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Dr

Mike Clark

Research Fellow In Transriptomics
Anatomy And Neuroscience
Risk genes for neuropsychiatric disorders
Nanopore sequencing
Gene Expression
Mental Health
RNA-seq
Splicing
lncRNAs
Genomics
Bioinformatics
Mike Clark's Profile Picture
Dr

Mike Clark

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Neurogenetics
Mike Clark's Profile Picture
Dr

Mike Clark

 

My group sits at the intersection of genomics and neuroscience, utilising a number of genomic approaches (RNA-Seq, long-read sequencing, targeted RNA sequencing and single cell sequencing) to investigate gene expression and function in the human brain and in neuropsychiatric disorders. Many regions in our DNA are known to confer risk to disease, including neuropsychiatric disorders, but the genes responsible and how they confer risk are often unknown.

We are interested in identifying these genes (both protein coding and noncoding) and how their expression can change to cause disease risk. We utilise both post-mortem human brain and neurons derived from induced pluripotent stem cells (iPSCs) to help answer these questions.


A second research interest of my group is to develop and utilise novel sequencing methods. We have worked in the past to help develop targeted RNA sequencing to allow highly sensitive detection and quantification of genes of interest. More recently we have focused on utilising Nanopore sequencing, a technology that can sequence both DNA and native RNA. We are very interested in applying Nanopore sequencing to many research questions and in developing novel applications for this technology.


In addition I have long-standing interests in multiple aspects of RNA biology including noncoding RNAs and RNA post-transcriptional regulation.

Scholarly Works

Displaying the 25 most recent scholarly works by Mike Clark.

Honours, Awards and Fellowships

2013

EMBO Long Term Fellowship

2013

CJ Martin Biomedical Fellowship

2013

Australian RNA Special Interest Group Young Investigator Award

2012

Dean's Award for Research Higher Degree Excellence

4

Awards

Credentials

Positions


Research Fellow In Transriptomics

Anatomy And Neuroscience

Education


Genomics and Computational Biology

The University of Queensland

Biochemistry

University of Otago

Biochemistry

University of Otago