Hongwei Qian

Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia.

Roberta Sartori, Adam Hagg, Sandra Zampieri, Andrea Armani, Catherine E Winbanks, Laís R Viana, Mouna Haidar, Kevin I Watt, Hongwei Qian, Camilla Pezzini, Pardis Zanganeh, Bradley J Turner, Anna Larsson, Gianpietro Zanchettin, Elisa S Pierobon, Lucia Moletta, Michele Valmasoni, Alberto Ponzoni, Shady Attar, Gianfranco Da Dalt, et al.

Journal article  |  2021  |  Science Translational Medicine

Most patients with advanced solid cancers exhibit features of cachexia, a debilitating syndrome characterized by progressive loss ..

Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease

K Watt, DC Henstridge, M Ziemann, CB Sim, MK Montgomery, D Samocha-Bonet, BL Parker, GT Dodd, ST Bond, TM Salmi, RS Lee, RE Thomson, A Hagg, JR Davey, H Qian, R Koopman, A El-Osta, JR Greenfield, MJ Watt, MA Febbraio, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Obesity is a major risk factor underlying the development of metabolic disease and a growing public health concern globally. Strat..

Fine-tuning the cardiac O-GlcNAcylation regulatory enzymes governs the functional and structural phenotype of the diabetic heart.

Darnel Prakoso, Shiang Y Lim, Jeffrey R Erickson, Rachel S Wallace, Jarmon G Lees, Mitchel Tate, Helen Kiriazis, Daniel G Donner, Darren C Henstridge, Jonathan R Davey, Hongwei Qian, Minh Deo, Laura J Parry, Amy J Davidoff, Paul Gregorevic, John C Chatham, Miles J De Blasio, Rebecca H Ritchie

Journal article  |  2021  |  Cardiovasc Res

AIMS: The glucose-driven enzymatic modification of myocardial proteins by the sugar moiety, β-N-acetylglucosamine (O-GlcNAc), is i..

Integrated Glycoproteomics Identifies a Role of N-Glycosylation and Galectin-1 on Myogenesis and Muscle Development

Ronnie Blazev, Christopher Ashwood, Jodie L Abrahams, Long H Chung, Deanne Francis, Pengyi Yang, Kevin Watt, Hongwei Qian, Gregory A Quaife-Ryan, James E Hudson, Paul Gregorevic, Morten Thaysen-Andersen, Benjamin L Parker

Journal article  |  2021  |  MOLECULAR & CELLULAR PROTEOMICS

Many cell surface and secreted proteins are modified by the covalent addition of glycans that play an important role in the develo..

TMEPAI/PMEPA1 Is a Positive Regulator of Skeletal Muscle Mass

Adam Hagg, Swati Kharoud, Georgia Goodchild, Craig A Goodman, Justin L Chen, Rachel E Thomson, Hongwei Qian, Paul Gregorevic, Craig A Harrison, Kelly L Walton

Journal article  |  2020  |  FRONTIERS IN PHYSIOLOGY

Inhibition of myostatin- and activin-mediated SMAD2/3 signaling using ligand traps, such as soluble receptors, ligand-targeting pr..

Gene therapy targeting cardiac phosphoinositide 3-kinase (p110 alpha) attenuates cardiac remodeling in type 2 diabetes

Darnel Prakoso, Miles J De Blasio, Mitchel Tate, Helen Kiriazis, Daniel G Donner, Hongwei Qian, David Nash, Minh Deo, Kate L Weeks, Laura J Parry, Paul Gregorevic, Julie R McMullen, Rebecca Helen Ritchie

Journal article  |  2020  |  AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Diabetic cardiomyopathy is a distinct form of heart disease that represents a major cause of death and disability in diabetic pati..

Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes

Jonathan R Davey, Emma Estevez, Rachel E Thomson, Martin Whitham, Kevin I Watt, Adam Hagg, Hongwei Qian, Darren C Henstridge, Helen Ludlow, Mark P Hedger, Sean L McGee, Melinda T Coughlan, Mark A Febbraio, Paul Gregorevic

Journal article  |  2020  |  FASEB JOURNAL

Type 2 diabetes (T2D) manifests from inadequate glucose control due to insulin resistance, hypoinsulinemia, and deteriorating panc..

Activin A-Induced Cachectic Wasting Is Attenuated by Systemic Delivery of Its Cognate Propeptide in Male Mice

Kelly L Walton, Justin L Chen, Quinn Arnold, Emily Kelly, Mylinh La, Louis Lu, George Lovrecz, Adam Hagg, Timothy D Colgan, Hongwei Qian, Paul Gregorevic, Craig A Harrison

Journal article  |  2019  |  ENDOCRINOLOGY

In cancer, elevated activin levels promote cachectic wasting of muscle, irrespective of tumor progression. In excess, activins A a..

Site-Specific Glycation and Chemo-enzymatic Antibody Sortagging for the Retargeting of rAAV6 to Inflamed Endothelium

Hannah A Pearce, Hongwei Qian, Timothy U Connell, Dexing Huang, Claudia Gottstein, Paul S Donnelly, Karlheinz Peter, Paul Gregorevic, Christoph E Hagemeyer

Journal article  |  2019  |  MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT

Gene therapy holds great potential for conditions such as cardiovascular disease, including atherosclerosis and also vascular canc..

Skeletal muscle-specific overexpression of heat shock protein 72 improves skeletal muscle insulin-stimulated glucose uptake but does not alter whole body metabolism

Jessica PS Marshall, Emma Estevez, Helene L Kammoun, Emily J King, Clinton R Bruce, Brian G Drew, Hongwei Qian, Peter Iliades, Paul Gregorevic, Mark A Febbraio, Darren C Henstridge

Journal article  |  2018  |  DIABETES OBESITY & METABOLISM

AIMS: The induction of heat shock protein 72 (Hsp72) via heating, genetic manipulation or pharmacological activation is metabolica..