Christopher McDevitt

Structure and Metal Binding Properties of Chlamydia trachomatis YtgA

Zhenyao Luo, Stephanie L Neville, Rebecca Campbell, Jacqueline R Morey, Shruti Menon, Mark Thomas, Bart A Eijkelkamp, Miranda P Ween, Wilhelmina M Huston, Bostjan Kobe, Christopher A McDevitt

Journal article  |  2020  |  Journal of Bacteriology

The obligate intracellular pathogen Chlamydia trachomatis is a globally significant cause of sexually transmitted bacterial infect..

The Role of Zinc Efflux during Acinetobacter baumannii Infection.

Saleh F Alquethamy, Felise G Adams, Varsha Naidu, Marjan Khorvash, Victoria G Pederick, Maoge Zang, James C Paton, Ian T Paulsen, Karl A Hassan, Amy K Cain, Christopher A McDevitt, Bart A Eijkelkamp

Journal article  |  2019  |  ACS Infectious Diseases

Acinetobacter baumannii is a ubiquitous Gram-negative bacterium, that is associated with significant disease in immunocompromised ..

Dietary zinc and the control of Streptococcus pneumoniae infection

Bart A Eijkelkamp, Jacqueline R Morey, Stephanie L Neville, Aimee Tan, Victoria G Pederick, Nerida Cole, Prashina P Singh, Cheryl-Lynn Y Ong, Raquel Gonzalez de Vega, David Clases, Bliss A Cunningham, Catherine E Hughes, Iain Comerford, Erin B Brazel, Jonathan J Whittall, Charles D Plumptre, Shaun R McColl, James C Paton, Alastair G McEwan, Philip A Doble, et al.

Journal article  |  2019  |  PLOS Pathogens

Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

Ian R Monk, Nausad Shaikh, Stephanie L Begg, Mike Gajdiss, Liam KR Sharkey, Jean YH Lee, Sacha J Pidot, Torsten Seemann, Michael Kuiper, Brit Winnen, Rikki Hvorup, Brett M Collins, Gabriele Bierbaum, Saumya R Udagedara, Jacqueline R Morey, Neha Pulyani, Benjamin P Howden, Megan J Maher, Christopher A McDevitt, Glenn F King, et al.

Journal article  |  2019  |  Nature Communications

Cr-Ag coatings: synthesis, microstructure and antimicrobial properties

Afshin Karami, Hu Zhang, Victoria G Pederick, Christopher A McDevitt, Mohammad Sharear Kabir, Song Xu, Paul Munroe, Zhifeng Zhou, Zonghan Xie

Journal article  |  2019  |  Surface Engineering

Defining the Role of the Streptococcus agalactiae Sht-Family Proteins in Zinc Acquisition and Complement Evasion

P Moulin, V Rong, A Ribeiro E Silva, VG Pederick, E Camlade, L Mereghetti, CA McDevitt, A Hiron

Journal article  |  2019  |  Journal of Bacteriology

Conformational and dynamic plasticity in substrate-binding proteins underlies selective transport in ABC importers

Marijn de Boer, Giorgos Gouridis, Ruslan Vietrov, Stephanie L Begg, Gea K Schuurman-Wolters, Florence Husada, Nikolaos Eleftheriadis, Bert Poolman, Christopher A McDevit, Thorben Cordes

Journal article  |  2019  |  eLife

The Role of the CopA Copper Efflux System in Acinetobacter baumannii Virulence

Saleh F Alquethamy, Marjan Khorvash, Victoria G Pederick, Jonathan J Whittall, James C Paton, Ian T Paulsen, Karl A Hassan, Christopher A McDevitt, Bart A Eijkelkamp

Journal article  |  2019  |  International Journal of Molecular Sciences

The structure and activity of the glutathione reductase from Streptococcus pneumoniae

Mwilye Sikanyika, David Aragao, Christopher A McDevitt, Megan J Maher

Journal article  |  2019  |  Acta Crystallographica Section F Structural Biology Communications

Synergy between Nutritional Immunity and Independent Host Defenses Contributes to the Importance of the MntABC Manganese Transporter during Staphylococcus aureus Infection

Jana N Radin, Jamie Zhu, Erin B Brazel, Christopher A McDevitt, Thomas E Kehl-Fie

Journal article  |  2019  |  Infection and Immunity

Identification of Novel Acinetobacter baumannii Host Fatty Acid Stress Adaptation Strategies

