Dr Hongwei Qian is a Research Fellow within the Centre for Muscle Research at the University of Melbourne. Hongwei completed his Bachelor of Medicine in Public Health at Shanghai Medical College, Fudan University, China (1984) and then undertook research as a visiting fellow at the National Institute for Occupational Safety and Health (NIOSH), Centre for Disease Control and Prevention (CDC) in the USA (1992-1995) studying molecular mechanisms of chemical carcinogenesis.
Hongwei completed his Ph.D. (1998) in Genetics and Developmental Biology at West Virginia University (USA). His postdoctoral studies took place at the Baker Heart and Diabetes institute (1998-2007), working with Prof. Walter Thomas to assess the molecular activation and deactivation of the angiotensin Type 1 receptor (AT1R). Since 2007 Hongwei has worked under the leadership of A/P Prof Paul Gregorevic, working in the field of viral vector production and is experienced in producing world-class adeno-associated viral and lentiviral vectors.
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Hongwei Qian's highlights
Hongwei Qian's selected work
Activin A-Induced Cachectic Wasting Is Attenuated by Systemic Delivery of Its Cognate Prop..
Site-Specific Glycation and Chemo-enzymatic Antibody Sortagging for the Retargeting of rAA..
Skeletal muscle-specific overexpression of heat shock protein 72 improves skeletal muscle ..
Gene delivery of medium chain acyl-coenzyme A dehydrogenase induces physiological cardiac ..
Specific targeting of TGF-beta family ligands demonstrates distinct roles in the regulatio..
Displaying the 45 most recent scholarly works by Hongwei Qian.
Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes
Jonathan R Davey, Emma Estevez, Rachel E Thomson, Martin Whitham, Kevin I Watt, Adam Hagg, Hongwei Qian, Darren C Henstridge, Helen Ludlow, Mark P Hedger, Sean L McGee, Melinda T Coughlan, Mark A Febbraio, Paul Gregorevic
Journal article | 2020 | The FASEB Journal
Type 2 diabetes (T2D) manifests from inadequate glucose control due to insulin resistance, hypoinsulinemia, and deteriorating panc..
Activin A-Induced Cachectic Wasting Is Attenuated by Systemic Delivery of Its Cognate Propeptide in Male Mice
Kelly L Walton, Justin L Chen, Quinn Arnold, Emily Kelly, Mylinh La, Louis Lu, George Lovrecz, Adam Hagg, Timothy D Colgan, Hongwei Qian, Paul Gregorevic, Craig A Harrison
Journal article | 2019 | Endocrinology
In cancer, elevated activin levels promote cachectic wasting of muscle, irrespective of tumor progression. In excess, activins A a..
Site-Specific Glycation and Chemo-enzymatic Antibody Sortagging for the Retargeting of rAAV6 to Inflamed Endothelium
Hannah A Pearce, Hongwei Qian, Timothy U Connell, Dexing Huang, Claudia Gottstein, Paul S Donnelly, Karlheinz Peter, Paul Gregorevic, Christoph E Hagemeyer
Journal article | 2019 | Molecular Therapy - Methods & Clinical Development
Skeletal muscle-specific overexpression of heat shock protein 72 improves skeletal muscle insulin-stimulated glucose uptake but does not alter whole body metabolism
Jessica PS Marshall, Emma Estevez, Helene L Kammoun, Emily J King, Clinton R Bruce, Brian G Drew, Hongwei Qian, Peter Iliades, Paul Gregorevic, Mark A Febbraio, Darren C Henstridge
Journal article | 2018 | Diabetes, Obesity and Metabolism
Gene delivery of medium chain acyl-coenzyme A dehydrogenase induces physiological cardiac hypertrophy and protects against pathological remodelling
