Boris Novakovic

Trained immunity, tolerance, priming and differentiation: distinct immunological processes

Maziar Divangahi, Peter Aaby, Shabaana Abdul Khader, Luis B Barreiro, Siroon Bekkering, Triantafyllos Chavakis, Reinout van Crevel, Nigel Curtis, Andrew R DiNardo, Jorge Dominguez-Andres, Raphael Duivenwoorden, Stephanie Fanucchi, Zahi Fayad, Elaine Fuchs, Melanie Hamon, Kate L Jeffrey, Nargis Khan, Leo AB Joosten, Eva Kaufmann, Eicke Latz, et al.

Journal article  |  2021  |  NATURE IMMUNOLOGY

Determinants of placental leptin receptor gene expression and association with measures at birth

Amanda Vlahos, Toby Mansell, David Burgner, Fiona Collier, Boris Novakovic, Richard Saffery

Journal article  |  2020  |  PLACENTA

INTRODUCTION: The leptin signalling pathway is important in metabolic health during pregnancy. However, few studies have investiga..

Hyper-Inflammatory Monocyte Activation Following Endotoxin Exposure in Food Allergic Infants

Melanie R Neeland, Boris Novakovic, Thanh D Dang, Kirsten P Perrett, Jennifer J Koplin, Richard Saffery

Journal article  |  2020  |  FRONTIERS IN IMMUNOLOGY

Several recent studies have reported a key role for innate cell hyper-responsiveness in food allergy. This has predominantly been ..

Sex matters: XIST and DDX3Y gene expression as a tool to determine fetal sex in human first trimester placenta

Denise Hoch, Boris Novakovic, Silvija Cvitic, Richard Saffery, Gernot Desoye, Alejandro Majali-Martinez

Journal article  |  2020  |  PLACENTA

Fetal sex influences placental function as well as maternal and fetal health, being an important factor to consider in pregnancy s..

A Potential Role for Epigenetically Mediated Trained Immunity in Food Allergy

Samira Imran, Melanie R Neeland, Rebecca Shepherd, Nicole Messina, Kirsten P Perrett, Mihai G Netea, Nigel Curtis, Richard Saffery, Boris Novakovic

Journal article  |  2020  |  ISCIENCE

The prevalence of IgE-mediated food allergy is increasing at a rapid pace in many countries. The association of high food allergy ..

β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1.

Simone JCFM Moorlag, Nargis Khan, Boris Novakovic, Eva Kaufmann, Trees Jansen, Reinout van Crevel, Maziar Divangahi, Mihai G Netea

Journal article  |  2020  |  Cell Rep

β-glucan is a potent inducer of epigenetic and functional reprogramming of innate immune cells, a process called "trained immunity..

Maternal Obesity Alters Placental Cell Cycle Regulators in the First Trimester of Human Pregnancy: New Insights for BRCA1

Denise Hoch, Martina Bachbauer, Caroline Poechlauer, Francisco Algaba-Chueca, Veronika Tandl, Boris Novakovic, Ana Megia, Martin Gauster, Richard Saffery, Andreas Glasner, Gernot Desoye, Alejandro Majali-Martinez

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In the first trimester of pregnancy, placental development involves a wide range of cellular processes. These include trophoblast ..

The emerging role of epigenetics in the immune response to vaccination and infection: a systematic review

Samantha Bannister, Nicole L Messina, Boris Novakovic, Nigel Curtis

Journal article  |  2020  |  EPIGENETICS

Extensive research has highlighted the role of infection-induced epigenetic events in the development of cancer. More recently, at..

Inhibition of Histone Demethylases LSD1 and UTX Regulates ERα Signaling in Breast Cancer.

Rosaria Benedetti, Carmela Dell'Aversana, Tommaso De Marchi, Dante Rotili, Ning Qing Liu, Boris Novakovic, Serena Boccella, Salvatore Di Maro, Sandro Cosconati, Alfonso Baldi, Emma Niméus, Johan Schultz, Urban Höglund, Sabatino Maione, Chiara Papulino, Ugo Chianese, Francesco Iovino, Antonio Federico, Antonello Mai, Hendrik G Stunnenberg, et al.

Journal article  |  2019  |  Cancers (Basel)

In breast cancer, Lysine-specific demethylase-1 (LSD1) and other lysine demethylases (KDMs), such as Lysine-specific demethylase 6..

Diabetes in pregnancy and epigenetic mechanisms-how the first 9 months from conception might affect the child' s epigenome and later risk of disease

Line Hjort, Boris Novakovic, Louise G Grunnet, Louise Maple-Brown, Peter Damm, Gernot Desoye, Richard Saffery

Journal article  |  2019  |  LANCET DIABETES & ENDOCRINOLOGY

Diabetes in pregnancy is not only associated with increased risk of pregnancy complications and subsequent maternal metabolic dise..