Hongwei Qian

Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes

Jonathan R Davey, Emma Estevez, Rachel E Thomson, Martin Whitham, Kevin I Watt, Adam Hagg, Hongwei Qian, Darren C Henstridge, Helen Ludlow, Mark P Hedger, Sean L McGee, Melinda T Coughlan, Mark A Febbraio, Paul Gregorevic

Journal article  |  2020  |  The FASEB Journal

Type 2 diabetes (T2D) manifests from inadequate glucose control due to insulin resistance, hypoinsulinemia, and deteriorating panc..

Activin A-Induced Cachectic Wasting Is Attenuated by Systemic Delivery of Its Cognate Propeptide in Male Mice

Kelly L Walton, Justin L Chen, Quinn Arnold, Emily Kelly, Mylinh La, Louis Lu, George Lovrecz, Adam Hagg, Timothy D Colgan, Hongwei Qian, Paul Gregorevic, Craig A Harrison

Journal article  |  2019  |  Endocrinology

In cancer, elevated activin levels promote cachectic wasting of muscle, irrespective of tumor progression. In excess, activins A a..

Site-Specific Glycation and Chemo-enzymatic Antibody Sortagging for the Retargeting of rAAV6 to Inflamed Endothelium

Hannah A Pearce, Hongwei Qian, Timothy U Connell, Dexing Huang, Claudia Gottstein, Paul S Donnelly, Karlheinz Peter, Paul Gregorevic, Christoph E Hagemeyer

Journal article  |  2019  |  Molecular Therapy - Methods & Clinical Development

Skeletal muscle-specific overexpression of heat shock protein 72 improves skeletal muscle insulin-stimulated glucose uptake but does not alter whole body metabolism

Jessica PS Marshall, Emma Estevez, Helene L Kammoun, Emily J King, Clinton R Bruce, Brian G Drew, Hongwei Qian, Peter Iliades, Paul Gregorevic, Mark A Febbraio, Darren C Henstridge

Journal article  |  2018  |  Diabetes, Obesity and Metabolism

Gene delivery of medium chain acyl-coenzyme A dehydrogenase induces physiological cardiac hypertrophy and protects against pathological remodelling

Bianca C Bernardo, Kate L Weeks, Thawin Pongsukwechkul, Xiaoming Gao, Helen Kiriazis, Nelly Cemerlang, Esther JH Boey, Yow Keat Tham, Chad J Johnson, Hongwei Qian, Xiao-Jun Du, Paul Gregorevic, Julie R McMullen

Journal article  |  2018  |  Clinical Science

Specific targeting of TGF-beta family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease

Justin L Chen, Kelly L Walton, Adam Hagg, Timothy D Colgan, Katharine Johnson, Hongwei Qian, Paul Gregorevic, Craig A Harrison

Journal article  |  2017  |  Proceedings of the National Academy of Sciences

Phosphoinositide 3-kinase (p110 alpha) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic dysfunction

Darnel Prakoso, Miles J De Blasio, Chengxue Qin, Sarah Rosli, Helen Kiriazis, Hongwei Qian, Xiao-Jun Du, Kate L Weeks, Paul Gregorevic, Julie R McMullen, Rebecca H Ritchie

Journal article  |  2017  |  Clinical Science

Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia

Justin L Chen, Kelly L Walton, Hongwei Qian, Timothy D Colgan, Adam Hagg, Matthew J Watt, Craig A Harrison, Paul Gregorevic

Journal article  |  2016  |  Cancer Research

Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

Catherine E Winbanks, Kate T Murphy, Bianca C Bernardo, Hongwei Qian, Yingying Liu, Patricio V Sepulveda, Claudia Beyer, Adam Hagg, Rachel E Thomson, Justin L Chen, Kelly L Walton, Kate L Loveland, Julie R McMullen, Buel D Rodgers, Craig A Harrison, Gordon S Lynch, Paul Gregorevic

Journal article  |  2016  |  Science Translational Medicine

Integrated expression analysis of muscle hypertrophy identifies Asb2 as a negative regulator of muscle mass

Jonathan R Davey, Kevin I Watt, Benjamin L Parker, Rima Chaudhuri, James G Ryall, Louise Cunningham, Hongwei Qian, Vittorio Sartorelli, Marco Sandri, Jeffrey Chamberlain, David E James, Paul Gregorevic

Journal article  |  2016  |  JCI Insight

Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis

Melinda T Coughlan, Gavin C Higgins, Nguyen Tuong-Vi, Sally A Penfold, Vicki Thallas-Bonke, Sih Mm Tan, Georg Ramm, Nicole J Van Bergen, Darren C Henstridge, Karly C Sourris, Brooke E Harcourt, Ian A Trounce, Portia M Robb, Adrienne Laskowski, Sean L McGee, Amanda J Genders, Ken Walder, Brian G Drew, Paul Gregorevic, Hongwei Qian, et al.

