Han Aw Yeang

Melanoma brain metastases that progress on BRAF-MEK inhibitors demonstrate resistance to ipilimumab-nivolumab that is associated with the Innate PD-1 Resistance Signature (IPRES)

Peter Kar Han Lau, Breon Feran, Lorey Smith, Arian Lasocki, Ramyar Molania, Kortnye Smith, Alison Weppler, Christopher Angel, Damien Kee, Prachi Bhave, Belinda Lee, Richard J Young, Amir Iravani, Hanxian Aw Yeang, Ismael A Vergara, David Kok, Kate Drummond, Paul Joseph Neeson, Karen E Sheppard, Tony Papenfuss, et al.

Journal article  |  2021  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

BACKGROUND: Melanoma brain metastases (MBMs) are a challenging clinical problem with high morbidity and mortality. Although first-..

Myeloma natural killer cells are exhausted and have impaired regulation of activation

Criselle D'Souza, Simon P Keam, Han Xian Aw Yeang, Michael Neeson, Kelden Richardson, Andy K Hsu, Rachael Canfield, Natalie Bezman, Michael Robbins, Hang Quach, David S Ritchie, Simon J Harrison, Joseph A Trapani, H Miles Prince, Paul A Beavis, Phillip K Darcy, Paul J Neeson

Journal article  |  2021  |  HAEMATOLOGICA

Not available.

Using Mass Cytometry to Analyze the Tumor-Infiltrating Lymphocytes in Human Melanoma

Daniela Tantalo, Nguyen Thu, Han Xian Aw Yeang, Joe Zhu, Sean Macdonald, Minyu Wang, Harini de Silva, Criselle D'Souza, Angela Pizzolla, Paul J Neeson

Journal article  |  2021  |  MELANOMA

Here we describe the application of mass cytometry to analyze tumor-infiltrating lymphocytes in human melanoma. Mass cytometry is ..

Multiplex Immunohistochemistry Analysis of Melanoma Tumor-Infiltrating Lymphocytes

Nguyen Thu, Nikolce Kocovski, Sean Macdonald, Han Xian Aw Yeang, Minyu Wang, Paul J Neeson

Book Chapter  |  2021  |  Methods in Molecular Biology

Tumor-infiltrating lymphocytes (TILs) are an important prognostic indicator in melanoma and play a key role in the patient's respo..

CD8 TISSUE-RESIDENT MEMORY T CELLS ARE TUMOUR REACTIVE AND INCREASE AFTER IMMUNOTHERAPY IN A CASE OF METASTATIC MUCOSAL MELANOMA

Angela Pizzolla, Simon Keam, Ismael Vergara, Franco Caramia, Minyu Wang, Nikolce Kocovski, Nguyen ThuNgoc, Sean Macdonald, Daniela Tantalo, Pasquale Petrone, Han Xian Aw Yeang, David Gyorki, Alison Weppler, George Au-Yeung, Shahneen Sandhu, Maurizio Perdicchio, Grant McArthur, Tony Papenfuss, Paul Neeson

Conference Proceedings  |  2020  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

Background Mucosal melanoma is a rare subtype of melanoma originating from mucosal tissues (1), metastases are very aggressive an..

Immune molecular profiling of a multiresistant primary prostate cancer with a neuroendocrine-like phenotype: a case report

Scott G Williams, Han Xian Aw Yeang, Catherine Mitchell, Franco Caramia, David J Byrne, Stephen B Fox, Sue Haupt, Ralf B Schittenhelm, Paul J Neeson, Ygal Haupt, Simon P Keam

Journal article  |  2020  |  BMC UROLOGY

BACKGROUND: Understanding the drivers of recurrence in aggressive prostate cancer requires detailed molecular and genomic understa..

Progression of BRAF mutant CNS metastases are associated with a transcriptional network bearing similarities with the innate PD-1 resistant signature (IPRES)

PKH Lau, B Feran, L Smith, A Lasocki, R Molania, K Smith, A Weppler, C Angel, D Kee, P Bhave, B Lee, HX Aw Yeang, I Vergara, D Kok, K Drummond, P Neeson, K Sheppard, T Papenfuss, S Sandhu, G McArthur

Conference Proceedings  |  2020  |  ANNALS OF ONCOLOGY

High-dimensional analyses reveal a distinct role of T-cell subsets in the immune microenvironment of gastric cancer

Minyu Wang, Yu-Kuan Huang, Joseph CH Kong, Yu Sun, Daniela G Tantalo, Han Xian Aw Yeang, Le Ying, Feng Yan, Dakang Xu, Heloise Halse, Natasha Di Costanzo, Ian R Gordon, Catherine Mitchell, Laura K Mackay, Rita A Busuttil, Paul J Neeson, Alex Boussioutas

Journal article  |  2020  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

OBJECTIVES: To facilitate disease prognosis and improve precise immunotherapy of gastric cancer (GC) patients, a comprehensive stu..

A Distinct Pretreatment Immune Gene Signature in Lentigo Maligna Is Associated with Imiquimod Response

Heloise Halse, Franco Caramia, Catriona A McLean, Minyu Wang, Han Xian Aw Yeang, Simon P Keam, Andreas Behren, Lena Ly, Martin Haskett, Jonathan Cebon, Grant A McArthur, Paul J Neeson, Victoria J Mar

Journal article  |  2020  |  JOURNAL OF INVESTIGATIVE DERMATOLOGY

Lentigo maligna (LM) is a common subtype of in situ melanoma on chronically sun-exposed skin, particularly the head and neck of ol..

Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK-cell effector function in patients with mantle cell lymphoma

Thijs WH Flinsenberg, Charnelle C Tromedjo, Nan Hu, Ye Liu, Yin Guo, Kevin YT Thia, Tahereh Noori, Xiaomin Song, Han X Aw Yeang, Daniela G Tantalo, Sasanka Handunnetti, John F Seymour, Andrew W Roberts, David Ritchie, Rachel Koldej, Paul J Neeson, Lai Wang, Joseph A Trapani, Constantine S Tam, Ilia Voskoboinik

Journal article  |  2020  |  HAEMATOLOGICA