Stephanie Neville

The structural basis of bacterial manganese import

Stephanie L Neville, Jennie Sjoehamn, Jacinta A Watts, Hugo MacDermott-Opeskin, Stephen J Fairweather, Katherine Ganio, Alex Carey Hulyer, Aaron P McGrath, Andrew J Hayes, Tess R Malcolm, Mark R Davies, Norimichi Nomura, So Iwata, Megan L O'Mara, Megan J Maher, Christopher A McDevitt

Journal article  |  2021  |  SCIENCE ADVANCES

Metal ions are essential for all forms of life. In prokaryotes, ATP-binding cassette (ABC) permeases serve as the primary import p..

A Trap-Door Mechanism for Zinc Acquisition by Streptococcus pneumoniae AdcA

Zhenyao Luo, Jacqueline R Morey, Evelyne Deplazes, Alina Motygullina, Aimee Tan, Katherine Ganio, Stephanie L Neville, Nikolaos Eleftheriadis, Michael Isselstein, Victoria G Pederick, James C Paton, Thorben Cordes, Jeffrey R Harmer, Bostjan Kobe, Christopher A McDevitt

Journal article  |  2021  |  MBIO

Zinc is an essential element in all domains of life. Nonetheless, how prokaryotes achieve selective acquisition of zinc from the e..

Cadmium stress dictates central carbon flux and alters membrane composition in Streptococcus pneumoniae

Stephanie L Neville, Bart A Eijkelkamp, Amber Lothian, James C Paton, Blaine R Roberts, Jason W Rosch, Christopher A McDevitt

Journal article  |  2020  |  COMMUNICATIONS BIOLOGY

Metal ion homeostasis is essential for all forms of life. However, the breadth of intracellular impacts that arise upon dysregulat..

Manganese import protects Salmonella enterica serovar Typhimurium against nitrosative stress

Shehla Yousuf, Joyce E Karlinsey, Stephanie L Neville, Christopher A McDevitt, Stephen J Libby, Ferric C Fang, Elaine R Frawley

Journal article  |  2020  |  METALLOMICS

Nitric oxide (NO˙) is a radical molecule produced by mammalian phagocytic cells as part of the innate immune response to bacterial..

Disruption of Phosphate Homeostasis Sensitizes Staphylococcus aureus to Nutritional Immunity

Jessica L Kelliher, Erin B Brazel, Jana N Radin, Eliot S Joya, Paola K Parraga Solorzano, Stephanie L Neville, Christopher A McDevitt, Thomas E Kehl-Fie

Journal article  |  2020  |  INFECTION AND IMMUNITY

To control infection, mammals actively withhold essential nutrients, including the transition metal manganese, by a process termed..

Intracellular Accumulation of Staphylopine Can Sensitize Staphylococcus aureus to Host-Imposed Zinc Starvation by Chelation-Independent Toxicity

Kyle P Grim, Jana N Radin, Paola K Parraga Solorzano, Jacqueline R Morey, Katie A Frye, Katherine Ganio, Stephanie L Neville, Christopher A McDevitt, Thomas E Kehl-Fie

Journal article  |  2020  |  JOURNAL OF BACTERIOLOGY

The host restricts the availability of zinc to prevent infection. To overcome this defense, Staphylococcus aureus and Pseudomonas ..

Experimental Evolution In Vivo To Identify Selective Pressures during Pneumococcal Colonization

Vaughn S Cooper, Erin Honsa, Hannah Rowe, Christopher Deitrick, Amy R Iverson, Jonathan J Whittall, Stephanie L Neville, Christopher A McDevitt, Colin Kietzman, Jason W Rosch

Journal article  |  2020  |  MSYSTEMS

Experimental evolution is a powerful technique to understand how populations evolve from selective pressures imparted by the surro..

Experimental Evolution in vivo to Identify Selective Pressures During Pneumococcal Colonization

Vaughn Cooper, Erin Honsa, Hannah Rowe, Christopher Deitrick, Amy Iverson, Jonathan Whittall, Stephanie Neville, Christopher McDevitt, Colin Kietzman, Jason Rosch

Journal article  |  2020

Experimental evolution is a powerful technique to understand how populations evolve from selective pressures imparted by the surro..

Structure and Metal Binding Properties of Chlamydia trachomatis YtgA

Zhenyao Luo, Stephanie L Neville, Rebecca Campbell, Jacqueline R Morey, Shruti Menon, Mark Thomas, Bart A Eijkelkamp, Miranda P Ween, Wilhelmina M Huston, Bostjan Kobe, Christopher A McDevitt

Journal article  |  2020  |  JOURNAL OF BACTERIOLOGY

The obligate intracellular pathogen Chlamydia trachomatis is a globally significant cause of sexually transmitted bacterial infect..

Dietary zinc and the control of Streptococcus pneumoniae infection

Bart A Eijkelkamp, Jacqueline R Morey, Stephanie L Neville, Aimee Tan, Victoria G Pederick, Nerida Cole, Prashina P Singh, Cheryl-Lynn Y Ong, Raquel Gonzalez de Vega, David Clases, Bliss A Cunningham, Catherine E Hughes, Iain Comerford, Erin B Brazel, Jonathan J Whittall, Charles D Plumptre, Shaun R McColl, James C Paton, Alastair G McEwan, Philip A Doble, et al.

Journal article  |  2019  |  PLOS PATHOGENS

Human zinc deficiency increases susceptibility to bacterial infection. Although zinc supplementation therapies can reduce the impa..