Stacey Keenan

GIP receptor deletion in mice confers resistance to high-fat diet-induced obesity via alterations in energy expenditure and adipose tissue lipid metabolism

Geke Aline Boer, Stacey N Keenan, Paula M Miotto, Jens Juul Holst, Matthew J Watt

Journal article  |  2021  |  AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucose-dependent insulinotropic polypeptide (GIP) is best known as an incretin hormone that is secreted from K-cells of the proxi..

Circulating cathepsin S improves glycaemic control in mice

Hamzeh Karimkhanloo, Stacey N Keenan, Emily W Sun, David A Wattchow, Damien J Keating, Magdalene K Montgomery, Matthew J Watt

Journal article  |  2021  |  JOURNAL OF ENDOCRINOLOGY

Cathepsin S (CTSS) is a cysteine protease that regulates many physiological processes and is increased in obesity and type 2 diabe..

Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control

Stacey N Keenan, William De Nardo, Jieqiong Lou, Ralf B Schittenhelm, Magdalene K Montgomery, James G Granneman, Elizabeth Hinde, Matthew J Watt

Journal article  |  2021  |  Journal of Lipid Research

Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and..

Impact of human visceral and glutealfemoral adipose tissue transplant on glycemic control in a mouse model of diet-induced obesity

Thomas Tsiloulis, Arthe Raajendiran, Stacey N Keenan, Geraldine Ooi, Renea A Taylor, Paul Burton, Matthew J Watt

Journal article  |  2020  |  AJP Endocrinology and Metabolism

Regional distribution of adipose tissue is an important factor in conferring cardiometabolic risk and obesity-related morbidity. W..

Inter-organelle Communication in the Pathogenesis of Mitochondrial Dysfunction and Insulin Resistance

Stacey N Keenan, Matthew J Watt, Magdalene K Montgomery

Journal article  |  2020  |  Current Diabetes Reports

PURPOSE OF REVIEW: Impairments in mitochondrial function in patients with insulin resistance and type 2 diabetes have been dispute..

The role of Ap2a2 in PPAR alpha-mediated regulation of lipolysis in adipose tissue

Magdalene K Montgomery, Jacqueline Bayliss, Stacey Keenan, Sarah Rhost, Stephen B Ting, Matthew J Watt

Journal article  |  2019  |  The FASEB Journal

Adipose tissue plays a major role in the regulation of systemic metabolic homeostasis, with the AP2 adaptor complex being importan..

Dysferlin deficiency alters lipid metabolism and remodels the skeletal muscle lipidome in mice[S]

Vanessa R Haynes, Stacey N Keenan, Jackie Bayliss, Erin M Lloyd, Peter Meikle, Miranda D Grounds, Matthew J Watt

Journal article  |  2019  |  The Journal of Lipid Research

Defects in the gene coding for dysferlin, a membrane-associated protein, affect many tissues, including skeletal muscles, with a r..

Perilipin 5 deletion in hepatocytes remodels lipid metabolism and causes hepatic insulin resistance in mice

Stacey N Keenan, Ruth C Meex, Jen CY Lo, Magdalene K Montgomery, Matthew J Watt

Journal article  |  2019  |  Obesity Research & Clinical Practice

Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice

Stacey N Keenan, Ruth C Meex, Jennifer CY Lo, Andrew Ryan, Shuai Nie, Magdalene K Montgomery, Matthew J Watt

Journal article  |  2019  |  Diabetes

Defects in hepatic lipid metabolism cause nonalcoholic fatty liver disease and insulin resistance, and these pathologies are close..