Stephanie Neville

Host-Mediated Copper Stress Is Not Protective against Streptococcus pneumoniae D39 Infection

Stephanie L Neville, Bliss A Cunningham, Eve A Maunders, Aimee Tan, Jacinta A Watts, Katherine Ganio, Bart A Eijkelkamp, Victoria G Pederick, Raquel Gonzalez de Vega, David Clases, Philip A Doble, Christopher A McDevitt

Journal article  |  2022  |  MICROBIOLOGY SPECTRUM

Metal ions are required by all organisms for the chemical processes that support life. However, in excess they can also exert toxi..

The Role of ZntA in Klebsiella pneumoniae Zinc Homeostasis

Eve A Maunders, Katherine Ganio, Andrew J Hayes, Stephanie L Neville, Mark R Davies, Richard A Strugnell, Christopher A McDevitt, Aimee Tan

Journal article  |  2022  |  MICROBIOLOGY SPECTRUM

Klebsiella pneumoniae is an opportunistic Gram-negative pathogen that is a leading cause of healthcare-associated infections, incl..

MntP and YiiP Contribute to Manganese Efflux in Salmonella enterica Serovar Typhimurium under Conditions of Manganese Overload and Nitrosative Stress

Annie Ouyang, Kendall M Gasner, Stephanie L Neville, Christopher A McDevitt, Elaine R Frawley

Journal article  |  2022  |  MICROBIOLOGY SPECTRUM

The divalent transition metal cation manganese is important for protein function, particularly under conditions of iron limitation..

Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

Erin B Brazel, Aimee Tan, Stephanie L Neville, Amy R Iverson, Saumya R Udagedara, Bliss A Cunningham, Mwilye Sikanyika, David MP De Oliveira, Bernhard Keller, Lisa Bohlmann, Ibrahim M El-Deeb, Katherine Ganio, Bart A Eijkelkamp, Alastair G McEwan, Mark von Itzstein, Megan J Maher, Mark J Walker, Jason W Rosch, Christopher A McDevitt

Journal article  |  2022  |  CELL REPORTS

Streptococcus pneumoniae is the primary cause of community-acquired bacterial pneumonia with rates of penicillin and multidrug-res..

The biochemical fate of Ag ions in Staphylococcus aureus, Escherichia coli, and biological media

Harley D Betts, Stephanie L Neville, Christopher A McDevitt, Christopher J Sumby, Hugh H Harris

Journal article  |  2021  |  JOURNAL OF INORGANIC BIOCHEMISTRY

Silver is commonly included in a range of household and medical items to provide bactericidal action. Despite this, the chemical f..

Conformation of the Solute-Binding Protein AdcAII Influences Zinc Uptake in Streptococcus pneumoniae

Marina L Zupan, Zhenyao Luo, Katherine Ganio, Victoria G Pederick, Stephanie L Neville, Evelyne Deplazes, Bostjan Kobe, Christopher A McDevitt

Journal article  |  2021  |  FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

Streptococcus pneumoniae scavenges essential zinc ions from the host during colonization and infection. This is achieved by the AT..

The structural basis of bacterial manganese import

Stephanie L Neville, Jennie Sjoehamn, Jacinta A Watts, Hugo MacDermott-Opeskin, Stephen J Fairweather, Katherine Ganio, Alex Carey Hulyer, Aaron P McGrath, Andrew J Hayes, Tess R Malcolm, Mark R Davies, Norimichi Nomura, So Iwata, Megan L O'Mara, Megan J Maher, Christopher A McDevitt

Journal article  |  2021  |  SCIENCE ADVANCES

Metal ions are essential for all forms of life. In prokaryotes, ATP-binding cassette (ABC) permeases serve as the primary import p..

A Trap-Door Mechanism for Zinc Acquisition by Streptococcus pneumoniae AdcA

Zhenyao Luo, Jacqueline R Morey, Evelyne Deplazes, Alina Motygullina, Aimee Tan, Katherine Ganio, Stephanie L Neville, Nikolaos Eleftheriadis, Michael Isselstein, Victoria G Pederick, James C Paton, Thorben Cordes, Jeffrey R Harmer, Bostjan Kobe, Christopher A McDevitt

Journal article  |  2021  |  MBIO

Zinc is an essential element in all domains of life. Nonetheless, how prokaryotes achieve selective acquisition of zinc from the e..

Cadmium stress dictates central carbon flux and alters membrane composition in Streptococcus pneumoniae

Stephanie L Neville, Bart A Eijkelkamp, Amber Lothian, James C Paton, Blaine R Roberts, Jason W Rosch, Christopher A McDevitt

Journal article  |  2020  |  COMMUNICATIONS BIOLOGY

Metal ion homeostasis is essential for all forms of life. However, the breadth of intracellular impacts that arise upon dysregulat..

Manganese import protects Salmonella enterica serovar Typhimurium against nitrosative stress

Shehla Yousuf, Joyce E Karlinsey, Stephanie L Neville, Christopher A McDevitt, Stephen J Libby, Ferric C Fang, Elaine R Frawley

Journal article  |  2020  |  METALLOMICS

Nitric oxide (NO˙) is a radical molecule produced by mammalian phagocytic cells as part of the innate immune response to bacterial..