Joe Ciccotosto

Genetic Modulators of Traumatic Brain Injury in Animal Models and the Impact of Sex-Dependent Effects

Chaitanya Inampudi, Giuseppe D Ciccotosto, Roberto Cappai, Peter J Crack

Journal article  |  2020  |  Journal of Neurotrauma

Traumatic brain injury (TBI) is a major health problem causing disability and death worldwide. There is no effective treatment, du..

Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: The Effects of Ageing and Sex

Phan H Truong, Giuseppe D Ciccotosto, Roberto Cappai

Journal article  |  2019  |  Neurochemical Research

Amyloid precursor protein and amyloid precursor-like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons

Phan H Truong, Giuseppe D Ciccotosto, Tobias D Merson, Loredana Spoerri, Mun Joo Chuei, Margaret Ayers, Yao Lulu Xing, Ben Emery, Roberto Cappai

Journal article  |  2019  |  Glia

Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death

Ashfaqul Hoque, Nicholas A Williamson, S Sadia Ameen, Giuseppe D Ciccotosto, M Iqbal Hossain, Jonathan S Oakhill, Dominic CH Ng, Ching-Seng Ang, Heung-Chin Cheng

Journal article  |  2019  |  CELL DEATH & DISEASE

Amyloid Precursor Protein Dimerisation Reduces Neurite Outgrowth

Luan Luu, Giuseppe D Ciccotosto, Laura J Vella, Lesley Cheng, Laila C Roisman, Gerhard Multhaup, Andrew F Hill, Lisa-Marie Munter, Roberto Cappai

Journal article  |  2019  |  Molecular Neurobiology

Modelling Airway Diffusion Kinetics of Tagged Dextran Complexes to Understand Airway Biology of Inhaled Biological Protein Therapeutics Reveals Marked Anatomical Variation

GP Anderson, G Ciccotosto, A Jarnecki, M Chuei, E Hansbauer, S Klingl, T Jaquin, G Matschiner, S Olwil

Conference Proceedings  |  2019  |  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Molecular Mechanisms of Neurotoxicity Induced by Polymyxins and Chemoprevention

Chongshan Dai, Xilong Xiao, Jichang Li, Giuseppe D Ciccotosto, Roberto Cappai, Shusheng Tang, Elena K Schneider-Futschik, Daniel Hoyer, Tony Velkov, Jianzhong Shen

Journal article  |  2019  |  ACS Chemical Neuroscience

Fluorescence imaging of the interaction of amyloid beta 40 peptides with live cells and model membrane

Elaheh Jamasbi, Mohammed Akhter Hossain, Marsha Tan, Frances Separovic, Giuseppe D Ciccotosto

Journal article  |  2018  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

DELINEATING THE NEUROPROTECTIVE ROLE OF THE AMYLOID PRECURSOR PROTEIN FAMILY IN TRAUMATIC BRAIN INJURY

Roberto Cappai, Chaitanya Inampudi, Frances Corrigan, Linh Lam, Blaine Roberts, Emma Thornton, Robert Vink, Giuseppe Ciccotosto, Peter Crack, Corinna Van den Heuvel

Conference Proceedings  |  2018  |  JOURNAL OF NEUROTRAUMA

Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways

Chongshan Dai, Giuseppe D Ciccotosto, Roberto Cappai, Yang Wang, Shusheng Tang, Daniel Hoyer, Elena K Schneider, Tony Velkov, Xilong Xiao

Journal article  |  2018  |  ACS Chemical Neuroscience

Polymyxins for CNS infections: Pharmacology and neurotoxicity

Tony Velkov, Chongshan Dai, Giuseppe D Ciccotosto, Roberto Cappai, Daniel Hoyer, Jian Li

Journal article  |  2018  |  Pharmacology & Therapeutics

Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis

Chongshan Dai, Giuseppe D Ciccotosto, Roberto Cappai, Shusheng Tang, Daowen Li, Sanlei Xie, Xilong Xiao, Tony Velkov

Journal article  |  2018  |  Molecular Neurobiology

Phosphorylation of a full length amyloid-beta peptide modulates its amyloid aggregation, cell binding and neurotoxic properties

