Maria Daglas

Deferiprone attenuates neuropathology and improves outcome following traumatic brain injury

Maria Daglas, Phan H Truong, Linh Q Miles, Sydney MA Juan, Shalini S Rao, Paul A Adlard

Journal article  |  2022  |  BRITISH JOURNAL OF PHARMACOLOGY

BACKGROUND AND PURPOSE: Traumatic brain injury (TBI) remains a leading cause of mortality and morbidity in young adults. The role ..

Altered amyloid precursor protein, tau-regulatory proteins, neuronal numbers and behaviour, but no tau pathology, synaptic and inflammatory changes or memory deficits, at 1 month following repetitive mild traumatic brain injury

Sydney MA Juan, Maria Daglas, Paul A Adlard

Journal article  |  2022  |  EUROPEAN JOURNAL OF NEUROSCIENCE

Repetitive mild traumatic brain injury, commonly experienced following sports injuries, results in various secondary injury proces..

Tau Pathology, Metal Dyshomeostasis and Repetitive Mild Traumatic Brain Injury: An Unexplored Link Paving the Way for Neurodegeneration

Sydney MA Juan, Maria Daglas, Paul A Adlard

Journal article  |  2022  |  JOURNAL OF NEUROTRAUMA

Repetitive mild traumatic brain injury (r-mTBI), commonly experienced by athletes and military personnel, causes changes in multip..

Chapter 13 The adaptive immune system in traumatic brain injury: A focus on T and B lymphocytes

Maria Daglas, Robert Lindsay Medcalf, Maithili Sashindranath

Book Chapter  |  2022

The adaptive immune system in traumatic brain injury: A focus on T and B lymphocytes

Maria Daglas, Robert Lindsay Medcalf, Maithili Sashindranath

Book Chapter  |  2022

Sex-dependent effects of tranexamic acid on blood-brain barrier permeability and the immune response following traumatic brain injury in mice

Maria Daglas, Adam Galle, Dominik F Draxler, Heidi Ho, Zikou Liu, Maithili Sashindranath, Robert L Medcalf

Journal article  |  2020  |  JOURNAL OF THROMBOSIS AND HAEMOSTASIS

BACKGROUND: Tranexamic acid (TXA) is an anti-fibrinolytic agent used to reduce bleeding in various conditions including traumatic ..

Activated CD8( ) T Cells Cause Long-Term Neurological Impairment after Traumatic Brain Injury in Mice

Maria Daglas, Dominik F Draxler, Heidi Ho, Fiona McCutcheon, Adam Galle, Amanda E Au, Pia Larsson, Julia Gregory, Frank Alderuccio, Maithili Sashindranath, Robert L Medcalf

Journal article  |  2019  |  CELL REPORTS

Traumatic brain injury (TBI) leaves many survivors with long-term disabilities. A prolonged immune response in the brain may cause..

Tranexamic acid modulates the cellular immune profile after traumatic brain injury in mice without hyperfibrinolysis

Dominik F Draxler, Maria Daglas, Anushka Fernando, Gryselda Hanafi, Fiona McCutcheon, Heidi Ho, Adam Galle, Julia Gregory, Pia Larsson, Charithani Keragala, David K Wright, Elnaz Tavancheh, Amanda E Au, Be'eri Niego, Kirsty Wilson, Magdalena Plebanski, Maithili Sashindranath, Robert L Medcalf

Journal article  |  2019  |  JOURNAL OF THROMBOSIS AND HAEMOSTASIS

BACKGROUND: Traumatic brain injury (TBI) is known to promote immunosuppression, making patients more susceptible to infection, yet..

Tranexamic Acid Influences the Immune Response, but not Bacterial Clearance in a Model of Post-Traumatic Brain Injury Pneumonia

Dominik F Draxler, Milena M Awad, Gryselda Hanafi, Maria Daglas, Heidi Ho, Charithani Keragala, Adam Galle, Antoine Roquilly, Dena Lyras, Maithili Sashindranath, Robert L Medcalf

Journal article  |  2019  |  JOURNAL OF NEUROTRAUMA

The antifibrinolytic agent, tranexamic acid (TXA), an inhibitor of plasmin formation, currently is evaluated to reduce bleeding in..

Tranexamic acid modulates the immune response and reduces postsurgical infection rates

Dominik F Draxler, Kah Yep, Gryselda Hanafi, Anoushka Winton, Maria Daglas, Heidi Ho, Maithili Sashindranath, Lisa M Wutzlhofer, Andrew Forbes, Isaac Goncalves, Huyen A Tran, Sophia Wallace, Magdalena Plebanski, Paul S Myles, Robert L Medcalf

Journal article  |  2019  |  BLOOD ADVANCES

Tranexamic acid (TXA) is an antifibrinolytic agent that blocks plasmin formation. Because plasmin is known to promote inflammatory..