Bianca C Bernardo, Kate L Weeks, Thawin Pongsukwechkul, Xiaoming Gao, Helen Kiriazis, Nelly Cemerlang, Esther JH Boey, Yow Keat Tham, Chad J Johnson, Hongwei Qian, Xiao-Jun Du, Paul Gregorevic, Julie R McMullen
Journal article | 2018 | Clinical Science
Specific targeting of TGF-beta family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease
Justin L Chen, Kelly L Walton, Adam Hagg, Timothy D Colgan, Katharine Johnson, Hongwei Qian, Paul Gregorevic, Craig A Harrison
Journal article | 2017 | Proceedings of the National Academy of Sciences
Phosphoinositide 3-kinase (p110 alpha) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic dysfunction
Darnel Prakoso, Miles J De Blasio, Chengxue Qin, Sarah Rosli, Helen Kiriazis, Hongwei Qian, Xiao-Jun Du, Kate L Weeks, Paul Gregorevic, Julie R McMullen, Rebecca H Ritchie
Journal article | 2017 | Clinical Science
Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice
Catherine E Winbanks, Kate T Murphy, Bianca C Bernardo, Hongwei Qian, Yingying Liu, Patricio V Sepulveda, Claudia Beyer, Adam Hagg, Rachel E Thomson, Justin L Chen, Kelly L Walton, Kate L Loveland, Julie R McMullen, Buel D Rodgers, Craig A Harrison, Gordon S Lynch, Paul Gregorevic
Journal article | 2016 | Science Translational Medicine
Integrated expression analysis of muscle hypertrophy identifies Asb2 as a negative regulator of muscle mass
Jonathan R Davey, Kevin I Watt, Benjamin L Parker, Rima Chaudhuri, James G Ryall, Louise Cunningham, Hongwei Qian, Vittorio Sartorelli, Marco Sandri, Jeffrey Chamberlain, David E James, Paul Gregorevic
Journal article | 2016 | JCI Insight
Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis
Melinda T Coughlan, Gavin C Higgins, Nguyen Tuong-Vi, Sally A Penfold, Vicki Thallas-Bonke, Sih Mm Tan, Georg Ramm, Nicole J Van Bergen, Darren C Henstridge, Karly C Sourris, Brooke E Harcourt, Ian A Trounce, Portia M Robb, Adrienne Laskowski, Sean L McGee, Amanda J Genders, Ken Walder, Brian G Drew, Paul Gregorevic, Hongwei Qian, et al.
Journal article | 2016 | Diabetes
Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy
Patricio V Sepulveda, Severine Lamon, Adam Hagg, Rachel E Thomson, Catherine E Winbanks, Hongwei Qian, Clinton R Bruce, Aaron P Russell, Paul Gregorevic
Journal article | 2015 | Scientific Reports
The atypical 'b' splice variant of phospholipase C beta 1 promotes cardiac contractile dysfunction
David R Grubb, Bryony Crook, Yi Ma, Jieting Luo, Hong Wei Qian, Xiao-Ming Gao, Helen Kiriazis, Xiao-Jun Du, Paul Gregorevic, Elizabeth A Woodcock
Journal article | 2015 | Journal of Molecular and Cellular Cardiology
A functional siRNA screen identifies genes modulating angiotensin II-mediated EGFR transactivation
Amee J George, Brooke W Purdue, Cathryn M Gould, Daniel W Thomas, Yanny Handoko, Hongwei Qian, Gregory A Quaife-Ryan, Kylie A Morgan, Kaylene J Simpson, Walter G Thomas, Ross D Hannan
Journal article | 2013 | Journal of Cell Science
The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass
Catherine E Winbanks, Justin L Chen, Hongwei Qian, Yingying Liu, Bianca C Bernardo, Claudia Beyer, Kevin I Watt, Rachel E Thomson, Timothy Connor, Bradley J Turner, Julie R McMullen, Lars Larsson, Sean L McGee, Craig A Harrison, Paul Gregorevic
Journal article | 2013 | Journal of Cell Biology
Lentiviral transduction of rat Sertoli cells as a means to modify gene expression.