Journal article  |  2016  |  Diabetes

Using AAV vectors expressing the beta 2-adrenoceptor or associated G alpha proteins to modulate skeletal muscle mass and muscle fibre size

Adam Hagg, Timothy D Colgan, Rachel E Thomson, Hongwei Qian, Gordon S Lynch, Paul Gregorevic

Journal article  |  2016  |  Scientific Reports

Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy

Patricio V Sepulveda, Severine Lamon, Adam Hagg, Rachel E Thomson, Catherine E Winbanks, Hongwei Qian, Clinton R Bruce, Aaron P Russell, Paul Gregorevic

Journal article  |  2015  |  Scientific Reports

The atypical 'b' splice variant of phospholipase C beta 1 promotes cardiac contractile dysfunction

David R Grubb, Bryony Crook, Yi Ma, Jieting Luo, Hong Wei Qian, Xiao-Ming Gao, Helen Kiriazis, Xiao-Jun Du, Paul Gregorevic, Elizabeth A Woodcock

Journal article  |  2015  |  Journal of Molecular and Cellular Cardiology

Development of Novel Activin-Targeted Therapeutics

Justin L Chen, Kelly L Walton, Sara L Al-Musawi, Emily K Kelly, Hongwei Qian, Mylinh La, Louis Lu, George Lovrecz, Mark Ziemann, Ross Lazarus, Assam El-Osta, Paul Gregorevic, Craig A Harrison

Journal article  |  2015  |  Molecular Therapy

The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size

KI Watt, BJ Turner, A Hagg, X Zhang, JR Davey, H Qian, C Beyer, CE Winbanks, KF Harvey, P Gregorevic

Journal article  |  2015  |  Nature Communications

Elevated expression of activins promotes muscle wasting and cachexia

Justin L Chen, Kelly L Walton, Catherine E Winbanks, Kate T Murphy, Rachel E Thomson, Yogeshwar Makanji, Hongwei Qian, Gordon S Lynch, Craig A Harrison, Paul Gregorevic

Journal article  |  2014  |  FASEB Journal

A functional siRNA screen identifies genes modulating angiotensin II-mediated EGFR transactivation

Amee J George, Brooke W Purdue, Cathryn M Gould, Daniel W Thomas, Yanny Handoko, Hongwei Qian, Gregory A Quaife-Ryan, Kylie A Morgan, Kaylene J Simpson, Walter G Thomas, Ross D Hannan

Journal article  |  2013  |  Journal of Cell Science

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass

Catherine E Winbanks, Justin L Chen, Hongwei Qian, Yingying Liu, Bianca C Bernardo, Claudia Beyer, Kevin I Watt, Rachel E Thomson, Timothy Connor, Bradley J Turner, Julie R McMullen, Lars Larsson, Sean L McGee, Craig A Harrison, Paul Gregorevic

Journal article  |  2013  |  Journal of Cell Biology

miR-206 Represses Hypertrophy of Myogenic Cells but Not Muscle Fibers via Inhibition of HDAC4

Catherine E Winbanks, Claudia Beyer, Adam Hagg, Hongwei Qian, Patricio V Sepulveda, Paul Gregorevic

Journal article  |  2013  |  PLoS One

Transduction of Skeletal Muscles with Common Reporter Genes Can Promote Muscle Fiber Degeneration and Inflammation

Catherine E Winbanks, Claudia Beyer, Hongwei Qian, Paul Gregorevic

Journal article  |  2012  |  PLoS One

Activin Signaling Regulates Sertoli Cell Differentiation and Function

Peter K Nicholls, Peter G Stanton, Justin L Chen, Justine S Olcorn, Jenna T Haverfield, Hongwei Qian, Kelly L Walton, Paul Gregorevic, Craig A Harrison

Journal article  |  2012  |  Endocrinology

Lentiviral transduction of rat Sertoli cells as a means to modify gene expression.

Peter K Nicholls, Peter G Stanton, Katarzyna E Rainczuk, Hongwei Qian, Paul Gregorevic, Craig A Harrison

Journal article  |  2012  |  Spermatogenesis

Primary cell culture is an established and widely used technique to study Sertoli cell function in vitro. However, the relative di..

