Huimeng Wang

RIPK3 controls MAIT cell accumulation during development but not during infection

Timothy Patton, Zhe Zhao, Xin Yi Lim, Eleanor Eddy, Huimeng Wang, Adam G Nelson, Bronte Ennis, Sidonia BG Eckle, Michael NT Souter, Troi J Pediongco, Hui-Fern Koay, Jian-Guo Zhang, Tirta M Djajawi, Cynthia Louis, Najoua Lalaoui, Nicolas Jacquelot, Andrew M Lew, Daniel G Pellicci, James McCluskey, Yifan Zhan, et al.

Journal article  |  2023  |  CELL DEATH & DISEASE

Cell death mechanisms in T lymphocytes vary according to their developmental stage, cell subset and activation status. The cell de..

CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells

Michael NT Souter, Wael Awad, Shihan Li, Troi Pediongco, Bronwyn S Meehan, Lucy J Meehan, Zehua Tian, Zhe Zhao, Huimeng Wang, Adam Nelson, Jérôme Le Nours, Yogesh Khandokar, T Praveena, Jacinta Wubben, Jie Lin, Lucy C Sullivan, George Lovrecz, Jeffrey YW Mak, Ligong Liu, Lyudmila Kostenko, et al.

Journal article  |  2022  |  Journal of Experimental Medicine

Mucosal-associated invariant T (MAIT) cells detect microbial infection via recognition of riboflavin-based antigens presented by t..

The balance of interleukin-12 and interleukin-23 determines the bias of MAIT1 versus MAIT17 responses during bacterial infection

Huimeng Wang, Adam G Nelson, Bingjie Wang, Zhe Zhao, Xin Yi Lim, Mai Shi, Lucy J Meehan, Xiaoxiao Jia, Katherine Kedzierska, Bronwyn S Meehan, Sidonia BG Eckle, Michael NT Souter, Troi J Pediongco, Jeffrey YW Mak, David P Fairlie, James McCluskey, Zhongfang Wang, Alexandra J Corbett, Zhenjun Chen

Journal article  |  2022  |  IMMUNOLOGY AND CELL BIOLOGY

Mucosal-associated invariant T (MAIT) cells are a major subset of innate-like T cells mediating protection against bacterial infec..

Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection

Zhe Zhao, Huimeng Wang, Mai Shi, Tianyuan Zhu, Troi Pediongco, Xin Yi Lim, Bronwyn S Meehan, Adam G Nelson, David P Fairlie, Jeffrey YW Mak, Sidonia BG Eckle, Marcela de Lima Moreira, Carolin Tumpach, Michael Bramhall, Cameron G Williams, Hyun Jae Lee, Ashraful Haque, Maximilien Evrard, Jamie Rossjohn, James McCluskey, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Mucosal-associated Invariant T (MAIT) cells are recognized for their antibacterial functions. The protective capacity of MAIT cell..

Mouse models illuminate MAIT cell biology

Huimeng Wang, Zhenjun Chen, James McCluskey, Alexandra J Corbett

Journal article  |  2021  |  MOLECULAR IMMUNOLOGY

The field of mucosal-associated invariant T cell (MAIT) biology has grown rapidly since the identification of the vitamin-B-based ..

Antigen Recognition by MR1-Reactive T Cells; MAIT Cells, Metabolites, and Remaining Mysteries

Alexandra J Corbett, Wael Awad, Huimeng Wang, Zhenjun Chen

Journal article  |  2020  |  FRONTIERS IN IMMUNOLOGY

Mucosal-associated Invariant T (MAIT) cells recognize vitamin B-based antigens presented by the non-polymorphic MHC class I relate..

Priming programed Mucosal-Associated Invariant T cells protect against systemic or local bacterial infection

Zhe Zhao, Mai Shi, Tianyuan Zhu, Huimeng Wang, Troi Pediongco, Xin Yi Lim, Bronwyn Meehan, Adam Nelson, David Fairlie, Jeffrey Mak, Sidonia Eckle, Jamie Rossjohn, James McCluskey, Alexandra Corbett, Zhenjun Chen

Journal article  |  2020

Mucosal-Associated Invariant T (MAIT) cells have potent antibacterial functions. Their protective capacity, in vivo, has been demo..

Study of MAIT Cell Activation in Viral Infections In Vivo

Timothy SC Hinks, Bonnie van Wilgenburg, Huimeng Wang, Liyen Loh, Marios Koutsakos, Katherine Kedzierska, Alexandra J Corbett, Zhenjun Chen

Journal article  |  2020  |  MAIT CELLS: METHODS AND PROTOCOLS

MAIT cells are abundant, highly evolutionarily conserved innate-like lymphocytes expressing a semi-invariant T cell receptor (TCR)..

Characterization and Purification of Mouse Mucosal-Associated Invariant T (MAIT) Cells

Zhenjun Chen, Huimeng Wang, Criselle D'Souza, Hui-Fern Koay, Bronwyn Meehan, Zhe Zhao, Troi Pediongco, Mai Shi, Tianyuan Zhu, Bingjie Wang, Lars Kjer-Nielsen, Sidonia BG Eckle, Jamie Rossjohn, David P Fairlie, Dale I Godfrey, Richard A Strugnell, James McCluskey, Alexandra J Corbett

Journal article  |  2019  |  Current protocols in immunology

This unit describes the utility of various mouse models of infection and immunization for studying mucosal-associated invariant T ..

IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection

Huimeng Wang, Lars Kjer-Nielsen, Mai Shi, Criselle D'Souza, Troi J Pediongco, Hanwei Cao, Lyudmila Kostenko, Xin Yi Lim, Sidonia BG Eckle, Bronwyn S Meehan, Tianyuan Zhu, Bingjie Wang, Zhe Zhao, Jeffrey YW Mak, David P Fairlie, Michele WL Teng, Jamie Rossjohn, Di Yu, Barbara Fazekas de St Groth, George Lovrecz, et al.

Journal article  |  2019  |  SCIENCE IMMUNOLOGY

Mucosal-associated invariant T (MAIT) cells are activated in a TCR-dependent manner by antigens derived from the riboflavin synthe..