Elaheh Jamasbi, Frances Separovic, Mohammed Akhter Hossain, Giuseppe Donato Ciccotosto

Journal article  |  2017  |  Molecular BioSystems

Minocycline attenuates colistin-induced neurotoxicity via suppression of apoptosis, mitochondrial dysfunction and oxidative stress

Chongshan Dai, Giuseppe D Ciccotosto, Roberto Cappai, Yang Wang, Shusheng Tang, Xilong Xiao, Tony Velkov

Journal article  |  2017  |  Journal of Antimicrobial Chemotherapy

MeCP2 interacts with chromosomal microRNAs in brain

Abdul Waheed Khan, Mark Ziemann, Haloom Rafehi, Scott Maxwell, Giuseppe D Ciccotosto, Assam El-Osta

Journal article  |  2017  |  Epigenetics

Neurotoxicity of Prion Peptides on Cultured Cerebellar Neurons

Giuseppe D Ciccotosto, Metta Jana, Roberto Cappai

Journal article  |  2017  |  Methods in molecular biology (Clifton, N.J.)

Oligomeric Amyloid-beta Toxicity Can Be Inhibited by Blocking Its Cellular Binding in Cortical Neuronal Cultures with Addition of the Triphenylmethane Dye Brilliant Blue G

Metta K Jana, Roberto Cappai, Giuseppe D Ciccotosto

Journal article  |  2016  |  ACS Chemical Neuroscience

Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics

Virginie Dinet, Giuseppe D Ciccotosto, Kimberley Delaunay, Celine Borras, Isabelle Ranchon-Cole, Corinne Kostic, Michele Savoldelli, Mohamed El Sanharawi, Laurent Jonet, Caroline Pirou, Na An, Marc Abitbol, Yvan Arsenijevic, Francine Behar-Cohen, Roberto Cappai, Frederic Mascarelli

Journal article  |  2016  |  MOLECULAR BRAIN

Membrane-bound tetramer and trimer A beta oligomeric species correlate with toxicity towards cultured neurons

Metta K Jana, Roberto Cappai, Chi LL Pham, Giuseppe D Ciccotosto

Journal article  |  2016  |  JOURNAL OF NEUROCHEMISTRY

Site of fluorescent label modifies interaction of melittin with live cells and model membranes

Elaheh Jamasbi, Giuseppe D Ciccotosto, Julien Tailhades, Roy M Robins-Browne, Cathryn L Ugalde, Robyn A Sharples, Nitin Patil, John D Wade, Mohammed Akhter Hossain, Frances Separovic

Journal article  |  2015  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

Combined deletions of amyloid precursor protein and amyloid precursor-like protein 2 reveal different effects on mouse brain metal homeostasis

B Elise Needham, Giuseppe D Ciccotosto, Roberto Cappai

Journal article  |  2014  |  METALLOMICS

Quantitation and localization of intracellular redox active metals by X-ray fluorescence microscopy in cortical neurons derived from APP and APLP2 knockout tissue

Giuseppe D Ciccotosto, Simon A James, Matteo Altissimo, David Paterson, Stefan Vogt, Barry Lai, Martin D de Jonge, Daryl L Howard, Ashley I Bush, Roberto Cappai

Journal article  |  2014  |  METALLOMICS

Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer's Disease Amyloid Precursor Protein

Jiang-Li Tan, Qiao-Xin Li, Giuseppe D Ciccotosto, Peter John Crouch, Janetta Gladys Culvenor, Anthony Robert White, Genevieve Evin

Journal article  |  2013  |  PLOS ONE

Aggregation Distributions on Cells Determined by Photobleaching Image Correlation Spectroscopy

Giuseppe D Ciccotosto, Noga Kozer, Timothy TY Chow, James WM Chon, Andrew HA Clayton

Journal article  |  2013  |  BIOPHYSICAL JOURNAL

Development of a Platinum Complex as an anti-Amyloid Agent for the Therapy of Alzheimer's Disease

Vijaya B Kenche, Lin W Hung, Keyla Perez, Irene Volitakes, Guiseppe Ciccotosto, Jeffrey Kwok, Nicole Critch, Nikki Sherratt, Mikhalina Cortes, Varsha Lal, Colin L Masters, Kazuma Murakami, Roberto Cappai, Paul A Adlard, Kevin J Barnham

