John Savill

Apoptotic Cell-Directed Resolution of Lung Inflammation Requires Myeloid αv Integrin-Mediated Induction of Regulatory T Lymphocytes.

Ailiang Zhang, Adam Lacy-Hulbert, Stephen Anderton, Christopher Haslett, John Savill

Journal article  |  2020  |  Am J Pathol

Intratracheal instillation of apoptotic cells enhances resolution of experimental lung inflammation by incompletely understood mec..

Apoptotic cells induce CD103 expression and immunoregulatory function in myeloid dendritic cell precursors through integrin αv and TGF-β activation.

Ailiang Zhang, Helena Paidassi, Adam Lacy-Hulbert, John Savill

Journal article  |  2020  |  PLoS One

In the mammalian gut CD103+ve myeloid DCs are known to suppress inflammation threatened by luminal bacteria, but stimuli driving D..

Exposure to the antimicrobial peptide LL-37 produces dendritic cells optimized for immunotherapy

Emily Gwyer Findlay, Andrew J Currie, Ailiang Zhang, Jana Ovciarikova, Lisa Young, Holly Stevens, Brian J McHugh, Marta Canel, Mohini Gray, Simon WF Milling, John DM Campbell, John Savill, Alan Serrels, Donald J Davidson

Journal article  |  2019  |  ONCOIMMUNOLOGY

Immunization of patients with autologous, ex vivo matured dendritic cell (DC) preparations, in order to prime antitumor T-cell res..

Granulocyte macrophage-colony stimulating factor: A key modulator of renal mononuclear phagocyte plasticity

Katie J Mylonas, Jennifer Anderson, Tara A Sheldrake, Emily E Hesketh, James A Richards, David A Ferenbach, David C Kluth, John Savill, Jeremy Hughes

Journal article  |  2019  |  IMMUNOBIOLOGY

Macrophage-colony stimulating factor (M-CSF) and granulocyte macrophage-colony stimulating factor (GM-CSF) play key roles in the d..

beta 8 Integrin Expression and Activation of TGF-beta by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage

Mathilde Boucard-Jourdin, David Kugler, Marie-Laure Endale Ahanda, Sebastien This, Jaime De Calisto, Ailiang Zhang, J Rodrigo Mora, Lynda M Stuart, John Savill, Adam Lacy-Hulbert, Helena Paidassi

Journal article  |  2016  |  JOURNAL OF IMMUNOLOGY

Activation of TGF-β by dendritic cells (DCs) expressing αvβ8 integrin is essential for the generation of intestinal regulatory T c..

11β-Hydroxysteroid Dehydrogenase Type 1 Is Expressed in Neutrophils and Restrains an Inflammatory Response in Male Mice.

Agnes E Coutinho, Tiina MJ Kipari, Zhenguang Zhang, Cristina L Esteves, Christopher D Lucas, James S Gilmour, Scott P Webster, Brian R Walker, Jeremy Hughes, John S Savill, Jonathan R Seckl, Adriano G Rossi, Karen E Chapman

Journal article  |  2016  |  Endocrinology

Endogenous glucocorticoid action within cells is enhanced by prereceptor metabolism by 11β-hydroxysteroid dehydrogenase type 1 (11..

alpha v Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells

Mridu Acharya, Anna Sokolovska, Jenny M Tam, Kara L Conway, Caroline Stefani, Fiona Raso, Subhankar Mukhopadhyay, Marianela Feliu, Elahna Paul, John Savill, Richard O Hynes, Ramnik J Xavier, Jatin M Vyas, Lynda M Stuart, Adam Lacy-Hulbert

Journal article  |  2016  |  NATURE COMMUNICATIONS

Integrin signalling triggers cytoskeletal rearrangements, including endocytosis and exocytosis of integrins and other membrane pro..

A NEW PRINT BMJ FOR ALL UK DOCTORS Low priority given to original research in the new print version of The BMJ

John Savill

Journal article  |  2015  |  BMJ-BRITISH MEDICAL JOURNAL

SUGAR'S WEB OF INFLUENCE Scientist-industry partnerships do not constitute a "tangled web"

John Savill

Journal article  |  2015  |  BMJ-BRITISH MEDICAL JOURNAL

UK funders' framework for health-related findings in research

Jeremy Farrar, John Savill

Journal article  |  2014  |  LANCET