Dilrukshi Herath

Assessing the efficacy of albendazole against hookworm in Vietnam using quantitative PCR and sodium nitrate flotation

Clare EF Dyer, Naomi E Clarke, Ng Nguyen Dinh, HMP Dilrukshi Herath, Sze Fui Hii, Russell Pickford, Rebecca J Traub, Susana Vaz Nery

Journal article  |  2022  |  PLOS NEGLECTED TROPICAL DISEASES

Preventive chemotherapy (PC), consisting of the regular distribution of anthelmintics to populations or groups of populations at r..

Whole-organism phenotypic screening methods used in early-phase anthelmintic drug discovery

HMP Dilrukshi Herath, Aya C Taki, Ali Rostami, Abdul Jabbar, Jennifer Keiser, Timothy G Geary, Robin B Gasser

Journal article  |  2022  |  BIOTECHNOLOGY ADVANCES

Diseases caused by parasitic helminths (worms) represent a major global health burden in both humans and animals. As vaccines agai..

Advances in the discovery and development of anthelmintics by harnessing natural product scaffolds

HMP Dilrukshi Herath, Aya C Taki, Brad E Sleebs, Andreas Hofmann, Nghi Nguyen, Sarah Preston, Rohan A Davis, Abdul Jabbar, Robin B Gasser

Journal article  |  2021  |  ADVANCES IN PARASITOLOGY, VOL 111

Widespread resistance to currently-used anthelmintics represents a major obstacle to controlling parasitic nematodes of livestock ..

Synthetic Kavalactone Analogues with Increased Potency and Selective Anthelmintic Activity against Larvae of Haemonchus contortus In Vitro

HMP Dilrukshi Herath, Aya C Taki, Nguyen Nghi, Jose Garcia-Bustos, Andreas Hofmann, Tao Wang, Guangxu Ma, Bill CH Chang, Abdul Jabbar, Brad E Sleebs, Robin B Gasser

Journal article  |  2020  |  MOLECULES

Kava extract, an aqueous rhizome emulsion of the plant Piper methysticum, has been used for centuries by Pacific Islanders as a ce..

A suicide inhibitor of nematode trehalose-6-phosphate phosphatases

Megan Cross, Mark York, Ewa Dlugosz, Jan Hendrik Straub, Sonja Biberacher, HMP Dilrukshi Herath, Stephanie A Logan, Jeong-Sun Kim, Robin B Gasser, John H Ryan, Andreas Hofmann

Journal article  |  2019  |  SCIENTIFIC REPORTS

Protein-based drug discovery strategies have the distinct advantage of providing insights into the molecular mechanisms of chemica..

Identification of Fromiamycalin and Halaminol A from Australian Marine Sponge Extracts with Anthelmintic Activity against Haemonchus contortus

H Herath, Sarah Preston, Abdul Jabbar, Jose Garcia-Bustos, Aya Taki, Russell Addison, Sasha Hayes, Karren Beattie, Sean McGee, Sheree Martin, Merrick Ekins, John Hooper, Bill Chang, Andreas Hofmann, Rohan Davis, Robin Gasser

Journal article  |  2019  |  Marine Drugs

There is an urgent need to discover and develop new anthelmintics for the treatment of parasitic nematodes of veterinary importanc..

DRfit: a Java tool for the analysis of discrete data from multi-well plate assays

Andreas Hofmann, Sarah Preston, Megan Cross, HMP Dilrukshi Herath, Anne Simon, Robin B Gasser

Journal article  |  2019  |  BMC BIOINFORMATICS

BACKGROUND: Analyses of replicates in sets of discrete data, typically acquired in multi-well plate formats, is a recurring task i..

Phenotypic screening of the "Kurz-box' of chemicals identifies two compounds (BLK127 and HBK4) with anthelmintic activity in vitro against parasitic larval stages of Haemonchus contortus

Thuy Nguyen Linh, Thomas Kurz, Sarah Preston, Hjoerdis Brueckmann, Beate Lungerich, HMP Dilrukshi Herath, Anson V Koehler, Tao Wang, Lenka Skalova, Abdul Jabbar, Robin B Gasser

Journal article  |  2019  |  PARASITES & VECTORS

BACKGROUND: Due to anthelmintic resistance problems, there is a need to discover and develop new drugs for the treatment and contr..

Selected alpha-pyrones from the plants Cryptocarya novoguineensis (Lauraceae) and Piper methysticum (Piperaceae) with activity against Haemonchus contortus in vitro

HMP Dilrukshi Herath, Sarah Preston, Abdul Jabbar, Jose Garcia-Bustos, Russell S Addison, Sasha Hayes, Topul Rali, Tao Wang, Anson Koehler, Bill CH Chang, Andreas Hofmann, Rohan A Davis, Robin B Gasser

Journal article  |  2019  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE

Due to the widespread occurrence and spread of anthelmintic resistance, there is a need to develop new drugs against resistant par..

Arylpyrrole and fipronil analogues that inhibit the motility and/or development of Haemonchus contortus in vitro.

HMP Dilrukshi Herath, Hongjian Song, Sarah Preston, Abdul Jabbar, Tao Wang, Sean L McGee, Andreas Hofmann, Jose Garcia-Bustos, Bill CH Chang, Anson V Koehler, Yuxiu Liu, Qiaoqiao Ma, Pengxiang Zhang, Qiqi Zhao, Qingmin Wang, Robin B Gasser

Journal article  |  2018  |  Int J Parasitol Drugs Drug Resist

Due to widespread drug resistance in parasitic nematodes, there is a need to develop new anthelmintics. Given the cost and time in..