Lahiru Gangoda

Absence of pro-survival A1 has no impact on inflammatory cell survival in vivo during acute lung inflammation and peritonitis

Lahiru Gangoda, Robyn L Schenk, Sarah A Best, Christina Nedeva, Cynthia Louis, Damian B D'Silva, Kirsten Fairfax, Andrew G Jarnicki, Hamsa Puthalakath, Kate D Sutherland, Andreas Strasser, Marco J Herold

Journal article  |  2021  |  CELL DEATH AND DIFFERENTIATION

Inflammation is a natural defence mechanism of the body to protect against pathogens. It is induced by immune cells, such as macro..

Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis

Monisha Samuel, Pamali Fonseka, Rahul Sanwlani, Lahiru Gangoda, Sing Ho Chee, Shivakumar Keerthikumar, Alex Spurling, Sai V Chitti, Damien Zanker, Ching-Seng Ang, Ishara Atukorala, Taeyoung Kang, Sanjay Shahi, Akbar L Marzan, Christina Nedeva, Claire Vennin, Morghan C Lucas, Lesley Cheng, David Herrmann, Mohashin Pathan, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

The concept that extracellular vesicles (EVs) from the diet can be absorbed by the intestinal tract of the consuming organism, be ..

Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma

Michael A Dengler, Charis E Teh, Rachel Thijssen, Lahiru Gangoda, Ping Lan, Marco J Herold, Daniel H Gray, Gemma L Kelly, Andrew W Roberts, Jerry M Adams

Journal article  |  2020  |  ONCOGENE

Apoptosis-regulating BCL-2 family members, which can promote malignant transformation and resistance to therapy, have become prime..

Characterization of a novel human BFL-1-specific monoclonal antibody

Lahiru Gangoda, Charis E Teh, Michael A Dengler, Sarah A Best, Clare E Weeden, Lin Tai, Erinna F Lee, Walter D Fairlie, Kate D Sutherland, Leonard C Harrison, Daniel H Gray, Andreas Strasser, Marco J Herold

Journal article  |  2020  |  CELL DEATH AND DIFFERENTIATION

Extracellular vesicles containing oncogenic mutant beta-catenin activate Wnt signalling pathway in the recipient cells

Hina Kalra, Lahiru Gangoda, Pamali Fonseka, Sai Chitti, Michael Liem, Shivakumar Keerthikumar, Monisha Samuel, Stephanie Boukouris, Haidar Al Saffar, Christine Collins, Christopher G Adda, Ching-Seng Ang, Suresh Mathivanan

Journal article  |  2019  |  JOURNAL OF EXTRACELLULAR VESICLES

Mutations in β-catenin, especially at the residues critical for its degradation, render it constitutively active. Here, we show th..

Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling

Kening Zhao, Mark Bleackley, David Chisanga, Lahiru Gangoda, Pamali Fonseka, Michael Liem, Hina Kalra, Haidar Al Saffar, Shivakumar Keerthikumar, Ching-Seng Ang, Christopher G Adda, Lanzhou Jiang, Kuok Yap, Ivan K Poon, Peter Lock, Vincent Bulone, Marilyn Anderson, Suresh Mathivanan

Journal article  |  2019  |  COMMUNICATIONS BIOLOGY

Extracellular vesicles (EVs) are membranous vesicles that are released by cells. In this study, the role of the Endosomal Sorting ..

BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals

Rahul Srivastava, Zhipeng Cao, Christina Nedeva, Samara Naim, Daniel Bachmann, Tatiana Rabachini, Lahiru Gangoda, Sanjay Shahi, Jason Glab, Joseph Menassa, Laura Osellame, Tao Nelson, Yuniel Fernandez-Marrero, Fiona Brown, Andrew Wei, Francine Ke, Lorraine O'Reilly, Marcel Doerflinger, Cody Allison, Andrew Kueh, et al.

Journal article  |  2019  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BCL-2 family proteins regulate the mitochondrial apoptotic pathway. BOK, a multidomain BCL-2 family protein, is generally believed..

Single-Cell Transcriptomics Identifies the Adaptation of Scart1( )V gamma 6( ) T Cells to Skin Residency as Activated Effector Cells

Likai Tan, Inga Sandrock, Ivan Odak, Yuval Aizenbud, Anneke Wilharm, Joana Barros-Martins, Yaara Tabib, Alina Borchers, Tiago Amado, Lahiru Gangoda, Marco J Herold, Marc Schmidt-Supprian, Jan Kisielow, Bruno Silva-Santos, Christian Koenecke, Avi-Hai Hovav, Christian Krebs, Immo Prinz, Sarina Ravens

Journal article  |  2019  |  CELL REPORTS

IL-17-producing γδ T cells express oligoclonal Vγ4+ and Vγ6+ TCRs, mainly develop in the prenatal thymus, and later persist as lon..

Inhibition of cathepsin proteases attenuates migration and sensitizes aggressive N-Myc amplified human neuroblastoma cells to doxorubicin

Lahiru Gangoda, Shivakumar Keerthikumar, Pamali Fonseka, Laura E Edgington, Ching-Seng Ang, Cemil Ozcitti, Matthew Bogyo, Belinda S Parker, Suresh Mathivanan

Journal article  |  2015  |  ONCOTARGET

Neuroblastoma arises from the sympathetic nervous system and accounts for 15% of childhood cancer mortality. Amplification of the ..