Journal article  |  2013  |  Angewandte Chemie - International Edition

Synthetic dityrosine-linked beta-amyloid dimers form stable, soluble, neurotoxic oligomers

W Mei Kok, Jade M Cottam, Giuseppe D Ciccotosto, Luke A Miles, John A Karas, Denis B Scanlon, Blaine R Roberts, Michael W Parker, Roberto Cappai, Kevin J Barnham, Craig A Hutton

Journal article  |  2013  |  CHEMICAL SCIENCE

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

Peng Lei, Scott Ayton, David I Finkelstein, Loredana Spoerri, Giuseppe D Ciccotosto, David K Wright, Bruce XW Wong, Paul A Adlard, Robert A Cherny, Linh Q Lam, Blaine R Roberts, Irene Volitakis, Gary F Egan, Catriona A McLean, Roberto Cappai, James A Duce, Ashley I Bush

Journal article  |  2012  |  Nature Medicine

Amyloid Precursor Protein Is Required for Normal Function of the Rod and Cone Pathways in the Mouse Retina

Tracy Ho, Kirstan A Vessey, Roberto Cappai, Virginie Dinet, Frederic Mascarelli, Giuseppe D Ciccotosto, Erica L Fletcher

Journal article  |  2012  |  PLOS ONE

Gene Knockout of tau Expression Does Not Contribute to the Pathogenesis of Prion Disease

Victoria A Lawson, Helen M Klemm, Jeremy M Welton, Colin L Masters, Peter Crouch, Roberto Cappai, Giuseppe D Ciccotosto

Journal article  |  2011  |  Journal of Neuropathology and Experimental Neurology

Suppression of Amyloid beta A11 Antibody Immunoreactivity by Vitamin C POSSIBLE ROLE OF HEPARAN SULFATE OLIGOSACCHARIDES DERIVED FROM GLYPICAN-1 BY ASCORBATE-INDUCED, NITRIC OXIDE (NO)-CATALYZED DEGRADATION

Fang Cheng, Roberto Cappai, Giuseppe D Ciccotosto, Gabriel Svensson, Gerd Multhaup, Lars-Ake Fransson, Katrin Mani

Journal article  |  2011  |  Journal of Biological Chemistry

Oligomerization and toxicity of A beta fusion proteins

Joanne M Caine, Prashant R Bharadwaj, Sonia E Sankovich, Giuseppe D Ciccotosto, Victor A Streltsov, Jose Varghese

Journal article  |  2011  |  Biochemical and Biophysical Research Communications

APP involvement in retinogenesis of mice

Virginie Dinet, Na An, Giuseppe D Ciccotosto, Julien Bruban, Agathe Maoui, Shayne A Bellingham, Andrew F Hill, Olav M Andersen, Anders Nykjaer, Laurent Jonet, Roberto Cappai, Frederic Mascarelli

Journal article  |  2011  |  Acta Neuropathologica

Stereospecific interactions are necessary for Alzheimer disease amyloid-beta toxicity

Giuseppe D Ciccotosto, Deborah J Tew, Simon C Drew, Danielle G Smith, Timothy Johanssen, Varsha Lal, Tong-Lay Lau, Keyla Perez, Cyril C Curtain, John D Wade, Frances Separovic, Colin L Masters, Jeffrey P Smith, Kevin J Barnham, Roberto Cappai

Journal article  |  2011  |  Neurobiology of Aging

Iron-Export Ferroxidase Activity of beta-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

James A Duce, Andrew Tsatsanis, Michael A Cater, Simon A James, Elysia Robb, Krutika Wikhe, Su Ling Leong, Keyla Perez, Timothy Johanssen, Mark A Greenough, Hyun-Hee Cho, Denise Galatis, Robert D Moir, Colin L Masters, Catriona McLean, Rudolph E Tanzi, Roberto Cappai, Kevin J Barnham, Giuseppe D Ciccotosto, Jack T Rogers, et al.

