My group sits at the intersection of genomics and neuroscience, utilising a number of genomic approaches (RNA-Seq, long-read sequencing, targeted RNA sequencing and single cell sequencing) to investigate gene expression and function in the human brain and in neuropsychiatric disorders. Many regions in our DNA are known to confer risk to disease, including neuropsychiatric disorders, but the genes responsible and how they confer risk are often unknown.
We are interested in identifying these genes (both protein coding and noncoding) and how their expression can change to cause disease risk. We utilise both post-mortem human brain and neurons derived from induced pluripotent stem cells (iPSCs) to help answer these questions.
A second research interest of my group is to develop and utilise novel sequencing methods. We have worked in the past to help develop targeted RNA sequencing to allow highly sensitive detection and quantification of genes of interest. More recently we have focused on utilising Nanopore sequencing, a technology that can sequence both DNA and native RNA. We are very interested in applying Nanopore sequencing to many research questions and in developing novel applications for this technology.
In addition I have long-standing interests in multiple aspects of RNA biology including noncoding RNAs and RNA post-transcriptional regulation.
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Mike Clark's selected work
Elucidating The Pathological Role And Predictive Value Of Mental Health Disorder Risk Gene..
Elucidating The Expression And Splicing Of Neuropsychiatric Disease Genes In Human Brain W..
Displaying the 4 most recent projects by Mike Clark.
Displaying the 25 most recent scholarly works by Mike Clark.
Long-read sequencing reveals the complex splicing profile of the psychiatric risk gene CACNA1C in human brain
Michael B Clark, Tomasz Wrzesinski, Aintzane B Garcia, Nicola AL Hall, Joel E Kleinman, Thomas Hyde, Daniel R Weinberger, Paul J Harrison, Wilfried Haerty, Elizabeth M Tunbridge
Journal article | 2019 | Molecular Psychiatry
RNA splicing is a key mechanism linking genetic variation with psychiatric disorders. Splicing profiles are particularly diverse i..
Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage
Joshua A Betts, Mahdi Moradi Marjaneh, Fares Al-Ejeh, Yi Chieh Lim, Wei Shi, Haran Sivakumaran, Romain Tropee, Ann-Marie Patch, Michael B Clark, Nenad Bartonicek, Adrian P Wiegmans, Kristine M Hillman, Susanne Kaufmann, Amanda L Bain, Brian S Gloss, Joanna Crawford, Stephen Kazakoff, Shivangi Wani, Shu W Wen, Bryan Day, et al.
Journal article | 2017 | The American Journal of Human Genetics
RNAcentral: a comprehensive database of non-coding RNA sequences
Anton I Petrov, Simon JE Kay, Ioanna Kalvari, Kevin L Howe, Kristian A Gray, Elspeth A Bruford, Paul J Kersey, Guy Cochrane, Robert D Finn, Alex Bateman, Ana Kozomara, Sam Griffiths-Jones, Adam Frankish, Christian W Zwieb, Britney Y Lau, Kelly P Williams, Patricia P Chan, Todd M Lowe, Jamie J Cannone, Robin R Gutell, et al.
Journal article | 2017 | Nucleic Acids Research
Quantitative gene profiling of long noncoding RNAs with targeted RNA sequencing
Michael B Clark, Tim R Mercer, Giovanni Bussotti, Tommaso Leonardi, Katelin R Haynes, Joanna Crawford, Marion E Brunck, Kim-Anh Le Cao, Gethin P Thomas, Wendy Y Chen, Ryan J Taft, Lars K Nielsen, Anton J Enright, John S Mattick, Marcel E Dinger
Journal article | 2015 | Nature Methods
RNAcentral: an international database of ncRNA sequences
Anton I Petrov, Simon JE Kay, Richard Gibson, Eugene Kulesha, Dan Staines, Elspeth A Bruford, Mathew W Wright, Sarah Burge, Robert D Finn, Paul J Kersey, Guy Cochrane, Alex Bateman, Sam Griffiths-Jones, Jennifer Harrow, Patricia P Chan, Todd M Lowe, Christian W Zwieb, Jacek Wower, Kelly P Williams, Corey M Hudson, et al.
Journal article | 2015 | Nucleic Acids Research
RNAcentral: An international database of ncRNA sequences
AI Petrov, SJE Kay, R Gibson, E Kulesha, D Staines, EA Bruford, MW Wright, S Burge, RD Finn, PJ Kersey, G Cochrane, A Bateman, S Griffiths-Jones, J Harrow, PP Chan, TM Lowe, CW Zwieb, J Wower, KP Williams, CM Hudson, et al.
Journal article | 2015 | Nucleic Acids Research
DNase I-hypersensitive exons colocalize with promoters and distal regulatory elements
Tim R Mercer, Stacey L Edwards, Michael B Clark, Shane J Neph, Hao Wang, Andrew B Stergachis, Sam John, Richard Sandstrom, Guoliang Li, Kuljeet S Sandhu, Yijun Ruan, Lars K Nielsen, John S Mattick, John A Stamatoyannopoulos
Journal article | 2013 | Nature Genetics
Pinstripe: a suite of programs for integrating transcriptomic and proteomic datasets identifies novel proteins and improves differentiation of protein-coding and non-coding genes
Dennis K Gascoigne, Seth W Cheetham, Pierre B Cattenoz, Michael B Clark, Paulo P Amaral, Ryan J Taft, Dagmar Wilhelm, Marcel E Dinger, John S Mattick
Journal article | 2012 | Bioinformatics
The Reality of Pervasive Transcription
Michael B Clark, Paulo P Amaral, Felix J Schlesinger, Marcel E Dinger, Ryan J Taft, John L Rinn, Chris P Ponting, Peter F Stadler, Kevin V Morris, Antonin Morillon, Joel S Rozowsky, Mark B Gerstein, Claes Wahlestedt, Yoshihide Hayashizaki, Piero Carninci, Thomas R Gingeras, John S Mattick
Journal article | 2011 | PLoS Biology
SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer
Marjan E Askarian-Amiri, Joanna Crawford, Juliet D French, Chanel E Smart, Martin A Smith, Michael B Clark, Kelin Ru, Tim R Mercer, Ella R Thompson, Sunil R Lakhani, Ana C Vargas, Ian G Campbell, Melissa A Brown, Marcel E Dinger, John S Mattick
Journal article | 2011 | RNA
The long and the short of it: unlocking nanopore long-read RNA sequencing data with short-read tools
Xueyi Dong, Luyi Tian, Quentin Gouil, Hasaru Kariyawasam, Shian Su, Ricardo De Paoli-Iseppi, Yair David Joseph Prawer, Michael B Clark, Kelsey Breslin, Megan Iminitoff, Marnie E Blewitt, Charity W Law, Matthew E Ritchie
Application of Oxford Nanopore Technologies' long-read sequencing platform to transcriptomic analysis is increasing in popularity...
RNA sequencing identifies a cryptic exon caused by a deep intronic variant in NDUFB10 resulting in isolated Complex I deficiency.
Guy Helman, Alison G Compton, Daniella H Hock, Marzena Walkiewicz, Gemma R Brett, Lynn Pais, Tiong Y Tan, Ricardo De Paoli-Iseppi, Michael B Clark, John Christodoulou, Susan M White, David R Thorburn, David A Stroud, Zornitza Stark, Cas Simons
The diagnosis of mitochondrial disorders remains a challenging and often unmet need. We sought to investigate a sibling pair with ..
Honours, Awards and Fellowships
Research Fellow In Transriptomics
Anatomy And Neuroscience
Genomics and Computational Biology
The University of Queensland
University of Otago
University of Otago