Kevin Watt

Tissue-specific expression of Cas9 has no impact on whole-body metabolism in four transgenic mouse lines

Simon T Bond, Aowen Zhuang, Christine Yang, Eleanor AM Gould, Tim Sikora, Yingying Liu, Ying Fu, Kevin Watt, Yanie Tan, Helen Kiriazis, Graeme Lancaster, Paul Gregorevic, Darren C Henstridge, Julie R McMullen, Peter J Meikle, Anna C Calkin, Brian G Drew

Journal article  |  2021  |  MOLECULAR METABOLISM

OBJECTIVE: CRISPR/Cas9 technology has revolutionized gene editing and fast tracked our capacity to manipulate genes of interest fo..

Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia.

Roberta Sartori, Adam Hagg, Sandra Zampieri, Andrea Armani, Catherine E Winbanks, Laís R Viana, Mouna Haidar, Kevin I Watt, Hongwei Qian, Camilla Pezzini, Pardis Zanganeh, Bradley J Turner, Anna Larsson, Gianpietro Zanchettin, Elisa S Pierobon, Lucia Moletta, Michele Valmasoni, Alberto Ponzoni, Shady Attar, Gianfranco Da Dalt, et al.

Journal article  |  2021  |  Science Translational Medicine

Most patients with advanced solid cancers exhibit features of cachexia, a debilitating syndrome characterized by progressive loss ..

Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease

K Watt, DC Henstridge, M Ziemann, CB Sim, MK Montgomery, D Samocha-Bonet, BL Parker, GT Dodd, ST Bond, TM Salmi, RS Lee, RE Thomson, A Hagg, JR Davey, H Qian, R Koopman, A El-Osta, JR Greenfield, MJ Watt, MA Febbraio, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Obesity is a major risk factor underlying the development of metabolic disease and a growing public health concern globally. Strat..

Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor

Choon Boon Sim, Belinda Phipson, Mark Ziemann, Haloom Rafehi, Richard J Mills, Kevin I Watt, Kwaku D Abu-Bonsrah, Ravi KR Kalathur, Holly K Voges, Doan T Dinh, Menno ter Huurne, Celine J Vivien, Antony Kaspi, Harikrishnan Kaipananickal, Alejandro Hidalgo, Leanne MD Delbridge, Rebecca L Robker, Paul Gregorevic, Cristobal G dos Remedios, Sean Lal, et al.

Journal article  |  2021  |  CIRCULATION

BACKGROUND: Despite in-depth knowledge of the molecular mechanisms controlling embryonic heart development, little is known about ..

Integrated Glycoproteomics Identifies a Role of N-Glycosylation and Galectin-1 on Myogenesis and Muscle Development

Ronnie Blazev, Christopher Ashwood, Jodie L Abrahams, Long H Chung, Deanne Francis, Pengyi Yang, Kevin Watt, Hongwei Qian, Gregory A Quaife-Ryan, James E Hudson, Paul Gregorevic, Morten Thaysen-Andersen, Benjamin L Parker

Journal article  |  2021  |  MOLECULAR & CELLULAR PROTEOMICS

Many cell surface and secreted proteins are modified by the covalent addition of glycans that play an important role in the develo..

Integrated Glycoproteomics Identifies a Role of N-Glycosylation and Galectin-1 on Myogenesis and Muscle Development.

Ronnie Blazev, Christopher Ashwood, Jodie L Abrahams, Long H Chung, Deanne Francis, Pengyi Yang, Kevin I Watt, Hongwei Qian, Gregory A Quaife-Ryan, James E Hudson, Paul Gregorevic, Morten Thaysen-Andersen, Benjamin L Parker

Journal article  |  2020  |  Mol Cell Proteomics

Many cell surface and secreted proteins are modified by the covalent addition of glycans that play an important role in the develo..

Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes

Jonathan R Davey, Emma Estevez, Rachel E Thomson, Martin Whitham, Kevin I Watt, Adam Hagg, Hongwei Qian, Darren C Henstridge, Helen Ludlow, Mark P Hedger, Sean L McGee, Melinda T Coughlan, Mark A Febbraio, Paul Gregorevic

Journal article  |  2020  |  FASEB JOURNAL

Type 2 diabetes (T2D) manifests from inadequate glucose control due to insulin resistance, hypoinsulinemia, and deteriorating panc..

Treatment of type 2 diabetes with the designer cytokine IC7Fc

Maria Findeisen, Tamara L Allen, Darren C Henstridge, Helene Kammoun, Amanda E Brandon, Laurie L Baggio, Kevin I Watt, Martin Pal, Lena Cron, Emma Estevez, Christine Yang, Greg M Kowalski, Liam O'Reilly, Casey Egan, Emily Sun, May Thai Le, Guy Krippner, Timothy E Adams, Robert S Lee, Joachim Groetzinger, et al.

Journal article  |  2019  |  NATURE

The gp130 receptor cytokines IL-6 and CNTF improve metabolic homeostasis but have limited therapeutic use for the treatment of typ..

This abstract has been withdrawn

Journal article  |  2019  |  Heart, Lung and Circulation

The Hippo Signaling Pathway in the Regulation of Skeletal Muscle Mass and Function

Kevin I Watt, Craig A Goodman, Troy A Hornberger, Paul Gregorevic

Journal article  |  2018  |  EXERCISE AND SPORT SCIENCES REVIEWS

The Hippo signaling pathway regulates the activity of the proteins Yes-associated protein (Yap) and transcriptional co-activator w..