Jhih-Hang Jiang, Karl A Hassan, Stephanie L Begg, Thusitha WT Rupasinghe, Varsha Naidu, Victoria G Pederick, Marjan Khorvash, Jonathan J Whittall, James C Paton, Ian T Paulsen, Christopher A McDevitt, Anton Y Peleg, Bart A Eijkelkamp

Journal article  |  2019  |  mBio

A Liposomal Platform for Sensing of Extracellular Analytes Near Cells

Xiaozhou Zhang, Sabrina Heng, Jinxin Pei, Jacqueline R Morey, Christopher A McDevitt, Andrew D Abell

Journal article  |  2018  |  Biosensors

Chemical Synergy between lonophore PBT2 and Zinc Reverses Antibiotic Resistance

Lisa Bohlmann, David MP De Oliveira, Ibrahim M El-Deeb, Erin B Brazel, Nichaela Harbison-Price, Cheryl-Iynn Y Ong, Tania Rivera-Hernandez, Scott A Ferguson, Amanda J Cork, Phan Minh-Duy, Amelia T Soderholm, Mark R Davies, Graeme R Nimmo, Gordon Dougan, Mark A Schembri, Gregory M Cook, Alastair G McEwan, Mark von Itzstein, Christopher A McDevitt, Mark J Walker

Journal article  |  2018  |  mBio

Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

Ian Monk, Nausad Shaikh, Stephanie Begg, Mike Gajdiss, Jean Lee, Sacha Pidot, Torsten Seemann, Michael Kuiper, Brit Winnen, Rikki Hvorup, Brett Collins, Gabriele Bierbaum, Benjamin Howden, Christopher McDevitt, Glenn King, Timothy Stinear

Journal article  |  2018

ABSTRACT WalKR (YycFG) is the only essential two-component regulator in the human pathogen Staphylococcus aureus. WalKR regulates ..

Exploring the Use of Structure and Polymer Incorporation to Tune Silver Ion Release and Antibacterial Activity of Silver Coordination Polymers

Rosemary J Young, Stephanie L Begg, Campbell J Coghlan, Christopher A McDevitt, Christopher J Sumby

Journal article  |  2018  |  European Journal of Inorganic Chemistry

Antimicrobial Susceptibility of Escherichia coli and Salmonella spp. Isolates From Healthy Pigs in Australia: Results of a Pilot National Survey

Amanda K Kidsley, Sam Abraham, Jan M Bell, Mark O'Dea, Tanya J Laird, David Jordan, Pat Mitchell, Christopher A McDevitt, Darren J Trott

Journal article  |  2018  |  Frontiers in Microbiology

Structural characterisation of the HT3 motif of the polyhistidine triad protein D from Streptococcus pneumoniae

Zhenyao Luo, Victoria G Pederick, James C Paton, Christopher A McDevitt, Bostjan Kobe

Journal article  |  2018  |  FEBS Letters

Arachidonic Acid Stress Impacts Pneumococcal Fatty Acid Homeostasis

Bart A Eijkelkamp, Stephanie L Begg, Victoria G Pederick, Claudia Trapetti, Melissa K Gregory, Jonathan J Whittall, James C Paton, Christopher A McDevitt

Journal article  |  2018  |  Frontiers in Microbiology

Biotin-mediated growth and gene expression in Staphylococcus aureus is highly responsive to environmental biotin

Jiulia Satiaputra, Bart A Eijkelkamp, Christopher A McDevitt, Keith E Shearwin, Grant W Booker, Steven W Polyak

Journal article  |  2018  |  Applied Microbiology and Biotechnology

An optimized SEC-SAXS system enabling high X-ray dose for rapid SAXS assessment with correlated UV measurements for biomolecular structure analysis

Timothy M Ryan, Jill Trewhella, James M Murphy, Jeremy R Keown, Lachlan Casey, F Grant Pearce, David C Goldstone, Kelan Chen, Zhenyao Luo, Bostjan Kobe, Christopher A McDevitt, Serena A Watkin, Adrian M Hawley, Stephen T Mudie, Vesna Samardzic Boban, Nigel Kirby

Journal article  |  2018  |  Journal of Applied Crystallography

Genome-Wide Mutagenesis of Dengue Virus Reveals Plasticity of the NS1 Protein and Enables Generation of Infectious Tagged Reporter Viruses

Nicholas S Eyre, Stephen M Johnson, Auda A Eltahla, Maria Aloi, Amanda L Aloia, Christopher A McDevitt, Rowena A Bull, Michael R Beard

Journal article  |  2017  |  Journal of Virology

The Metallophore Staphylopine Enables Staphylococcus aureus To Compete with the Host for Zinc and Overcome Nutritional Immunity

