Andrew Sutherland

Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD mice

Satoru Akazawa, Leanne Mackin, Gaurang Jhala, Stacey Fynch, Tara Catterall, Claudia Selck, Kate L Graham, Balasubramanian Krishnamurthy, Evan G Pappas, Chun-Ting J Kwong, Andrew PR Sutherland, Thomas WH Kay, Thomas C Brodnicki, Helen E Thomas

Journal article  |  2021  |  DIABETOLOGIA

AIMS/HYPOTHESIS: Stimulator of IFN genes (STING) is a central hub for cytosolic nucleic acid sensing and its activation results in..

IL-17F induces inflammation, dysfunction and cell death in mouse islets

Tara Catterall, Stacey Fynch, Thomas WH Kay, Helen E Thomas, Andrew PR Sutherland

Journal article  |  2020  |  SCIENTIFIC REPORTS

Type 17 immune responses, typified by the production of the cytokines IL-17A and IL-17F, have been implicated in the development o..

IL-21 regulates SOCS1 expression in autoreactive CD8( ) T cells but is not required for acquisition of CTL activity in the islets of non-obese diabetic mice

Andrew PR Sutherland, Kate L Graham, Michelle Papadimitriou, Gaurang Jhala, Prerak Trivedi, Tara Catterall, Stacey Fynch, Thomas WH Kay, Helen E Thomas

Journal article  |  2019  |  SCIENTIFIC REPORTS

In type 1 diabetes, maturation of activated autoreactive CD8+ T cells to fully armed effector cytotoxic T lymphocytes (CTL) occurs..

Replacing murine insulin 1 with human insulin protects NOD mice from diabetes.

Colleen M Elso, Nicholas A Scott, Lina Mariana, Emma I Masterman, Andrew PR Sutherland, Helen E Thomas, Stuart I Mannering

Journal article  |  2019  |  PLoS One

Type 1, or autoimmune, diabetes is caused by the T-cell mediated destruction of the insulin-producing pancreatic beta cells. Non-o..

Differential regulation of pro-inflammatory cytokine signalling by protein tyrosine phosphatases in pancreatic beta-cells

William J Stanley, Prerak M Trivedi, Andrew P Sutherland, Helen E Thomas, Esteban N Gurzov

Journal article  |  2017  |  JOURNAL OF MOLECULAR ENDOCRINOLOGY

Type 1 diabetes (T1D) is characterized by the destruction of insulin-producing β-cells by immune cells in the pancreas. Pro-inflam..

Linking obesity with type 2 diabetes: the role of T-bet

Jibran A Wali, Helen E Thomas, Andrew PR Sutherland

Journal article  |  2014  |  DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY

Obesity is a major predisposing factor for the development of type 2 diabetes (T2D) and is an escalating public health issue aroun..

IL-21 Promotes CD8( ) CTL Activity via the Transcription Factor T-bet

Andrew PR Sutherland, Nicole Joller, Monia Michaud, Sue M Liu, Vijay K Kuchroo, Michael J Grusby

Journal article  |  2013  |  JOURNAL OF IMMUNOLOGY

CD8(+) T cells are fundamental for immune-mediated clearance of viral infections and contribute to immune pathology in autoimmune ..

Type-I IFN drives the differentiation of short-lived effector CD8( ) T cells in vivo

Melanie Wiesel, Josh Crouse, Gregor Bedenikovic, Andrew Sutherland, Nicole Joller, Annette Oxenius

Journal article  |  2012  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Two subsets of CD8(+) T cells are generated early during an immune response; one of these subsets forms the memory pool, known as ..

Overexpression of the CTLA-4 Isoform Lacking Exons 2 and 3 Causes Autoimmunity

Sue M Liu, Andrew PR Sutherland, Zheng Zhang, Daniel B Rainbow, Francisco J Quintana, Alison M Paterson, Arlene H Sharpe, Mohamed Oukka, Linda S Wicker, Vijay K Kuchroo

Journal article  |  2012  |  JOURNAL OF IMMUNOLOGY

CTLA-4 is a potent inhibitor of T cell activation, primarily upon binding to its costimulatory ligands (B7.1 and B7.2) expressed o..

Zinc Finger Protein Zbtb20 Is Essential for Postnatal Survival and Glucose Homeostasis

Andrew PR Sutherland, Hai Zhang, Ye Zhang, Monia Michaud, Zhifang Xie, Mary-Elizabeth Patti, Michael J Grusby, Weiping J Zhang

Journal article  |  2009  |  MOLECULAR AND CELLULAR BIOLOGY

Zbtb20 is a member of the POK family of proteins, which function primarily as transcriptional repressors via interactions mediated..