Stephanie Neville

Experimental Evolution In Vivo To Identify Selective Pressures during Pneumococcal Colonization.

Vaughn S Cooper, Erin Honsa, Hannah Rowe, Christopher Deitrick, Amy R Iverson, Jonathan J Whittall, Stephanie L Neville, Christopher A McDevitt, Colin Kietzman, Jason W Rosch

Journal article  |  2020  |  mSystems

Experimental evolution is a powerful technique to understand how populations evolve from selective pressures imparted by the surro..

Disruption of Phosphate Homeostasis Sensitizes Staphylococcus aureus to Nutritional Immunity

Jessica L Kelliher, Erin B Brazel, Jana N Radin, Eliot S Joya, Paola K Parraga Solorzano, Stephanie L Neville, Christopher A McDevitt, Thomas E Kehl-Fie

Journal article  |  2020  |  Infection and Immunity

To control infection, mammals actively withhold essential nutrients, including the transition metal manganese, by a process termed..

Intracellular Accumulation of Staphylopine Can Sensitize Staphylococcus aureus to Host-Imposed Zinc Starvation by Chelation-Independent Toxicity

Kyle P Grim, Jana N Radin, Paola K Parraga Solorzano, Jacqueline R Morey, Katie A Frye, Katherine Ganio, Stephanie L Neville, Christopher A McDevitt, Thomas E Kehl-Fie

Journal article  |  2020  |  Journal of Bacteriology

The host restricts the availability of zinc to prevent infection. To overcome this defense, Staphylococcus aureus and Pseudomonas ..

Structure and Metal Binding Properties of Chlamydia trachomatis YtgA

Zhenyao Luo, Stephanie L Neville, Rebecca Campbell, Jacqueline R Morey, Shruti Menon, Mark Thomas, Bart A Eijkelkamp, Miranda P Ween, Wilhelmina M Huston, Bostjan Kobe, Christopher A McDevitt

Journal article  |  2020  |  Journal of Bacteriology

The obligate intracellular pathogen Chlamydia trachomatis is a globally significant cause of sexually transmitted bacterial infect..

Dietary zinc and the control of Streptococcus pneumoniae infection

Bart A Eijkelkamp, Jacqueline R Morey, Stephanie L Neville, Aimee Tan, Victoria G Pederick, Nerida Cole, Prashina P Singh, Cheryl-Lynn Y Ong, Raquel Gonzalez de Vega, David Clases, Bliss A Cunningham, Catherine E Hughes, Iain Comerford, Erin B Brazel, Jonathan J Whittall, Charles D Plumptre, Shaun R McColl, James C Paton, Alastair G McEwan, Philip A Doble, et al.

Journal article  |  2019  |  PLOS Pathogens

Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

Ian R Monk, Nausad Shaikh, Stephanie L Begg, Mike Gajdiss, Liam KR Sharkey, Jean YH Lee, Sacha J Pidot, Torsten Seemann, Michael Kuiper, Brit Winnen, Rikki Hvorup, Brett M Collins, Gabriele Bierbaum, Saumya R Udagedara, Jacqueline R Morey, Neha Pulyani, Benjamin P Howden, Megan J Maher, Christopher A McDevitt, Glenn F King, et al.

Journal article  |  2019  |  NATURE COMMUNICATIONS

Conformational and dynamic plasticity in substrate-binding proteins underlies selective transport in ABC importers

Marijn de Boer, Giorgos Gouridis, Ruslan Vietrov, Stephanie L Begg, Gea K Schuurman-Wolters, Florence Husada, Nikolaos Eleftheriadis, Bert Poolman, Christopher A McDevit, Thorben Cordes

Journal article  |  2019  |  eLife

The role of metal ions in the virulence and viability of bacterial pathogens

Stephanie L Begg

Journal article  |  2019  |  Biochemical Society Transactions

Identification of Novel Acinetobacter baumannii Host Fatty Acid Stress Adaptation Strategies

Jhih-Hang Jiang, Karl A Hassan, Stephanie L Begg, Thusitha WT Rupasinghe, Varsha Naidu, Victoria G Pederick, Marjan Khorvash, Jonathan J Whittall, James C Paton, Ian T Paulsen, Christopher A McDevitt, Anton Y Peleg, Bart A Eijkelkamp