Kyle P Grim, Brian San Francisco, Jana N Radin, Erin B Brazel, Jessica L Kelliher, Paola K Parraga Solorzano, Philip C Kim, Christopher A McDevitt, Thomas E Kehl-Fie

Journal article  |  2017  |  mBio

The zinc efflux activator SczA protects Streptococcus pneumoniae serotype 2 D39 from intracellular zinc toxicity

Julia E Martin, Katherine A Edmonds, Kevin E Bruce, Gregory C Campanello, Bart A Eijkelkamp, Erin B Brazel, Christopher A McDevitt, Malcolm E Winkler, David P Giedroc

Journal article  |  2017  |  Molecular Microbiology

Zinc stress induces copper depletion in Acinetobacter baumannii

Karl A Hassan, Victoria G Pederick, Liam DH Elbourne, Ian T Paulsen, James C Paton, Christopher A McDevitt, Bart A Eijkelkamp

Journal article  |  2017  |  BMC Microbiology

Autoinducer 2 Signaling via the Phosphotransferase FruA Drives Galactose Utilization by Streptococcus pneumoniae, Resulting in Hypervirulence

Claudia Trappetti, Lauren J McAllister, Austen Chen, Hui Wang, Adrienne W Paton, Marco R Oggioni, Christopher A McDevitt, James C Paton

Journal article  |  2017  |  mBio

Metal ion Toxicity and Oxidative Stress in Streptococcus Pneumoniae

CA McDevitt, SL Begg, JC Paton

Book Chapter  |  2016

Microstructured Optical Fiber-based Biosensors: Reversible and Nanoliter-Scale Measurement of Zinc Ions

Sabrina Heng, Christopher A McDevitt, Roman Kostecki, Jacqueline R Morey, Bart A Eijkelkamp, Heike Ebendorff-Heidepriem, Tanya M Monro, Andrew D Abell

Journal article  |  2016  |  ACS Applied Materials & Interfaces

The First Histidine Triad Motif of PhtD Is Critical for Zinc Homeostasis in Streptococcus pneumoniae

Bart A Eijkelkamp, Victoria G Pederick, Charles D Plumptre, Richard M Harvey, Catherine E Hughes, James C Paton, Christopher A McDevitt

Journal article  |  2016  |  Infection and Immunity

Characterizing the conformational dynamics of metal-free PsaA using molecular dynamics simulations and electron paramagnetic resonance spectroscopy

Evelyne Deplazes, Stephanie L Begg, Jessica H van Wonderen, Rebecca Campbell, Bostjan Kobe, James C Paton, Fraser MacMillan, Christopher A McDevitt, Megan L O'Mara

Journal article  |  2015  |  Biophysical Chemistry

Heterogeneous nucleation is required for crystallization of the ZnuA domain of pneumococcal AdcA

Zhenyao Luo, Jacqueline R Morey, Christopher A McDevitt, Bostjan Kobe

Journal article  |  2015  |  Acta Crystallographica Section F Structural Biology Communications

ZnuA and zinc homeostasis in Pseudomonas aeruginosa

Victoria G Pederick, Bart A Eijkelkamp, Stephanie L Begg, Miranda P Ween, Lauren J McAllister, James C Paton, Christopher A McDevitt

Journal article  |  2015  |  Scientific Reports

Manganese uptake and streptococcal virulence

Bart A Eijkelkamp, Christopher A McDevitt, Todd Kitten

Journal article  |  2015  |  BioMetals

Discovery of Novel Pneumococcal Surface Antigen A (PsaA) Inhibitors Using a Fragment-based Drug Design Approach

Megha Bajaj, Sreeman K Mamidyala, Johannes Zuegg, Stephanie L Begg, Miranda P Ween, Zhenyao Luo, Johnny X Huang, Alastair G McEwan, Bostjan Kobe, James C Paton, Christopher A McDevitt, Matthew A Cooper

Journal article  |  2015  |  ACS Chemical Biology

Host-imposed manganese starvation of invading pathogens: two routes to the same destination

Jacqueline R Morey, Christopher A McDevitt, Thomas E Kehl-Fie

Journal article  |  2015  |  BioMetals

Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae

Stephanie L Begg, Bart A Eijkelkamp, Zhenyao Luo, Rafael M Counago, Jacqueline R Morey, Megan J Maher, Cheryl-lynn Y Ong, Alastair G McEwan, Bostjan Kobe, Megan L O'Mara, James C Paton, Christopher A McDevitt

Journal article  |  2015  |  Nature Communications

IDENTIFICATION OF VOLATILE ORGANIC COMPOUND DIFFERENCES IN PSEUDOMONAS AERUGINOSA EPIDEMIC STRAINS VIA MS-SIFT GAS ANALYSIS

