Rachel Thomson

Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia.

Roberta Sartori, Adam Hagg, Sandra Zampieri, Andrea Armani, Catherine E Winbanks, Laís R Viana, Mouna Haidar, Kevin I Watt, Hongwei Qian, Camilla Pezzini, Pardis Zanganeh, Bradley J Turner, Anna Larsson, Gianpietro Zanchettin, Elisa S Pierobon, Lucia Moletta, Michele Valmasoni, Alberto Ponzoni, Shady Attar, Gianfranco Da Dalt, et al.

Journal article  |  2021  |  Science Translational Medicine

Most patients with advanced solid cancers exhibit features of cachexia, a debilitating syndrome characterized by progressive loss ..

Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease

K Watt, DC Henstridge, M Ziemann, CB Sim, MK Montgomery, D Samocha-Bonet, BL Parker, GT Dodd, ST Bond, TM Salmi, RS Lee, RE Thomson, A Hagg, JR Davey, H Qian, R Koopman, A El-Osta, JR Greenfield, MJ Watt, MA Febbraio, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Obesity is a major risk factor underlying the development of metabolic disease and a growing public health concern globally. Strat..

TMEPAI/PMEPA1 Is a Positive Regulator of Skeletal Muscle Mass

Adam Hagg, Swati Kharoud, Georgia Goodchild, Craig A Goodman, Justin L Chen, Rachel E Thomson, Hongwei Qian, Paul Gregorevic, Craig A Harrison, Kelly L Walton

Journal article  |  2020  |  FRONTIERS IN PHYSIOLOGY

Inhibition of myostatin- and activin-mediated SMAD2/3 signaling using ligand traps, such as soluble receptors, ligand-targeting pr..

Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes

Jonathan R Davey, Emma Estevez, Rachel E Thomson, Martin Whitham, Kevin I Watt, Adam Hagg, Hongwei Qian, Darren C Henstridge, Helen Ludlow, Mark P Hedger, Sean L McGee, Melinda T Coughlan, Mark A Febbraio, Paul Gregorevic

Journal article  |  2020  |  FASEB JOURNAL

Type 2 diabetes (T2D) manifests from inadequate glucose control due to insulin resistance, hypoinsulinemia, and deteriorating panc..

Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

Catherine E Winbanks, Kate T Murphy, Bianca C Bernardo, Hongwei Qian, Yingying Liu, Patricio V Sepulveda, Claudia Beyer, Adam Hagg, Rachel E Thomson, Justin L Chen, Kelly L Walton, Kate L Loveland, Julie R McMullen, Buel D Rodgers, Craig A Harrison, Gordon S Lynch, Paul Gregorevic

Journal article  |  2016  |  SCIENCE TRANSLATIONAL MEDICINE

Patients with advanced cancer often succumb to complications arising from striated muscle wasting associated with cachexia. Excess..

Using AAV vectors expressing the beta 2-adrenoceptor or associated G alpha proteins to modulate skeletal muscle mass and muscle fibre size

Adam Hagg, Timothy D Colgan, Rachel E Thomson, Hongwei Qian, Gordon S Lynch, Paul Gregorevic

Journal article  |  2016  |  SCIENTIFIC REPORTS

Anabolic β2-adrenoceptor (β2-AR) agonists have been proposed as therapeutics for treating muscle wasting but concerns regarding po..

Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy

Patricio V Sepulveda, Severine Lamon, Adam Hagg, Rachel E Thomson, Catherine E Winbanks, Hongwei Qian, Clinton R Bruce, Aaron P Russell, Paul Gregorevic

Journal article  |  2015  |  SCIENTIFIC REPORTS

Follistatin is an inhibitor of TGF-β superfamily ligands that repress skeletal muscle growth and promote muscle wasting. According..

Elevated expression of activins promotes muscle wasting and cachexia

Justin L Chen, Kelly L Walton, Catherine E Winbanks, Kate T Murphy, Rachel E Thomson, Yogeshwar Makanji, Hongwei Qian, Gordon S Lynch, Craig A Harrison, Paul Gregorevic

Journal article  |  2014  |  FASEB JOURNAL

In models of cancer cachexia, inhibiting type IIB activin receptors (ActRIIBs) reverse muscle wasting and prolongs survival, even ..

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass

Catherine E Winbanks, Justin L Chen, Hongwei Qian, Yingying Liu, Bianca C Bernardo, Claudia Beyer, Kevin I Watt, Rachel E Thomson, Timothy Connor, Bradley J Turner, Julie R McMullen, Lars Larsson, Sean L McGee, Craig A Harrison, Paul Gregorevic

Journal article  |  2013  |  JOURNAL OF CELL BIOLOGY

Although the canonical transforming growth factor β signaling pathway represses skeletal muscle growth and promotes muscle wasting..

Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin

Catherine E Winbanks, Kate L Weeks, Rachel E Thomson, Patricio V Sepulveda, Claudia Beyer, Hongwei Qian, Justin L Chen, James M Allen, Graeme I Lancaster, Mark A Febbraio, Craig A Harrison, Julie R McMullen, Jeffrey S Chamberlain, Paul Gregorevic

Journal article  |  2012  |  JOURNAL OF CELL BIOLOGY

Follistatin is essential for skeletal muscle development and growth, but the intracellular signaling networks that regulate follis..