Ali Motazedian

Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses

Kah Lok Chan, Juliana Gomez, Chelisa Cardinez, Nishi Kumari, Christina E Sparbier, Enid YN Lam, Miriam M Yeung, Sylvain Garciaz, James A Kuzich, Doen Ming Ong, Fiona C Brown, Yih-Chih Chan, Dane Vassiliadis, Elanor N Wainwright, Ali Motazedian, Andrea Gillespie, Katie A Fennell, Junyun Lai, Imran G House, Laura Macpherson, et al.

Journal article  |  2022  |  CANCER CELL

There is increasing recognition of the prognostic significance of tumor cell major histocompatibility complex (MHC) class II expre..

Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK Dependent Cell Death

Sylvain Garciaz, Andrew A Guirguis, Sebastian Muller, Fiona C Brown, Yih-Chih Chan, Ali Motazediani, Caitlin L Rowe, James A Kuzich, Kah Lok Chan, Kevin Tran, Lorey Smith, Laura MacPherson, Brian Liddicoat, Enid YN Lam, Tatiana Caneque, Marian L Burr, Veronique Litalien, Giovanna Pomilio, Mathilde Poplineau, Estelle Duprez, et al.

Journal article  |  2022  |  CANCER DISCOVERY

UNLABELLED: Cancer cell metabolism is increasingly recognized as providing an exciting therapeutic opportunity. However, a drug th..

3005 – GROUP F SOX GENES CONTROL HUMAN EMBRYONIC VASCULAR PATTERNING VIA NOTCH SIGNALING

Freya Bruveris, Andrew Elefanty, Ana Rita Leitoguinho, Ali Motazedian, Elizabeth Ng, Koula Sourris, Ed Stanley, Katerina Vlahos

Conference Proceedings  |  2021  |  Experimental Hematology

MSL pushes genomic instability over the edge

Ali Motazedian, Mark A Dawson

Journal article  |  2021  |  NATURE CELL BIOLOGY

Human yolk sac-like haematopoiesis generates RUNX1-, GFI1- and/or GFI1B-dependent blood and SOX17-positive endothelium

Freya F Bruveris, Elizabeth S Ng, Ana Rita Leitoguinho, Ali Motazedian, Katerina Vlahos, Koula Sourris, Robyn Mayberry, Penelope McDonald, Lisa Azzola, Nadia M Davidson, Alicia Oshlack, Edouard G Stanley, Andrew G Elefanty

Journal article  |  2020  |  Development

The genetic regulatory network controlling early fate choices during human blood cell development are not well understood. We used..

Multipotent RAG1 progenitors emerge directly from haemogenic endothelium in human pluripotent stem cell-derived haematopoietic organoids

Ali Motazedian, Freya F Bruveris, Santhosh V Kumar, Jacqueline V Schiesser, Tyrone Chen, Elizabeth S Ng, Ann P Chidgey, Christine A Wells, Andrew G Elefanty, Edouard G Stanley

Journal article  |  2020  |  NATURE CELL BIOLOGY

Defining the ontogeny of the human adaptive immune system during embryogenesis has implications for understanding childhood diseas..

Induced pluripotent stem cell macrophages present antigen to proinsulin-specific T cell receptors from donor-matched islet-infiltrating T cells in type 1 diabetes

Kriti Joshi, Colleen Elso, Ali Motazedian, Tanya Labonne, Jacqueline V Schiesser, Fergus Cameron, Stuart I Mannering, Andrew G Elefanty, Edouard G Stanley

Journal article  |  2019  |  DIABETOLOGIA

AIMS/HYPOTHESIS: Type 1 diabetes is an autoimmune disorder characterised by loss of insulin-producing beta cells of the pancreas. ..

3176 – MULTIPOTENT RAG1 PROGENITORS EMERGE DIRECTLY FROM HEMOGENIC ENDOTHELIUM IN HUMAN PSC DERIVED HEMOPOIETIC ORGANOIDS

Ali Motazedian, Freya Bruveris, Santhosh Kumar, Jacqueline Schiesser, Tyrone Chen, Elizabeth Ng, Ann Chidgey, Christine Wells, Andrew Elefanty, Edouard Stanley

Conference Proceedings  |  2019  |  Experimental Hematology

RUNX1 AND GROUP F SOX GENES ARE REQUIRED AT DISTINCT STAGES FOR HUMAN HAEMATOPOIETIC DEVELOPMENT

Freya Bruveris, Elizabeth Ng, Ana Rita Leitoguinho, Ali Motazedian, Katerina Vlahos, Koula Sourris, Penelope McDonald, Nadia Davidson, Alicia Oshlack, Edouard Stanley, Andrew Elefanty

Conference Proceedings  |  2019  |  Experimental Hematology

The use of simultaneous reprogramming and gene correction to generate an osteogenesis imperfecta patient COL1A1 c. 3936 G > T iPSC line and an isogenic control iPSC line

Sara Howden, Hani Hosseini Far, Ali Motazedian, Andrew G Elefanty, Edouard G Stanley, Shireen R Lamande, John F Bateman

Journal article  |  2019  |  STEM CELL RESEARCH

To develop a disease model for the human 'brittle bone' disease, osteogenesis imperfecta, we used a simultaneous reprogramming and..