Journal article  |  2010  |  Cell

A domain level interaction network of amyloid precursor protein and A beta of Alzheimer's disease

Victoria M Perreau, Sandra Orchard, Paul A Adlard, Shayne A Bellingham, Roberto Cappai, Giuseppe D Ciccotosto, Tiffany F Cowie, Peter J Crouch, James A Duce, Genevieve Evin, Noel G Faux, Andrew F Hill, Ya Hui Hung, Simon A James, Qiao-Xin Li, Su San Mok, Deborah J Tew, Anthony R White, Ashley I Bush, Henning Hermjakob, et al.

Journal article  |  2010  |  Proteomics

Alleviating Transcriptional Inhibition of the Norepinephrine Slc6a2 Transporter Gene in Depolarized Neurons

Harikrishnan Kn, Richard Bayles, Giuseppe D Ciccotosto, Scott Maxwell, Roberto Cappai, Gregory J Pelka, Patrick PL Tam, John Christodoulou, Assam El-Osta

Journal article  |  2010  |  Journal of Neuroscience

Histidine 14 Modulates Membrane Binding and Neurotoxicity of the Alzheimer's Disease Amyloid-beta Peptide

Danielle G Smith, Giuseppe D Ciccotosto, Deborah J Tew, Keyla Perez, Cyril C Curtain, John F Boas, Colin L Masters, Roberto Cappai, Kevin J Barnham

Journal article  |  2010  |  Journal of Alzheimer's Disease

Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses

Efrat Abramov, Iftach Dolev, Hilla Fogel, Giuseppe D Ciccotosto, Eyal Ruff, Inna Slutsky

Journal article  |  2009  |  Nature Neuroscience

MEROZOITE SURFACE PROTEIN 2 HAS A POTENTIAL ROLE IN THE ATTACHMENT OF PLASMODIUM FALCIPARUM MEROZOITES TO ERYTHROCYTES DURING INVASION

Jesse L Schloegel, Christopher G Adda, Fiona Durand, Vince J Murphy, Kleo Vingas, Giuseppe D Ciccotosto, Roberto Cappai, Barnham J Kevin, Michael Foley, Robin F Anders

Conference Proceedings  |  2009  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Stimulus pattern dependence of the Alzheimer's disease amyloid-beta 42 peptide's inhibition of long term potentiation in mouse hippocampal slices

Jeffrey P Smith, Varsha Lal, David Bowser, Roberto Cappai, Colin L Masters, Giuseppe D Ciccotosto

Journal article  |  2009  |  Brain Research

Amyloid-beta Peptide (A beta) Neurotoxicity Is Modulated by the Rate of Peptide Aggregation: A beta Dimers and Trimers Correlate with Neurotoxicity

Lin Wai Hung, Giuseppe D Ciccotosto, Eleni Giannakis, Deborah J Tew, Keyla Perez, Colin L Masters, Roberto Cappai, John D Wade, Kevin J Barnham

Journal article  |  2008  |  Journal of Neuroscience

Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth

BE Needham, ME Wlodek, GD Ciccotosto, BC Fam, CL Masters, J Proietto, S Andrikopoulos, R Cappai

Journal article  |  2008  |  Journal of Pathology

Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth

BE Needham, ME Wlodek, GD Ciccotosto, BC Fam, CL Masters, J Proietto, S Andrikopoulos, R Cappai

Journal article  |  2008  |  Journal of Pathology

Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease

Kevin J Barnham, Vijaya B Kenche, Giuseppe D Ciccotosto, David P Smith, Deborah J Tew, Xiang Liu, Keyla Perez, Greg A Cranston, Timothy J Johanssen, Irene Volitakis, Ashley I Bush, Colin L Masters, Anthony R White, Jeffrey P Smith, Robert A Cherny, Roberto Cappai

Journal article  |  2008  |  Proceedings of the National Academy of Sciences of the United States of America

Stabilization of neurotoxic soluble beta-sheet-rich conformations of the Alzheimer's disease amyloid-beta peptide

Deborah J Tew, Stephen P Bottomley, David P Smith, Giuseppe D Ciccotosto, Jeffrey Babon, Mark G Hinds, Colin L Masters, Roberto Cappai, Kevin J Barnham

Journal article  |  2008  |  Biophysical Journal

Neurotoxicity from glutathione depletion is mediated by Cu-dependent p53 activation

Tai Du, Giuseppe D Ciccotosto, Greg A Cranston, Gulcan Kocak, Colin L Masters, Peter J Crouch, Roberto Cappai, Anthony R White

Journal article  |  2008  |  Free Radical Biology and Medicine

Neurotoxicity of prion peptides on cultured cerebellar neurons

GD Ciccotosto, R Cappai, AR White

Journal article  |  2008  |  Methods in Molecular Biology

Neurotoxicity of prion peptides on cultured cerebellar neurons.

