Magdalene Montgomery

Western Diet Induced Remodelling of the Tongue Proteome

Mriga Dutt, Yaan-Kit Ng, Jeffrey Molendijk, Hamzeh Karimkhanloo, Luoping Liao, Ronnie Blazev, Magdalene K Montgomery, Matthew J Watt, Benjamin L Parker

Journal article  |  2021  |  PROTEOMES

The tongue is a heavily innervated and vascularized striated muscle that plays an important role in vocalization, swallowing and d..

Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease

K Watt, DC Henstridge, M Ziemann, CB Sim, MK Montgomery, D Samocha-Bonet, BL Parker, GT Dodd, ST Bond, TM Salmi, RS Lee, RE Thomson, A Hagg, JR Davey, H Qian, R Koopman, A El-Osta, JR Greenfield, MJ Watt, MA Febbraio, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Obesity is a major risk factor underlying the development of metabolic disease and a growing public health concern globally. Strat..

Ectodysplasin A Is Increased in Non-Alcoholic Fatty Liver Disease, But Is Not Associated With Type 2 Diabetes

Jacqueline Bayliss, Geraldine J Ooi, William De Nardo, Yazmin Johari Halim Shah, Magdalene K Montgomery, Catriona McLean, William Kemp, Stuart K Roberts, Wendy A Brown, Paul R Burton, Matthew J Watt

Journal article  |  2021  |  FRONTIERS IN ENDOCRINOLOGY

Ectodysplasin A (EDA) was recently identified as a liver-secreted protein that is increased in the liver and plasma of obese mice ..

EGFRvIII Promotes Cell Survival during Endoplasmic Reticulum Stress through a Reticulocalbin 1-Dependent Mechanism

Juliana Gomez, Zammam Areeb, Sarah F Stuart, Hong PT Nguyen, Lucia Paradiso, Ahmad Zulkifli, Sonakshi Madan, Vijay Rajagopal, Magdalene K Montgomery, Hui K Gan, Andrew M Scott, Jordan Jones, Andrew H Kaye, Andrew P Morokoff, Rodney B Luwor

Journal article  |  2021  |  CANCERS

Reticulocalbin 1 (RCN1) is an endoplasmic reticulum (ER)-residing protein, involved in promoting cell survival during pathophysiol..

Circulating cathepsin S improves glycaemic control in mice

Hamzeh Karimkhanloo, Stacey N Keenan, Emily W Sun, David A Wattchow, Damien J Keating, Magdalene K Montgomery, Matthew J Watt

Journal article  |  2021  |  JOURNAL OF ENDOCRINOLOGY

Cathepsin S (CTSS) is a cysteine protease that regulates many physiological processes and is increased in obesity and type 2 diabe..

Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control

Stacey N Keenan, William De Nardo, Jieqiong Lou, Ralf B Schittenhelm, Magdalene K Montgomery, James G Granneman, Elizabeth Hinde, Matthew J Watt

Journal article  |  2021  |  JOURNAL OF LIPID RESEARCH

Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and..

Epicardial Adipose Tissue Accumulation Confers Atrial Conduction Abnormality

Chrishan J Nalliah, James R Bell, Antonia JA Raaijmakers, Helen M Waddell, Simon P Wells, Gabriel B Bernasochi, Magdalene K Montgomery, Simon Binny, Troy Watts, Subodh B Joshi, Elaine Lui, Choon Boon Sim, Marco Larobina, Michael O'Keefe, John Goldblatt, Alistair Royse, Geoffrey Lee, Enzo R Porrello, Matthew J Watt, Peter M Kistler, et al.

Journal article  |  2020  |  JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

BACKGROUND: Clinical studies have reported that epicardial adipose tissue (EpAT) accumulation associates with the progression of a..

SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control

Magdalene K Montgomery, Jacqueline Bayliss, Camille Devereux, Ayenachew Bezawork-Geleta, David Roberts, Cheng Huang, Ralf B Schittenhelm, Andrew Ryan, Scott L Townley, Luke A Selth, Trevor J Biden, Gregory R Steinberg, Dorit Samocha-Bonet, Ruth CR Meex, Matthew J Watt

Journal article  |  2020  |  SCIENCE TRANSLATIONAL MEDICINE

Intertissue communication is a fundamental feature of metabolic regulation, and the liver is central to this process. We have iden..

Molecular regulators of lipid metabolism in the intestine - Underestimated therapeutic targets for obesity?

Mercedes Davalos-Salas, John M Mariadason, Matthew J Watt, Magdalene K Montgomery

Journal article  |  2020  |  BIOCHEMICAL PHARMACOLOGY

The incidence of obesity and type 2 diabetes continues to rise across the globe necessitating the need to identify new therapeutic..

Inter-organelle Communication in the Pathogenesis of Mitochondrial Dysfunction and Insulin Resistance

Stacey N Keenan, Matthew J Watt, Magdalene K Montgomery

Journal article  |  2020  |  CURRENT DIABETES REPORTS

PURPOSE OF REVIEW: Impairments in mitochondrial function in patients with insulin resistance and type 2 diabetes have been dispute..