Phosphoinositide 3-Kinase p110 alpha Is a Master Regulator of Exercise-Induced Cardioprotection and PI3K Gene Therapy Rescues Cardiac Dysfunction

Kate L Weeks, Xiaoming Gao, Xiao-Jun Du, Esther JH Boey, Aya Matsumoto, Bianca C Bernardo, Helen Kiriazis, Nelly Cemerlang, Joon Win Tan, Yow Keat Tham, Thomas F Franke, Hongwei Qian, Marie A Bogoyevitch, Elizabeth A Woodcock, Mark A Febbraio, Paul Gregorevic, Julie R McMullen

Journal article  |  2012  |  Circulation. Heart Failure

Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin

Catherine E Winbanks, Kate L Weeks, Rachel E Thomson, Patricio V Sepulveda, Claudia Beyer, Hongwei Qian, Justin L Chen, James M Allen, Graeme I Lancaster, Mark A Febbraio, Craig A Harrison, Julie R McMullen, Jeffrey S Chamberlain, Paul Gregorevic

Journal article  |  2012  |  Journal of Cell Biology

Heteromerization of angiotensin receptors changes trafficking and arrestin recruitment profiles

Enzo R Porrello, Kevin DG Pfleger, Ruth M Seeber, Hongwei Qian, Cristina Oro, Fe Abogadie, Lea MD Delbridge, Walter G Thomas

Journal article  |  2011  |  Cellular Signaling

Measuring oxidative burden and predicting pharmacological response in coronary artery disease patients with a novel direct activator of haem-free/oxidised sGC.

Ingo Ahrens, Jonathon Habersberger, Nadège Baumlin, Hongwei Qian, Belinda K Smith, Johannes-Peter Stasch, Christoph Bode, Harald HHW Schmidt, Karlheinz Peter

Journal article  |  2011  |  Atherosclerosis

OBJECTIVE: The soluble guanylate cyclase (sGC) activator Cinaciguat (BAY 58-2667) represents a novel class of drugs that selective..

Determination of the Exact Molecular Requirements for Type 1 Angiotensin Receptor Epidermal Growth Factor Receptor Transactivation and Cardiomyocyte Hypertrophy

Nicola J Smith, Hsiu-Wen Chan, Hongwei Qian, Allison M Bourne, Katherine M Hannan, Fiona J Warner, Rebecca H Ritchie, Richard B Pearson, Ross D Hannan, Walter G Thomas

Journal article  |  2011  |  Hypertension

Dissociation of pentameric to monomeric C-reactive protein on activated platelets localizes inflammation to atherosclerotic plaques.

Steffen U Eisenhardt, Jonathon Habersberger, Andrew Murphy, Yung-Chih Chen, Kevin J Woollard, Nicole Bassler, Hongwei Qian, Constantin von Zur Muhlen, Christoph E Hagemeyer, Ingo Ahrens, Jaye Chin-Dusting, Alex Bobik, Karlheinz Peter

Journal article  |  2009  |  Circulation Research

C-reactive protein (CRP) is a predictor of cardiovascular risk. It circulates as a pentamer (pentameric CRP) in plasma. The in viv..

Type 1 angiotensin receptor pharmacology: signaling beyond G proteins.

Cristina Oro, Hongwei Qian, Walter G Thomas

Journal article  |  2007  |  Pharmacology & Therapeutics

Drugs that inhibit the production of angiotensin II (AngII) or its access to the type 1 angiotensin receptor (AT(1)R) are prescrib..

Helix I of beta-arrestin is involved in postendocytic trafficking but is not required for membrane translocation, receptor binding, and internalization.

Diem T Dinh, Hongwei Qian, Ruth Seeber, Esther Lim, Kevin Pfleger, Karin A Eidne, Walter G Thomas

Journal article  |  2005  |  Molecular Pharmacology

beta-Arrestins bind to phosphorylated, seven-transmembrane-spanning, G protein-coupled receptors (GPCRs), including the type 1 ang..

When 6 is 9: 'uncoupled' AT1 receptors turn signalling on its head.

WG Thomas, H Qian, NJ Smith

Journal article  |  2004  |  Cellular and Molecular Life Sciences

The type 1 angiotensin receptor (AT(1)) activates an array of intracellular signalling pathways that control cell and tissue respo..

Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane.

