Rachel Thomson

Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease.

KI Watt, DC Henstridge, M Ziemann, CB Sim, MK Montgomery, D Samocha-Bonet, BL Parker, GT Dodd, ST Bond, TM Salmi, RS Lee, RE Thomson, A Hagg, JR Davey, H Qian, R Koopman, A El-Osta, JR Greenfield, MJ Watt, MA Febbraio, et al.

Journal article  |  2021  |  Nature Communications

Obesity is a major risk factor underlying the development of metabolic disease and a growing public health concern globally. Strat..

TMEPAI/PMEPA1 Is a Positive Regulator of Skeletal Muscle Mass

Adam Hagg, Swati Kharoud, Georgia Goodchild, Craig A Goodman, Justin L Chen, Rachel E Thomson, Hongwei Qian, Paul Gregorevic, Craig A Harrison, Kelly L Walton

Journal article  |  2020  |  Frontiers in Physiology

Inhibition of myostatin- and activin-mediated SMAD2/3 signaling using ligand traps, such as soluble receptors, ligand-targeting pr..

Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes

Jonathan R Davey, Emma Estevez, Rachel E Thomson, Martin Whitham, Kevin I Watt, Adam Hagg, Hongwei Qian, Darren C Henstridge, Helen Ludlow, Mark P Hedger, Sean L McGee, Melinda T Coughlan, Mark A Febbraio, Paul Gregorevic

Journal article  |  2020  |  The FASEB Journal

Type 2 diabetes (T2D) manifests from inadequate glucose control due to insulin resistance, hypoinsulinemia, and deteriorating panc..

Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

Catherine E Winbanks, Kate T Murphy, Bianca C Bernardo, Hongwei Qian, Yingying Liu, Patricio V Sepulveda, Claudia Beyer, Adam Hagg, Rachel E Thomson, Justin L Chen, Kelly L Walton, Kate L Loveland, Julie R McMullen, Buel D Rodgers, Craig A Harrison, Gordon S Lynch, Paul Gregorevic

Journal article  |  2016  |  Science Translational Medicine

Patients with advanced cancer often succumb to complications arising from striated muscle wasting associated with cachexia. Excess..

Using AAV vectors expressing the beta 2-adrenoceptor or associated G alpha proteins to modulate skeletal muscle mass and muscle fibre size

Adam Hagg, Timothy D Colgan, Rachel E Thomson, Hongwei Qian, Gordon S Lynch, Paul Gregorevic

Journal article  |  2016  |  SCIENTIFIC REPORTS

Anabolic β2-adrenoceptor (β2-AR) agonists have been proposed as therapeutics for treating muscle wasting but concerns regarding po..

Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy

Patricio V Sepulveda, Severine Lamon, Adam Hagg, Rachel E Thomson, Catherine E Winbanks, Hongwei Qian, Clinton R Bruce, Aaron P Russell, Paul Gregorevic

Journal article  |  2015  |  Scientific Reports

Follistatin is an inhibitor of TGF-β superfamily ligands that repress skeletal muscle growth and promote muscle wasting. According..

Elevated expression of activins promotes muscle wasting and cachexia

Justin L Chen, Kelly L Walton, Catherine E Winbanks, Kate T Murphy, Rachel E Thomson, Yogeshwar Makanji, Hongwei Qian, Gordon S Lynch, Craig A Harrison, Paul Gregorevic

Journal article  |  2014  |  FASEB JOURNAL

In models of cancer cachexia, inhibiting type IIB activin receptors (ActRIIBs) reverse muscle wasting and prolongs survival, even ..

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass

Catherine E Winbanks, Justin L Chen, Hongwei Qian, Yingying Liu, Bianca C Bernardo, Claudia Beyer, Kevin I Watt, Rachel E Thomson, Timothy Connor, Bradley J Turner, Julie R McMullen, Lars Larsson, Sean L McGee, Craig A Harrison, Paul Gregorevic

Journal article  |  2013  |  JOURNAL OF CELL BIOLOGY

Although the canonical transforming growth factor β signaling pathway represses skeletal muscle growth and promotes muscle wasting..

Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin

Catherine E Winbanks, Kate L Weeks, Rachel E Thomson, Patricio V Sepulveda, Claudia Beyer, Hongwei Qian, Justin L Chen, James M Allen, Graeme I Lancaster, Mark A Febbraio, Craig A Harrison, Julie R McMullen, Jeffrey S Chamberlain, Paul Gregorevic

Journal article  |  2012  |  JOURNAL OF CELL BIOLOGY

Follistatin is essential for skeletal muscle development and growth, but the intracellular signaling networks that regulate follis..

Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1, a FGF2 downstream gene.

Francesca Pellicano, Rachel E Thomson, Gareth J Inman, Tomoko Iwata

Journal article  |  2010  |  BMC Cancer

BACKGROUND: Coiled-coil domain containing 115 (Ccdc115) or coiled coil protein-1 (ccp1) was previously identified as a downstream ..