Alexander Barrow

A Transcriptional Signature of PDGF-DD Activated Natural Killer Cells Predicts More Favorable Prognosis in Low-Grade Glioma

Yuhan Sun, Alexander James Sedgwick, Yaseelan Palarasah, Stefano Mangiola, Alexander David Barrow

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

The binding of platelet-derived growth factor D (PDGF-DD) to the NKp44 receptor activates a distinct transcriptional program in pr..

Sialic acid-binding immunoglobulin-like lectin (Sigelac)-15 is a rapidly internalised cell-surface antigen expressed by acute myeloid leukaemia cells.

Huan Cao, Andreas Neerincx, Bernard de Bono, Ursula Lakner, Catherine Huntington, John Elvin, Emma Gudgin, Clare Pridans, Mark A Vickers, Brian Huntly, John Trowsdale, Alexander D Barrow

Journal article  |  2021  |  Br J Haematol

Sialic acid-binding immunoglobulin-like lectin (Siglec)-15 has recently been identified as a critical tumour checkpoint, augmentin..

Toward precision immunotherapy using multiplex immunohistochemistry and in silico methods to define the tumor immune microenvironment

Samuel S Widodo, Ryan A Hutchinson, Yitong Fang, Stefano Mangiola, Paul J Neeson, Phillip K Darcy, Alexander D Barrow, Christopher M Hovens, Marija Dinevska, Stanley S Stylli, Theo Mantamadiotis

Journal article  |  2021  |  CANCER IMMUNOLOGY IMMUNOTHERAPY

Recent developments in cancer immunotherapy promise better outcomes for cancer patients, although clinical trials for difficult to..

The Role of NK Cells and Innate Lymphoid Cells in Brain Cancer

Alexander James Sedgwick, Nazanin Ghazanfari, Patrick Constantinescu, Theo Mantamadiotis, Alexander David Barrow

Journal article  |  2020  |  FRONTIERS IN IMMUNOLOGY

The brain is considered an immune privileged site due to the high selectivity of the blood-brain barrier which restricts the passa..

The Natural Cytotoxicity Receptors in Health and Disease

Alexander David Barrow, Claudia Jane Martin, Marco Colonna

Journal article  |  2019  |  FRONTIERS IN IMMUNOLOGY

The Natural Cytotoxicity Receptors (NCRs), NKp46, NKp44, and NKp30, were some of the first human activating Natural Killer (NK) ce..

Innate lymphoid cell sensing of tissue vitality

Alexander David Barrow, Marco Colonna

Journal article  |  2019  |  CURRENT OPINION IN IMMUNOLOGY

Innate lymphoid cells (ILCs) constitute a heterogeneous population of cytokine-secreting cells that colonize different tissues and..

Exploiting NK Cell Surveillance Pathways for Cancer Therapy

Alexander David Barrow, Marco Colonna

Journal article  |  2019  |  CANCERS

Natural killer (NK) cells can evoke potent anti-tumour activity. This function is largely mediated through a battery of specialise..

Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor

Alexander D Barrow, Melissa A Edeling, Vladimir Trifonov, Jingqin Luo, Piyush Goyal, Benjamin Bohl, Jennifer K Bando, Albert H Kim, John Walker, Mary Andahazy, Mattia Bugatti, Laura Melocchi, William Vermi, Daved H Fremont, Sarah Cox, Marina Cella, Christian Schmedt, Marco Colonna

Journal article  |  2018  |  CELL

Many tumors produce platelet-derived growth factor (PDGF)-DD, which promotes cellular proliferation, epithelial-mesenchymal transi..

Jak3 deficiency blocks innate lymphoid cell development

ML Robinette, M Cella, JB Telliez, TK Ulland, AD Barrow, K Capuder, S Gilfillan, L-L Lin, LD Notarangelo, M Colonna

Journal article  |  2018  |  MUCOSAL IMMUNOLOGY

Loss-of-function mutations in the tyrosine kinase JAK3 cause autosomal recessive severe combined immunodeficiency (SCID). Defects ..

Tailoring Natural Killer cell immunotherapy to the tumour microenvironment

Alexander David Barrow, Marco Colonna

Journal article  |  2017  |  SEMINARS IN IMMUNOLOGY

Natural killer (NK) cells are cytotoxic and cytokine-secreting cells that can mediate potent anti-tumour activity. Accumulating ev..