Bruce D Wyse, Ian A Prior, Hongwei Qian, Isabel C Morrow, Susan Nixon, Cornelia Muncke, Teymuras V Kurzchalia, Walter G Thomas, Robert G Parton, John F Hancock

Journal article  |  2003  |  Journal of Biological Chemistry

The mechanisms involved in angiotensin II type 1 receptor (AT1-R) trafficking and membrane localization are largely unknown. In th..

Arresting angiotensin type 1 receptors.

Walter G Thomas, Hongwei Qian

Journal article  |  2003  |  Trends in Endocrinology and Metabolism

The type 1 angiotensin (AT(1)) receptor mediates the homeostatic and pathological actions of the peptide hormone, angiotensin II. ..

Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptors

AC Holloway, HW Qian, L Pipolo, J Ziogas, SI Miura, S Karnik, BR Southwell, MJ Lew, WG Thomas

Journal article  |  2002  |  Molecular Pharmacology

Adenoviral-directed expression of the type 1A angiotensin receptor promotes cardiomyocyte hypertrophy via transactivation of the epidermal growth factor receptor

WG Thomas, Y Brandenburger, DJ Autelitano, T Pham, HW Qian, RD Hannan

Journal article  |  2002  |  Circulation Research

Association of beta-Arrestin 1 with the type 1A angiotensin II receptor involves phosphorylation of the receptor carboxyl terminus and correlates with receptor internalization.

H Qian, L Pipolo, WG Thomas

Journal article  |  2001  |  Molecular Endocrinology

Arrestins bind to phosphorylated G protein-coupled receptors and participate in receptor desensitization and endocytosis. Although..

Casein kinase II sites in the intracellular C-terminal domain of the thyrotropin-releasing hormone receptor and chimeric gonadotropin-releasing hormone receptors contribute to beta-arrestin-dependent internalization.

AC Hanyaloglu, M Vrecl, KM Kroeger, LE Miles, H Qian, WG Thomas, KA Eidne

Journal article  |  2001  |  Journal of Biological Chemistry

We have previously shown that the mammalian gonadotropin-releasing hormone receptor (GnRHR), a unique G-protein-coupled receptor (..

Agonist-induced phosphorylation of the angiotensin II (AT(1A)) receptor requires generation of a conformation that is distinct from the inositol phosphate-signaling state.

WG Thomas, H Qian, CS Chang, S Karnik

Journal article  |  2000  |  Journal of Biological Chemistry

G protein-coupled receptors are thought to isomerize between distinct inactive and active conformations, an idea supported by rece..

Identification of protein kinase C phosphorylation sites in the angiotensin II (AT1A) receptor.

H Qian, L Pipolo, WG Thomas

Journal article  |  1999  |  Biochemical Journal

Protein kinase C (PKC) phosphorylates the C-terminus of the type 1 angiotensin II receptor (AT(1)), although the exact site(s) of ..

Identification of a Ca2 /calmodulin-binding domain within the carboxyl-terminus of the angiotensin II (AT1A) receptor.

WG Thomas, L Pipolo, H Qian

Journal article  |  1999  |  FEBS Letters

To identify regulators of the type 1A angiotensin II receptor (AT1A), we investigated the interaction of cellular proteins with a ..

Induction of micronuclei in V79 cells by fractions of roofing asphalt fume condensate.

H Qian, W Whong, L Olsen, J Nath, T Ong

Journal article  |  1999  |  Mutation Research/Genetic Toxicology and Environmental Mutagenesis

More than 50,000 workers in the United States are exposed to roofing asphalt fumes that may pose genotoxic and potential carcinoge..

Induction of DNA adducts in vivo in rat lung cells by fume condensates of roofing asphalt.

HW Qian, T Ong, J Nath, WZ Whong

Journal article  |  1998  |  Teratogenesis, Carcinogenesis, and Mutagenesis

Many workers in the highway construction and roofing industries are potentially exposed to asphalt fumes. However, little is known..

Detection of genomic instability in lung cancer tissues by random amplified polymorphic DNA analysis.

TM Ong, B Song, HW Qian, ZL Wu, WZ Whong

Journal article  |  1998  |  Carcinogenesis

Genomic instability resulting in multiple mutations is believed to be a driving force in the carcinogenic process. In this study, ..

Induction of micronuclei in cultured mammalian cells by fume condensates of roofing asphalt.

HW Qian, T Ong, WZ Whong

Journal article  |  1996  |  American Journal of Industrial Medicine

A considerable number of workers in the United States are employed in asphalt industries and are potentially exposed to asphalt fu..