T Goddard, M Parsons, R Butler, D Miller, C Mcdevitt, V Pederick, T Kidd, J Martin, D Parsons

Conference Proceedings  |  2015  |  RESPIROLOGY

Acquisition and Role of Molybdate in Pseudomonas aeruginosa

Victoria G Pederick, Bart A Eijkelkamp, Miranda P Ween, Stephanie L Begg, James C Paton, Christopher A McDevitt

Journal article  |  2014  |  Applied and Environmental Microbiology

Overlapping Functionality of the Pht Proteins in Zinc Homeostasis of Streptococcus pneumoniae

Charles D Plumptre, Catherine E Hughes, Richard M Harvey, Bart A Eijkelkamp, Christopher A McDevitt, James C Paton

Journal article  |  2014  |  Infection and Immunity

The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis

Jessica H van Wonderen, Roisin M McMahon, Megan L O'Mara, Christopher A McDevitt, Andrew J Thomson, Ian D Kerr, Fraser MacMillan, Richard Callaghan

Journal article  |  2014  |  FEBS Journal

Extracellular Zinc Competitively Inhibits Manganese Uptake and Compromises Oxidative Stress Management in Streptococcus pneumoniae

Bart A Eijkelkamp, Jacqueline R Morey, Miranda P Ween, Cheryl-Iynn Y Ong, Alastair G McEwan, James C Paton, Christopher A McDevitt

Journal article  |  2014  |  PLoS ONE

AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae

Charles D Plumptre, Bart A Eijkelkamp, Jacqueline R Morey, Felix Behr, Rafael M Counago, Abiodun D Ogunniyi, Bostjan Kobe, Megan L O'Mara, James C Paton, Christopher A McDevitt

Journal article  |  2014  |  Molecular Microbiology

Improving the stability and function of purified ABCB1 and ABCA4: The influence of membrane lipids

Naomi L Pollock, Christopher A McDevitt, Richard Collins, Petronella HM Niesten, Stephen Prince, Ian D Kerr, Robert C Ford, Richard Callaghan

Journal article  |  2014  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

Imperfect coordination chemistry facilitates metal ion release in the Psa permease

Rafael M Counago, Miranda P Ween, Stephanie L Begg, Megha Bajaj, Johannes Zuegg, Megan L O'Mara, Matthew A Cooper, Alastair G McEwan, James C Paton, Bostjan Kobe, Christopher A McDevitt

Journal article  |  2014  |  Nature Chemical Biology

Microstructured Optical Fibers and Live Cells: A Water-Soluble, Photochromic Zinc Sensor

Sabrina Heng, Christopher A McDevitt, Daniel B Stubing, Jonathan J Whittall, Jeremy G Thompson, Timothy K Engler, Andrew D Abell, Tanya M Monro

Journal article  |  2013  |  Biomacromolecules

Degrees of chloroquine resistance in Plasmodium - Is the redox system involved?

Adele M Lehane, Christopher A McDevitt, Kiaran Kirk, David A Fidock

Journal article  |  2012  |  International Journal for Parasitology: Drugs and Drug Resistance

Prokaryotic Substrate-Binding Proteins as Targets for Antimicrobial Therapies

Rafael M Counago, Christopher A McDevitt, Miranda P Ween, Bostjan Kobe

Journal article  |  2012  |  Current Drug Targets

The role of ATP-binding cassette transporters in bacterial pathogenicity

Victoria G Lewis, Miranda P Ween, Christopher A McDevitt

Journal article  |  2012  |  Protoplasma

A Molecular Mechanism for Bacterial Susceptibility to Zinc

Christopher A McDevitt, Abiodun D Ogunniyi, Eugene Valkov, Michael C Lawrence, Bostjan Kobe, Alastair G McEwan, James C Paton

Journal article  |  2011  |  PLoS Pathogens

Central Role of Manganese in Regulation of Stress Responses, Physiology, and Metabolism in Streptococcus pneumoniae

Abiodun D Ogunniyi, Layla K Mahdi, Michael P Jennings, Alastair G McEwan, Christopher A McDevitt, Mark B Van der Hoek, Christopher J Bagley, Peter Hoffmann, Katherine A Gould, James C Paton

Journal article  |  2010  |  Journal of Bacteriology

Generating Inhibitors of P-Glycoprotein: Where to, Now?

Emily Crowley, Christopher A McDevitt, Richard Callaghan

Journal article  |  2010  |  Methods in molecular biology (Clifton, N.J.)

