Koen Degeling

Circulating Tumour DNA as a Potential Cost-Effective Biomarker to Reduce Adjuvant Chemotherapy Overtreatment in Stage II Colorectal Cancer

Yat Hang To, Koen Degeling, Suzanne Kosmider, Rachel Wong, Margaret Lee, Catherine Dunn, Grace Gard, Azim Jalali, Vanessa Wong, Maarten IJzerman, Peter Gibbs, Jeanne Tie

Journal article  |  2021  |  PHARMACOECONOMICS

BACKGROUND AND OBJECTIVE: Substantial adjuvant chemotherapy (AC) overtreatment for stage II colorectal cancer results in a health ..

Comparing survival outcomes for advanced cancer patients who access comprehensive genomic sequencing using a registry-based synthetic control arm.

Sophie O Haire, Koen Degeling, Fanny Franchini, Ben Tran, Stephen James Luen, Kortnye Maureen Smith, Stephen B Fox, Jayesh Desai, Maarten J IJzerman

Conference Proceedings  |  2021  |  Journal of Clinical Oncology

e18851 Background: Studies evaluating the clinical benefit from Comprehensive Genomic Sequencing (CGS) in cancer patients (pts) h..

Health Economic Evidence for Liquid- and Tissue-based Molecular Tests that Inform Decisions on Prostate Biopsies and Treatment of Localised Prostate Cancer: A Systematic Review

Koen Degeling, Amanda Pereira-Salgado, Niall M Corcoran, Paul C Boutros, Peter Kuhn, Maarten J IJzerman

Journal article  |  2021  |  EUROPEAN UROLOGY OPEN SCIENCE

Context: Several liquid- and tissue-based biomarker tests (LTBTs) are available to inform the need for prostate biopsies and treat..

An inverse stage-shift model to estimate the excess mortality and health economic impact of delayed access to cancer services due to the COVID-19 pandemic

Koen Degeling, Nancy N Baxter, Jon Emery, Mark A Jenkins, Fanny Franchini, Peter Gibbs, G Bruce Mann, Grant McArthur, Benjamin J Solomon, Maarten J IJzerman

Journal article  |  2021  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

AIM: Decreased cancer incidence and reported changes to clinical management indicate that the COVID-19 pandemic has delayed cancer..

Using Metamodeling to Identify the Optimal Strategy for Colorectal Cancer Screening

Hendrik Koffijberg, Koen Degeling, Maarten J IJzerman, Veerle MH Coupe, Marjolein JE Greuter

Journal article  |  2021  |  VALUE IN HEALTH

OBJECTIVES: Metamodeling can address computational challenges within decision-analytic modeling studies evaluating many strategies..

Comparing Modeling Approaches for Discrete Event Simulations With Competing Risks Based on Censored Individual Patient Data: A Simulation Study and Illustration in Colorectal Cancer

K Degeling, MJ IJzerman, CGM Groothuis-Oudshoorn, MD Franken, M Koopman, MS Clements, H Koffijberg

Journal article  |  2021  |  Value in Health

Objectives: This study aimed to provide detailed guidance on modeling approaches for implementing competing events in discrete eve..

Lifetime Health and Economic Outcomes of Active Surveillance, Radical Prostatectomy, and Radiotherapy for Favorable-Risk Localized Prostate Cancer

K Degeling, NM Corcoran, A Pereira-Salgado, AA Hamid, S Siva, MJ IJzerman

Journal article  |  2021  |  Value in Health

Objectives: To estimate the lifetime health and economic outcomes of selecting active surveillance (AS), radical prostatectomy (RP..

Towards Routine Implementation of Liquid Biopsies in Cancer Management: It Is Always Too Early, until Suddenly It Is Too Late

Maarten J IJzerman, Jasper de Boer, Arun Azad, Koen Degeling, Joel Geoghegan, Chelsee Hewitt, Frederic Hollande, Belinda Lee, Yat Ho To, Richard W Tothill, Gavin Wright, Jeanne Tie, Sarah-Jane Dawson

Journal article  |  2021  |  DIAGNOSTICS

Blood-based liquid biopsies are considered a new and promising diagnostic and monitoring tool for cancer. As liquid biopsies only ..

HEADROOM ANALYSIS OF LOW-DOSE CT FOR COMBINATION SCREENING OF LUNG CANCER, CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND CARDIOVASCULAR DISEASE IN THE NETHERLANDS

C Behr, E Koffijberg, K Degeling, M IJzerman

Conference Proceedings  |  2020  |  VALUE IN HEALTH

Evaluating the resource implications of different service delivery models for offering additional genomic findings

Martin Vu, Koen Degeling, Melissa Martyn, Elly Lynch, Belinda Chong, Clara Gaff, Maarten J IJzerman

Journal article  |  2020  |  GENETICS IN MEDICINE

PURPOSE: To evaluate the resource implications of different delivery models for the provision of additional findings (AF) in genom..