Xin-Yi Chai

Investigation of nerve pathways mediating colorectal dysfunction in Parkinson's disease model produced by lesion of nigrostriatal dopaminergic neurons

Xin-yi Chai, Shanti Diwakarla, Ruslan V Pustovit, Rachel M McQuade, Madeleine Di Natale, Charlotte M Ermine, Clare L Parish, David I Finkelstein, John B Furness

Journal article  |  2020  |  NEUROGASTROENTEROLOGY AND MOTILITY

BACKGROUND: Gastrointestinal (GI) dysfunction, including constipation, is a common non-motor symptom of Parkinson's disease (PD). ..

Chronic isolation stress is associated with increased colonic and motor symptoms in the A53T mouse model of Parkinson's disease

Shanti Diwakarla, David I Finkelstein, Remy Constable, Olivia Artaiz, Madeleine Di Natale, Rachel M McQuade, Enie Lei, Xin-yi Chai, Mitchell T Ringuet, Linda J Fothergill, Victoria A Lawson, Laura J Ellett, Joel P Berger, John B Furness

Journal article  |  2019  |  NEUROGASTROENTEROLOGY AND MOTILITY

BACKGROUND: Chronic stress exacerbates motor deficits and increases dopaminergic cell loss in several rodent models of Parkinson's..

Muscarinic receptor 1 allosteric modulators stimulate colorectal emptying in dog, mouse and rat and resolve constipation

Ruslan V Pustovit, Yasuo Itomi, Mitchell Ringuet, Shanti Diwakarla, Xin-yi Chai, Rachel M McQuade, Yasuhiro Tsukimi, John B Furness

Journal article  |  2019  |  NEUROGASTROENTEROLOGY AND MOTILITY

BACKGROUND: Because M1 muscarinic receptors are expressed by enteric neurons, we investigated whether positive allosteric modulato..