Megha Rajasekhar

Quantification of parasite clearance in Plasmodium knowlesi infections.

Jeyamalar T Thurai Rathnam, Matthew J Grigg, Saber Dini, Timothy William, Sitti Saimah Sakam, Daniel J Cooper, Giri S Rajahram, Bridget E Barber, Nicholas M Anstey, Ali Haghiri, Megha Rajasekhar, Julie A Simpson

Journal article  |  2023  |  Malar J

BACKGROUND: The incidence of zoonotic Plasmodium knowlesi infections in humans is rising in Southeast Asia, leading to clinical st..

Reducing the risk of Plasmodium vivax after falciparum infections in co-endemic areas-a randomized controlled trial (PRIMA).

Kamala Thriemer, Tamiru Shibru Degaga, Michael Christian, Mohammad Shafiul Alam, Benedikt Ley, Mohammad Sharif Hossain, Mohammad Golam Kibria, Tedla Teferi Tego, Dagimawie Tadesse Abate, Sophie Weston, Amalia Karahalios, Megha Rajasekhar, Julie A Simpson, Angela Rumaseb, Hellen Mnjala, Grant Lee, Rodas Temesgen Anose, Fitsum Getahun Kidane, Adugna Woyessa, Kevin Baird, et al.

Journal article  |  2022  |  Trials

BACKGROUND: Plasmodium vivax forms dormant liver stages that can reactivate weeks or months following an acute infection. Recurren..

miR-155-overexpressing monocytes resemble HLAhighISG15 synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4 T-cell activation.

Anton M Olsson, Giovanni AM Povoleri, Domenico Somma, Michael L Ridley, Tatiana Rizou, Sylvine Lalnunhlimi, Lucy Macdonald, Megha Rajasekhar, Rocio T Martinez-Nunez, Mariola Kurowska-Stolarska, Leonie S Taams

Journal article  |  2022  |  Clin Exp Immunol

MicroRNAs (miRs) are known to regulate pro-inflammatory effector functions of myeloid cells, and miR dysregulation is implicated i..

Are cause of death data for Shanghai fit for purpose? A retrospective study of medical records

Lei Chen, Tian Xia, Zheng-An Yuan, Rasika Rampatige, Jun Chen, Hang Li, Timothy Adair, Hui-Ting Yu, Martin Bratschi, Philip Setel, Megha Rajasekhar, HR Chowdhury, Saman Hattotuwa Gamage, Bo Fang, Omair Azam, Romain Santon, Zhen Gu, Ziwen Tan, Chunfang Wang, Alan D Lopez, et al.

Journal article  |  2022  |  BMJ OPEN

OBJECTIVES: To assess the quality of cause of death reporting in Shanghai for both hospital and home deaths. DESIGN AND SETTING: M..

Where there is no hospital: improving the notification of community deaths.

Tim Adair, Megha Rajasekhar, Khin Sandar Bo, John Hart, Viola Kwa, Md Ashfaqul Amin Mukut, Matthew Reeve, Nicola Richards, Margarita Ronderos-Torres, Don de Savigny, Daniel Cobos Muñoz, Alan D Lopez

Journal article  |  2020  |  BMC Medicine

BACKGROUND: Globally, an estimated two-thirds of all deaths occur in the community, the majority of which are not attended by a ph..

Addressing critical knowledge and capacity gaps to sustain CRVS system development

Tim Adair, Nicola Richards, Avita Streatfield, Megha Rajasekhar, Deirdre McLaughlin, Alan D Lopez

Journal article  |  2020  |  BMC MEDICINE

BACKGROUND: Improving civil registration and vital statistics (CRVS) systems requires strengthening the capacity of the CRVS workf..

Identifying microRNA determinants of human myelopoiesis

Megha Rajasekhar, Ulf Schmitz, Stephane Flamant, Justin J-L Wong, Charles G Bailey, William Ritchie, Jeff Holst, John EJ Rasko

Journal article  |  2018  |  SCIENTIFIC REPORTS

Myelopoiesis involves differentiation of hematopoietic stem cells to cellular populations that are restricted in their self-renewa..

MicroRNA-155 contributes to enhanced resistance to apoptosis in monocytes from patients with rheumatoid arthritis

Megha Rajasekhar, Anton M Olsson, Kathryn JA Steel, Mirella Georgouli, Ushan Ranasinghe, Christine Brender Read, Klaus S Frederiksen, Leonie S Taams

Journal article  |  2017  |  JOURNAL OF AUTOIMMUNITY

Monocytes and macrophages are key mediators of inflammation in rheumatoid arthritis (RA). Their persistence at the inflammatory si..

Phenotypic, Functional, and Gene Expression Profiling of Peripheral CD45RA and CD45RO CD4 CD25 CD127(low) Treg Cells in Patients With Chronic Rheumatoid Arthritis

Gina J Walter, Veerle Fleskens, Klaus S Frederiksen, Megha Rajasekhar, Bina Menon, Jens G Gerwien, Hayley G Evans, Leonie S Taams

Journal article  |  2016  |  ARTHRITIS & RHEUMATOLOGY

OBJECTIVE: Conflicting evidence exists regarding the suppressive capacity of Treg cells in the peripheral blood (PB) of patients w..

Mass administration of azithromycin and Streptococcus pneumoniae carriage: cross-Sectional surveys in the Gambia

Sarah E Burr, Sally Milne, James Jafali, Ebrima Bojang, Megha Rajasekhar, John Hart, Emma M Harding-Esch, Martin J Holland, David CW Mabey, Ansumana Sillah, Robin L Bailey, Anna Roca

Journal article  |  2014  |  BULLETIN OF THE WORLD HEALTH ORGANIZATION

OBJECTIVE: To evaluate the effect of repeated mass drug administration (MDA) of azithromycin in the Gambia on the nasopharyngeal c..