Koen Degeling

Health Economic Evidence for Liquid- and Tissue-based Molecular Tests that Inform Decisions on Prostate Biopsies and Treatment of Localised Prostate Cancer: A Systematic Review

Koen Degeling, Amanda Pereira-Salgado, Niall M Corcoran, Paul C Boutros, Peter Kuhn, Maarten J IJzerman

Journal article  |  2021  |  European Urology Open Science

Context: Several liquid- and tissue-based biomarker tests (LTBTs) are available to inform the need for prostate biopsies and treat..

An inverse stage-shift model to estimate the excess mortality and health economic impact of delayed access to cancer services due to the COVID-19 pandemic

Koen Degeling, Nancy N Baxter, Jon Emery, Mark A Jenkins, Fanny Franchini, Peter Gibbs, G Bruce Mann, Grant McArthur, Benjamin J Solomon, Maarten J IJzerman

Journal article  |  2021  |  Asia-Pacific Journal of Clinical Oncology

AIM: Decreased cancer incidence and reported changes to clinical management indicate that the COVID-19 pandemic has delayed cancer..

Using Metamodeling to Identify the Optimal Strategy for Colorectal Cancer Screening

Hendrik Koffijberg, Koen Degeling, Maarten J IJzerman, Veerle MH Coupe, Marjolein JE Greuter

Journal article  |  2021  |  Value in Health

OBJECTIVES: Metamodeling can address computational challenges within decision-analytic modeling studies evaluating many strategies..

Towards Routine Implementation of Liquid Biopsies in Cancer Management: It Is Always Too Early, until Suddenly It Is Too Late

Maarten J IJzerman, Jasper de Boer, Arun Azad, Koen Degeling, Joel Geoghegan, Chelsee Hewitt, Frederic Hollande, Belinda Lee, Yat Ho To, Richard W Tothill, Gavin Wright, Jeanne Tie, Sarah-Jane Dawson

Journal article  |  2021  |  Diagnostics

Blood-based liquid biopsies are considered a new and promising diagnostic and monitoring tool for cancer. As liquid biopsies only ..

HEADROOM ANALYSIS OF LOW-DOSE CT FOR COMBINATION SCREENING OF LUNG CANCER, CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND CARDIOVASCULAR DISEASE IN THE NETHERLANDS

C Behr, E Koffijberg, K Degeling, M IJzerman

Conference Proceedings  |  2020  |  Value in Health

Evaluating the resource implications of different service delivery models for offering additional genomic findings

Martin Vu, Koen Degeling, Melissa Martyn, Elly Lynch, Belinda Chong, Clara Gaff, Maarten J IJzerman

Journal article  |  2020  |  Genetics in Medicine

PURPOSE: To evaluate the resource implications of different delivery models for the provision of additional findings (AF) in genom..

Simulating Progression-Free and Overall Survival for First-Line Doublet Chemotherapy With or Without Bevacizumab in Metastatic Colorectal Cancer Patients Based on Real-World Registry Data

Koen Degeling, Hui-Li Wong, Hendrik Koffijberg, Azim Jalali, Jeremy Shapiro, Suzanne Kosmider, Rachel Wong, Belinda Lee, Matthew Burge, Jeanne Tie, Desmond Yip, Louise Nott, Adnan Khattak, Stephanie Lim, Susan Caird, Peter Gibbs, Maarten IJzerman

Journal article  |  2020  |  PharmacoEconomics

BACKGROUND: Simulation models utilizing real-world data have potential to optimize treatment sequencing strategies for specific pa..

Evaluation of the performance of algorithms mapping EORTC QLQ-C30 onto the EQ-5D index in a metastatic colorectal cancer cost-effectiveness model

Mira D Franken, Anne de Hond, Koen Degeling, Cornelis JA Punt, Miriam Koopman, Carin A Uyl-de Groot, Matthijs M Versteegh, Martijn GH van Oijen

Journal article  |  2020  |  Health and Quality of Life Outcomes

BACKGROUND: Cost-effectiveness models require quality of life utilities calculated from generic preference-based questionnaires, s..

HEADROOM ANALYSIS OF LUNG CANCER SCREENING WITH LOW-DOSE CT: ASSESSING THE IMPACT OF EXTENDING SCREENING TO ALSO INCLUDE CARDIOVASCULAR DISEASE AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Carina M Behr, Hendrik Koffijberg, Koen Degeling, Maarten IJzerman

Conference Proceedings  |  2020  |  MEDICAL DECISION MAKING

Do assumptions in health economic evaluations hamper drug uptake?

Fanny Franchini, Koen Degeling, Amanda Pereira-Salgado, Ben Tran, George Au-Yeung, Grant A McArthur, Belinda Lee, Benjamin J Solomon, Peter Gibbs, Maarten J IJzerman

Conference Proceedings  |  2020  |  Journal of Clinical Oncology

e19289 Background: Health economic studies of anti-cancer systemic treatments typically make strong assumptions regarding the num..