Camilla Thornton

STIM1 Is Required for Remodeling of the Endoplasmic Reticulum and Microtubule Cytoskeleton in Steering Growth Cones

Macarena Pavez, Adrian C Thompson, Hayden J Arnott, Camilla B Mitchell, Ilaria D'Atri, Emily K Don, John K Chilton, Ethan K Scott, John Y Lin, Kaylene M Young, Robert J Gasperini, Lisa Foa

Journal article  |  2019  |  Journal of Neuroscience

The spatial and temporal regulation of calcium signaling in neuronal growth cones is essential for axon guidance. In growth cones,..

Mouse Models for Exploring the Biological Consequences and Clinical Significance of PIK3CA Mutations

Camilla B Mitchell, Wayne A Phillips

Journal article  |  2019  |  Biomolecules

The phosphatidylinositol 3-kinase (PI3K) pathway is involved in a myriad of cellular signalling pathways that regulate cell growth..

Tropomyosin Tpm 2.1 loss induces glioblastoma spreading in soft brain-like environments

Camilla B Mitchell, Bronte Black, Faith Sun, Wojciech Chrzanowski, Justin Cooper-White, Benois Maisonneuve, Brett Stringer, Bryan Day, Mate Biro, Geraldine M O'Neill

Journal article  |  2019  |  Journal of Neuro-Oncology

INTRODUCTION: The brain is a very soft tissue. Glioblastoma (GBM) brain tumours are highly infiltrative into the surrounding healt..

Small molecule targeting of the actin associating protein tropomyosin Tpm3.1 increases neuroblastoma cell response to inhibition of Rac-mediated multicellular invasion.

Camilla B Mitchell, Justine R Stehn, Geraldine M O'Neill

Journal article  |  2018  |  Cytoskeleton

The migration and invasion of cells through tissues in the body is facilitated by a dynamic actin cytoskeleton. The actin-associat..

How does calcium interact with the cytoskeleton to regulate growth cone motility during axon pathfinding?

Robert J Gasperini, Macarena Pavez, Adrian C Thompson, Camilla B Mitchell, Holly Hardy, Kaylene M Young, John K Chilton, Lisa Foa

Journal article  |  2017  |  Molecular and Cellular Neuroscience

The precision with which neurons form connections is crucial for the normal development and function of the nervous system. The de..

Cyclin-dependent kinase 7 is a therapeutic target in high-grade glioma.

SA Greenall, YC Lim, CB Mitchell, KS Ensbey, BW Stringer, AL Wilding, GM O'Neill, KL McDonald, DJ Gough, BW Day, TG Johns

Journal article  |  2017  |  Oncogenesis

High-grade glioma (HGG) is an incurable brain cancer. The transcriptomes of cells within HGG tumors are highly heterogeneous. This..

The focal adhesion targeting domain of p130Cas confers a mechanosensing function

Peta M Bradbury, Kylie Turner, Camilla Mitchell, Kaitlyn R Griffin, Shiloh Middlemiss, Loretta Lau, Rebecca Dagg, Elena Taran, Justin Cooper-White, Ben Fabry, Geraldine M O'Neill

Journal article  |  2017  |  Journal of Cell Science

Members of the Cas family of focal adhesion proteins contain a highly conserved C-terminal focal adhesion targeting (FAT) domain. ..

Rac GTPase regulation of 3D invasion in neuroblastomas lacking MYCN amplification.

Camilla B Mitchell, Geraldine M O'Neill

Journal article  |  2017  |  Cell Adhesion & Migration

Neuroblastomas are highly invasive tumors that occur in pediatric patients and treatment of invasive disease remains a challenge. ..

Cooperative cell invasion: matrix metalloproteinase-mediated incorporation between cells.

Camilla B Mitchell, Geraldine M O'Neill

Journal article  |  2016  |  Molecular Biology of the Cell

Progression to metastatic disease is a leading cause of cancer death. Tumors are a complex mixture of cell types, both genetically..

STIM1 is necessary for store-operated calcium entry in turning growth cones.

Camilla B Mitchell, Robert J Gasperini, David H Small, Lisa Foa

Journal article  |  2012  |  Journal of Neurochemistry

Coordinated calcium signalling is vital for neuronal growth cone function and axon pathfinding. Although store-operated calcium en..