Joe Ciccotosto

Sex-dependent effects of amyloid precursor-like protein 2 in the SOD1-G37R transgenic mouse model of MND

Phan H Truong, Peter J Crouch, James BW Hilton, Catriona A McLean, Roberto Cappai, Giuseppe D Ciccotosto

Journal article  |  2021  |  CELLULAR AND MOLECULAR LIFE SCIENCES

Motor neurone disease (MND) is a neurodegenerative disorder characterised by progressive destruction of motor neurons, muscle para..

Genetic Modulators of Traumatic Brain Injury in Animal Models and the Impact of Sex-Dependent Effects

Chaitanya Inampudi, Giuseppe D Ciccotosto, Roberto Cappai, Peter J Crack

Journal article  |  2020  |  JOURNAL OF NEUROTRAUMA

Traumatic brain injury (TBI) is a major health problem causing disability and death worldwide. There is no effective treatment, du..

Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: The Effects of Ageing and Sex

Phan H Truong, Giuseppe D Ciccotosto, Roberto Cappai

Journal article  |  2019  |  NEUROCHEMICAL RESEARCH

The amyloid precursor protein (APP) is a member of a conserved gene family that includes the amyloid precursor-like proteins 1 (AP..

Amyloid precursor protein and amyloid precursor-like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons

Phan H Truong, Giuseppe D Ciccotosto, Tobias D Merson, Loredana Spoerri, Mun Joo Chuei, Margaret Ayers, Yao Lulu Xing, Ben Emery, Roberto Cappai

Journal article  |  2019  |  GLIA

The identification of factors that regulate myelination provides important insight into the molecular mechanisms that coordinate n..

Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death

Ashfaqul Hoque, Nicholas A Williamson, S Sadia Ameen, Giuseppe D Ciccotosto, M Iqbal Hossain, Jonathan S Oakhill, Dominic CH Ng, Ching-Seng Ang, Heung-Chin Cheng

Journal article  |  2019  |  CELL DEATH & DISEASE

Excitotoxicity, caused by overstimulation or dysregulation of ionotropic glutamate receptors (iGluRs), is a pathological process d..

Amyloid Precursor Protein Dimerisation Reduces Neurite Outgrowth

Luan Luu, Giuseppe D Ciccotosto, Laura J Vella, Lesley Cheng, Laila C Roisman, Gerhard Multhaup, Andrew F Hill, Lisa-Marie Munter, Roberto Cappai

Journal article  |  2019  |  MOLECULAR NEUROBIOLOGY

The amyloid precursor protein (APP) undergoes extensive metabolism, and its transport and proteolytic processing can be modulated ..

Modelling Airway Diffusion Kinetics of Tagged Dextran Complexes to Understand Airway Biology of Inhaled Biological Protein Therapeutics Reveals Marked Anatomical Variation

GP Anderson, G Ciccotosto, A Jarnecki, M Chuei, E Hansbauer, S Klingl, T Jaquin, G Matschiner, S Olwil

Conference Proceedings  |  2019  |  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Molecular Mechanisms of Neurotoxicity Induced by Polymyxins and Chemoprevention

Chongshan Dai, Xilong Xiao, Jichang Li, Giuseppe D Ciccotosto, Roberto Cappai, Shusheng Tang, Elena K Schneider-Futschik, Daniel Hoyer, Tony Velkov, Jianzhong Shen

Journal article  |  2019  |  ACS CHEMICAL NEUROSCIENCE

Neurotoxicity is one major unwanted side-effects associated with polymyxin (i.e., colistin and polymyxin B) therapy. Clinically, c..

Fluorescence imaging of the interaction of amyloid beta 40 peptides with live cells and model membrane

Elaheh Jamasbi, Mohammed Akhter Hossain, Marsha Tan, Frances Separovic, Giuseppe D Ciccotosto

Journal article  |  2018  |  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Amyloid beta peptides (Aβ) found in plaques in the brain have been widely recognised as a hallmark of Alzheimer's disease although..

DELINEATING THE NEUROPROTECTIVE ROLE OF THE AMYLOID PRECURSOR PROTEIN FAMILY IN TRAUMATIC BRAIN INJURY

Roberto Cappai, Chaitanya Inampudi, Frances Corrigan, Linh Lam, Blaine Roberts, Emma Thornton, Robert Vink, Giuseppe Ciccotosto, Peter Crack, Corinna Van den Heuvel

Conference Proceedings  |  2018  |  JOURNAL OF NEUROTRAUMA