Christopher McDevitt

Absence of high priority critically important antimicrobial resistance in Salmonella sp. isolated from Australian commercial egg layer environments

Tania Veltman, David Jordan, Christopher A McDevitt, Jan Bell, Benjamin P Howden, Mary Valcanis, Mark O'Dea, Sam Abraham, Peter Scott, Jessica H Kovac, Raymond Chia, Barry Combs, Kapil Chousalkar, Timothy Wilson, Darren J Trott

Journal article  |  2021  |  International Journal of Food Microbiology

The development of antimicrobial resistance in foodborne pathogens is a growing public health concern. This study was undertaken t..

A Trap-Door Mechanism for Zinc Acquisition by Streptococcus pneumoniae AdcA

Zhenyao Luo, Jacqueline R Morey, Evelyne Deplazes, Alina Motygullina, Aimee Tan, Katherine Ganio, Stephanie L Neville, Nikolaos Eleftheriadis, Michael Isselstein, Victoria G Pederick, James C Paton, Thorben Cordes, Jeffrey R Harmer, Bostjan Kobe, Christopher A McDevitt

Journal article  |  2021  |  mBio

Zinc is an essential element in all domains of life. Nonetheless, how prokaryotes achieve selective acquisition of zinc from the e..

Cadmium stress dictates central carbon flux and alters membrane composition in Streptococcus pneumoniae

Stephanie L Neville, Bart A Eijkelkamp, Amber Lothian, James C Paton, Blaine R Roberts, Jason W Rosch, Christopher A McDevitt

Journal article  |  2020  |  Communications Biology

Metal ion homeostasis is essential for all forms of life. However, the breadth of intracellular impacts that arise upon dysregulat..

Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis

David MP De Oliveira, Lisa Bohlmann, Trent Conroy, Freda E-C Jen, Arun Everest-Dass, Karl A Hansford, Raghu Bolisetti, Ibrahim M El-Deeb, Brian M Forde, Phan Minh-Duy, Jake A Lacey, Aimee Tan, Tania Rivera-Hernandez, Stephan Brouwer, Nadia Keller, Timothy J Kidd, Amanda J Cork, Michelle J Bauer, Gregory M Cook, Mark R Davies, et al.

Journal article  |  2020  |  Science Translational Medicine

The emergence of polymyxin resistance in carbapenem-resistant and extended-spectrum β-lactamase (ESBL)-producing bacteria is a cri..

Manganese import protects Salmonella enterica serovar Typhimurium against nitrosative stress

Shehla Yousuf, Joyce E Karlinsey, Stephanie L Neville, Christopher A McDevitt, Stephen J Libby, Ferric C Fang, Elaine R Frawley

Journal article  |  2020  |  Metallomics

Nitric oxide (NO˙) is a radical molecule produced by mammalian phagocytic cells as part of the innate immune response to bacterial..

The molecular basis of Acinetobacter baumannii cadmium toxicity and resistance

Saleh Alquethamy, Felise Adams, Ram Maharjan, Natasha Delgado, Maoge Zang, James Paton, Karl Hassan, Ian Paulsen, Christopher McDevitt, Amy Cain, Bart Eijkelkamp

Journal article  |  2020

ABSTRACT Acinetobacter species are ubiquitous Gram-negative bacteria that can be found in water, soil and as commensals of the hum..

Structural and functional characterizations of the C-terminal domains of CzcD proteins

Saumya R Udagedara, Daniel M La Porta, Christian Spehar, Ghruta Purohit, Matthew JA Hein, Monique E Fatmous, G Patricia Casas Garcia, Katherine Ganio, Christopher A McDevitt, Megan J Maher

Journal article  |  2020  |  Journal of Inorganic Biochemistry

Zinc is a potent antimicrobial component of the innate immune response at the host-pathogen interface. Bacteria subvert or resist ..

Disruption of Phosphate Homeostasis Sensitizes Staphylococcus aureus to Nutritional Immunity

Jessica L Kelliher, Erin B Brazel, Jana N Radin, Eliot S Joya, Paola K Parraga Solorzano, Stephanie L Neville, Christopher A McDevitt, Thomas E Kehl-Fie

Journal article  |  2020  |  Infection and Immunity

To control infection, mammals actively withhold essential nutrients, including the transition metal manganese, by a process termed..

Intracellular Accumulation of Staphylopine Can Sensitize Staphylococcus aureus to Host-Imposed Zinc Starvation by Chelation-Independent Toxicity

Kyle P Grim, Jana N Radin, Paola K Parraga Solorzano, Jacqueline R Morey, Katie A Frye, Katherine Ganio, Stephanie L Neville, Christopher A McDevitt, Thomas E Kehl-Fie

Journal article  |  2020  |  Journal of Bacteriology

The host restricts the availability of zinc to prevent infection. To overcome this defense, Staphylococcus aureus and Pseudomonas ..

Experimental Evolution In Vivo To Identify Selective Pressures during Pneumococcal Colonization

Vaughn S Cooper, Erin Honsa, Hannah Rowe, Christopher Deitrick, Amy R Iverson, Jonathan J Whittall, Stephanie L Neville, Christopher A McDevitt, Colin Kietzman, Jason W Rosch

Journal article  |  2020  |  mSystems

Experimental evolution is a powerful technique to understand how populations evolve from selective pressures imparted by the surro..