Karimkhanloo, Stacey N Keenan, Emily W Sun, David A Wattchow, Damien J Keating, Magdalene K Montgomery, Matthew J Watt

Journal article  |  2021  |  JOURNAL OF ENDOCRINOLOGY

Cathepsin S (CTSS) is a cysteine protease that regulates many physiological processes and is increased in obesity and type 2 diabe..