Han Aw Yeang

Immune molecular profiling of a multiresistant primary prostate cancer with a neuroendocrine-like phenotype: a case report

Scott G Williams, Han Xian Aw Yeang, Catherine Mitchell, Franco Caramia, David J Byrne, Stephen B Fox, Sue Haupt, Ralf B Schittenhelm, Paul J Neeson, Ygal Haupt, Simon P Keam

Journal article  |  2020  |  BMC Urology

BACKGROUND: Understanding the drivers of recurrence in aggressive prostate cancer requires detailed molecular and genomic understa..

High-dimensional analyses reveal a distinct role of T-cell subsets in the immune microenvironment of gastric cancer

Minyu Wang, Yu-Kuan Huang, Joseph CH Kong, Yu Sun, Daniela G Tantalo, Han Xian Aw Yeang, Le Ying, Feng Yan, Dakang Xu, Heloise Halse, Natasha Di Costanzo, Ian R Gordon, Catherine Mitchell, Laura K Mackay, Rita A Busuttil, Paul J Neeson, Alex Boussioutas

Journal article  |  2020  |  Clinical and Translational Immunology

Objectives: To facilitate disease prognosis and improve precise immunotherapy of gastric cancer (GC) patients, a comprehensive stu..

A Distinct Pretreatment Immune Gene Signature in Lentigo Maligna Is Associated with Imiquimod Response

Heloise Halse, Franco Caramia, Catriona A McLean, Minyu Wang, Han Xian Aw Yeang, Simon P Keam, Andreas Behren, Lena Ly, Martin Haskett, Jonathan Cebon, Grant A McArthur, Paul J Neeson, Victoria J Mar

Journal article  |  2020  |  Journal of Investigative Dermatology

Lentigo maligna (LM) is a common subtype of in situ melanoma on chronically sun-exposed skin, particularly the head and neck of ol..

Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK-cell effector function in patients with mantle cell lymphoma

Thijs WH Flinsenberg, Charnelle C Tromedjo, Nan Hu, Ye Liu, Yin Guo, Kevin YT Thia, Tahereh Noori, Xiaomin Song, Han X Aw Yeang, Daniela G Tantalo, Sasanka Handunnetti, John F Seymour, Andrew W Roberts, David Ritchie, Rachel Koldej, Paul J Neeson, Lai Wang, Joseph A Trapani, Constantine S Tam, Ilia Voskoboinik

Journal article  |  2020  |  Haematologica: the hematology journal

Increased and co-localized CD4 FOXP3 and CD8 T cells is a strong independent prognostic indicator in gastric cancer

Minyu Wang, Yu-Kuan Huang, Joe Kong, Yu Sun, Daniela Tantalo, Han Xian Aw Yeang, Le Ying, Feng Yan, Dakang Xu, Heloise Halse, Natasha di Costanzo, Ian Gordon, Catherine Mitchell, Laura Mackay, Rita Busuttil, Paul Neeson, Alex Boussioutas

Conference Proceedings  |  2019  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

Accumulation of CD103( ) CD8( ) T cells in a cutaneous melanoma micrometastasis

Katharina Hochheiser, Han Xian Aw Yeang, Teagan Wagner, Candani Tutuka, Andreas Behren, Jason Waithman, Christopher Angel, Paul J Neeson, Thomas Gebhardt, David E Gyorki

Journal article  |  2019  |  Clinical and Translational Immunology

Objective: The immune system can halt cancer progression by suppressing outgrowth of clinically occult micrometastases in a state ..

Cutting Edge: Human CD49e- NK Cells Are Tissue Resident in the Liver.

Han Xian Aw Yeang, Sytse J Piersma, Yiing Lin, Liping Yang, Olga N Malkova, Cathrine Miner, Alexander S Krupnick, William C Chapman, Wayne M Yokoyama

Journal article  |  2017  |  The Journal of Immunology

Most knowledge on NK cells is based on studies of what are now known as conventional NK cells in the mouse spleen or human periphe..

De novo assembly and transcriptome analysis of Plasmodium gallinaceum identifies the Rh5 interacting protein (ripr), and reveals a lack of EBL and RH gene family diversification

Elvin J Lauron, Han Xian Aw Yeang, Samantha M Taffner, Ravinder NM Sehgal

Journal article  |  2015  |  Malaria Journal

BACKGROUND: Malaria parasites that infect birds can have narrow or broad host-tropisms. These differences in host specificity make..

Heme oxygenase-1 regulates dendritic cell function through modulation of p38 MAPK-CREB/ATF1 signaling.

Laith MA Al-Huseini, Han Xian Aw Yeang, Junnat M Hamdam, Swaminathan Sethu, Naif Alhumeed, Wai Wong, Jean G Sathish

Journal article  |  2014  |  Journal of Biological Chemistry

Dendritic cells (DCs) are critical for the initiation of immune responses including activation of CD8 T cells. Intracellular react..

Nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) modulates dendritic cell immune function through regulation of p38 MAPK-cAMP-responsive element binding protein/activating transcription factor 1 signaling.

Laith MA Al-Huseini, Han Xian Aw Yeang, Swaminathan Sethu, Naif Alhumeed, Junnat M Hamdam, Yulia Tingle, Laiche Djouhri, Neil Kitteringham, B Kevin Park, Christopher E Goldring, Jean G Sathish

Journal article  |  2013  |  Journal of Biological Chemistry

Nrf2 is a redox-responsive transcription factor that has been implicated in the regulation of DC immune function. Loss of Nrf2 res..