Peter K Nicholls, Peter G Stanton, Katarzyna E Rainczuk, Hongwei Qian, Paul Gregorevic, Craig A Harrison
Journal article | 2012 | Spermatogenesis
Primary cell culture is an established and widely used technique to study Sertoli cell function in vitro. However, the relative di..
Phosphoinositide 3-Kinase p110 alpha Is a Master Regulator of Exercise-Induced Cardioprotection and PI3K Gene Therapy Rescues Cardiac Dysfunction
Kate L Weeks, Xiaoming Gao, Xiao-Jun Du, Esther JH Boey, Aya Matsumoto, Bianca C Bernardo, Helen Kiriazis, Nelly Cemerlang, Joon Win Tan, Yow Keat Tham, Thomas F Franke, Hongwei Qian, Marie A Bogoyevitch, Elizabeth A Woodcock, Mark A Febbraio, Paul Gregorevic, Julie R McMullen
Journal article | 2012 | Circulation. Heart Failure
Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin
Catherine E Winbanks, Kate L Weeks, Rachel E Thomson, Patricio V Sepulveda, Claudia Beyer, Hongwei Qian, Justin L Chen, James M Allen, Graeme I Lancaster, Mark A Febbraio, Craig A Harrison, Julie R McMullen, Jeffrey S Chamberlain, Paul Gregorevic
Journal article | 2012 | Journal of Cell Biology
Measuring oxidative burden and predicting pharmacological response in coronary artery disease patients with a novel direct activator of haem-free/oxidised sGC.
Ingo Ahrens, Jonathon Habersberger, Nadège Baumlin, Hongwei Qian, Belinda K Smith, Johannes-Peter Stasch, Christoph Bode, Harald HHW Schmidt, Karlheinz Peter
Journal article | 2011 | Atherosclerosis
OBJECTIVE: The soluble guanylate cyclase (sGC) activator Cinaciguat (BAY 58-2667) represents a novel class of drugs that selective..
Determination of the Exact Molecular Requirements for Type 1 Angiotensin Receptor Epidermal Growth Factor Receptor Transactivation and Cardiomyocyte Hypertrophy
Nicola J Smith, Hsiu-Wen Chan, Hongwei Qian, Allison M Bourne, Katherine M Hannan, Fiona J Warner, Rebecca H Ritchie, Richard B Pearson, Ross D Hannan, Walter G Thomas
Journal article | 2011 | Hypertension
Dissociation of pentameric to monomeric C-reactive protein on activated platelets localizes inflammation to atherosclerotic plaques.
Steffen U Eisenhardt, Jonathon Habersberger, Andrew Murphy, Yung-Chih Chen, Kevin J Woollard, Nicole Bassler, Hongwei Qian, Constantin von Zur Muhlen, Christoph E Hagemeyer, Ingo Ahrens, Jaye Chin-Dusting, Alex Bobik, Karlheinz Peter
Journal article | 2009 | Circulation Research
C-reactive protein (CRP) is a predictor of cardiovascular risk. It circulates as a pentamer (pentameric CRP) in plasma. The in viv..
Type 1 angiotensin receptor pharmacology: signaling beyond G proteins.
Cristina Oro, Hongwei Qian, Walter G Thomas
Journal article | 2007 | Pharmacology & Therapeutics
Drugs that inhibit the production of angiotensin II (AngII) or its access to the type 1 angiotensin receptor (AT(1)R) are prescrib..
Helix I of beta-arrestin is involved in postendocytic trafficking but is not required for membrane translocation, receptor binding, and internalization.
Diem T Dinh, Hongwei Qian, Ruth Seeber, Esther Lim, Kevin Pfleger, Karin A Eidne, Walter G Thomas
Journal article | 2005 | Molecular Pharmacology
beta-Arrestins bind to phosphorylated, seven-transmembrane-spanning, G protein-coupled receptors (GPCRs), including the type 1 ang..
Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane.
Bruce D Wyse, Ian A Prior, Hongwei Qian, Isabel C Morrow, Susan Nixon, Cornelia Muncke, Teymuras V Kurzchalia, Walter G Thomas, Robert G Parton, John F Hancock
Journal article | 2003 | Journal of Biological Chemistry
The mechanisms involved in angiotensin II type 1 receptor (AT1-R) trafficking and membrane localization are largely unknown. In th..
Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptors
AC Holloway, HW Qian, L Pipolo, J Ziogas, SI Miura, S Karnik, BR Southwell, MJ Lew, WG Thomas
Journal article | 2002 | Molecular Pharmacology
Association of beta-Arrestin 1 with the type 1A angiotensin II receptor involves phosphorylation of the receptor carboxyl terminus and correlates with receptor internalization.
H Qian, L Pipolo, WG Thomas
Journal article | 2001 | Molecular Endocrinology
Arrestins bind to phosphorylated G protein-coupled receptors and participate in receptor desensitization and endocytosis. Although..
Casein kinase II sites in the intracellular C-terminal domain of the thyrotropin-releasing hormone receptor and chimeric gonadotropin-releasing hormone receptors contribute to beta-arrestin-dependent internalization.
AC Hanyaloglu, M Vrecl, KM Kroeger, LE Miles, H Qian, WG Thomas, KA Eidne
Journal article | 2001 | Journal of Biological Chemistry
We have previously shown that the mammalian gonadotropin-releasing hormone receptor (GnRHR), a unique G-protein-coupled receptor (..
Agonist-induced phosphorylation of the angiotensin II (AT(1A)) receptor requires generation of a conformation that is distinct from the inositol phosphate-signaling state.
WG Thomas, H Qian, CS Chang, S Karnik
Journal article | 2000 | Journal of Biological Chemistry
G protein-coupled receptors are thought to isomerize between distinct inactive and active conformations, an idea supported by rece..
Identification of protein kinase C phosphorylation sites in the angiotensin II (AT1A) receptor.
H Qian, L Pipolo, WG Thomas
Journal article | 1999 | Biochemical Journal
Protein kinase C (PKC) phosphorylates the C-terminus of the type 1 angiotensin II receptor (AT(1)), although the exact site(s) of ..
Identification of a Ca2 /calmodulin-binding domain within the carboxyl-terminus of the angiotensin II (AT1A) receptor.
WG Thomas, L Pipolo, H Qian
Journal article | 1999 | FEBS Letters
To identify regulators of the type 1A angiotensin II receptor (AT1A), we investigated the interaction of cellular proteins with a ..
Induction of micronuclei in V79 cells by fractions of roofing asphalt fume condensate.
H Qian, W Whong, L Olsen, J Nath, T Ong
Journal article | 1999 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis
More than 50,000 workers in the United States are exposed to roofing asphalt fumes that may pose genotoxic and potential carcinoge..
Induction of DNA adducts in vivo in rat lung cells by fume condensates of roofing asphalt.
HW Qian, T Ong, J Nath, WZ Whong
Journal article | 1998 | Teratogenesis, Carcinogenesis, and Mutagenesis
Many workers in the highway construction and roofing industries are potentially exposed to asphalt fumes. However, little is known..
Detection of genomic instability in lung cancer tissues by random amplified polymorphic DNA analysis.
TM Ong, B Song, HW Qian, ZL Wu, WZ Whong
Journal article | 1998 | Carcinogenesis
Genomic instability resulting in multiple mutations is believed to be a driving force in the carcinogenic process. In this study, ..
Induction of micronuclei in cultured mammalian cells by fume condensates of roofing asphalt.
HW Qian, T Ong, WZ Whong
Journal article | 1996 | American Journal of Industrial Medicine
A considerable number of workers in the United States are employed in asphalt industries and are potentially exposed to asphalt fu..