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Dr

Liam Sharkey

Research Officer
Microbiology and Immunology
science & technology
life sciences & biomedicine
microbiology
staphylococcus-aureus
anti-bacterial agents
microbial sensitivity tests
tetracycline resistance
drug resistance, bacterial
binding
Liam Sharkey's Profile Picture
Dr

Liam Sharkey

 
Division
Medicine, Dentistry and Health Sciences
 
Primary Interest
Bacteriology
Liam Sharkey's Profile Picture
Dr

Liam Sharkey

 
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Liam's  Short Profile
 

Projects

Displaying the 1 most recent project by Liam Sharkey.

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Re-sensitising multidrug resistant Staphylococcus aureus to existing antibiotics

2021 - 2021
Active

1

Projects

Project Types

1

Internal Research Grant

Scholarly Works

Displaying the 8 most recent scholarly works by Liam Sharkey.

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Molecular Mechanisms of Antibiotic Resistance - Part II

Liam KR Sharkey, Alex J O'Neill

Book Chapter  |  2020

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Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

Ian R Monk, Nausad Shaikh, Stephanie L Begg, Mike Gajdiss, Liam KR Sharkey, Jean YH Lee, Sacha J Pidot, Torsten Seemann, Michael Kuiper, Brit Winnen, Rikki Hvorup, Brett M Collins, Gabriele Bierbaum, Saumya R Udagedara, Jacqueline R Morey, Neha Pulyani, Benjamin P Howden, Megan J Maher, Christopher A McDevitt, Glenn F King, et al.

Journal article  |  2019  |  NATURE COMMUNICATIONS

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Biosynthesis and Ether-Bridge Formation in Nargenicin Macrolides

Sacha J Pidot, Marion Herisse, Liam Sharkey, Liselle Atkin, Jessica L Porter, Torsten Seemann, Benjamin P Howden, Mark A Rizzacasa, Timothy P Stinear

Journal article  |  2019  |  Angewandte Chemie International Edition

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Biosynthesis and Ether‐Bridge Formation in Nargenicin Macrolides

Sacha J Pidot, Marion Herisse, Liam Sharkey, Liselle Atkin, Jessica L Porter, Torsten Seemann, Benjamin P Howden, Mark A Rizzacasa, Timothy P Stinear

Journal article  |  2019  |  Angewandte Chemie

Abstract: The nargenicin family of antibiotics are macrolides containing a rare ether‐bridged cis‐decalin motif. Several of these ..

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Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

Ian Monk, Nausad Shaikh, Stephanie Begg, Mike Gajdiss, Jean Lee, Sacha Pidot, Torsten Seemann, Michael Kuiper, Brit Winnen, Rikki Hvorup, Brett Collins, Gabriele Bierbaum, Benjamin Howden, Christopher McDevitt, Glenn King, Timothy Stinear

Journal article  |  2018

ABSTRACT WalKR (YycFG) is the only essential two-component regulator in the human pathogen Staphylococcus aureus. WalKR regulates ..

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Antibiotic Resistance ABC-F Proteins: Bringing Target Protection into the Limelight

Liam KR Sharkey, Alex J O'Neill

Journal article  |  2018  |  ACS Infectious Diseases

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1-((2,4-Dichlorophenethyl)Amino)3-Phenoxypropan-2-ol Kills Pseudomonas aeruginosa through Extensive Membrane Damage

Valerie Defraine, Veerle Liebens, Evelien Loos, Toon Swings, Bram Weytjens, Carolina Fierro, Kathleen Marchal, Liam Sharkey, Alex J O'Neill, Romu Corbau, Arnaud Marchand, Patrick Chaltin, Maarten Fauvart, Jan Michiels

Journal article  |  2018  |  Frontiers in Microbiology

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ABC-F Proteins Mediate Antibiotic Resistance through Ribosomal Protection

Liam KR Sharkey, Thomas A Edwards, Alex J O'Neill

Journal article  |  2016  |  mBio

8

Scholarly Works

Keyword Analysis

Clinical Health (organs, Diseases and Abnormal Conditions)
Microbiology
Medical Microbiology

Credentials

Positions

Research Officer

Microbiology and Immunology

Education

Doctor of Philosophy

University of Leeds

Biomedical science research

University of Bristol

Biochemistry

University of Bristol

Links