Journal article  |  2019  |  mBio

Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

Ian Monk, Nausad Shaikh, Stephanie Begg, Mike Gajdiss, Jean Lee, Sacha Pidot, Torsten Seemann, Michael Kuiper, Brit Winnen, Rikki Hvorup, Brett Collins, Gabriele Bierbaum, Benjamin Howden, Christopher McDevitt, Glenn King, Timothy Stinear

Journal article  |  2018

ABSTRACT WalKR (YycFG) is the only essential two-component regulator in the human pathogen Staphylococcus aureus. WalKR regulates ..

Exploring the Use of Structure and Polymer Incorporation to Tune Silver Ion Release and Antibacterial Activity of Silver Coordination Polymers

Rosemary J Young, Stephanie L Begg, Campbell J Coghlan, Christopher A McDevitt, Christopher J Sumby

Journal article  |  2018  |  EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Arachidonic Acid Stress Impacts Pneumococcal Fatty Acid Homeostasis

Bart A Eijkelkamp, Stephanie L Begg, Victoria G Pederick, Claudia Trapetti, Melissa K Gregory, Jonathan J Whittall, James C Paton, Christopher A McDevitt

Journal article  |  2018  |  FRONTIERS IN MICROBIOLOGY

Antimicrobial resistance in healthcare, agriculture and the environment: the biochemistry behind the headlines

Henrietta Venter, Michael L Henningsen, Stephanie L Begg

Book Chapter  |  2017  |  Essays in Biochemistry

Metal ion Toxicity and Oxidative Stress in Streptococcus Pneumoniae

CA McDevitt, SL Begg, JC Paton

Book Chapter  |  2016

Characterizing the conformational dynamics of metal-free PsaA using molecular dynamics simulations and electron paramagnetic resonance spectroscopy

Evelyne Deplazes, Stephanie L Begg, Jessica H van Wonderen, Rebecca Campbell, Bostjan Kobe, James C Paton, Fraser MacMillan, Christopher A McDevitt, Megan L O'Mara

Journal article  |  2015  |  Biophysical Chemistry

ZnuA and zinc homeostasis in Pseudomonas aeruginosa

Victoria G Pederick, Bart A Eijkelkamp, Stephanie L Begg, Miranda P Ween, Lauren J McAllister, James C Paton, Christopher A McDevitt

Journal article  |  2015  |  SCIENTIFIC REPORTS

Discovery of Novel Pneumococcal Surface Antigen A (PsaA) Inhibitors Using a Fragment-based Drug Design Approach

Megha Bajaj, Sreeman K Mamidyala, Johannes Zuegg, Stephanie L Begg, Miranda P Ween, Zhenyao Luo, Johnny X Huang, Alastair G McEwan, Bostjan Kobe, James C Paton, Christopher A McDevitt, Matthew A Cooper

Journal article  |  2015  |  ACS Chemical Biology

Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae

Stephanie L Begg, Bart A Eijkelkamp, Zhenyao Luo, Rafael M Counago, Jacqueline R Morey, Megan J Maher, Cheryl-lynn Y Ong, Alastair G McEwan, Bostjan Kobe, Megan L O'Mara, James C Paton, Christopher A McDevitt

Journal article  |  2015  |  NATURE COMMUNICATIONS

Acquisition and Role of Molybdate in Pseudomonas aeruginosa

Victoria G Pederick, Bart A Eijkelkamp, Miranda P Ween, Stephanie L Begg, James C Paton, Christopher A McDevitt

Journal article  |  2014  |  Applied and Environmental Microbiology

Imperfect coordination chemistry facilitates metal ion release in the Psa permease

Rafael M Counago, Miranda P Ween, Stephanie L Begg, Megha Bajaj, Johannes Zuegg, Megan L O'Mara, Matthew A Cooper, Alastair G McEwan, James C Paton, Bostjan Kobe, Christopher A McDevitt

Journal article  |  2014  |  Nature Chemical Biology