Joe Ciccotosto

Splice Variants of G Protein-Coupled Receptors Expressed in Cancers: Effective Targeting with Monoclonal Antibodies and Antibody-Like Scaffolds As Ligands Irrespective of the Pharmacological Status of Isoforms

PJ Wookey, P Gupta, DL Hare, GD Ciccotosto, CJ Hutchings

Book Chapter  |  2022

Visualising biodistribution and biokinetics of inhaled biologicals: application of light sheet imaging technology

Giuseppe Ciccotosto, Andrew Jarnicki, Robert O'Donoghue, Mun-Joo Chuei, Caitlin O'Brien, Gabriela Segal, Ellie Cho, Eva-Maria Hansbauer, Stefan Kling, Thomas Jaquin, Gabriele Matschiner, Shane Olwill, Gary P Anderson

Conference Proceedings  |  2021  |  EUROPEAN RESPIRATORY JOURNAL

Simultaneous inhibition of CTGF and Autotaxin reduces lung fibrosis and improves lung function in mice

Robert JJ O'Donoghue, Caitlin O'Brien, Mun Joo Chuei, Vanessa Welk, Thomas Jaquin, Goran Martic, Ellie H-J Cho, Kathryn Stok, Delaney Haugan, Gabrielle Matschiner, Giuseppe Ciccotosto, Andrew G Jarnicki, Gary P Anderson

Conference Proceedings  |  2021  |  EUROPEAN RESPIRATORY JOURNAL

Sex-dependent effects of amyloid precursor-like protein 2 in the SOD1-G37R transgenic mouse model of MND

Phan H Truong, Peter J Crouch, James BW Hilton, Catriona A McLean, Roberto Cappai, Giuseppe D Ciccotosto

Journal article  |  2021  |  CELLULAR AND MOLECULAR LIFE SCIENCES

Motor neurone disease (MND) is a neurodegenerative disorder characterised by progressive destruction of motor neurons, muscle para..

The Alzheimer's Disease Amyloid Precursor Protein and its Neuritogenic Actions

Luan Luu, Giuseppe D Ciccotosto, Roberto Cappai

Journal article  |  2021  |  CURRENT ALZHEIMER RESEARCH

The Amyloid Precursor Protein (APP) is principally known and studied for its involvement in Alzheimer's disease as the source of t..

Genetic Modulators of Traumatic Brain Injury in Animal Models and the Impact of Sex-Dependent Effects

Chaitanya Inampudi, Giuseppe D Ciccotosto, Roberto Cappai, Peter J Crack

Journal article  |  2020  |  JOURNAL OF NEUROTRAUMA

Traumatic brain injury (TBI) is a major health problem causing disability and death worldwide. There is no effective treatment, du..

Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: The Effects of Ageing and Sex

Phan H Truong, Giuseppe D Ciccotosto, Roberto Cappai

Journal article  |  2019  |  NEUROCHEMICAL RESEARCH

The amyloid precursor protein (APP) is a member of a conserved gene family that includes the amyloid precursor-like proteins 1 (AP..

Amyloid precursor protein and amyloid precursor-like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons

Phan H Truong, Giuseppe D Ciccotosto, Tobias D Merson, Loredana Spoerri, Mun Joo Chuei, Margaret Ayers, Yao Lulu Xing, Ben Emery, Roberto Cappai

Journal article  |  2019  |  GLIA

The identification of factors that regulate myelination provides important insight into the molecular mechanisms that coordinate n..

Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death

Ashfaqul Hoque, Nicholas A Williamson, S Sadia Ameen, Giuseppe D Ciccotosto, M Iqbal Hossain, Jonathan S Oakhill, Dominic CH Ng, Ching-Seng Ang, Heung-Chin Cheng

Journal article  |  2019  |  CELL DEATH & DISEASE

Excitotoxicity, caused by overstimulation or dysregulation of ionotropic glutamate receptors (iGluRs), is a pathological process d..

Amyloid Precursor Protein Dimerisation Reduces Neurite Outgrowth

Luan Luu, Giuseppe D Ciccotosto, Laura J Vella, Lesley Cheng, Laila C Roisman, Gerhard Multhaup, Andrew F Hill, Lisa-Marie Munter, Roberto Cappai

Journal article  |  2019  |  MOLECULAR NEUROBIOLOGY

The amyloid precursor protein (APP) undergoes extensive metabolism, and its transport and proteolytic processing can be modulated ..