Purification and structural analyses of ABCG2

Christopher A McDevitt, Richard Collins, Ian D Kerr, Richard Callaghan

Journal article  |  2009  |  Advanced Drug Delivery Reviews

Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?

Christopher A McDevitt, Emily Crowley, Gemma Hobbs, Kate J Starr, Ian D Kerr, Richard Callaghan

Journal article  |  2008  |  FEBS Journal

Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography

Christopher A McDevitt, Chitra A Shintre, J Guenter Grossmann, Naomi L Pollock, Stephen M Prince, Richard Callaghan, Robert C Ford

Journal article  |  2008  |  FEBS Letters

How can we best use structural information on P-glycoprotein to design inhibitors?

Christopher A McDevitt, Richard Callaghan

Journal article  |  2007  |  Pharmacology & Therapeutics

Subunit composition and in vivo substrate-binding characteristics of Escherichia coli Tat protein complexes expressed at native levels

Christopher A McDevitt, Grant Buchanan, Frank Sargent, Tracy Palmer, Ben C Berks

Journal article  |  2006  |  FEBS Journal

Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2

Christopher A McDevitt, Richard F Collins, Michael Conway, Szabolcs Modok, Janet Storm, Ian D Kerr, Robert C Ford, Richard Callaghan

Journal article  |  2006  |  Structure

The TatA component of the twin-arginine protein transport system forms channel complexes of variable diameter

U Gohlke, L Pullan, CA McDevitt, I Porcelli, E de Leeuw, T Palmer, HR Saibil, BC Berks

Journal article  |  2005  |  Proceedings of the National Academy of Sciences

Characterisation of Tat protein transport complexes carrying inactivating mutations

CA McDevitt, MG Hicks, T Palmer, BC Berks

Journal article  |  2005  |  Biochemical and Biophysical Research Communications

Ion motive electron transfer pathways involving type II molybdoenzymes of the DMSO reductase family

AG Mcewan, PV Bernhardt, N Creevey, GR Hanson, CA McDevitt

Conference Proceedings  |  2004  |  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structural characterisation of the Mo(V) high-g unsplit species from Rhodobacter capsulatus dimethylsulfoxide reductase

GR Hanson, I Lane, CJ Noble, AG McEwan, N Benson

Conference Proceedings  |  2003  |  JOURNAL OF INORGANIC BIOCHEMISTRY

CW and pulsed EPR spectroscopy reveal a new structural motif for the active site Mo centre and an unusual [4Fe-4S]( ) cluster in dimethylsulfide dehydrogenase.

GR Hanson, CJ Noble, CA McDevitt, AG McEwan

Conference Proceedings  |  2003  |  JOURNAL OF INORGANIC BIOCHEMISTRY

Characterization of the redox centers in dimethyl sulfide dehydrogenase from Rhodovulum sulfidophilum

CA McDevitt, GR Hanson, CJ Noble, MR Cheesman, AG McEwan

Journal article  |  2002  |  Biochemistry

Molecular analysis of dimethyl sulphide dehydrogenase from Rhodovulum sulfidophilum: its place in the dimethyl sulphoxide reductase family of microbial molybdopterin-containing enzymes

CA McDevitt, P Hugenholtz, GR Hanson, AG McEwan

Journal article  |  2002  |  Molecular Microbiology

The DMSO reductase family of microbial molybdenum enzymes; Molecular properties and role in the dissimilatory reduction of toxic elements

AG McEwan, JP Ridge, CA McDevitt, P Hugenholtz

Journal article  |  2002  |  Geomicrobiology Journal

XSophe, a computer simulation software suite for the analysis of electron paramagnetic resonance spectra.

GR Hanson, CJ Noble, KE Gates, K Burrage

Conference Proceedings  |  2001  |  JOURNAL OF INORGANIC BIOCHEMISTRY

Dimethylsulfide dehydrogenase from rhodovulum sulfidophilum: EPR spectroscopy and biochemical analysis reveal its place in the DMSO reductase family of molybdenum enzymes

GR Hanson, CA McDevitt, AG McEwan

Conference Proceedings  |  2001  |  JOURNAL OF INORGANIC BIOCHEMISTRY

Aerobic nitrate respiration in a nitrite-oxidising bioreactor

C McDevitt, P Burrell, LL Blackall, AG McEwan

Journal article  |  2000  |  FEMS Microbiology Letters

Aerobic nitrate respiration in a nitrite-oxidising bioreactor

C McDevitt, P Burrell, LL Blackall, AG McEwan

Journal article  |  2000  |  FEMS Microbiology Letters