Giuseppe D Ciccotosto, Roberto Cappai, Anthony R White

Book Chapter  |  2008  |  Methods in Molecular Biology

Prion peptide (PrP) neurotoxicity has been modelled in vitro by using synthetic peptides derived from the PrP(C) sequence. The maj..

The function of the amyloid precursor protein family

R Cappai, B Elise Needham, GD Ciccotosto

Book Chapter  |  2007

Trafficking of a secretory granule membrane protein is sensitive to copper

Mithu De, Giuseppe D Ciccotosto, Richard E Mains, Betty A Eipper

Journal article  |  2007  |  Journal of Biological Chemistry

Concentration dependent Cu2 induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide

David P Smith, Giuseppe D Ciccotosto, Deborah J Tew, Michelle T Fodero-Tavoletti, Timothy Johanssen, Colin L Masters, Kevin J Barnham, Roberto Cappai

Journal article  |  2007  |  Biochemistry

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge

David P Smith, Danielle G Smith, Cyril C Curtain, John F Boas, John R Pilbrow, Giuseppe D Ciccotosto, Tong-Lay Lau, Deborah J Tew, Keyla Perez, John D Wade, Ashley I Bush, Simon C Drew, Frances Separovic, Colin L Masters, Roberto Cappai, Kevin J Barnham

Journal article  |  2006  |  Journal of Biological Chemistry

Correlative studies support lipid peroxidation is linked to PrPres propagation as art early primary pathogenic event in prion disease

MW Brazier, V Lewis, GD Ciccotosto, GM Klub, VA Lawson, R Cappai, JW Ironside, CL Masters, AF Hill, AR White, S Collins

Journal article  |  2006  |  Brain Research Bulletin

The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-nitric oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo

R Cappai, F Cheng, GD Ciccotosto, BE Needham, CL Masters, G Multhaup, LA Fransson, K Mani

Journal article  |  2005  |  Journal of Biological Chemistry

Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutaselike structures and inhibition of neurotoxicity

AK Tickler, DG Smith, GD Ciccotosto, DJ Tew, CC Curtain, D Carrington, CL Masters, AI Bush, RA Cherny, R Cappai, JD Wade, KJ Barnham

Journal article  |  2005  |  Journal of Biological Chemistry

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta(1-42)

PJ Crouch, R Blake, JA Duce, GD Ciccotosto, QX Li, KJ Barnham, CC Curtain, RA Cherny, R Cappai, T Dyrks, CL Masters, IA Trounce

Journal article  |  2005  |  Journal of Neuroscience

Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution

GD Ciccotosto, D Tew, CC Curtain, D Smith, D Carrington, CL Masters, AI Bush, RA Cherny, R Cappai, KJ Barnham

Journal article  |  2004  |  Journal of Biological Chemistry

Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts

SA Bellingham, GD Ciccotosto, BE Needham, LR Fodero, AR White, CL Masters, R Cappai, J Camakaris

Journal article  |  2004  |  Journal of Neurochemistry

Mutagenesis-toxicity studies of the amyloid beta peptide of Alzheimer's disease

GD Ciccotosto, CC Curtain, D Tew, D Carrington, CL Masters, RA Cherny, AI Bush, R Cappai, KJ Barnham

Conference Proceedings  |  2004  |  Neurobiology of Aging

The mechanism by which A beta produces hydrogen peroxide and its role in neurotoxicity

KJ Barnham, F Haeffner, GD Ciccotosto, CC Curtain, D Tew, CL Masters, RA Chemy, R Cappai, AI Bush

