Nicholas Hardcastle

Impact of Medical Operability and Total Metastatic Ablation on Outcomes After SABR for Oligometastases

Shankar Siva, Gavin Jones, Mathias Bressel, Mark Shaw, Sarat Chander, Julie Chu, Nikki Plumridge, Keelan Byrne, Gargi Kothari, Nicholas Hardcastle, Mathieu Gaudreault, Tomas Kron, Greg Wheeler, Michael MacManus, Gerard G Hanna, David L Ball, Steven David

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

PURPOSE: Medical operability is prognostic for survival after SABR in primary malignancies. This study investigated the prognostic..

Systematic endoscopic staging of mediastinum to determine impact on radiotherapy for locally advanced lung cancer (SEISMIC): protocol for a prospective single arm multicentre interventional study

Daniel P Steinfort, Shankar Siva, Kanishka Rangamuwa, Percy Lee, David Fielding, Phan Nguyen, Barton R Jennings, Shaun Yo, Nick Hardcastle, Gargi Kothari, Laurence Crombag, Jouke Annema, Kazuhiro Yasufuku, David E Ost, Louis B Irving

Journal article  |  2022  |  BMC PULMONARY MEDICINE

BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is established as the preferred method of..

The impact of inter-observer variation in delineation on robustness of radiomics features in non-small cell lung cancer

Gargi Kothari, Beverley Woon, Cameron J Patrick, James Korte, Leonard Wee, Gerard G Hanna, Tomas Kron, Nicholas Hardcastle, Shankar Siva

Journal article  |  2022  |  SCIENTIFIC REPORTS

Artificial intelligence and radiomics have the potential to revolutionise cancer prognostication and personalised treatment. Manua..

Practical considerations of single-fraction stereotactic ablative radiotherapy to the lung

Therese MJ Kang, Nicholas Hardcastle, Anurag K Singh, Ben J Slotman, Gregory MM Videtic, Kevin L Stephans, Felipe Coun Counago, Alexander V. Louie, Matthias Guckenberger, Susan V. Harden, Nikki M Plumridge, Shankar Siva

Journal article  |  2022  |  LUNG CANCER

Stereotactic ablative radiotherapy (SABR) is a well-established treatment for patients with medically inoperable early-stage non-s..

Assessing organ at risk position variation and its impact on delivered dose in kidney SABR

Mathieu Gaudreault, Shankar Siva, Tomas Kron, Nicholas Hardcastle

Journal article  |  2022  |  RADIATION ONCOLOGY

BACKGROUND: Delivered organs at risk (OARs) dose may vary from planned dose due to interfraction and intrafraction motion during k..

Feasibility of biology-guided radiotherapy using PSMA-PET to boost to dominant intraprostatic tumour

Mathieu Gaudreault, David Chang, Nicholas Hardcastle, Price Jackson, Tomas Kron, Michael S Hofman, Shankar Siva

Journal article  |  2022  |  CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY

BACKGROUND: Biology-guided radiotherapy (BgRT) delivers dose to tumours triggered from positron emission tomography (PET) detectio..

MIRSIG position paper: the use of image registration and fusion algorithms in radiotherapy

Nicholas Lowther, Rob Louwe, Johnson Yuen, Nicholas Hardcastle, Adam Yeo, Michael Jameson

Journal article  |  2022  |  PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE

The report of the American Association of Physicists in Medicine (AAPM) Task Group No. 132 published in 2017 reviewed rigid image ..

Impact of operability and total metastatic ablation on outcomes after SABR for oligometastases

S Siva, M Bressel, P Sogono, M Shaw, S Chander, J Chu, N Plumridge, K Byrne, G Kothari, N Bucknell, N Hardcastle, T Kron, G Wheeler, M MacManus, GG Hanna, DL Ball, S David

Conference Proceedings  |  2022  |  RADIOTHERAPY AND ONCOLOGY

Utility of Biology-Guided Radiotherapy to De Novo Metastases Diagnosed During Staging of High-Risk Biopsy-Proven Prostate Cancer

Mathieu Gaudreault, David Chang, Nicholas Hardcastle, Price Jackson, Tomas Kron, Gerard G Hanna, Michael S Hofman, Shankar Siva

Journal article  |  2022  |  FRONTIERS IN ONCOLOGY

BACKGROUND: Biology-guided radiotherapy (BgRT) uses real-time functional imaging to guide radiation therapy treatment. Positron em..

Quantitative assessment of ventilation-perfusion relationships with gallium-68 positron emission tomography/computed tomography imaging in lung cancer patients.

Zhuorui Li, Pierre-Yves Le Roux, Jason Callahan, Nicholas Hardcastle, Michael S Hofman, Shankar Siva, Tokihiro Yamamoto

Journal article  |  2022  |  Phys Imaging Radiat Oncol

Pulmonary functional imaging has demonstrated potential to improve thoracic radiotherapy. The purpose of this study was twofold: 1..