Conference Proceedings  |  2004  |  Neurobiology of Aging

Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid

KJ Barnham, F Haeffner, GD Ciccotosto, CC Curtain, D Tew, C Mavros, K Beyreuther, D Carrington, CL Masters, RA Cherny, R Cappai, AI Bush

Journal article  |  2004  |  FASEB Journal

Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation

KJ Barnham, GD Ciccotosto, AK Tickler, FE Ali, DG Smith, NA Williamson, YH Lam, D Carrington, D Tew, G Kocak, I Volitakis, F Separovic, CJ Barrow, JD Wade, CL Masters, RA Cherny, CC Curtain, AI Bush, R Cappai

Journal article  |  2003  |  Journal of Biological Chemistry

Menkes protein contributes to the function of peptidylglycine alpha-amidating monooxygenase

TC Steveson, GD Ciccotosto, XM Ma, GP Mueller, RE Mains, BA Eipper

Journal article  |  2003  |  Endocrinology

Methionine oxidation: Implications for the mechanism of toxicity of the beta-amyloid peptide from Alzheimer's disease

GD Ciccotosto, KJ Barnham, RA Cherny, CL Masters, AI Bush, CC Curtain, R Cappai, D Tew

Journal article  |  2003  |  Letters in Peptide Science

Modulation of Alzheimer's Disease Aβ pathways for rational therapeutic intervention: secretase inhibition and metalloprotein active compounds.

G EVIN, undefined Sernee, K BARNHAM, undefined Holsinger, J CULVENOR, D HOKE, Q LI, undefined Smith, C MAYNARD, N WILLIAMSON, G CICCOTOSTO, S MOK, I VOLITAKIS, G KOCAK, undefined Carrington, undefined Opazo, AK TICKLER, undefined Huang, undefined Beyreuther, R CAPPAI, et al.

Book Chapter  |  2003

Breeding stock-specific variation in peptidylglycine alpha-amidating monooxygenase messenger ribonucleic acid splicing in rat pituitary.

GD Ciccotosto, TA Hand, RE Mains, BA Eipper

Journal article  |  2000  |  Endocrinology

Peptidylglycine alpha-amidating monooxygenase (PAM) is a bifunctional enzyme that catalyzes the carboxyl-terminal amidation of gly..

Induction of integral membrane PAM expression in AtT-20 cells alters the storage and trafficking of POMC and PC1.

GD Ciccotosto, MR Schiller, BA Eipper, RE Mains

Journal article  |  1999  |  The Journal of cell biology

Peptidylglycine alpha-amidating monooxygenase (PAM) is an essential enzyme that catalyzes the COOH-terminal amidation of many neur..

Glycine-extended gastrin acts as an autocrine growth factor in a nontransformed colon cell line

F Hollande, A Imdahl, T Mantamadiotis, GD Ciccotosto, A Shulkes, GS Baldwin

Journal article  |  1997  |  Gastroenterology

Gastrin processing and secretion in patients with end-stage renal failure.

GD Ciccotosto, JK Dawborn, KJ Hardy, A Shulkes

Journal article  |  1996  |  Journal of Clinical Endocrinology and Metabolism

Gastrin circulates at higher than normal concentrations in patients with end-stage renal failure (ESRF). However, it remains uncle..

Ontogeny of gastrin and cholecystokinin in the colon and duodenum of sheep.

GD Ciccotosto, A Shulkes

Journal article  |  1996  |  Regulatory Peptides

The different roles of gastrin and cholecystokinin in the fetus compared to the adult may be reflected in different distribution p..

Expression, processing, and secretion of gastrin in patients with colorectal carcinoma.

GD Ciccotosto, A McLeish, KJ Hardy, A Shulkes

Journal article  |  1995  |  Gastroenterology

BACKGROUND & AIMS: The relationship between gastrin and the development of colorectal carcinoma (CRC) remains controversial. Probl..

Pharmacokinetics and organ specific metabolism of glycine-extended and amidated gastrin in sheep.

GD Ciccotosto, A Shulkes

Journal article  |  1992  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Glycine (Gly)-extended gastrin has been described as the inactive precursor form of the biologically active amidated gastrin. The ..